Conserved Protein Domain Family
GT4_GT28_WabH-like

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cd03811: GT4_GT28_WabH-like 
family 4 and family 28 glycosyltransferases similar to Klebsiella WabH
This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core.
Statistics
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PSSM-Id: 340839
View PSSM: cd03811
Aligned: 63 rows
Threshold Bit Score: 147.12
Threshold Setting Gi: 15895580
Created: 15-Dec-2005
Updated: 9-Jun-2017
Structure
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Aligned Rows:
 
putative
Feature 1:putative ADP-binding pocket [chemical binding site]
Evidence:
  • Comment:Some of the residues involved in ADP binding bind indirectly.
  • Comment:Based on similarity to sequences with known structure

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                     #                                                                  
gi 60459541    2 RILFVIDGlp-gGGAEKVVLTLAAQf------------lRDGDRVSLISLRDvceyplpegldyqvva---------drc 59
gi 33632236    3 RVAVHLHQls-lGGAERITVMWCQWl------------vAMGHHVQLFLGQSdkseffapp------------------- 50
gi 32444551    4 KIACVIHSld-gGGAERVMAGLASRl------------aDREHSVTLITLDDgkhdrhevdprvsr-------------l 57
gi 28901263    5 KILHIINDlsqnGGAQKFLVDLVLEh-------------NPEYEIKILVLCAendyleqls------------------- 52
gi 32471694   75 RVLLMASSmr-gGGSELQTAMLARHl------------dRGRFDVHLYLTQAvgdllstipndvtihh--------ppes 133
gi 32476522    2 NIDLIITEmn-fGGAERALTQLAIGl------------rDRGDDVRLFSFGKlptadslpkgndrlvqq------lhdeg 62
gi 28898241    6 RILYVHYGdnwiRGSEVVLLDLILGi------------dRDKFEPIVWSNCQpliekcqdlgikaehst-------fnlv 66
gi 39997074    2 KVLHVIDSgg-lYGAEVMLLNLAAEq------------aAMGLEPVIASIGDplcgekplekeavr-------------r 55
gi 296100518  10 KILLLDTGke-wGGGTNSMLELLKRi------------dRDKFDITCCFYNDysraggqtigqvlnsigiplivipqhkq 76
gi 17433756  163 RLALCTGSlg-sGGAERQISRLAIEiarkyrqkgkigglKVEEPVELIIRSLtpelrqdfflkevleeqvev-leiakit 240
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 60459541   60 rkpwrkltelsrRARQLDAAVVRAEQqg------------qFDLVLSNlhkt----------driVARSRALRe------ 111
gi 33632236   51 ---asvkiirrpAGLLSVIWLRRLLLqn------------pPDLCIGItt--------------rPAVNLLLAsvg---- 97
gi 32444551   58 sidvlstpgntvSLWSRTLRLRSTIAsg------------nFDVVLSFcd--------------aTNWLTLLAtrg---- 107
gi 28901263   53 ----argiqcfnWQTLSLSEKWSLLRw--------------PDLVHGHly--------------pSIYLALLAig----- 95
gi 32471694  134 fsprisdripggLLKRQAEWFRDLIRra------------dVDVIYDRtfh------------mtLIAGHPIVqrgss-- 187
gi 32476522   63 ievtsggvqtsrGFLPATIQLRRWLArr------------pGSLIQTFlw-------------haNVLGILNAss----- 112
gi 28898241   67 ggwcaprwditgWNNLIKQGSALIEKh-------------nIDLVHVNsg--------------gPCQWMSLAarm---- 115
gi 39997074   56 glrverfrmrpgANIAGAFSVLRFAWre------------qCDVLHSHgy-------------kgNILFGFMPral---- 106
gi 296100518  77 pawakllkeagrGLLFFSRNARKAFTrhvdtlwrirpnvskIETLFSHggfdtlymnnqpgsneeGYLAAAKLq------ 150
gi 17433756  241 gnlfddatiespELRLLLSHLPPVCKygikhlv-phlcerkLDYLSVWqd-------------saCLMIALAAliagvpr 306
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 60459541  112 -------rNVWFCLHGVFSasylghrtgfdrwmkqqkikriyqgRNAVTVSDAVGRDLVEEfalrpaQLKTIYNPFDITA 184
gi 33632236   98 -----crwPVVVAERNYPPsnpqsliwsl------lrrllypsaALHVVQTQRIADWLHQLgl--ssTSVVLPNPVVWPL 164
gi 32444551  108 -----lgvPVVVSERSDPKhqslgraref------lrrqlypkaYRVVCLSDDVAVTLQSQtr---cHTLVIPSAIEVPK 173
gi 28901263   96 -------kKRIQTEHCSYNrrrdyplfkf------ieyvlywghHYTVSISEKVQEELVKFmpryqhKYRVVHNGVDLNR 162
gi 32471694  188 ----grpcPRVSTIVSPPEvalplvekrfvwlkrqrlaqayrrsAAVVAVSEAARRSAIRYyglpesLVQTIRNPIDVDS 263
gi 32476522  113 ------rqPRVAGIRVAEPnslrlave----------rqtlrkvDHVVCVSRAVETFAQQQlnlspdRTSVIPNAVDVDA 176
