Conserved Protein Domain Family
GT4-like

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cd03814: GT4-like 
glycosyltransferase family 4 proteins
This family is most closely related to the GT4 family of glycosyltransferases and includes a sequence annotated as alpha-D-mannose-alpha(1-6)phosphatidyl myo-inositol monomannoside transferase from Bacillus halodurans. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria and eukaryotes.
Statistics
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PSSM-Id: 340842
View PSSM: cd03814
Aligned: 31 rows
Threshold Bit Score: 272.63
Threshold Setting Gi: 161159882
Created: 15-Dec-2005
Updated: 9-Jun-2017
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10175309    2 RIALFTDTYIPQvNGVARTMKRLVDHLek--rQVEYALYMPETIekldrfe-----snihtfaSLPFFLYPECRIALPNV 74
gi 19551712    2 RVAIVAESFLPNvNGVTNSVLRVLEHLka--nGHDALVIAPGARdfeeeighy-lgfeivrvpTVRVPLIDSLPIGVPLP 78
gi 159482398   2 ALFVEPSPFSHI-SGMKNRFQCLIRNLre--aGDEVRVFTPDPHapseyhg-----arvvgvlGFKLPFYSSPTLLLSLG 73
gi 161159882   2 KILDVAEFFSSRgGGVRSYLEELVRQGsr--rGHEIVVVAPGPRdevvpler----grivrvaGPPMPYDPTYHALLRLG 75
gi 66850706   14 KVLLTTESLGPV-NGVSRTTGSLIDYLrr--nEVDLMVVAPKFAgaqqaeqp----eanlrlpGYPLPYNPDLTLVYPFR 86
gi 13880095   35 RVAIVAESFLPQvNGVSNSVVKVLEHLrr--tGHEALVIAPDTPpgedraerlhdgvrvhrvpSRMFPKVTTLPLGVPTF 112
gi 15599507    2 HIADMTMFYAPAsGGVRTYLEAKHRHLwh-ypGIRHSVLVPGASyrqang--------ihevpAPPLPFGNGYRFPLRRG 72
gi 16126201   27 RLVDTTMLYAPRsGGVRRYLSSKRAWLashrpDVRHTLVVPGARdfhdgr-------gqvsiyAAPLPFGAGYRWPVVKQ 99
gi 145230185   2 PPFIPPSEDFPS-ILKGKRILLTTESL-----GPVNGVSRTTGK-------------------LIEYLRRNGVELAVVAP 56
gi 16125008    7 RIVDVAEFYSPTgGGVRTYIDRKLEVAeq--lGHELFVIAPGPEdrfesrrs----ggviwvrAPRLPFDANYYMFWDAA 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10175309   75 FKLrqql--tsfqPDLLHIA-----TPFNVGLSGLQHGk--kYGIPMVGSYHTHFD------HYLHYYKLQFMSawl--- 136
gi 19551712   79 SVTsvlr---eynPDIIHLA-----SPFVLGGAAAFAAr--qLRIPAIAIYQTDVA------GFSQRYHLAPLAtas--- 139
gi 159482398  74 LSVnvlwqlltrrPDVIHVS-----APGLMVFAAALYAk--lLAVPLVVSYHTHVP------EYIPKYTWRGLVepm--- 137
gi 161159882  76 AARaiir---reaPDVVQAS-----APYTAALVAASAR----EVPLRTFVYHSDQIs-----TYAAPLLDRVRPravara 138
gi 66850706   87 LKDiyke---paqPDIVYVA-----SPASLGFQLLLYLrqlrKPPVVLLNFQTDLS------AYSEIILPSPLSrwsvwl 152
gi 13880095  113 RMLralr---gfdPDVVHLA-----SPALLGYGGLHAAr--rLGVPTVAVYQTDVP------GFASSYGIPMTAraa--- 173
gi 15599507   73 PWRkvlr---nlqPDLIEVG-----DPYLTAWAALDARr--rLDVPVIGFYHSDLP------LLVSNRMGAWLGtna--- 133
gi 16126201  100 TWMerli---rqqPDLIEAG-----DPYTPGLAALRAGd--aLGVPVVGFCHTDLG------KLAALHIGDWAEkpv--- 160
gi 145230185  57 QFTs--------sPSQQQDTi---dTTIRLPGYPLPYNp--dLTLTDLSSYSSIIFp-----KPLSTFAVWLLSlv---- 114
gi 16125008   81 PVHkhld---alaPDLVEASspwrgAWVVAGWRGRAARam-fMHADPVAIYPQRWFggvaspERVDRWFEWFWR------ 150
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10175309  137 -----wkYVKWFHQPFERTFVPSVETmr---hlQKHGFQRLALWTRGVDCERFHPKQRHRSYainll-----pkdkAVLL 203
gi 19551712  140 -----weWIKTVHNMCQRTLAPSSMSid---elRDHGINDIFHWARGVDSKRFHPGKRSVALrkswd----psgakKIVG 207
gi 159482398 138 -----wsIIRWFTRTADLALVTSHAMkvreraaGWEDAEQLLVWPRGVDAEVFHPRHRCAAMrqrlsg---gvpeaPLLL 209
gi 161159882 139 iegalfaWPRALSRRFDATIAPGTFIae---qlRSHGCERVHRVTFGVKRGDFGPARADAALrrgllgrfadepsaALLL 215
