Conserved Protein Domain Family
TCP1_gamma

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cd03337: TCP1_gamma 
TCP-1 (CTT or eukaryotic type II) chaperonin family, gamma subunit. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings. In contrast to bacterial group I chaperonins (GroEL), each ring of the eukaryotic cytosolic chaperonin (CTT) consists of eight different, but homologous subunits. Their common function is to sequester nonnative proteins inside their central cavity and promote folding by using energy derived from ATP hydrolysis. The best studied in vivo substrates of CTT are actin and tubulin.
Statistics
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PSSM-Id: 239453
View PSSM: cd03337
Aligned: 21 rows
Threshold Bit Score: 703.285
Threshold Setting Gi: 19069275
Created: 6-Jan-2006
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
Feature 1:stacking interactions
Evidence:
  • Comment:interactions of one subunit to subunits of the second ring
  • Comment:annotation based on structure of bacterial homolog GroEL

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                       
gi 1006731    4 PVVFMNASQERTTGRQAQISNITAAKAVADVIRTCLGPKAMLKMLLDpmGGLVLTNDGHAILREIDvaHPAAKSMLELSR 83
gi 3393020    4 PVFVMNTNGNRQVGHKAQMSNIQAAKAVADVIRTCLGPRAMLKMLLDpvGSVLLTNDGHAILREIEvaHPAAKSMIELAR 83
gi 71023969   6 PVFVMNTGPERQTGRKAQISNITAAKTVADVIRTCLGPKAMLKMILDpmGGILLTNDGNAILREVEvaHPAAKSMIELSR 85
gi 62359233   6 PVIVLNQKMERQTGRKAQLNNIEAARVVSGLISSTLGPCAMLKMILDpmGGTVLTNDGNCILREIDvvHPAAKHMLELAR 85
gi 1906364    6 AVFILNQNAKREQGRKAQTANIKAARAVSDIVRTTLGPKSMLKMLLDpmGGIVLTNDGNAILREIDvaHPAAKSMIELAR 85
gi 67588010   5 QVLVVQQPSQRDQGRKAQLRNIQAGKTVADVVRTTLGPKAMLKMLLDplGGIVLTNDGNSILREVDvaHPGAKSIIELSR 84
gi 66812868   4 PVFVLNTNAKRENQKEAQQGIFLAVKSVASIIKTCLGPKAMLKMILDpmGTTVVTNDGNAILREIDvtHPAAKSMIELSR 83
gi 56466732   4 PVLVLNTNTKRENGRKAQLANIMAGKTVADLIRTCLGPKSMLKMLIDpqAGVTITSDGNSVLRDLTveHPAAKYMIELSR 83
gi 71076306   4 QVYVLSQGTESERREMARMNNIKASKTVADVIRTTMGPRSMLKMILDsmGSVVMTNDGNAILRELDvaHPAAKAMLEVSR 83
gi 68350678   5 MYLVFKPSLKKESDRKAQLATIQASKALSDIVRTTLGPRSMLKMLLDpmGGIVITNDGNSILREIDvnNPGAKSLIELSR 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                       
gi 1006731   84 TQDEEVGDGTTTVIILAGEILAQCAPYLIEkNIHPVIIIQALKKALTDALEVIKQ----VSKPVdv------enDAAMKK 153
