2BI0


Conserved Protein Domain Family
FkbR2

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cd03451: FkbR2 
Click on image for an interactive view with Cn3D
FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. The function of FkbR2 is unknown.
Statistics
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PSSM-Id: 239535
View PSSM: cd03451
Aligned: 39 rows
Threshold Bit Score: 110.372
Threshold Setting Gi: 41409750
Created: 7-Mar-2002
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
putative activeputative
Conserved site includes 7 residues -Click on image for an interactive view with Cn3D
Feature 1:putative active site [active site]
Evidence:
  • Comment:based on the active sites of (R)-hydratase and the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                    #    # #  #               #  ##                    
2BI0_A       12 GPYFDDLSKGQVFDWAPGVTLSLGLAAAHQSIVGNRLRLALDSDLCAAvtgXPGPLAHPGLVCDVAIGQSTLAtqr-vkA 90
gi 16127886   7 GNYFEDFRLGQRLVHATPRTVTAGDVALYTALYGPRFSLFSSDAFAQGc-gLMSAPVDPLIAFHVVFGKTVPDislnavA 85
gi 24215327  29 GRYLEEFTEGEIFEHPREITIDRAFAQEFATTFMDANPLFLSAPYAKAh-gFQDMLVSSLQVFNIALSLGVQNdsekalA 107
gi 13425414 192 PHAFEDYAIGEKIDHVDGMAVEEAEHQMATRLWQNTAKVHFNQFERAKd-pSGRRLVYGGVVISTAKALSFNGlqn-agL 269
gi 76260205   8 GNFFEDFRLGQTIVHATPRTITEGDVALYTSLYGSRFALTSSTPFAQSl-gLERAPIDSLLVFHIVFGKTVPDislnaiA 86
gi 76260205 193 NYLWDDYEVGEKIDHVDGVTIEEAEHMQATRLYQNTARVHFNLHVEREg-rFGRRIVYGGHIISLARSLSFNGlan-alS 270
gi 68560021   7 GNYFEDFRVGMKIRHATPRTLTEGDRSLYIGLTGSRAALCTAETNARDl-gMERRPLEDLLVFNTAFGKTVPDislnavA 85
gi 23015162 198 PHLWDDYAVGEKIDHVDGMTIEEAEHMMATRLWQNTAKVHFNQYTEGQg-rFGRRLIYGGHIISLARALSFNGlgn-afK 275
gi 68181132   7 GYFFEDYHVGQSLHHATSRTLHDGDVAMYQALYGPRFALQSSWDFASPgssLRNPVMDDLITFHTVFGKTVPDislnavA 86
gi 55377544 241 LERADTENAAVAYRHERGRTMDDQLVAGLPLATLNTARQHHNRDEMADs-pSGDIVAYGDVTRSVALAHARSDea--tyR 317
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                       
2BI0_A       91 NLFYRGLRFHRFPAVGDTLYTRTEVVGLRanspkpgrAPTGLAGLRXTTIDRT---------------DRLVLDFYRCAX 155
gi 16127886  86 NLGYAEGRFLAPVFPGDTLSAVSDVIGLKen----snRKTGVVYVRTTGVNQR---------------GEPVLSYVRWVM 146
gi 24215327 108 NLGYYNVQFLKPVYPGDTLSAKTKILKVDdk----gsDKPGIVSVRTICLNQN---------------KELVLQYERKIM 168
gi 13425414 270 ILAINGGRHVAPFFAGGTVFAWSEVLDKAd------lGAVGALRLRLVATKDRpcddfpdkdaegaynPAVILDFDYWAA 343
gi 76260205  87 NLGYAGGRFGAVVYPGDTLSTTSKVIGLRqn----kdGKTGVVYVHSVGVNQW---------------DEVVLEYIRWVM 147
gi 76260205 271 IAAINSGRHTNPSFAGDTIYAWSEILAKMaip---grTDIGALRVRTVATKDRpchdfpyrdaegnydPAVVLDFDYTVL 347
gi 68560021  86 NLGYAEVRFLAHVYPGDTLAVESEVIGLKen----tsGKSGVVYVRSMARNQH---------------GREVLSWVRWVM 146
gi 23015162 276 IVAINGGRHTNPTFAGDTIHAWTEVLEKIevp---grKDVGALRLRLVATKNCl-------------aPLPPQGGKRXGF 339
gi 68181132  87 NLGYAEGRFLARVESGDTIHARSEIIGLKqn----snGKTGIVWVRTRGFSNV---------------DVPVLEYVRWVM 147
gi 55377544 318 ERRFADEQFHDFVTLGDTVYGFTRVLDCDpda---gpERAGAVTFEHVAFNQD---------------QTPVYSGRRTAL 379

                ....*
Feature 1            
2BI0_A      156 LPASP 160
gi 16127886 147 VRKRD 151
gi 24215327 169 IYRSN 173
gi 13425414 344 VPKRG 348
gi 76260205 148 VRKRD 152
gi 76260205 348 MPRRG 352
gi 68560021 147 VHKRD 151
gi 23015162 340 RRQRG 344
gi 68181132 148 VRKRD 152
gi 55377544 380 IQRDT 384

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