gi 66850706  153 --lavvqGFLFSNPAVHTIFYPSSSIlry-lkdAGAPATRAVKLGRGVDTILFHPSRRDEAFrkeia-----pdgeIILV 224
gi 13880095  174 -----waWFRHLHRLADRTLAPSTATme---slIAQGIPRVHRWARGVDVQRFAPSARNEVLrrrws-----pdgkPIVG 240
gi 15599507  134 -----dnYVSKLYGHFDRVLAPSRVMae---klMRLGVADVHVQPLGVDLVTFHPSNRDPGLrqelg----ldeetRLLV 201
gi 16126201  161 -----qkRWAAIYRQFDQAVAPSRFIag---rlIEAGVRDAIGLPLGVDTAIFHPERGDRDGlrrrlg---lspkdRLLV 229
gi 145230185 115 ------eGYLFRTPCIHTIFYPCSDVlty-lksTNTPIRKTHRLGRGVDTSLFNPSRRSQSLrdtla-----pngeAILL 182
gi 16125008  151 -------YLRSLRRHFDTTVAGGHWLak---rfEQHGLGPVAGIPLGIDRAAFSPDFRDPALrarlleacgmpqdaKLAL 220
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10175309  204 YVGRLApEKDLATLVAIMSLLprelnekiQWMIVGDGPSLPEMkk------qCPSNVTFTGy-lKGEELAAAYAsADLFV 276
gi 19551712  208 FVGRLAsEKGVECLAGLSGRSd------iQLVIVGDGPEAKYLq-------eMMPDAIFTGa-lGGEELATTYAsLDLFV 273
gi 159482398 210 YVGRLGaEKNLDALRCVMEAVpg-----cRLALVGDGPARPQLeq-----hlAGLPVTFMGm-lRGDELSAAYAsADVFV 278
gi 161159882 216 VACRLAvEKRVALVIDAARELaar--rpvALAVLGDGPERARLerr----aaALPQVTFLGfakDRATYAALHAsADVFV 289
gi 66850706  225 CVCRLAlEKGFEFLAVAAAKLaeek-lpfKLLIVGGNRNPEVErnihrlfdtVRDHVIFTGf-lTGEPLARAYAsGDLFL 302
gi 13880095  241 FVGRLApEKHVDRLTGLAASGa------vRLVIVGDGIDRARLq-------sAMPTAVFTGa-rYGKELAEAYAsMDVFV 306
gi 15599507  202 FAGRGSrEKNLPVLLDAIQRLgd----gyHLLLVGSNMPTRVP---------RNTSVVDHFc--DSREVARLLAsSDALL 266
gi 16126201  230 FAGRPArEKKLDVLVAAVERLgd----pyKLLFVGAGGGAPVSd--------RTLCIDYVR---DPVELASILAsCDAFV 294
gi 145230185 183 TVCRIApEKGFEFLAEAVTHLlsstkipfKLVIVGGNANPAVTsriqslfhhISSHVIFLGf-rTGEELASIYAsADIFL 261
gi 16125008  221 AVGRFHpEKRWPMVIEATVKAska--tpiGLVVVGDGIDRARVrra----aaGQPNVHLIPpirDRPLLAAHLAsADVLV 294
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10175309  277 FPSATETFGNVVLEAFAsGTPAIVADRGGVTEIVEhgKSGMICKAgdahtf---------iqaieHLLMNRSKRAEMGYE 347
gi 19551712  274 HPGEFETFCQAIQEAQAsGVPTIGPRAGGPIDLINegVNGLLLDVvdfket---------lpaaaEWILDDSRHSEMCAA 344
gi 159482398 279 MPSETETLGFVVLEAMAsGLPVVAVAAGGLKDILAp-AAASASSPggsssaadlaaaaaaaqlvaALAASPELRASVGAA 357
gi 161159882 290 HGGAAETFGFVLGEALCsGLPLVVPAAGAALDFVQp-GAAEVYAPraspge--------vaaaieRVLARPREERVAAAR 360
gi 66850706  303 HCSITETFGLVVLEAMAsGLPVVARDQGGPSDIVRhqETGYLVPPndietf---------valvrQVSRDSQLLASLALA 373
gi 13880095  307 HSGEHETFCQVVQEALAsGLPVIAPDAGGPRDLITphRTGLLLPVgefehr--------lpdavaHLVHERQRYALAARR 378
gi 15599507  267 HAGDQETFGLVALEAMAsGIPVVAVRAGALAEIVPe-RCGVLCAPnngdam---------acavrELFSHDVELRGQRAR 336
gi 16126201  295 HANDNEPFGLIVLEAMAcGLPVVGVSAGGVAESVDa-AVGQLAVAseataf---------adaieALFERDVTVVGEAAR 364
gi 145230185 262 HCSITETFGLVVLEAMAsGLPVIARDQGGPSDIVRnqETGYLVSVaegevgv-------fsglvgEMLRDGRLRGRLGKG 334
gi 16125008  295 HGCDSETFGLLPAEAMAsGLPLVGPDRGGFADLAQp-ESAEIYRSgdtnaa--------aaallrLLARDPAQLRTAALQ 365
                        410       420
                 ....*....|....*....|..
gi 10175309  348 ARQyalTQSWERifDDLLEQYE 369
gi 19551712  345 AWEgvkDKTWEAlcTQLLQHYA 366
gi 159482398 358 ARAeveRYGWGEatRVLREEQY 379
gi 161159882 361 AAGerlPTSDEHfeALFALYAD 382
gi 66850706  374 ARTyaeDTTWEKinRRVAQQMA 395
gi 13880095  379 SVL---GRSWPVvcDELLGHYE 397
gi 15599507  337 RHVe-rQHAWDAvvAGLLLHYH 357
gi 16126201  365 RRAv-eRHGWDAvfTELCLIYD 385
gi 145230185 335 ARLfaeDMTWEKinRRVVGRMA 356
gi 16125008  366 AAAg-vRPDVDHfaELFEHYRT 386
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