1TOT


Conserved Protein Domain Family
ZZ

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cd02249: ZZ 
Click on image for an interactive view with Cn3D
Zinc finger, ZZ type. Zinc finger present in dystrophin, CBP/p300 and many other proteins. The ZZ motif coordinates one or two zinc ions and most likely participates in ligand binding or molecular scaffolding. Many proteins containing ZZ motifs have other zinc-binding motifs as well, and the majority serve as scaffolds in pathways involving acetyltransferase, protein kinase, or ubiqitin-related activity. ZZ proteins can be grouped into the following functional classes: chromatin modifying, cytoskeletal scaffolding, ubiquitin binding or conjugating, and membrane receptor or ion-channel modifying proteins.
Statistics
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PSSM-Id: 239069
Aligned: 28 rows
Threshold Bit Score: 45.8883
Created: 12-Dec-2003
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:Zinc-binding sites [ion binding site]
Evidence:
  • Comment:6 conserved cysteines and 2 conserved histidines coordinate 2 zinc ions
  • Structure:1TOT: ZZ domain binds zinc
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1        #  #            #  #           #  #        #   #     
1TOT_A       7 YTCNECKh--HVe-TRWHCTVCe------DYDLCINCYNTk---SH--THKMVKW 47   house mouse
EAL20331   582 SECTICLtalFS--NRFKCVSCp------KFDLCRSCYQKvd-eIHp-AHAFLSL 626  Cryptococcus neoformans var. neoformans B...
EAA62905  1022 RVCNNCLk-eFDegKMVSCADCd------DFDLCITCILGhkhgHHp-SHTFVLL 1068 Aspergillus nidulans FGSC A4
CAD11405   367 RTCNCCIq-dLPeaEFVHCQTCd------DFDLCKVCFAKnr-hGHhpKHAFSPI 413  Neurospora crassa
EAA69340   336 RTCNCCVq-eHPeaEFLHCRMCe------DFDLCQSCFARds-hGHhpKHSFAPA 382  Gibberella zeae PH-1
CAG80738   505 FVCDYCLe-pISe-ARFHCQSCv------DFDVCSSCYPSra-kSHaqKHGFVQL 550  Yarrowia lipolytica CLIB99
EAA78179  1607 SFCDACLm-nNYg-LRFHCDVCw------DFDLCFKCYRSqn-iIHp-KHSFTNP 1651 Gibberella zeae PH-1
EAA74706  1612 MFCDCCLl-dIYg-FYYTCSTCf------ECDLCDKCYLSvs-kIHp-AHSSFMK 1656 Gibberella zeae PH-1
EAA63852  1669 YSCDICLs-tIWg-PVYECETCl------DFTACKKCHGRin-lYH--GHLRLEN 1712 Aspergillus nidulans FGSC A4
T12463     167 FKCDNCGiepIQg-VRWHCQDCppemsldFCDSCSDCLHEt--dIHkeDHQLEPI 218  human

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