1Z0N,2F15,2QLV,3NME


Conserved Protein Domain Family
E_set_AMPKbeta_like_N

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cd02859: E_set_AMPKbeta_like_N 
Click on image for an interactive view with Cn3D
N-terminal Early set domain, a glycogen binding domain, associated with the catalytic domain of AMP-activated protein kinase beta subunit
E or "early" set domains are associated with the catalytic domain of AMP-activated protein kinase beta subunit glycogen binding domain at the N-terminal end. AMPK is a metabolic stress sensing protein that senses AMP/ATP and has recently been found to act as a glycogen sensor as well. The protein functions as an alpha-beta-gamma heterotrimer. This N-terminal domain is the glycogen binding domain of the beta subunit. This domain is also a member of the CBM48 (Carbohydrate Binding Module 48) family whose members include pullulanase, maltooligosyl trehalose synthase, starch branching enzyme, glycogen branching enzyme, glycogen debranching enzyme, and isoamylase.
Statistics
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PSSM-Id: 199889
Aligned: 207 rows
Threshold Bit Score: 43.3565
Threshold Setting Gi: 218675944
Created: 14-Jul-2005
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
glycogen
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:glycogen binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                #                                 #       #            ##
1Z0N_C         12 PTVFRWtg--gGKEVYLSGSFNNWs----KLPXTRSqn----nfVAILDLpeGEHQYKFFVDG-QWTHDpse--pivTSQ 78   Norway rat
YP_003797269   35 GVRFVVsv-saAETVAVVGSFNGWsp--tAHIMTRVgsk--gfwSAVVSLpsGEHAFMYLVDGtTWVVPpaae-dfvTDG 108  Candidatus Ni...
ZP_08005100    43 QVTFSYqg--eAQQVRVAGSFTGWqd--gALAMTKGenn---kwSKTIHLspGVYEYKFILDDgNWIADp------aNSK 109  Bacillus sp. ...
YP_004168000    8 SAVFTLalddtVQEVLLKGSWNDWk----PEVMKRKgrg---efSKTKRLkpGRYEFGYEIDG-VWRVDesl--pavASP 77   Nitratifracto...
YP_002952871  119 EVTFVArf-pgAQQVAVIGSFNDWmp--gRHVMHKAlgs--dvfSLTVNLpsGRYVYAFLVDG-TLLETdssallqeDDG 192  Desulfovibrio...
CBX27334       14 KVTFIIei-qkAEKVSLIGDFNKWne--kTHTMKKEnndv-wkkSIFLDP--GRYEYKFQVDG-QWQTDpnnd-qlcQNN 85   uncultured De...
ZP_07198537    18 RVTLNFea-phAESVLLMGDFNQWne--kRHPMKQGkng---iwEKIIVVqpGRYEYRFLVDG-MWQNDpane-nicSNC 89   delta proteob...
YP_002509570   36 EVTFTYdn-pgAEEVYLIGQMNGWtendpAMKMEMNddg---lwEITITLakGVYEYKFFVDG-EYKTDfd-----nPET 105  Halothermothr...
YP_002601616   14 RIEFTFha-pgATEVMIFGDFNKWng--kKHRMKKGslg---vwKKTLVLapGTYEYKYRVDG-KWQEDpttl-hsrLNP 85   Desulfobacter...
YP_847990     132 QVVLALrs-peARSVAVMGSFNGWr----AEPCEPRtvdgetrwTVTLQLpsGRYEYAFVVDG-KKIIPdpgaglheEDG 205  Syntrophobact...
Feature 1         # # #     
1Z0N_C         79 LGTVNNIIQV 88   Norway rat
YP_003797269  109 FGNTNGVVTV 118  Candidatus Nitrospira defluvii
ZP_08005100   110 TGNGNSLLAI 119  Bacillus sp. 2_A_57_CT2
YP_004168000   78 FGSQNSLLEV 87   Nitratifractor salsuginis DSM 16511
YP_002952871  193 FGHTNSVLII 202  Desulfovibrio magneticus RS-1
CBX27334       86 FGTYNNYIVV 95   uncultured Desulfobacterium sp.
ZP_07198537    90 FGSNNNILEI 99   delta proteobacterium NaphS2
YP_002509570  106 TGPYNNSVAR 115  Halothermothrix orenii H 168
YP_002601616   86 FGTYNNLLTV 95   Desulfobacterium autotrophicum HRM2
YP_847990     206 FGNHNAVLLV 215  Syntrophobacter fumaroxidans MPOB

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