gi 28898241  116 -----nhvPLVTQLHCHYTlrdrfs-------------lglhlsPKLICVSKDVGREILRDgyp-eeQLHVVHNGVSLDD 176
gi 39997074  107 -----rrlPMVTTLHGWTWtggmdrmglye----wldrlslrfvDAVVMVNDAMRRKIDLP------GIHVVPNGIPLAG 171
gi 296100518 151 -------aRLIQHCRIEPVlspplvk------------lvnahaTKIIAVSHGVEQVLLQHgir-pdLCTTVNNAIDIYQ 210
gi 17433756  307 iqlglrglPPVVRKRLFKPeyeplyqal-------avvpgvdfmSNNHCVTRHYADWLKLEa----kHFQVVYNGVLPPS 375
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                    ###                                                 
gi 60459541  185 LRAEaead---------serPDGDYLIHVGRFhpGKRHDRLLEAYAQSgi-------dAPLVLLGQGKPEQEQrlr---- 244
gi 33632236  165 PVQDpilqp------dhfmsSDVRVVLAMGTKpfQKGFDRLLQAFQELapr----ypdLVLALVGVHPDHPDLaa----- 229
gi 32444551  174 EFRTrlkpite---rqsdpgQAKCHLVAVGRLerEKGFDRLIRSLGDLpdd----apdWELTIHGEGSQRDHLes----- 241
gi 28901263  163 FPMTakqah-------diseKATINIGMVGRLheHKDHETLIHAIAKLpe-------cYHLHLAGDGDRKASLqr----- 223
gi 32471694  264 IRGSagsse------pglepDGSLRLVVVGRMtpEKGHATLLSAIGILakdwpeqlpaLRFRLIGDGPLRGDLesrwkdm 337
gi 32476522  177 FASAdpidwt-----dlgwpADSPVVLFVGRLhtQKGLEHLQRTVERFape----dshRKLVLIGNGPLQNELa------ 241
gi 28898241  177 SEAPidika------rlgipANAFTFLSVGSLikRKGFDRLIHAMRMHnyh----qtnPHLVIVGDGEERENLmq----- 241
gi 39997074  172 EAERpavpldp---rivefcRGGITLGAIGRLspEKGFDILLDAVREVaet----npgVRLALLGEGVERDALea----- 239
gi 296100518 211 PLPDrramrq-----rlgidDETFVFGSIGSLipRKANHHTLEALAQFslkh--peakWKMVLVGEGPERDALaa----- 278
gi 17433756  376 TEPSsevphkiwqqftqktqDADTTIGGVFRFvgDKNPFAWIDFAARYlqh----hpaTRFVLVGDGDLRAEAqk----- 446
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                             #                      #                                   
gi 60459541  245 -qlAKTLHIDDRVWFKGfQKNPLPWIKg-ARMLVLSSDSEGFGNVVVEALLlHIPVASTRCPgGVTEILTGELARGLAdl 322
gi 33632236  230 -plQRTGSLRPRIVLPGrVGNPADWYQr-ADLFVLSSRYEGSPNVLLEAMAaGCPCLAVDCPtGPHEVIRHGANGWLLpe 307
gi 32444551  242 --lASKLNLASRVKFPGwTRPIWPVYQs-ADCFVLPSRYEGFPSALLEAMAcSTAVLTVDAGgAVREIIDHGRNGWLVtn 318
gi 28901263  224 --lAQSLNVSPRVHFHGvVSDIPRFLSd-MDIYVQSSHVEGFGLAAVEAMAaGLPVLSSDVP-GLDEVTGSSEYLFEVgd 299
gi 32471694  338 vlaAGPKDAIHRVEFAGaIQPACSEIAa-ADGLVLPSHFEGLPNVVLEAFAlQTPVIATRAG-GAVELQKSSDEPTCHwa 415
gi 32476522  242 --tWAKQVSGDRVRVLTwQSNIASWIAa-SRVVVLPSRYEGMPNVILEAMAaGKPVVSSRVE-GSQELIGHDPNQGFEln 317
gi 28898241  242 --lVTDLGMQDRVHFAGeQTNAGAWMSgnADAFISGAYEEAFGLVVGEAALaKLPIVAPKTG-GIPELFEHNHSALLYpn 318
gi 39997074  240 --kIRELGLTERVLLPGyVPDANRYLPl-FRAFVLSSLTEGLPMVILEAMLaGVPIVATRVG-GVPEVLDGGAAGLLAep 315
gi 296100518 279 --qAQNLGIASHVIFTGfQNTPFDYLAt-FDAFILASKSEGLPRVVLEAMLlNIPVIGSQVT-GTAELIDHASTGLLFpw 354
gi 17433756  447 --rAEQLGILERILFVGaSRDVGYWLQk-MNVFILFSRYEGLPNVLIEAQMvGVPVISTPAG-GSAECFIEGVSGFILdd 522
                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....
Feature 1                                                              
gi 60459541  323 tspala----qtmqsiyhNPPAIDDAALekf------------svVSICQQYRQ 360
gi 33632236  308 rtdgfdlamgietclnqpAECRRLGQAAre-------------irDQFSPAKVQ 348
gi 32444551  319 ddaal------ragllhcLTSTELRERFaa-------------qaGEVTDRYGW 353
gi 28901263  300 snlla-------qkvaelCEDAALYNSAshysvnr----aklytiDKFREGYYG 342
gi 32471694  416 vpadpg----slaraireFAEQADQRQLhva------------naDRLIRENHD 453
gi 32476522  318 ddtal------vhslerfLADEDLATQTgqa------------nqSRVRSQFTV 353
gi 28898241  319 qgmagl-----lnaiqlvMQDADLREKLaen------------ayLHASQNLTT 355
gi 39997074  316 rhagsl-----agcvsrlIGDDLLAARLaer------------grHLVETRYAA 352
gi 296100518 355 sdvsql-----aqhldsiWTDADLRARLata------------arQNVCRNYAI 391
gi 17433756  523 a--------------qtvNLDQACRYAEklvnlwrsrtgicqqtqSFLQERFTV 562

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