Conserved Protein Domain Family
GT4_Bme6-like

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cd03821: GT4_Bme6-like 
Brucella melitensis Bme6 and similar proteins
This family is most closely related to the GT4 family of glycosyltransferases. Bme6 in Brucella melitensis has been shown to be involved in the biosynthesis of a polysaccharide.
Statistics
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PSSM-Id: 340848
View PSSM: cd03821
Aligned: 13 rows
Threshold Bit Score: 310.84
Threshold Setting Gi: 83591922
Created: 15-Dec-2005
Updated: 9-Jun-2017
Structure
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Aligned Rows:
 
putative
Feature 1:putative ADP-binding pocket [chemical binding site]
Evidence:
  • Comment:Some of the residues involved in ADP binding bind indirectly.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                        #                                                               
gi 5478236     2 KIIHVIGSYd--pAKGGPQAVVVRLAAAq--aSLGHRVTIVSYSDDavsrraaeatami----pdfdkvqtlllpMPDIY 73
gi 118470651   2 RILQVVTLFspdgLYGGPTRVALNQSAEl--aGRGHEVTIAGAARGyealpselngv-------pvklfaatnilRRSGF 72
gi 2621430    14 RILHVTPYFkpswEAGGPPRSVYDLASRq--vSAGHEVTVYTTDGFkrrldvevnrpldv-dgirtyyfrnlsmyLAGNM 90
gi 32471970   45 RVAMVTSSVt--rAAGGLAPIVLRLTASl--vNSGYPATILSVEDEywsdvskkig---------aaageafpacGPAKV 111
gi 17131958    6 KILHYIPVYapawKFGGPVLSVSRLCEGl--aALGHEVEVFTSNAGlenqselplnqp------virnqvkvkyfQQEPG 77
gi 17133572    2 KILQIVPSIs--lIYGGPSQMVLGLSPAl--vKAGAEVTIITTDSNgdsgqkpldvnlnv--pikqdgyeiiyfrCSPFR 75
gi 125988048   3 KILRVIPSMd--pQKGGPSEGIRQLQQEihrqRLNIKCDIVCMDDLseeakdve--------------yasiyavGKGKG 66
gi 15890177    2 KIIHVIASId--pKHGGLQAVAMRLAAAq--aGLGLDVNIVSYGDAaieaqvkeigrsi----phfenihwhllpPAGRL 73
gi 20502738    6 RNLHITTVVkdssKHGGGMLAVAYSVHKylcsKLSNASFISSCASCy----------------------------KVENS 57
gi 77404734    2 KVALVTALLs--pAAGGLASSVPSLARGl--tRKGVDTHVVGVEDPedpgagsr--------------wgqnvhsHVQPL 63
gi 17134378    2 NVLHVIPSIa--pIRGGPSQAVLEMVKAl--rDANIEAEIATTNDNgkellnvplgqythyqevpvwffprfspaINSLR 77
gi 22299564   25 VFICLEWQP----HAGGHVKCWERFAEAashyPERIDLTIYFLGAKhqtlevaanvryql--lppqfsthsleimRQGAG 98
gi 83591922    4 VAVLVTLPWt--aDAGGHVKVWERFAEAaepfADRASLTVYFLGPTdqtvvrnraarfrl--lparlgtdripllSQGAG 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 5478236    74 ETFTGGhtanavTALIRGADFVHLHGi--WETNLLRASMlcrrfHIPYCVCCCGMLDGAaf------------------- 132
gi 118470651  73 AWTYAPgltswlRRNWREFDTVHVHLa--RDLVTMPVAAvvrrrGIPYVLQTHGMVVPTnh------------------- 131
gi 2621430    91 NLPVPLklpyvaWREIREFDVVHIHEh--RTFLAAVVATlasraGVPYIVQPHGSVPTMsr------------------- 149
gi 32471970  112 RSAVRYspglhrRLEQLCPEVAHTHGl--WQYPSMAVLKwgqstKRPWVVSPQGMLDKWal------------------- 170
gi 17131958   78 MGINCPgmeqavTARAKEFDIIHITGv--WQRTSGAACKaaknqGVPYIVSPRGALGPYsw------------------- 136
gi 17133572   76 RYKFSLdllnwlKIHAREYDIAHIHAl--FSPVSSAAATicrqqKLPYVLRPLGTLDPAdl------------------- 134
gi 125988048  67 VYSYSEslknwlEENVKKYDFVIIHGi--WQYHSYIASKlciknSIPYFLYTHGMLDPWfkk------------------ 126
gi 15890177   74 ETLFCFrgrrmlKALLKDASFMHIHGv--WEPFLLYASKlaraaGVPYCICPAGMLDHWsl------------------- 132
