Conserved Protein Domain Family
GT4_WavL-like

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cd03819: GT4_WavL-like 
Vibrio cholerae WavL and similar sequences
This family is most closely related to the GT4 family of glycosyltransferases. WavL in Vibrio cholerae has been shown to be involved in the biosynthesis of the lipopolysaccharide core.
Statistics
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PSSM-Id: 340846
View PSSM: cd03819
Aligned: 23 rows
Threshold Bit Score: 195.266
Threshold Setting Gi: 163847157
Created: 15-Dec-2005
Updated: 9-Jun-2017
Structure
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Aligned Rows:
 
putative
Feature 1:putative ADP-binding pocket [chemical binding site]
Evidence:
  • Comment:Some of the residues involved in ADP binding bind indirectly.
  • Comment:Based on similarity to sequences with known structure

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                        #                                                               
gi 51892236    4 ILLAAMALd-----lGGAETHVISLARELhrRGHRVVVASAGGRMvplleergip-hivvpmasrNPLAMARAYRRLRRL 77
gi 159179454  36 ILQVLPALv-----sGGVERGTIDVARAQieAGWRALVVSNGGPMvhelerigat-hitmpihskNPLIWRANFDRMVDL 109
gi 161785817  15 ILQVLPALd-----aGGIEQGTIEMADAItrAGGVALVACAGGRLlarlrhaggv-hmpidlrtkNPLRILLNARRLARL 88
gi 67004472   15 ILQVVPALv-----sGGVERGTIEVAKYLkiLGHTPIIISAGGTLvkeldkedil-hiemnssskNPFVILNNAKLIAEI 88
gi 39545763    3 ILMALSQLe-----vTGAEVYATTVGNELtrRGHQVFYVSDTLTKahagpgf------klrfnkrSILRRFWHVFYLVYL 71
gi 153934589 268 ILMLIDALn-----iGGTEMYVLELAKSLekLGAHVVIGTSGGPLvevfkhy------glkvvkiPFTSDYISNKNIMKL 336
gi 15677553    7 ILNIVSAKi-----wGGGEQYVYDVSKALglRGCTMFTAVNKNNElmhrrfs------evssvftTRLHTLNGLFSLYAL 75
gi 163847157   3 ILFITGEYpp---qpGGVGDYTQRLGQALvrNGHEALVVTVVKRKwqiwqits----dgdralpaPAGRAGWGIGSLGRL 75
gi 19713867    3 ILMALSQLe-----iTGAEVYATTIADELieRGNKVYIVSDTLTTptkaeyi------klefnkrSLLKRIEHIKFLYNL 71
gi 37521764    5 IWTIFYQFdpwgtsiGGIQTAIRACIRYAp-EVFDLRLVGTAGDDrhpvgqwrdgeldgrqlrflPLFVSGDDNVRRKIP 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 51892236   78 Ia----------EHQIGLIHAHARI------PAWLCALAVRgkgiPLVTTYHGVYNAgf------------------pWK 123
gi 159179454 110 Iw----------RERVDLVHARSRI------PAWIAFRAARrnrvPFVTTFHQRPAArtal--------------krlYN 159
gi 161785817  89 Ir----------AQGVHLVHARSRA------PGWSAALACRrtgvPLVTTWHGVYREsvpg--------------krrYN 138
gi 67004472   89 Ik----------KYNVDIVHTRSRA------PAWSSYLATKwtnaKFLTTFHGVYNIpnsf--------------kkyYN 138
gi 39545763   72 Ik----------KHHIQLVHAHSRA------SGWSSYVACKltgtPMITTVHGRQPVha------------------sRK 117
gi 153934589 337 Ikltk---kiidEEKINLLHCHLFA------SMRLGNDIYRs--yKIPYIVTLHGLFypn----------------dvLF 389
gi 15677553   76 Trf-------irKNRISHLMIHTGK------IAALSILLKKltgvRLIFVKHNVVANktd----------------fyHR 126
gi 163847157  76 Trlv-----hqlRPDWCHIQYQTGAyqmkigVNLLPLLLRRsr-lPTAITYHDLLPPylfpka---------gvvrewVT 140
gi 19713867   72 Ik----------EKDIQIVHAHSRA------SSWSCQVACKlagiPLITTTHGRQPIhf------------------sRK 117
gi 37521764   84 TtltytaallgkRIEGDFLHFHRLE------PALAARGWSG----EKTYFVHNDVRAqmltserkdallwqrfpsgyfAL 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                   ###  
gi 51892236  124 YLTTFGQRAIAVSEDVRRHle--gpLGAPPAIIRVIPNGFETGEFRPGldiapll------relgvdRTGPHVVHASRlt 195
gi 159179454 160 SVMVRGDRVIAISHYVADRli--adYGLDPARLRVIPRGVDLSLFDPErvsaerlvr--lverwripDGVPVVVLPARvt 235
gi 161785817 139 AVMASGRRVIAISAFIAQRla--rdYGVGPDRLRLIPRGVDTARFDPDivrgpriqa--laeqwglpEDAAIIMLPGRit 214
gi 67004472  139 SIMLKGEKVIAVSNFVKQHll--enYKIDEDKIVVIERGVNCDYFDPAnltpeklkk--crdkydapSNVPIILMPSRmt 214
gi 39545763  118 AFHALGFRAVAVCEDIASQii--dnLGVDPAIVQVLRNGIETDKFQPVsa---------------pdNAKPVIAIIGRls 180
gi 153934589 390 ESCINATKIIAVSKPIKKLies-klGSRIRGEIMVLPNGIDMENFHPQhtvkdfk------tqlgipENSQIITYCSRld 462