gi 3393020   84 TQDEEVGDGTTSVIILAGEILAAASPLLDR-KIHPVVMIRSFKQALEDALSIIDE----ITLPVnv------ddNAEMFR 152
gi 71023969  86 TQDEEVGDGTTSVIILAGEILAQSLPQLER-SIHPVVIISAFKKALARALEIVEE----ISVPVdv------tnDKDMLA 154
gi 62359233  86 AQDEEVGDGTTSVIILTGEILSLSKPLLER-GIHPLKIVKGFSLALTDALAAIEK----IATSIdp------ndIKQLEE 154
gi 1906364   86 AQDEEVGDGTTSVIILAGEILSAVESFLER-DIHPTVIVGAYFQALEEIVRLTES----YGEPIdi------enENDLQK 154
gi 67588010  85 TIDEEVGDGTTSVVVLAGEFLACAEPLLQK-NIHPTIIAKGYLRALDDSIKFMEE----MSVKLdv------nnKESLVS 153
gi 66812868  84 AQDENVGDGTTSVVILAAEVLASSELFIEK-KIHPHYIIKAFRMALDDSLSIVDQy--sVAIDLk--------nRPEVLK 152
gi 56466732  84 TQDETVGDGTTSVVILCGEVLQVAEPWIQK-GIHPTIIISGFLDALEDALESLHE----ISTTIdlsn--pkvvSGVVRS 156
gi 71076306  84 AQEEQVGDGTTSVVILAGEVIAMAEPLLKC-GIHPILITQGYQKALDFLLSEAERssfeINIKGieilglkseaAGPIMT 162
gi 68350678  85 SLDEEVGDGTTSCVILCGELLSNCASLIKK-EIHPTEIIQGLMEALDDALKALDN----ISIPVni------ndHNKLLQ 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                       
gi 1006731  154 LIQASIGtkyv----------ihwSEKMCELALDAVKTVRkdlgqtvege------------------pnfeidikrYVR 205
gi 3393020  153 LIRTCIGtklv----------arwSDLMCHLALRAVRTVAstsngrm------------------------eidikrYAR 198
gi 71023969 155 LIKTSIGtkfv----------srwSEQMCKLALKAVRTVAmvdstagssas---------------sdpsktvdikrYAR 209
gi 62359233 155 VVRACLGtkyn----------sheDDLMCKMAVEATLRVVvenkvtgq----------------------kevdikrYAK 202
gi 1906364  155 IVSSCIGtkfs----------skwGNLIVDLAVKAVKSVYkkegdyv------------------------eidvkrYAK 200
gi 67588010 154 VVDSCLKtkfs----------grwGSLISSMALKAAETVSiansgsp-----------------------keidikrYVR 200
gi 66812868 153 VVQSCIGtkfi----------gkwGSLMCNLALDAVMTVHiqeedgr-----------------------seidikrYAK 199
gi 56466732 157 CIGTTFMnt--------------wNDILCKLAIEAVTICAggdlmkakg--------------------kedidtkrYAR 202
gi 71076306 163 VLKNSLStkfv----------srwMDLMCNLALEAVSIVArgrgaevrkglvgvtkdarskgdeaelgasvdidikrFCR 232
gi 68350678 154 IIQSSLStkfsnrwgdlisklaldSIFKLHKSTHNRTNGTnctnglngvsdg-------------lpdavkpldikrLIK 220
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                       
gi 1006731  206 VEKIPGgdvlDSRVLk-gVLLNKDVVHPkmsrHIENPRVVLLDCPLEYkkgesqtnieiekeedwnril-qieeeqvqlm 283
gi 3393020  199 VEKVPGge-iESSCVldgVMLNKDVTHPkmrrRIENPRIVLLDCPLEYrkgesqtnieiskdtdwnril-eieeeqvkrm 276
gi 71023969 210 VEKVPGgtieDCRVLd-gVMLNKDVTHPkmrrRIENPRIILLDCPLEYkkgesqtnieitreedwnkil-eieeqqiqam 287
