2G62,2HV7,2IXP,2IXN


Conserved Protein Domain Family
PTPA

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cd04087: PTPA 
Click on image for an interactive view with Cn3D
Phosphotyrosyl phosphatase activator (PTPA) is also known as protein phosphatase 2A (PP2A) phosphatase activator. PTPA is an essential, well conserved protein that stimulates the tyrosyl phosphatase activity of PP2A. It also reactivates the serine/threonine phosphatase activity of an inactive form of PP2A. Together, PTPA and PP2A constitute an ATPase. It has been suggested that PTPA alters the relative specificity of PP2A from phosphoserine/phosphothreonine substrates to phosphotyrosine substrates in an ATP-hydrolysis-dependent manner. Basal expression of PTPA is controlled by the transcription factor Yin Yang1 (YY1). PTPA has been suggested to play a role in the insertion of metals to the PP2A catalytic subunit (PP2Ac) active site, to act as a chaperone, and more recently, to have peptidyl prolyl cis/trans isomerase activity that specifically targets human PP2Ac.
Statistics
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PSSM-Id: 239754
Aligned: 45 rows
Threshold Bit Score: 308.31
Created: 13-Aug-2003
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 13 residues -Click on image for an interactive view with Cn3D
Feature 1:peptide binding pocket
Evidence:
  • Structure: 1IXP_AC; Saccharomyces cerevisiae Ypa1 PTPA binds two suc-AAPK-pNa peptide molecules; defined at 4A contact distance.
    View structure with Cn3D
  • Comment:Succinyl-AlaAlaProLys-paranitroanilide (suc-AAPK-pNa) is a standard substrate used in biochemical activity assays for peptidyl-proline isomerases.
  • Comment:Mutations of residues in the peptide binding pocket disrupt in vivo activity of PTPA.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                     
2G62_A     49 DYIGFILTLNEGVkgkkltf-----------------eyrvseAIEKLVALLNTLDRWIDETPPVdq--------psRFG 103 human
2IXP_A     37 RIKYHLHKYTTLIshcsdpdp--------------hatassiaMVNGLMGVLDKLAHLIDETPPLpg--------prRYG 94  baker's yeast
XP_668144  30 DIIDFIKLLSESIkgkilvqqheye------ergkersdigfnSIINILKLLSKLDSNIDEIPPIkq--------pmRFG 95  Cryptosporidium ho...
XP_646488  52 DLLEYIQTLSDKIkskpnst-----------------ktqnsnEIKNIVSMLNEISVYIDNIPPLaq--------pmRYG 106 Dictyostelium disc...
XP_649210  30 RVFQTLHLLNDSIkrmsfds----------------pkikvtpKIESILKQIEQLSKFIDEIPPVnle-------ksRYG 86  Entamoeba histolyt...
CAJ06978   58 RILAYVQGCSEAVestpnhqrls-----------atvddcddtVRYLVTDYLPRLHDIVTAIPLEdma-------qqRFG 119 Leishmania major
EAL28185   30 ELIAYINTVSTTIqglrlsd-----------------sipvspAITRLAGIFDQLEAMIHNNPPImvdnaasfassiEQG 92  Drosophila pseudoo...
EAA36780   36 LITRFIALVSDSIqglpfgn-----------------apdpseNCKKLLAILEKAHQMFKDTPPVsr--------dvRYG 90  Giardia lamblia AT...
AAZ12938   33 KIVSYVQCCAEAVeemsrsawlq-----------qrreekhptIVFFTDVFFPHLRSIVASIPLEdmk-------qqRFG 94  Trypanosoma brucei
NP_702169  28 DIIEFITNLNKSVvgvemkpledfklcnendminndnflflskNVYNIFQLIKNMNKCIDSCPPInq--------ssRFG 99  Plasmodium falcipa...
