1EH9,2BHZ,3M07


Conserved Protein Domain Family
E_set_MTHase_like_N

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cd02853: E_set_MTHase_like_N 
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N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins
E or "early" set domains are associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (MTHase) and similar proteins at the N-terminal end. This subfamily also includes bacterial alpha amylases and 1,4-alpha-glucan branching enzymes which are highly similar to MTHase. Maltooligosyl trehalose synthase (MTSase) and MTHase work together to produce trehalose. MTSase is responsible for converting the alpha-1,4-glucosidic linkage to an alpha,alpha-1,1-glucosidic linkage at the reducing end of the maltooligosaccharide through an intramolecular transglucosylation reaction, while MTHase hydrolyzes the penultimate alpha-1,4 linkage of the reducing end, resulting in the release of trehalose. The N-terminal domain of MTHase may be related to the immunoglobulin and/or fibronectin type III superfamilies. These domains are associated with different types of catalytic domains at either the N-terminal or C-terminal end and may be involved in homodimeric/tetrameric/dodecameric interactions. Members of this family include members of the alpha amylase family, sialidase, galactose oxidase, cellulase, cellulose, hyaluronate lyase, chitobiase, and chitinase, among others.
Statistics
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PSSM-Id: 199883
Aligned: 162 rows
Threshold Bit Score: 76.0178
Created: 1-Jul-2005
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1EH9_A         3 AYKIDg-nEVIFTLWAPYQKSVKLKVle-----kGLYEMERDEkGYFTITLNnvkVRDRYKYVLDDa-SEIPDPASRYQP 75  Sulfolobus solf...
CAC49676      15 GANFIdsdTCRFRLWAPDEREVDLVLg------gAVHKMQSLDgGWFEITLAa-kAGERYCFRLADg-TEVADPASSAQE 86  Sinorhizobium m...
YP_470770     24 GAEVDa-sGVSFRLWAPARERCFLVIee-----nSEYRMTANDgGYFCLYLPglaAGTRYRFHFGDtgDLLADPASRFQP 97  Rhizobium etli ...
YP_971325     10 GARLLpegGVHFTLWAPAASRLTLHHrrapgaepAQVPGRRDAdGFWQATVPeagPDTLYQWQADNg-PLVPDPASRSNP 88  Acidovorax aven...
NP_396219     10 GAQRHqsgDTDFSIWAPASATVKLWLn------dAEFDMHTAGdGWHDITKPa-lPGDRYGFVLADr-TRVADPASNRQQ 81  Agrobacterium t...
YP_002823317  10 GANLTsgdVAYFRLWAPDERAVRLVLe------gVSHSMRAVEdGWFEVSAEa-rAGDRYWFELADa-TRVADPASCAQP 81  Rhizobium sp. N...
YP_002943895  10 GATVRgdgGVDFALWAPSMHGVTLVHtpag-gkeASHAMAQDTdGWHRLTLAdarAGDLYAYRLADg-TTMPDPASRFNP 87  Variovorax para...
YP_004155306  11 GATVQa-dGVAFALWAPSAETIVLEHq------sESRPMTRDG-GWHRLTVPsakPGDRYSYRLADg-TRVPDPASRCNP 81  Variovorax para...
ABB37800      10 GPRRLpdgSWLFRLWTTRRKPAVLVIeap---cpQEIPMKACGgGWREARTApmpAGALYRIRLGD--ELLADPASAHQP 84  Desulfovibrio d...
AEM41252       4 GATISq-nGTWFRLWAPKCANVQLVLse-----aETVPMRTNGqGWHEIEVPgvtAGTLYRFALPDr-SLIADPASRFQP 76  Ketogulonigeniu...
1EH9_A        76 EGVHGPSQII 85  Sulfolobus solfataricus
CAC49676      87 REASGTSIVV 96  Sinorhizobium meliloti 1021
YP_470770     98 DGPSGPSVVV 107 Rhizobium etli CFN 42
YP_971325     89 DGPHGPSRVT 98  Acidovorax avenae subsp. citrulli AAC00-1
NP_396219     82 EGPRGPSLIV 91  Agrobacterium tumefaciens str. C58
YP_002823317  82 DGASGPSMLV 91  Rhizobium sp. NGR234
YP_002943895  88 QDVHGPSQVV 97  Variovorax paradoxus S110
YP_004155306  82 DDVHGPSLVI 91  Variovorax paradoxus EPS
ABB37800      85 QGIDGPSMTD 94  Desulfovibrio desulfuricans subsp. desulfuricans str. G20
AEM41252      77 QGLDGPSAVI 86  Ketogulonigenium vulgarum WSH-001
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