gi 20502738   58 WIVGELgirtffISNKAIGDITHVHGv--WTPFEFFVIKaakkrNSKIVVSPHGALEPWaf------------------- 116
gi 77404734   64 RTPFRYapdigtTLASLRPDVVDVQGi--WTYPSLANLRhhigfGTPYVITPRGMLDPWar------------------- 122
gi 17134378   78 EFAFSKeltiwlWKNIHNYDLLHIHAi--FSYASTAAMAiarlrKIPYIVRPLGQLCEWsl------------------- 136
gi 22299564   99 MTDVAPfhw-alRRYLPQHQVFHITDtfsFAQTVRRFCRq---qRRPLLSSIHTDLPLLtrtysreii------------ 162
gi 83591922   80 HTDLSGflp-rlGGELTDYDVVMSTDvfsFGRTAERVCAs---aGIPLVHSVHTDVVHFteiygprivtralgqrlggwi 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 5478236   133 ---------------iHALNRDEIELMRPLgl------------------------------------kAPSLVIPNGVF 161
gi 118470651 132 ---------------sLATPLDRMWTHDILrharavfflds-----------------vereqliavagPDLRLVELGNG 179
gi 2621430   150 --------------atLKEVFDFIAGNRIMygasrivatstve-------------sgfyrkvypkldaEAIVKVPNPVD 202
gi 32471970  171 ---------------dQSPVKKRVASIAFEskhlgqagcvhala------------egeyeairafgirSPICLIPNGVD 223
gi 17131958  137 ---------------qQKTAKKILYYFWQEhfnvtnaagvhyts------------kqelqechwlqlpGKSFIVPNGLN 189
gi 17133572  135 ---------------qKKKQLKKLYVEIIErrnlsgaaaihfts------------eqeakvsarfgvaTHDLVIPLGVI 187
gi 125988048 127 -------------nypLKHIKKMLYWTLIErkvvnnaeaviftse----------eekilarqsfpfyePKEFVTAYGTS 183
gi 15890177  133 ---------------gQRSWKKKIALMLCYrrmlneaaflhlln------------vdemaavetlnfqARNLIIPNGVF 185
gi 20502738  117 ---------------qSKGLKKRIAWYLYQkrilteadliivns------------qkerdnlrrlglnGPIAVIPNGII 169
gi 77404734  123 ---------------dHSRWKKALVRHLFEdqhlakafclrata------------tmeaehlrsfglrNPIAVVPNSVS 175
gi 17134378  137 ---------------qQSAIKKQIYLQLIEksnlnnskyihfts------------eqeqqetsllnltSPSFILPHGLS 189
gi 22299564  163 -------wrlsgrsrgQKFWRWLWLKQLQVdqwfgcqakrklagfmrasdrvlvsrqqdadwlltflppERVAWFQRGID 235
gi 83591922  156 vkhyhlgrrfaggierRLHQHWAACRHIIVsrpldaer------------------------vhkvcpeMPVSFLRRGVD 211
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                     ###                                                
gi 5478236   162 LNEVevgdmd-------vpglpARRFILFLSRLHYKKRLDILADAYCRIaph---frdVDLVVAGPDGGAEDAfrrki-- 229
gi 118470651 180 VPEYptahs--------grtlgRAPEVLFAARMHARKRPVVFIEMARELlas---gmdARFTLVGPDEGEGPAira---- 244
gi 2621430   203 IPHRpsrglfr-----kkwgleDARIILYLGRIHERKGLDILLRAFRDMde------dTVLVITGPDDHYLERlmgli-- 269
gi 32471970  224 SPEFaigqepa-----wkndcgDRRVLLFLGRIHPKKGLSELIEAWRMLneqdpvtckWFLAIVGWDDGNHLQalrqq-- 296
gi 17131958  190 TEFWqptlegakawrkshnigeDEFIFLNVGRLHHKKGLDLLSQSLVPLqh-----lnWRMIFVGSDDDGTQVklqqq-- 262
gi 17133572  188 PPQKkadnsli----sqlgipeNIPLILFMSRIDPKKGLNLLIPALEKLlai---gnnFHFVLAGTNPQDPDYeqqikdq 260
gi 125988048 184 GSIFdkeiarsef-nkkfpflkGKKILLYMGRIHEKKGCDILIKSYAKIske---hndYHLFIAGPDTSAYAKtlkdl-- 257
gi 15890177  186 AEEFdplparghf-rqkialahGRRYILFLSRLHIKKGIDILASAFAAIcet---yvdVDLVVAGPPGGAEGHfmhlv-- 259
gi 20502738  170 LDGYdkqsa---------mkseREKIILYFSRLDKKKGIELLIKAWRKVkdk----rgYKLHIQGYGDQSYRLflhdm-- 234
gi 77404734  176 IPPLqggs----------nprpGMRRLLFLSRIHPKKGLPYLLRAWAAVeda---rpdWELIIAGPDELNHTKemqly-- 240