Feature 1                                                                                     
2G62_A    104 NKAYRTWYAKLDEEa----ENLVATVVpth--------------------------laaAVPEVAVYLKESVGNSTRIDY 153 human
2IXP_A     95 NLACREWHHKLDERl----PQWLQEMLpse--------------------------yheVVPELQYYLGNSFGSSTRLDY 144 baker's yeast
XP_668144  96 NKAFQTWYDKTNQTc----TSYISDILken--------------------------sdeYLQEVKSYFVESFGNRSRVDY 145 Cryptosporidium ho...
XP_646488 107 NKAYRTFYQKLLDNv----EELHKHLLpqs--------------------------mhsSIIELSSYLMDAMGNQTRLDY 156 Dictyostelium disc...
XP_649210  87 NISFRTWHKRVEEYs----VDFHKAILpee--------------------------lypFISEFHGYLMDSFGSPVRIDY 136 Entamoeba histolyt...
CAJ06978  120 NRAKRVFHARLEETvvadmEKLVRTFPtsagrs--------------------eeaitdMATEVAAYVMDSFGNATRLDY 179 Leishmania major
EAL28185   93 NKAYRRWSRSMLRGi----YPMVEKAVpas--------------------------kcqYVNELGQYLSGSFGNATRIDY 142 Drosophila pseudoo...
EAA36780   91 NPSFRTFVQKLRESc----TAWHQEILpaq--------------------------yqeATIELDAYFLDMFGSEKRLDY 140 Giardia lamblia AT...
AAZ12938   95 NRSFRVFHSRLEENifdlmRGLVATLNrglgdtterqnrdisagevlkearanengddpLVLELAEYMKDAFGNSVRIDY 174 Trypanosoma brucei
NP_702169 100 NRGFQHFCDAYYKEv----DEYLPHALsesni----------------------pniseHTYQISYYLKNSIGNKKRIDY 153 Plasmodium falcipa...
Feature 1                                                                                     
2G62_A    154 GTGHEAAFAAFLCCLCKIGVlrvdd------------------------------qiaiVFKVFNRYLEVMRKLQKTYRM 203 human
2IXP_A    145 GTGHELSFMATVAALDMLGMfphm-------------------------------rgadVFLLFNKYYTIMRRLILTYTL 193 baker's yeast
XP_668144 146 GTGHELNFILFLMCIHRLGAfqknd------------------------------lpdlILVVFYRYILLMRRLQSIYLL 195 Cryptosporidium ho...
XP_646488 157 GTGHELHFVVWTYCLRRIGFlkstd------------------------------eediVLNVFTTYLDLVRKLQRVYGL 206 Dictyostelium disc...
XP_649210 137 GSGHELHFFCWIVLLVQLKVineee------------------------------ypaiILKVFRNYLYLCRKLQNVYRL 186 Entamoeba histolyt...
CAJ06978  180 GSGHELHFFIVIMICLEEHGdgggslkdepavlvplevpppppvppmeraevrkrrqdyIFYIFHEYMRLVRRLQKRYSL 259 Leishmania major
EAL28185  143 GTGHELSFLFFLCSLFRAQIlqeed------------------------------vaasALVIFARYLKFVRRLQVIYTM 192 Drosophila pseudoo...
EAA36780  141 GTGHELNFVCWAFSFIRLSIlserd-----------------------------dfiniGLRLFPAYLQLAQDIQNIYTL 191 Giardia lamblia AT...
AAZ12938  175 GTGHELHFFIVMLICMQECGdngaplqsdvpvvvphkvqrpppppveqrdallqlrramVFDVFSAYLSFMRHLQHHYKL 254 Trypanosoma brucei
NP_702169 154 GTGHELNFLLFLFCLNKINFfipsd------------------------------ykhlVLVLYRQYLEGVRRVQIIYTV 203 Plasmodium falcipa...
