1UC7,1VRS


Conserved Protein Domain Family
DsbDgamma

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cd02953: DsbDgamma 
Click on image for an interactive view with Cn3D
DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD alpha). DsbD beta, a transmembrane domain comprising of eight helices, acquires its reducing potential from the cytoplasmic thioredoxin. DsbD alpha transfers the acquired reducing potential from DsbD gamma to target proteins such as the periplasmic protein disulphide isomerases, DsbC and DsbG. This flow of reducing potential from the cytoplasm through DsbD allows DsbC and DsbG to act as isomerases in the oxidizing environment of the bacterial periplasm. DsbD also transfers reducing potential from the cytoplasm to specific reductases in the periplasm which are involved in the maturation of cytochromes.
Statistics
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PSSM-Id: 239251
View PSSM: cd02953
Aligned: 60 rows
Threshold Bit Score: 107.303
Threshold Setting Gi: 46579412
Created: 13-Oct-2004
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
catalyticDsbD alpha
Conserved site includes 2 residues -Click on image for an interactive view with Cn3D
Feature 1:catalytic residues [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                               #  #                                                    
1UC7_A       16 VDELNQALVEakgKPVMLDLYADWCVACKEFEKYTFSDPQVQKALA--DTVLLQANVTandaqDVALLKHLNVLGLPTIL 93
1VRS_D       19 VDELNQALVEakgKPVMLDLYADWCVASKEFEKYTFSDPQVQKALA--DTVLLQANVTandaqDVALLKHLNVLGLPTIL 96
gi 24375158  73 PEKIAPLVAQg--YTVFVDITSDWCSICQTNKAEVTHREQVVNALMadDIILMQGNWSeadntIAGYMQYEGIPGTPYNK 150
gi 32477205 771 EAKLKQYQAEg--RTVMIDFTAKWCVNCIVNYNVALNTEPTRQLIEelDAVPMLADWTdqdaeIEAKLKELQSRSIPVLA 848
gi 46201661 575 PMTLARLISDg--KVVFVDVTADWCITCKVNKAAVIERGEVAKRLSspGVVALRADWTkpdegISRYLASFGRYGIPFNA 652
gi 48766100 605 PEAVARLVAEg--KTVLVDVTAQWCVTCKVNKATVLDAAPTRALLDsgRLSGLRADWTrpdpaIAAYLASFGRFGIPFNA 682
gi 56459324 586 QQRIDEAVANg--QTVFVDVTADWCVTCQANKVGVLLQDPVFTALGkeHVTRLRGDWTkanesITQYLKANNTFGVPFNK 663
gi 59713507 317 ERTIDDYVKQg--KTVFVNVSADWCITCKTNKIGVILQNPVYPALQqeNVITMQGDWThpshkITEYLKKHQRYGVPLTV 394
gi 67938784 635 PSLFEELLEKk--KTVFLEFTADWCITCKVLEASVLGNNDVVEALHrpDVAAVRADWTsrddaVTALMQRFGRSGVPLFV 712
gi 68545624  71 ADKIPMLVQGg--YTVFVDLHSDWCMACQTNRVGILHRPEVVSTLLsgKVVLMQANWSqeserIAPHYGKVAAPGSPFNK 148
                        90       100
                ....*....|....*....|....*...
Feature 1                                   
1UC7_A       94 FFDgqgQEHPQARVTGFMdaETFSAHLR 121
1VRS_D       97 FFDgqgQEHPQARVTGFMdaETFSAHLR 124
gi 24375158 151 IYGp--RNPNGIVLPSKLtiEAVINGLA 176
gi 32477205 849 IYPg-kSPAEPIVLRDLVsqQMVLDALE 875
gi 46201661 653 VYGp--SAPDGIALPELPgeADILAAMD 678
gi 48766100 683 VYGp--GAPQGIALPELLseNALLEAVA 708
gi 56459324 664 VYGp--GAPDGITLPVVLskDKVMDALE 689
gi 59713507 395 VYGp--NTPQGLTLPVLLdgDEVIHALN 420
gi 67938784 713 IIPh-gELDRAVVLPEVVtvDMLLRELE 739
gi 68545624 149 VYGp--GLPRGQILPAELsaSDVITAIR 174

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