1QGV,1PQN


Conserved Protein Domain Family
DIM1
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cd02954: DIM1 
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Dim1 family; Dim1 is also referred to as U5 small nuclear ribonucleoprotein particle (snRNP)-specific 15kD protein. It is a component of U5 snRNP, which pre-assembles with U4/U6 snRNPs to form a [U4/U6:U5] tri-snRNP complex required for pre-mRNA splicing. Dim1 interacts with multiple splicing-associated proteins, suggesting that it functions at multiple control points in the splicing of pre-mRNA as part of a large spliceosomal complex involving many protein-protein interactions. U5 snRNP contains seven core proteins (common to all snRNPs) and nine U5-specific proteins, one of which is Dim1. Dim1 adopts a thioredoxin fold but does not contain the redox active CXXC motif. It is essential for G2/M phase transition, as a consequence to its role in pre-mRNA splicing.
Links
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Statistics
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PSSM-Id: 239252
Aligned: 27 rows
Threshold Bit Score: 157.071
Created: 16-Mar-2005
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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first criticalsecond critical
Conserved site includes 6 residues -Click on image for an interactive view with Cn3D
Feature 1:first critical site
Evidence:
  • Comment:The inability of mutants to rescue null and temperature-sensitive mutations in S. pombe revealed two critical sites for Dim1 function.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                # ##                                                                 
1QGV_A     10 NGWQVDQAILSEEDRVVVIRFGHD-----------WDPTCMKMDEVLYSIAEKVKNFAVIYLVDIT--EVPDFNKMYELY 76  human
AAB68131   11 TGWHVDQAIVTETKRLVVIRFGRK-----------NDRQCMIMDELLSSIAERVRNFAVIYLCDID--EVSDFDEMYELT 77  baker's yeast
CAD25156    7 SLDAVNGAVGGTSCKLVVVRFGDR-----------GDPLCIHMDGLLERICLALSNYVEIYVCERS--SVRELVDPMGLD 73  Encephalitozoon cu...
EAA40496   16 NAYAVDMAIQHESARIVVVRFGLP-----------DTAACAEMDELLAETMVRLSRMAIFYTVDRN--VVSGFDELYELE 82  Giardia lamblia AT...
Q9NX01     10 SKKEVDQAIKSTAEKVLVLRFGRD-----------EDPVCLQLDDILSKTSSDLSKMAAIYLVDVD--QTAVYTQYFDIS 76  human
EAL51936   10 NAWQVDQAILAEEEKVVIIRFGRD-----------YDPECMQMDHRLASIQEQISRMAVIYVVDID--QTPDFNVMYELY 76  Entamoeba histolyt...
AAX69726    9 SAWDVDRHIVLEGEKLVLIRFSHYgeateqeedmaHTLSTRQIDEVLVALAPKVRKYCTIYVVSTL--EVPEFNVMYELG 86  Trypanosoma brucei
AAH91710   10 SKRDVDQAIKTTAEKVLVLRFGRD-----------EDHVCLQLDDILSKTSHDLSKMASIYIVDVD--KVPVYTQYFDIS 76  African clawed frog
XP_416612  10 CKKEVDQAIKSVAEKVLVLRFGRD-----------NDAVCLQLDDILAKTAHDLSKMAVIYLVDVN--KVPVYTQYFDIS 76  chicken
AAS49089   18 TKEEIDRVIRDTIDEVLVLRFGRS-----------SDAVCLQHDEILAKSVRDVSKFAKVALVDVDseDVQVYVKYFDIT 86  thale cress

Feature 1                 ###                                   
1QGV_A     77 D---PCTVMFFFRNKHIMIDLGTGNNNKINWAMEDkQEMVDIIETVYRGA 123 human
AAB68131   78 D---PMTVMFFYHNKHMMCDFGTGNNNKLNFIVDDkQEMIDILETIFRGA 124 baker's yeast
CAD25156   74 S---PVNIMCFFNRRHIKIDCSSGDNDKINFFIENeEMLIELFTLAYKAG 120 Encephalitozoon cuniculi GB-M1
EAA40496   83 Dd--DFALLFYYRGRRMQCDFGRFGKYKLTVVPPStDTFIDVISELYYNA 130 Giardia lamblia ATCC 50803
Q9NX01     77 Y---IPSTVFFFNGQHMKVDYGSPDHTKFVGSFKTkQDFIDLIEVIYRGA 123 human
EAL51936   77 D---PVTVMFFYRKKHIQVDLGTGNNNKINFVINNkEDLITIIECVYTGA 123 Entamoeba histolytica HM-1:IMSS
AAX69726   87 HsrePFAVMFFYRNAHIRVDVGTGNNNKINFVVSE-DELLSIADAAYRAG 135 Trypanosoma brucei
AAH91710   77 Y---IPSTIFFFNGQHMKVDYGSPDHTKFVGSFKTkQDFIDLIEVIYRGA 123 African clawed frog
XP_416612  77 Y---IPSTVFFFNGQHMKVDYGSPDHTKFVGSFKTkQDFIDLIEVIYRGA 123 chicken
AAS49089   87 L---FPSTIFFFNAHHMKLDSGTADHTKWVGAFHIkQDFIDVVEAIYRGA 133 thale cress

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