Conserved Protein Domain Family
MDH_1B

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cd04510: MDH_1B (this model, PSSM-Id:58495 is obsolete)
malate dehydrogenases (MDH) cytoplasmic and cytosolic, isozyme B; member of the family of NAD-dependent 2-hydroxycarboxylate dehydrogenases. MDH is one of the key enzymes in the citric acid cycle, facilitating both the conversion of malate to oxaloacetate and replenishing levels of oxalacetate by reductive carboxylation of pyruvate. Members of this cd are localized to the cytoplasm and cytosol.
Statistics
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PSSM-Id: 58495
View PSSM: cd04510
Aligned: 5 rows
Threshold Bit Score: -1
Threshold Setting Gi: 0
Created: 27-Oct-2006
Updated: 30-Oct-2006
Structure
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Aligned Rows:
 
Feature 1:NAD binding site
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                        
NP_001034934 131 PLQVWITSASAPACYNLIPILTSGEVFgmhteiSITLFDNKqaeeHLKSLVVETQDLASPvlRSVSICTkveEAFRQAHV 210 human
XP_421952    131 PLQIWITSASAPTCYQLIPLLASGDVFgmtteiSIHLLDAVqfkeCLSGIVMEAEDMAFPllRSISAHTevdKAFLQADV 210 chicken
XP_692742    131 PLHIWISSALNPVCYSLIPHLFTPGLFsglpifSLHLMDTSgseeMLQALKMETVDLAIPrlHEVTIHSdqmLAFQEAHF 210 zebrafish
XP_001201789 125 PLQVCITNSSSPIAYHMVNEIARGDVLghdnevSIRLLTKPedkdYVEGQCMEVFDLACPllRGVKVYTdatAALTGVHV 204 purple urchin
AAM18871     131 PLHVCVINAARSPAYHVLPSLVNGKILree-eiALHLHDSEenleKLKGLEMEVFDLSFPflKEISVTTdlpTAFQNAHI 209 Florida lancelet
Feature 1                                                                                        
NP_001034934 211 IVVLDDSTNKEVFT--LEDCLRSRVPLCRLYGYLIEknaheSVRVIVGGRTFVNLKTVLLMRYAP-RIAHNIIAVALGVE 287 human
XP_421952    211 IIVLDDILLKRGTLt-LENCIRTVSEICQVYAPLIEknaksGVRIISTGKTFVNLKAMMIITYGPsIKPENVIAVATSWE 289 chicken
XP_692742    211 IIFLDDQQPAGEYNd-EQNDKDQVAEHFHRYGQLIEtnaqkDVRVLVAGDFFINMKCSLLIENAPsIDPRNFVAMTTQLE 289 zebrafish
XP_001201789 205 AVFLDEFCLMEEENakLGGVSQEGCAQFALYGRILNqyaeqDVKVLIGGRGKLNFSALMLKHNAPrIARQNIIITPRLQE 284 purple urchin
AAM18871     210 AIVLDDFDQGGKED--AIGDMETKVSFYKRVAEAINqtaskDIRVLVAGTGPLNSLVSILIDHTPsIPRQNIAAVAQVKE 287 Florida lancelet
Feature 1                                  #                                                     
NP_001034934 288 GEAKAILARKLKTAPSYIKDVIIWGNISGNNYVDLRKTRVYRYESAIWGPLHYsr-----pvLNLIFDSEWVKREFVAIL 362 human
XP_421952    290 SAAKAMLARKLNMNTAGVKDVIVWGNVTGCTYIDLSHAKLYRCDSAIWGPANFsr-----plLNLIYDSKWINSEFISAQ 364 chicken
XP_692742    290 YEARTQLAQKLSVKTSDITNVIVWGNISGSFHIDLQRAKVFRYDGAIRGPDGFsqhvmemiyDWKWLKTDFRSLLHKHRA 369 zebrafish
XP_001201789 285 NRAKAAIARKINVNTAGVADLIIWGNIGGITHFDISQARVYKYEGAIWGPSSFsrpvtevvhDEKWLQTEYPQLLQNHPD 364 purple urchin
AAM18871     288 RQAKSLLAKRLTVNSAGVCDVIVWGNVGGTTYTDVSRARVHGYDGAIWGPPSYscsvsemvhDNKWLEGEFLEQLQSRSH 367 Florida lancelet
Feature 1                                                                                        
NP_001034934 363 KNLTTTgrqfGGILAAHSIATTLKYWYHGSPPGEIVSLGILSEGQFGIPKGIVFSMPVKFENGTWVVLTDLKDVEISEQI 442 human
XP_421952    365 SSLRSRvchcAGMLPAHAVATALRYWFHGSPPGEIVSMGVLSEGQFCIPEGIIFSMPVRFQNGSWEVVTELEINEKTQEV 444 chicken
XP_692742    370 TISSKTnk-aTAISTTNAILAILKAWNNAESPEEVFSLGVLSTGQFGIPAGLVFSMPVSFTDGHWSVRSDVIVTDELRVN 448 zebrafish
XP_001201789 365 ALATMLnh-kVAMSEAHALTSILTHWYNGSPDKEIFSLGVYSDGWYDLPVDIFFSLPVKFQKGAWEVVQDRQVTTEIRAQ 443 purple urchin
AAM18871     368 TIQDSLqh-sADLSMAAAISSTLSYWWNGSPEGQLFSLAVCSEGFYNIPEGVVFSFPVMFHKGSWEVVQDIDMNEDMRVM 446 Florida lancelet
Feature 1                        
NP_001034934 443 MTRMTSDLIQEKLVAL 458 human
XP_421952    445 LECLSYDLIQEKRVAL 460 chicken
XP_692742    449 LDACADELRMERDMAA 464 zebrafish
XP_001201789 444 LDQITNELIHERYVIF 459 purple urchin
AAM18871     447 LSSITAQLVEEKDLLL 462 Florida lancelet

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