gi 17134378  190 ITNIipdarqrl--rqhfnlpeDEPIILFLSRLHPKKGLDYLIPALEKIsn-----yrFTFVLAGSGSPDYETevksl-- 260
gi 22299564  236 RDRFhprlrnpqw-lreeyhlpEGPIILFVGRVDASKNVLLLARAAQRLanq---gkvFHVLIVGEGAQAVLVkd----- 306
gi 83591922  212 TKRFdpalrdrlwlerahgvppSRKLLVFAGRVDASKRAMVAVRAARTLiea---ghdVGLLLAGTGEDLEPAra----- 283
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                             #                      #                                   
gi 5478236   230 -aeygLQHRVHMPGGLYGLAKIAALKRAACFCLPSRq--EGFSVAITEALACGAPVVITDACHFPEVGEA---GAGVVCA 303
gi 118470651 245 --algGDPRITWEGALSPEAIPARMAEADVYVLPSVr--EPFPMSVLEAMSVGLPVVVTDDCGLAPIIEQc--GCGAVTD 318
gi 2621430   270 -delgIGERVLLTGPLYEMDKLEAYVDADVFVLPSAskyESFGNSAAEAIACGTPVVVTSSCGISEWMDP---GDGIIAR 345
gi 32471970  297 aadagLSDCIGFYGPVFDGGKSATLSSANAFVLPSYs--EGMPMAVLEAWSHGLVAAITPKCNLSEGYEH---GGAVKIL 371
gi 17131958  263 fqsanLSDRVLFLERCEPKELPVIYSAANLFVLPSRh--ENFGNVVVESLACGCPVLISDKVGLHDEVTE---GCVGWVR 337
gi 17133572  261 isnssLRSHSTITGFVTGELKASLLQAADLFVLPSYy--ENFGIAVAEAMVAGVPVIISDQVHIWQQVRDs--ESGWVGT 336
gi 125988048 258 vsslnLNDKVTWGGMLSGDVKWGAYYSSEIFCLASHq--ENFGIVVAEALSCEIPVVTTTKVNIWREIERa--DAGMIAI 333
gi 15890177  260 -kklnIRHRVFMVGAIYGKAKLEAMVDADCFCLPSRq--EGFSMAITEALACGTPVVITDQCHFPEVGSA---DAGLIVS 333
gi 20502738  235 vskfgLEEEILFIDPSYDEKRWASFFSASFYILPSYs--ENFGITVAEALISGLPAITTTEMPWEDLTNE---GIGWSVK 309
gi 77404734  241 -arklNVSRVRWLGPIHGEAKSSLYAGADIFILPTHa--ENFGLVVAEALSHGVPAITTRNAPWSGLREY---GCGWWID 314
gi 17134378  261 lvshsIQNRTCFTGFVKGEIKDILLQGADLFALTSHs--ENFGVAVLEALSAGVPVLVTPGVALANLVTQq--NLGYVTE 336
gi 22299564  307 ----lLGDRVTLTGKIPQEKLGAIYASSDLFVFPSEs--ETGPNVVVEARAAGLPVVISGFDGGRKYVQAs-gEDGVVVY 379
gi 83591922  284 ----lLGPRLVAPGVVPQDDLARLMACGDLFVFPSVs--ETAGNVVLEALASGLPVVVSGRPGGCAGFVGadgANGRVVD 357
                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
Feature 1                                                                         
gi 5478236   304 LNa----EMVGDALAGVLEd----lDKAAQMGASGAkl-----------vRENYTWPRIARQTIE 349
gi 118470651 319 PSv----SGLAAAVGAILRdr--ahTKSIGERGRETv-------------VERFGMRPVGDRLVS 364
gi 2621430   346 PSa----RDLRDAIIRVLKe-----RDSFNPSAEKFd-------------PESISETFEDIYLEV 388
gi 32471970  372 PEp----HSIASGLQSILRlke-seQAIRSQMARAFa-------------EEQFSWKIIANKFRS 418
gi 17131958  338 SRv---vSEWTEAIREFIQy-----PKKMQEVILASrk----------yvESTYSIKRTALQMAN 384
gi 17133572  337 TEv----ESLVELLQQALQnp--qeCQRRGLNAQNYa-------------LQNFSWDAIAGQIIQ 382
gi 125988048 334 DNd----DSFTEILNEFLKkye-ndRERLRGNALRCf-------------KENFDIKLVAKSFNN 380
gi 15890177  334 VDa----AEVAKALASMLGnp--arARTMGENGRRLv-------------LEKFTWPAIAHATLE 379
gi 20502738  310 CNe----SAIAEAITEAIGi----dESKLALMRRRAvd----------yaEKHFSWETIVQDYGL 356
gi 77404734  315 LNd----QTLRATLLQATEl----pRRALGEMGRKGra----------wmEKDFGEEKLASNMLE 361
gi 17134378  337 LDv----NYIAASIQQALDy-----PQKAKEMGDRArq----------liCEKYTWDKVAGQLQE 382
gi 22299564  380 SRd---pQDWAAAIAPLLDdt--hyRQRMGAQAHQItqatcptwreafeqSILCQWEAVAQAYGW 439
gi 83591922  358 DRggnvvEAWRRALVEVLSgdgeakRRAARASVEGTrhlwt----diyehDLLDVWEAVAGGRRD 418

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