4B43


Conserved Protein Domain Family
IF2_mtIF2_II
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cd03702: IF2_mtIF2_II 
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Domain II of bacterial and mitochondrial Initiation Factor 2
This family represents domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homolog mtIF2. IF2, the largest initiation factor, is an essential GTP binding protein. In E. coli, three natural forms of IF2 exist in the cell, IF2alpha, IF2beta1, and IF2beta2. Bacterial IF-2 is structurally and functionally related to eukaryotic mitochondrial mtIF-2.
Links
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Statistics
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PSSM-Id: 293903
Aligned: 96 rows
Threshold Bit Score: 105.969
Created: 23-Aug-2004
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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putative rRNA
Conserved site includes 6 residues -Click on image for an interactive view with Cn3D
Feature 1:putative rRNA binding site [nucleic acid binding site]
Evidence:
  • Comment:based on the structure of Oryctolagus cuniculus (eukaryotic) 80S initiation complex
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                 #  #                           #  #                    #    #       
4B43_A    246 EPRGVILESKLDKqaGIIANMLVQEGTFRVGDYVVAGeAYGRIR--AMMDADGNQRKEAGPGSAVQVLGf-qELPHAGDV 322 Thermus thermophil...
AAC63272  319 LVEGVIIDCSNHIgrGKLVTALIQRGTLKKGCLLVSGiASAKVR--SMFNDSGNPILKAKPSEVVQILGw-kELPNVGDE 395 honey bee
AAF56796  336 LVEGIVVESKTDPrrGKLSTAIVSRGTLRKGSVLLSGlAHAKVR--GLFDHNGQPLSEAPPGTPVEILGw-rELPLAGDL 412 fruit fly
AAS52651  326 LVEGWILESEVQKtlGNVSTVLIKKGIIRKGAVLLSGnTYCKVR--NLIGENGASVAMATPAQAVEVTGw-kQLPMAGDQ 402 Ashbya gossypii AT...
XP_451475 320 VCEGWVLESEVKKavGNVATVLLKKGVMNKGDILISGnSICKVR--AMLNEHGAQVTKALPSQAVEIVGw-kSLPNAGDE 396 Kluyveromyces lact...
XP_444851 322 VAEGWILESKVRKtiGNAATVLVKKGTIKKGDILLCGnTYCKVRsmRGSDENNKSLNLAPPAEAVEISGw-kDLPDVGDE 400 Candida glabrata C...
O59683    346 PFQGWIVESSVTKgvGSSATVVVKRGTVKKGMYLVAGkSWCKVR--SLVDVNKKSIKQVLPGQAAQVYGw-kDLPIAGDL 422 fission yeast
CAA94822  330 KVEAVIIESSVVHgiGKVCTLVVSRGTLKKGCVLVAGsSWCRVK--TMHDENGKIVQVATPSQPVRVSGwkdDLPTPGDL 407 nematode
AAX70027  376 RCEVTVIETNGVNt-TTEVAGIVRCGKVRAGQVLVAGmTYAVVR--KVLDEHGQIIQEAGPSQPVVLHGf-rVHPKPGSV 451 Trypanosoma brucei
CAJ04623  354 RAEMYVLESRNLG--VSEVAAVVRCGTVKPGQVFVTGtVYGTVK--RILDDHGATLDEARPSMPVVLHGf-rVPPKPGSV 428 Leishmania major

Feature 1                        
4B43_A    323 VEWVPDLEAAKEIAEERKE 341 Thermus thermophilus HB8
AAC63272  396 ILEVENDKILQEVIKFRQK 414 honey bee
AAF56796  413 ILEVETEKKAHAVLKYREH 431 fruit fly
AAS52651  403 VIQVDSEAIAKKYVGKRLH 421 Ashbya gossypii ATCC 10895
XP_451475 397 VIQAKSESIAKKYVARRQH 415 Kluyveromyces lactis NRRL Y-1140
XP_444851 401 IIQVKSESVAKKYITKRQK 419 Candida glabrata CBS 138
O59683    423 AYEVKSESEAKRILSDIYR 441 fission yeast
CAA94822  408 VLEAETVDRAQKAVNLRID 426 nematode
AAX70027  452 LLQVSSESHAQKFYHFMKE 470 Trypanosoma brucei
CAJ04623  429 MMQVSSEKHAEKFSYFMRE 447 Leishmania major

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