gi 62359233 203 IEKIPGgsvsDSVVLd-gVMFNKDHIHPkmrrYIEKPRILLLDCPLEYkkpettinvevgqatdwelll-kqeedyvrgl 280
gi 1906364  201 VEKIPGglleESVVLd-gVMFNKDVTHPgmrrYIENPRVVLLDCPLEYkkgesmtnmeftkeedfkkalmmeeeevkkmc 279
gi 67588010 201 IEKIPGgeieDSYVLd-gVVVNKDVVHPrmkrLIINPKVLLLDCTLEYkkgesqtnveitkeadweall-rqeeeeveam 278
gi 66812868 200 VEKIPGgdisDCRVIr-gVMLNKDVTHPkmkrMIKNPRIVLLDCSLEYkkgesdtmvditneddfsall-kieeeyvqri 277
gi 56466732 203 VEKIAGgefsESMVVk-gVVLNKDVVHSkmrrRIDKPRVVLLDCSLEYtkgesqtdvevttatdfgkli-eleeqyvkrl 280
gi 71076306 233 IEKIPGatveDCCVId-gVVLNKDVIHPdmrkYIKNPRILLLDCPLEYkkaqsmmnvelfqgksdlgdilkveedyirth 311
gi 68350678 221 VEKIIGgyieDSKVLd-gVVVNKDVVHAnmsrRIENPRILILDCTLEYkkgesqtmvdiydesvwnkll-lqeeteikqm 298
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                       
gi 1006731  284 ceqilavrptLVITEKgVSDLAQHYLLk-gGCSVLRrvKKSDNNRIARVTGATIVnr-vEDLKESDVGTNCGLFKVEMig 361
gi 3393020  277 cdyiiavkpdLVITEKgVSDLAQHYLLk-aNITALRrtRKSDNNRIARACGANIVnrleDLREKDVGTGCGLFYIDKLgd 355
gi 71023969 288 cekiiefqpdLVFTEKgVSDLAQHYLLk-aNITCIRrvRKTDNNRIARATGATIVnrvdDLRDADVGTRCGLFHIEKLgd 366
gi 62359233 281 cqtiisfkpdVVITEKgASDLAAHFLHk-aQITCIRrlRKTDNNRIARATGATIIsr-vAELTEDHIGHAGLMEIKKIgd 358
gi 1906364  280 aedilrvkpdVVITEKgVSDTAQHFLLkygNCTVIRriRKTDNNRIARVTGATIAnr-pEELQESDVGTKCGLFEIKKig 358
gi 67588010 279 ckdiiatgcnVVFTEKgVSDLAQHFLVk-aGISVIRrvRKSDNNRIARVTGATIAsr-tEELTPNDLGTCCGRFEVKKig 356
gi 66812868 278 cediiklkpdLVFTEKgVSDLAQHFFVk-kGITCLRrlKKSENNRIARISGATIVsr-tDELQESDIGTGCGLFEIRKig 355
gi 56466732 281 ceniirvkpdLVITEKgISDIAQHYLQk-aGISALRrvRKNDNLRLVRATGASIVyr-tEDLKETDVGVAGLFEVKKIgd 358
gi 71076306 312 vekilsfkpdLVITEKgVADQATHMFVq-hGVTVLRrvRKTDNVRLAAVSGATIVsr-vEELQESDVGTYAGLYELQKig 389
gi 68350678 299 cqyiinsncnLVVTEKgVSDLAQHYLVk-aGISCLRrvRKSDTNRISKACGATIVnr-pEEITESDIGHRCKLFHVDKig 376
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                  #    
gi 1006731  362 deYFSFLDNCKe-pKACTIMLRGGSKDILNEIDRNLQDAMAVARNVMLSpSLSPGGGATEMAVSVKLAEKakqleGIQQW 440
gi 3393020  356 -eYYTFLTGCKn-pKACTILLRGPSKDIINEVERNLQDAMAVARNVFFHpKLSPGGGATEMAVSVRLAEKarsieGVAQW 433
gi 71023969 367 -eYFTFLEECKe-pKACTILLRGPSKDILNEIDRNLADAMAVARNVVFNpLLAPGGGATEMAIAYGLSEYakeleGVEVG 444
gi 62359233 359 -eYFTFITGCTs-gKACSVVLRGASKDTINEMERNLHDAMCVARNIILEpRVVYGASALEMYVSSYLMNRsksitGVQQA 436
