2YZQ


Conserved Protein Domain Family
CBS_pair_arch2_repeat2

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cd04614: CBS_pair_arch2_repeat2 
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Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains present in archaea, repeat 2
This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains found in Inosine monophosphate (IMP) dehydrogenases and related proteins including IMP dehydrogenase IX from Methanothermobacter. IMP dehydrogenase is an essential enzyme in the de novo biosynthesis of Guanosine monophosphate (GMP), catalyzing the NAD-dependent oxidation of IMP to xanthosine monophosphate (XMP). The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called Bateman domain or a CBS pair based on crystallographic studies in bacteria. The CBS pair was used as a basis for this cd hierarchy since the human CBS proteins can adopt the typical core structure and form an intramolecular CBS pair. The interface between the two CBS domains forms a cleft that is a potential ligand binding site. The CBS pair coexists with a variety of other functional domains and this has been used to help in its classification here. It has been proposed that the CBS domain may play a regulatory role, although its exact function is unknown. Mutations of conserved residues within this domain are associated with a variety of human hereditary diseases, including congenital myotonia, idiopathic generalized epilepsy, hypercalciuric nephrolithiasis, and classic Bartter syndrome (CLC chloride channel family members), Wolff-Parkinson-White syndrome (gamma 2 subunit of AMP-activated protein kinase), retinitis pigmentosa (IMP dehydrogenase-1), and homocystinuria (cystathionine beta-synthase).
Statistics
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PSSM-Id: 341386
View PSSM: cd04614
Aligned: 18 rows
Threshold Bit Score: 175.545
Threshold Setting Gi: 160286268
Created: 28-Nov-2006
Updated: 31-Jul-2017
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 17 residues -Click on image for an interactive view with Cn3D
Feature 1:SAM binding site [chemical binding site]
Evidence:
  • Structure:2YZQ; Pyrococcus horikoshii conserved protein, with bound SAM, contacts 4A
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                #             # # ##  #                              
2YZQ_A    131 YYQRYVSIVWEgTPLKAALKALLlsnsMALPVVDsegNLVGIVDeTDLLRDSEivrimks--telaassEEEWILEshpt 208 Pyrococcus horikoshii
CBH37297  134 YIGDNTMAVWDdMPLSVVGRIMElarvKAAPVLNlelELVGLITdLDLINVVViedtteqs-dlslgsdEDAWTWEgmrd 212 uncultured archaeon
AET64369  129 YFEKMTVALWDeMPLPVAGAVMEyanvQASPVIDselKLVGIVSdRDLINASViedsvems-dmssandEDEWTWEstrd 207 Methanosaeta harun...
KCZ72245  135 YVASGVVAVWSdTPILVAGAIMDladvKAVPILDsnlALLGVASdKDLIGASAiedrtevs-nmsagsdDDAWTWEslrd 213 Candidatus Methano...
ADI73042  130 YLNGGLVPVWDeTPLPVVAKIMEfsnvNVSPVLDkslGFVGLISdRDIISASIiedsvevsdmsataedEDEWTWEsird 209 Methanohalobium ev...
ERG88587  137 VAGQEVNCVYAeTPLPVGEQQLSfagvPYAVVLDeaaKPTGMLTeEDVIAVARvvegeddt-gesianqDSEWSWEgika 215 halophilic archaeo...
AGN01065  132 IATRSVITAYQgTPLAVAERQLFhadmPYAVVLDdegGMAGVFTeQDVIEVAEvvegetkt-gnsfadqDDDWMWEgikg 210 Salinarchaeum sp. ...
ESP89537  136 VAGDEVNTVYVgTPLTVTERQLYfarvPYAIALDe-eGMAGMVTeVDIVDVARvvegaddt-gdsiadeDDDWKWEgikg 213 Candidatus Halobon...
AEN06609  134 ICRDDINATYEgTPLPVAEREIGlanvPYTIALDdegEMSGVLTeADIVDVARvveseedt-gasmasdDEDWKWEsiks 212 halophilic archaeo...
ERH10886  132 VASEAVNCVYAeTPLTVAERELShagvPYAVVLDd-eGTTGILTeVDILAVARvvegetet-gesianqDDEWAWEgika 209 halophilic archaeo...
Feature 1                           #   ###                 #######                    
2YZQ_A    209 llfek---felqlpnkpVAEIMTr--DVIVATPHMTVHEVALKMAKYSIEQLPVIRgegDLIGLIRDFDLLKV 276 Pyrococcus horikoshii
CBH37297  213 tmrlyydvskiklpdklVKDVLVk--DVITVTRNSEVSDCAKKMSENKFDQLPVISargKLTGMLIDRDLLRV 283 uncultured archaeon
AET64369  208 tlnfyygvsrislrkipVKQAMV---PAVTAIKTSEVSECARVMMRKGIDQLPVVTahqKLAGMLKDSDLLWA 277 Methanosaeta harundinacea...
KCZ72245  214 tmnlyysiskiklpdtpVRDILKhigEPETAVLSSQVSDCARKMRRNRVDQLPVISserKLLGLLRDKDLLKS 286 Candidatus Methanopereden...
ADI73042  210 tmsiyysvsrikapnvaTSEIMVt--DLITATPMSGVSECALSMKRHDIDQIPVINgngDLLGLLRDRDLLKA 280 Methanohalobium evestigat...
ERG88587  216 vgnsylptrnveipaspVAEFMTp--ELVTVGTHRTVRAAAQLLIQHKIEQLPMVSa-dHLEGIVQDMHLLEA 285 halophilic archaeon J07HX5
AGN01065  211 vgsrsvttrdvelpegtVADFMTg--DVVTISQSKTAQDAAQAMITHDVEQIPLVSg-gDLAGIVRDVDLLAA 280 Salinarchaeum sp. Harcht-...
ESP89537  214 vgsayiptrnveipvepVSEFMTe--EVVTVSKTRSVTEVAQEMISNDIEQVPLVTg-gDVAGIVRDVHVVAA 283 Candidatus Halobonum tyrr...
AEN06609  213 vgnryistrnvefpikpVSTFMTe--DVVSISRSKTAQDAAKLMINNDIEQIPVLGg-gELGGVVRDTHLLEA 282 halophilic archaeon DL31
ERH10886  210 vgnsymptrnveipdesVSAFMTg--DIVSISGSLPVAEAAKLMIEHGIEQIPMMEg-nSLAGIVQDIHLLEA 279 halophilic archaeon J07HX64

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