gi 15677553  127 LIQKNTDRFICVSRLVYDVqt---aDNPFKEKYRIVHNGIDTGRFPPSqek--------------pdSRFFTVAYAGRis 189
gi 163847157 141 LLPARTARAVIVTNPEDETt-----LRAARVRPRLIPIGANIDPVLPEgydrsiw-----radlgvsDEMPLIAYFGLls 210
gi 19713867  118 LIKAFGNYSIAVCENIKKHmi--ndIGFSENKVSVILNPVNYKKLDLEkk----------------vNDKKVISIVGRls 179
gi 37521764  154 ERQILGDFDQILSCNSESTtfyrerYPRLAGRIHTFRYMLDTSLYHPPtpgeelaqrralaaqmglePETRFLLFAGRlh 233
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                       #
gi 51892236  196 d----efADTAVALLQALPRLneq-------fptIRLWILGDGNRYAEVarlad----evnrrLGREAARAVGh--RLDV 258
gi 159179454 236 ------rWKGHDLLVQALSRLqr---------gsFHCLMVGEDGGRRSVkaalep---viaklGLTPHVHFVGr--TDDM 295
gi 161785817 215 ------pWKGQALLLEALARMeaqeqarggsgrdWACVFVGPARRRDRFarsltq--maetqpALRGRVYFAGl--CADM 284
gi 67004472  215 ------sWKGHLVLVEALSKLkh---------rdFYCLMVGDISRHPNFtnrvke---liatlKLQNKIQIFGn--DSDI 274
gi 39545763  181 ------gPKGELCYRLLDEVLdld--------acQVKVVSGSQLPERFV--------------RFRDRVDFVGy--VEDV 230
gi 153934589 463 wgktfaaEAFIFACFTLMAKNk-----------hLHAFVIGDGADKNLIthevn----ilnkmLKRDAIHVVGa--KFDV 525
gi 15677553  190 ------pEKGLENLIEACVILhrk-------ypqIRLKLAGDGHPDYMCrlkrd-----vsasGAEPFVSFEGf--TEKL 249
gi 163847157 211 ------pGKGIDLLIDLIADQp-----------aWRLLIIGGAATSPTDrvyaktiqqrletlSLRDRVIITGhiaAERV 273
gi 19713867  180 ------gPKGDVAYDLLEILSqdel-----lskyKVCLIGGKELPERFLk-------------FKKKYIEFIGy-vPNIQ 234
gi 37521764  234 ------aQKDPLLLLRAVQELde---------pgVHLLMAGAGELETEIrrtv-------galGLADRVSLLGpvpRERM 291
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                   #                                                    
gi 51892236  259 PAFFnlADCVVAVA--------RTATEAMLCERPVIIAGEG-----GYRGILTPErip------lyaGSNFTAREGGTPL 319
gi 159179454 296 PAAYklADVVVSASldpe-pfgRVMIEAQAMGRPIVATDHG-----GARETVLPGe-----------TGWLVKPNDADAL 358
gi 161785817 285 PAALalADVVVMPSlrpe-pfgRVVIEAQAMARPVIVAAHG-----AAMETVAHGq-----------TGLLVPPGDASAL 347
gi 67004472  275 INLYgiSDIIVSASiepe-afgRTIIEGQAMEKLVIATNIG-----GAVETINNN------------ITGFHVEPNNAEA 336
gi 39545763  231 PALMaqCDLVIGAG--------RVAMEALLCGRPAFAIGEA-----KAIGLVTGQn----------lDEALASNFGDIGP 287
gi 153934589 526 LPYYqnADIVVGTA--------RVALEAMSCGKPVIAVGNH-----GYTGIINPRcm---------nEQWNMYFGDHDSI 583
gi 15677553  250 ASFYrqSDVVVLPSlvpe-afgLSLCEAMYCRTAVISNTLG-----AQKEIVEHHq-----------SGILLDRLTPESL 312
gi 163847157 274 SAYLhaCDLIVLPFrdgaslrrGSLLAALAHGCAVITTPPAspataAALTGVVHFaaahpeslktaiISLLSNPNARLRL 353
gi 19713867  235 EKIFe-SDIVIGAG--------RVAFESLLNKTALIAVGET-----EYIGFVNKEnl---------dKSLASNFGDIGSM 291
gi 37521764  292 AVLHraSTLVVLSSvye--glpLVVLEALSSGKPVVSTASG-----DTPRILVSG------------SGLISRERTPTAL 352
                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
Feature 1                                                                                 
gi 51892236  320 NPAVlaadi------agllAPGNEAERQRLg--------------------------------rAGREFVVAS 354
gi 159179454 359 AQGIkaal--------gldAEGRERLSARAv--------------------------------eHVRENFSRY 391
gi 161785817 348 AGAIravl--------dmaPEDAAALGAAAr--------------------------------aSVQASYTTA 380
gi 67004472  337 LAEKidycf------silgTDTAKKIQEAAr---------------------------------HTVINNFSL 370
gi 39545763  288 RDLAi--------------DFAALKTQIAPalssgsvfdvirqriqaeyglagvvsglesiyqdAVVETLRRE 346
gi 153934589 584 KKADplal-------ekdlNGLLQDTEACKslgk---------------------------wgrRWCEEKFDN 622
gi 15677553  313 ADEIerl---------vlnPETKNALATAAh---------------------------------QCVAARFTI 343
gi 163847157 354 SEAAr-------------qAARRFDWQNIA----------------------------------AAHLELYRS 379
gi 19713867  292 KYPKiekeillndikkalnLSENEKEELKDi---------------------------------IFKETNLQN 331
gi 37521764  353 ADALrtvlh-----hpsafPAERCLEAARPyqartvv---------------------gelaneMLARFQTRR 399

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