gi 1906364  359 deYFSFMTKCEn-pKACSILLRGASKDVLNEIERNLHDALGVARNVMVNpKLVPGGGAIEMELACRLMEFsqkieGMQQW 437
gi 67588010 357 deYFCFLTESKt-pKACSILLRGGSKDVLNELERNLHDALAVARNILLDpALLPGGGGTEMAISCYLNEKsfsidDTQVW 435
gi 66812868 356 deYFTFLEDCKe-pKACTILLRGASKDILNEVERNLTDALNVARNIVLDpRLVPGGGAIEMALSQALSEKsksieGLHQL 434
gi 56466732 359 -eYYAFISECEk-sTACTILLRGGSKDVLNEVERNLQDAMASCKNLIARpELVPGGGASEMHIATTLSKKaknieGKKQW 436
gi 71076306 390 deFFSFIHQSGgkaSACTIVLRGASKSTLLEIERNIQDAMHVCRNIILDpRLVIGGGCFEAHLSTALSQYadtlvGKPQL 469
gi 68350678 377 deYYSFFDLCTd-pKACSILLRGSSKDVLNEIERNLYDALSICRNIIYNcKLLPGGGATEVYISNFLNQQisrkvGLRRL 455
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                    #        #       ##  #                                             
gi 1006731  441 PYQAVADAMECIPRTLIQNAGGD------PIRLLSQLRAKhaqg------nftTGIDGdkgkiVDMVSYGIWEPEVIKQQ 508
gi 3393020  434 PYRAVADAIEIIPRTLVQNCGAN------PIKALTELRAKhaeg------qhsFGIDGetgrvVDMHEYGVWEPEAVKLQ 501
gi 71023969 445 PIRAVSDAMEVIPRTLIQNCGGN------AIKTLTTLRAKhang------qhsYGVDGetgkvVEMKEYGLYESAAVKIQ 512
gi 62359233 437 AYQAVAMALEVVPRILTSNCGAN------VIRTVTELRARhamp-----dgdyWGVDGttgdiVDVRSLRVVEPAAVKVQ 505
gi 1906364  438 PFKALAGALEVIPRTLAQNCGAD------VVRVMTELRAKhandk----eglyWGIDGntgkiRDMRESNVWDPISVKQQ 507
gi 67588010 436 AYKAFAQALEIIPKTLAQNCGAN------VMKTLTLLKSHylpssatrgqkpvHGINGctgaiTNVTELGIWDTLAVKQQ 509
gi 66812868 435 PYKALAQSLECIPKILAQNCGAN------TVKLLTELRAKhatnp---tenytYGVDGdngtiVDMKQLGIWDTHSVKVQ 505
gi 56466732 437 PYSSIAVAMEVIPRTLAANCGVD------VVKVITELRAKhisnk----enstFGIDGmkgtiVDMKELGVWEPYEVKAQ 506
gi 71076306 470 VIKAVAKSLEVIPRTLLQNCGGN------IIRTITELKAAhtsd-----pncqLGVDGvtgllVNCKEQGIWDPLSTKLQ 538
gi 68350678 456 SYECASKAFQVIPKTLAQNCGVNpstalrAGNSCLKLMSDlllmhg--ngevhMGINGetgqiINVVNHNLYDIFLVKSQ 533
                       570       580
                ....*....|....*....|.
Feature 1                            
gi 1006731  509 SVKTAIESACLLLRVDDIVSG 529
gi 3393020  502 SIKTAIESACLLLRVDDIVSG 522
gi 71023969 513 TLKTAIESASLLLRVDDVVSA 533
gi 62359233 506 ALKTAIEAASMILRVDDVVSG 526
gi 1906364  508 TLKTSIEATCMLLRIDDIVSG 528
gi 67588010 510 VYKTAVEATLMLLRIDDVLSS 530
gi 66812868 506 TLKTAIESACTMLRVDHIASA 526
gi 56466732 507 CIKTAIEAACTLLRVDDVVSG 527
gi 71076306 539 VLKAAIENACMILRVDDIFSC 559
gi 68350678 534 IYKSSFESVSHCLLCLYVIED 554

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