1YTF,1JFI,1VOK,1YTB


Conserved Protein Domain Family
TBP_eukaryotes

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cd04516: TBP_eukaryotes 
Click on image for an interactive view with Cn3D
eukaryotic TATA box binding protein (TBP): Present in archaea and eukaryotes, TBPs are transcription factors that recognize promoters and initiate transcription. TBP has been shown to be an essential component of three different transcription initiation complexes: SL1, TFIID and TFIIIB, directing transcription by RNA polymerases I, II and III, respectively. TBP binds directly to the TATA box promoter element, where it nucleates polymerase assembly, thus defining the transcription start site. TBP's binding in the minor groove induces a dramatic DNA bending while its own structure barely changes. The conserved core domain of TBP, which binds to the TATA box, has a bipartite structure, with intramolecular symmetry generating a saddle-shaped structure that sits astride the DNA.
Statistics
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PSSM-Id: 239952
Aligned: 33 rows
Threshold Bit Score: 244.436
Created: 1-Nov-2006
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 23 residues -Click on image for an interactive view with Cn3D
Feature 1:DNA interaction surface [nucleic acid binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1         ## #                                    ##   # #      # #   # # # #         
1YTF_A      4 VPTLQNIVATVTLGc----------RLDLKTVALhaRNAEYNpkRFAAVIMRIREPKTTALIFASGKMVVTGAKSEDDSK 73  baker's yeast
1YTB_A      4 VPTLQNIVATVTLGc----------RLDLKTVALhaRNAEYNpkRFAAVIMRIREPKTTALIFASGKMVVTGAKSEDDSK 73  baker's yeast
11136      48 EIRLQNIVATFSVNc----------ELDLKAINSrtRNSEYSpkRFRGVIMRMHSPRCTALIFRTGKVICTGARNEIEAD 117 fruit fly
417904     49 SLNIHNIISSANLCi----------DINLRLVAVsiRNAEYNpsKINTLIIRLNKPQCTALIFKNGRIMLTGTRTKKDSI 118 malaria parasite P...
3915894    53 HPEIVNVVSTFQLGv----------KLELRKIVQkaRNAEYNpkRFAGAIMRISSPKSTALIFQTGKIVCTGTRSIEESK 122 Entamoeba histolytica
XP_627107  69 TPEIQNIIASVHLQc----------ELDLRMIAIsaRNAEYNpkKVNAVVMRLRDPKCTGLLFRSGRLMITGARLENDAK 138 Cryptosporidium pa...
XP_654935  38 KPVIQNIVATVELDc----------TINLQDVVRrvRNAEYNpkRFGALIIRITNPKTTALVFHSGKLVVTGGKTVDDSR 107 Entamoeba histolyt...
AAX26791   50 KPVIHNMVSTVDLGc----------PIELRKLVLhvRSAEYNprRFPGVVIRLREPRVTCLVFGTGRMVCTGARSEADAN 119 Schistosoma japonicum
XP_954156  43 IPVVQNIVASVHLGe----------ELDLREIAIstRNAEYNprKFNALVLRMQNPKCTGLIFRTGRIIITGSKTIEDAK 112 Theileria annulata...
EAR92317   13 TPKIQNVVATIKMIrqdgnsskqkqTFDLQEIAQkcRNTQYNpkRFPAVFMRIKDPKATGLIYSSGNMTIVGTRSTNESQ 92  Tetrahymena thermo...
Feature 1                            #    # #                              ##    #            
1YTF_A     74 LASRKYARIIQKIGFaa---kfTDFKIQNIVGSCDVKFPIRLEGLAFShg--tfSSYEPElFPGLIYRMVk--------P 140 baker's yeast
1YTB_A     74 LASRKYARIIQKIGFaa---kfTDFKIQNIVGSCDVKFPIRLEGLAFShg--tfSSYEPElFPGLIYRMVk--------P 140 baker's yeast
11136     118 IGSRKFARILQKLGFpv---kfMEYKLQNIVATVDLRFPIRLENLNHVhg--qfSSYEPEmFPGLIYRMVk--------P 184 fruit fly
417904    119 MGCKKIAKIIKIVTKdkv--kfCNFKIENIIASANCNIPIRLEVLAHDhk--eyCNYEPElFAGLVYRYKpt-----snL 189 malaria parasite P...
3915894   123 IASKKYAKIIKKIGYpi---hySNFNVQNIVGSCDVKFQIALRTLVDSyl--afCQYEPEvFPGLVYRMAs--------P 189 Entamoeba histolytica
XP_627107 139 LGGKKMAKICQKSGFpkv--kfTNFKMENIIATADCKFPIRLEGLAYDhr--dfCNYEPElFPGLVYRYHpdn----spT 210 Cryptosporidium pa...
XP_654935 108 LAGRKYARILQRLGYnv---kfNHFKIQNVVASCDMKFAISLKELIQLap--kiTKYEPEiFPGVVYRLAd--------P 174 Entamoeba histolyt...
AAX26791  120 LGSRKCARIIQKLGFdv---kfMNFTIQNMVGLADLRFPVRLEGVQLAne--qmTQYEPEiFPALIYRIIk--------P 186 Schistosoma japonicum
XP_954156 113 LGGKRMAKMIRKETGldl--kfNNFKIENIIATFSCNVPIRLEVFSQEhk--dlCNYEPEfFAGLVYRCRin-----eeS 183 Theileria annulata...
EAR92317   93 TAAERIFGIIKKQLNvdcrfenKEVQVRNIVASCKLGYPVCLDKIHDDkdhkqfSTYDDT-FPGLIYRYMlnpgeqkkkN 171 Tetrahymena thermo...
Feature 1           # # #   #                      
1YTF_A    141 KIVLLIFVSGKIVLTGAKqREEIYQAFEAIYPVLSEF 177 baker's yeast
1YTB_A    141 KIVLLIFVSGKIVLTGAKqREEIYQAFEAIYPVLSEF 177 baker's yeast
11136     185 RIVLLIFVNGKVVFTGAKsRKDIMDCLEAISPILLSF 221 fruit fly
417904    190 KSVILIFVSGKIIITGCKsVNKLYTVFQDIYNVLIQY 226 malaria parasite P. falciparum
3915894   190 KVTLLVFSTGKVVLTGAKdEESLNLAYKNIYPILLAN 226 Entamoeba histolytica
XP_627107 211 KAVLLLFVSGKVIVTGCKnYQEICNVFDNIYPVLCQY 247 Cryptosporidium parvum Iowa II
XP_654935 175 KMVLLIFASGKIVFTGGKeIEQINKAFSEIYKILLQV 211 Entamoeba histolytica HM-1:IMSS
AAX26791  187 RLVMLIFVNGKVVMTGAKsREHLYEALNNVYPILYNY 223 Schistosoma japonicum
XP_954156 184 EAVLLIFVSGNVIITGCKsPQEIQYVFKIMYPILHQY 220 Theileria annulata strain Ankara
EAR92317  172 NIIALVFASGKMVFTGAKsQEDIQQAYDKIKPEFVAF 208 Tetrahymena thermophila SB210

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