Feature 1            ##                                                                       
2G62_A    204 EPAGSQGVWgLDDFQFLPFIWGSSQLidh------------------------------pylEPRHFVDEKAVNENHkDY 253 human
2IXP_A    194 EPAGSHGVWgLDDHFHLVYILGSSQWqllda---------------------------qaplQPREILDKSLVREYKdTN 246 baker's yeast
XP_668144 196 EPAGSRGVWgLDDYQFLPFLFGSAQLinsne---------------------------lfpvLTNQILDRSILEIYSaKS 248 Cryptosporidium ho...
XP_646488 207 EPAGTHGVWsLDDYQFIPFIWGASQLignp-----------------------------fdiKPASVTIEKVVDQYYkEY 257 Dictyostelium disc...
XP_649210 187 EPAGSHGVWgIDDYQFLPFIFGSAQLikh------------------------------pylKPDSILDKSLVSLYEhDN 236 Entamoeba histolyt...
CAJ06978  260 EPAGSHGVWgLDDYHHIPYIFGGAQLinaevqpvkp-----------------aagqeamlvLPKHICDRAKVEMLKdSY 322 Leishmania major
EAL28185  193 ESAGSHGAYsLDTFQFMPFLWGVAQLsye------------------------------apfSPRQMLDADVVSRYRsEY 242 Drosophila pseudoo...
EAA36780  192 EPAGSHGAWsMDDYNMLPFVWGSSQLinr-------------------------------rlKPTDIFFPEKLTEHK-DN 239 Giardia lamblia AT...
AAZ12938  255 EPAGSHGVWgLDDYHHLPFVFGASQLinkevptatpetttnannnaengsensngnanheliLPKHVCEADIVRRHAeEY 334 Trypanosoma brucei
NP_702169 204 EPAGSRGAWgLDDFQFLVFLFGAAQLsyn------------------------------rkiKTDDIEKKELLELWApKY 253 Plasmodium falcipa...
Feature 1                           ##  ##    #        ##         ####        
2G62_A    254 MFLECILFITEMKTG-PFAEHSNQLWNISa--VPSWSKVNQGLIRMYKAECLEKFPVIQHFKFG 314 human
2IXP_A    247 FYCQGINFINEVKMG-PFEEHSPILYDIAv-tVPRWSKVCKGLLKMYSVEVLKKFPVVQHFWFG 308 baker's yeast
XP_668144 249 LYINSIQHILNMKTNvYFAECSPILYSLTs--VPTWEKIYSGMIKMYVAEILNKFPVAQHILFG 310 Cryptosporidium hominis TU502
XP_646488 258 LYIACIKYINTVKKG-PFHEHSRDLFNISg--AASWQKINTGMMKKFYDDVLSKVPIIQHFLFG 318 Dictyostelium discoideum AX4
XP_649210 237 FYFDCVAYIYKVKNRaPFFESSPDLFNISa--AESWEKINKGMFTKYHAECLDKYPIVQHFLFG 298 Entamoeba histolytica HM-1:IMSS
CAJ06978  323 LYFSMIAWILENKTG-PFHEHSNMLYNISg--VEHWSKIYSGMVKMFAAEVLAKYNVSQHLLFG 383 Leishmania major
EAL28185  243 LLIGSIGHVSDTKMG-TFAMHSCQLWSLAa--LSSWTKIYRSLLFMYLNEVLAHFEIMQHIRFG 303 Drosophila pseudoobscura
EAA36780  240 LYIMMIQNITTVKTG-DLRITSPFLSEIHlqqDTTWSRIHTGMMKHYQNEVLCKWPIMQHFWFG 302 Giardia lamblia ATCC 50803
AAZ12938  335 LYFAQVLWVIENKSG-PFFEHSSMLYNISg--VDSWKKTYTGMVKMYAAEVLLKFNVVQHLLFG 395 Trypanosoma brucei
NP_702169 254 LYFDALKYISMIKHA-PFHESSQMLYDISg--VETWEKICNGLLKMYQAEIIQKRQILQHILFG 314 Plasmodium falciparum 3D7

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