1JJ7,1MV5,1MV5,1MT0,1XMI


Conserved Protein Domain Family
ABCC_MRP_Like

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cd03228: ABCC_MRP_Like 
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ATP-binding cassette domain of multidrug resistance protein-like transporters
The MRP (Multidrug Resistance Protein)-like transporters are involved in drug, peptide, and lipid export. They belong to the subfamily C of the ATP-binding cassette (ABC) superfamily of transport proteins. The ABCC subfamily contains transporters with a diverse functional spectrum that includes ion transport, cell surface receptor, and toxin secretion activities. The MRP-like family, similar to all ABC proteins, have a common four-domain core structure constituted by two membrane-spanning domains, each composed of six transmembrane (TM) helices, and two nucleotide-binding domains (NBD). ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.
Statistics
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PSSM-Id: 213195
View PSSM: cd03228
Aligned: 249 rows
Threshold Bit Score: 130.196
Threshold Setting Gi: 15901196
Created: 27-Jan-2005
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
  next features
Conserved site includes 9 residues -Click on image for an interactive view with Cn3D
Feature 1:ATP binding site [chemical binding site]
Evidence:
  • Comment:Walker A, Walker B, Q-loop, D-loop, and H-loop form the nucleotide binding site
  • Structure:1JJ7; Mg-ADP, 4.0A contacts
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                            ## ###                                    
1JJ7_A      15 VQFQDVSFAYpnrpdvlvLQGLTFTLRPgEVTALVGPNGSGKSTVAALLQNlyqptgGQLLLDgkplpqyehrylhrqVA 94   human
NP_214076  332 IEFRDVSVKInrk---eiLKNVNLSVYRgSKVGIKGHTGSGKSTFVKLIPRlle-yeGEIFVDhtelrefklkslrekIG 407  Aquifex aeolicus...
AAK03557   340 IEVENLSFAYade---qiLSNLNLRLQKgQILGIHGRSGSGKSTLLKLMMRfydpqtGVIRINgtdlkqintlslrdhIA 416  Pasteurella mult...
NP_973156  340 VDADNINFRYddm---evLQDVSISVKKdEIVGLCGKSGSGKSTLLRLIMRffdplsGEVKMSgidikkintaslreaVS 416  Treponema dentic...
BAB79933   339 IEYKDVSFAYkgk--envLKDVNIDIKLgDKIAVIGESGTGKSTFVKLLMRfwdvtkGEISLGnknvkeiqtkelrkkMA 416  Clostridium perf...
AAO35770   340 IETLNVSFSYntk--diiLENINIKFKKgNIVGIVGESGSGKSTLLKLFMRfwdattGNIKINnenikdiktsslrgmQS 417  Clostridium teta...
NP_064693 1312 IKIHDLCVRYennl-kpvLKHVKAYIKPgQKVGICGRTGSGKSSLSLAFFRmvdifdGKIVIDgidisklplhtlrsrLS 1390 human
O60706    1312 IKIHDLCVRYennl-kpvLKHVKAYIKPgQKVGICGRTGSGKSSLSLAFFRmvdifdGKIVIDgidisklplhtlrsrLS 1390 human
P36028    1285 VELKNLSLRYsphs-skaLDNVSFKVKAgTKVGIVGRTGAGKSSIIAAIYRlsdwenGTITIDnkdikhiplerlrnsIS 1363 baker's yeast
P26363    1213 MTVKNLSANYidgg-ntvLENISFSLSPgQRVGLLGRTGSGKSTLLSAFLRlls-tqGDIQIDgvswqtiplqkwrkaFG 1290 African clawed frog
Feature 1         #                                                                            
1JJ7_A      95 AVGQepqVFGRSLQENIaygltqkptmeeitaaavksga-----------------hsfisglpqgydtevdeagsqLSG 157  human
NP_214076  408 FLSQevmVFRGSVRENLliakpdateeemlkalelakc-------------------dfvlnspegldkfleeggknLSG 468  Aquifex aeolicus...
AAK03557   417 YITQqtyIFNETIYENIlmanrtaskaqvieaakkasi------------------hdfimslpegydtqinelgsnLSD 478  Pasteurella mult...
NP_973156  417 YITQqtyIFKKSIYENIllanrnaskedvieaakkaai------------------hdfimslpegydtkmtelggnLSS 478  Treponema dentic...
BAB79933   417 LMGQetsLFNMSIEDNIkigkldatldevkeaakkagi------------------hefimgledgyktkvgelggnLSS 478  Clostridium perf...
AAO35770   418 FVTQetfLFNDTIEENIrigkkdatlneikeackkasi------------------nefieslpkgyktnvgelgenLSG 479  Clostridium teta...
NP_064693 1391 IILQdpiLFSGSIRFNLdpeckctddrlwealeiaqlk-------------------nmvkslpggldavvteggenFSV 1451 human
O60706    1391 IILQdpiLFSGSIRFNLdpeckctddrlwealeiaqlk-------------------nmvkslpggldavvteggenFSV 1451 human
P36028    1364 CIPQdptLFDGTVRSNLdpfdrysdvqiygvlskvglieecdelclifeqeqpnfsshklrnrfidlntvvksggsnLSQ 1443 baker's yeast
P26363    1291 VIPQkvfIFSGSIRKNLdpygkwsdeellkvteevglk-------------------liidqfpgqldfvlldggcvLSH 1351 African clawed frog
Feature 1                           ##                                 #                  
1JJ7_A     158 GQRQAVALARALIRkPCVLILDDATSALDans-qlqVEQLLYESperysrsVLLITQHLSLVeqaDHILFLEgGA 231  human
NP_214076  469 GEKQRLALARIFLKnPEIVILDEATSALDpkt-eeeVIYNLYKFlke--ktIFAVAHRPFIFnfcDVILEFEgGR 540  Aquifex aeolicus VF5
AAK03557   479 GEKQRIGIARAFLHnAPIILLDEPTSNLDsln-eaiILQSLLTVkae--klIVLVSHRASTMaicDQVIQIEnGR 550  Pasteurella multocida...
NP_973156  479 GEKQRLGLARAFLHkAPLLLLDEPTGNLDsln-ealILNSIYQEkkd--kgVLIVSHRKSTVnaaDKIVYIEkGR 550  Treponema denticola A...
BAB79933   479 GEKQRIGLARVFLReSEIVILDEPTSNLDtln-egiILKSIRTYlkd--ktLILITHRKSTTrvcEKVFRINkGN 550  Clostridium perfringe...
AAO35770   480 GERQRLGLARAFLHnGDMILLDEPTSNLDsln-ekvIIKTLKNEcrd--ktVILVSHRMSTVaiaDEIYTMK-NK 550  Clostridium tetani E88
NP_064693 1452 GQRQLFCLARAFVRkSSILIMDEATASIDmatenilQKVVMTAFadrtvvtMAHRVHTILTAdlvIVMKRGNiLE 1526 human
O60706    1452 GQRQLFCLARAFVRkSSILIMDEATASIDmatenilQKVVMTAFadrtvvtMAHRVSSIMDAglvLVFSEGIlVE 1526 human
P36028    1444 GQRQLLCLARSMLGaRNIMLIDEATASIDyisdakiQKTIRETMknttiltIAHRLRSVIDYdkiLVMEMGRvKE 1518 baker's yeast
P26363    1352 GHKQLVCLARSVLSkAKILLLDEPSAHLDpitfqiiRKTLKHAFadctvilSEHRLEAMLECqrfLVIEDNTvRQ 1426 African clawed frog

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