Conserved Protein Domain Family
FtsZ_type1

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cd02201: FtsZ_type1 
Click on image for an interactive view with Cn3D
Filamenting temperature sensitive mutant Z, type 1
FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at the site of bacterial cell division, which is required for constriction of cell membrane and cell envelope to yield two daughter cells.
Statistics
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PSSM-Id: 276961
View PSSM: cd02201
Aligned: 273 rows
Threshold Bit Score: 205.711
Threshold Setting Gi: 170174590
Created: 8-Feb-2005
Updated: 5-Feb-2015
Structure
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Program:
Drawing:
Aligned Rows:
 
nucleotideSulA
Conserved site includes 18 residues -Click on image for an interactive view with Cn3D
Feature 1:nucleotide binding site [chemical binding site]
Evidence:
  • Structure:1FSZ: Methanocaldococcus jannaschii FtsZ with bound GDP (defined using 4.0 A contacts)
    View structure with Cn3D
  • Citation:PMID 9722999

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                ###  #                                                                  
1FSZ_A        38 AKITVVGCGGAGNNTITRLKMEGi----eGAKTVAINTDAQQLIRTk-aDKKILIGKkltrgLGAGGNPKIGEEAAKESA 112
gi 341578456  44 IKLKVIGIGGAGNNAVQMMELEKy----pSVEFIVANTDAQALAKNk-cPNKLALGKes-rgLGAGSDPEVGQARAKESS 117
gi 343128250   8 VKVKVIGIGGAGNNAINLLLEEDl----pNVELWIANTDYQDLEKSk-cTNKLYLKGds-egYGAGGDPKIGKKAAEDSI 81
gi 292553094  25 ISLKVIGVGGAGNNAVELMLKDKy----pNIEFIVANTDAQALTKNs-cSKKIALGSkdsrgLGAGSDPDVGKKRANESS 99
gi 1346051    18 LKIGVFGIGGAGNNIVDASLYHYpnlaseNIHFYAINSDLQHLAFKtnvKNKLLIQDhtnkgFGAGGDPAKGASLAISFQ 97
gi 2494601    18 IKIAVFGIGGAGNNIIDDMLRMHpelqtaNVQFFALNTDLQHLKTKryvQNKAVIQFeeskgLGVGGDPQKGAVLAHHFL 97
gi 480549585   6 IKIKVIGIGNAGLNICESLIERQn----tNIEIYAADTDKNKLNKTk-iTNKIILGTsl-ngSGTGGDPKLGAQAAEESS 79
gi 238809923  15 VKLKVIGVGGAGNNAINLMLDENl----pNVELLVANSDRQDLVKSl-cPNKILLGDst-rgFGAGGDPKVGRECALESI 88
gi 640837483   8 IKIKVIGVGGAGNNIVSSLVSKEl----eNIDLIVANTDFQVLNNCp-vEKKIYLGDst-kgLGTGGDPEIGAQCAKESI 81
gi 144575078  36 IKLCVIGVGGGGNNAVKMIQAAGf----sNVNFIIANTDDQALSLNp-cENKISLGKdt-rgLGAGSDPEIGEKSARESV 109
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                         ## ####                        #   #    #                      
1FSZ_A       113 EEIKAAIqdsdMVFITCGLGGGTGTGSAPVVAEISKKIgalTVAVVTLPFVMEGk-vRMKNAMEGLERLKQHTDTLVVIP 191
gi 341578456 118 RKIEEKIkdadVVIITAGLGGGTGTGAAPVVAEIARNNgalTIAIVTTPFSTEGk-kRTRIAKEGIEKLKEKVDSYIVLS 196
gi 343128250  82 REIDDVLqdtdLLIITAGLGGGTGTGAAPVIAKAAKDKgivTLAIVSTPFTIFEgsrRKKIALEGLEELKNSTDSYIVLS 161
gi 292553094 100 REIEDNLkgsdVVILTAGFGGGTGTGATPVIAQIAKNVgalTIAVITTPAKYEGk-kKLNIALREIEVLKKSVDAYIVIS 178
gi 1346051    98 EQFNTLTdgydFCILVAGFGKGTGTGATPVFSKILKTKkilNVAIVTYPSLNEGl-tVRNKATKGLEILNKATDSYMLFC 176
gi 2494601    98 EQFHKLSdsfdFCILVAGFGKGTGTGATPVFSKFLSNKgvlNLSIVSYPAMCEGl-kAREKAAKGLERLNQATDSFMLFR 176
gi 480549585  80 EQIAQIIddcnMLIIVSGFGGGTGTGASETIAKLARNKnilTLAIITLPMADIVgkrKLELANNYLEKLTQCVNSYMVID 159
gi 238809923  89 KEIQKSLentdIVIISAGLGGGTGTGAAPVIAEAAKKMgilTVAVVTTPFELIEgkhKSLIAQEGLKKLSEVVDSYIVIS 168
gi 640837483  82 DEIEKSIegadIVVVVAGLGKGTGTGSGPVIAQTAKQKgilTLAMVATPFEQFEgsrVSAIANQGLRQLKDSVNAYMVLS 161
gi 144575078 110 DEIEEALkgadVVLVTAGLGGGTGTGAAPVIAEAAKKMgalTIGIVTTPFSYEGp-kRKRIAKNGIQELSKVVDSYIVLS 188
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        #               #  ##  #                                                        
1FSZ_A       192 NEKLFeivpnmplklAFKVADEVLINAVKGLVELITKDglINVDFADVKAVMNN------------GGLAMIGIGESDSe 259
gi 341578456 197 NERLLqqygdvpiddAYTKSNVYLKNIINTIHDILYRIgtINIDFADMRRILEK------------SGLTLIGLGQASGk 264
gi 343128250 162 NDKLMqsnlegnsedAFKFANITLKNSIKAIWEVIFEKftINIDFNDLRKVLKN------------GSQTFISIGKGFGn 229
gi 292553094 179 NQKLDelfgefpiedAYKASNNSLKTTIIAIHDILYRTgkINIDYADVRKILDD------------SGLAVVALGTASGk 246
gi 1346051   177 NEKCTn--------gIYQLANTEIVSAIKNLIELITIPlqQNIDFEDVRAFFQTkktnq--dqqlfTVTHPFSFSFDSKd 246
gi 2494601   177 NDRCTd--------gIYQLANVAIVKTIKNIIELINLPlqQNIDFEDIRSFFKKpaqrleneanlfRVTNTFTFSFDAHn 248
gi 480549585 160 NNRMLqqnaelpmyqAVKMANVAVETTIDVIDDIISNVsdLNIDFSDIKSALIN------------GGKIVVASGKSQNg 227
gi 238809923 169 NQKLVenyrnlpvqeAFKVSNYTLKNSIKIIRDIIFETgfINLDFNDLRQVLLD------------GKETIIGIGNGFGk 236
gi 640837483 162 NEKLVqqnidfpfsqAFKMIDEIVAKCLSTITQIINQPtkINVDFNDFKAILQN------------GGKIVIGSGKAQGd 229
gi 144575078 189 NDKLAenfgdlpiedSFQLANITLKNIILAFHDILYRIgtINIDYADVVKILGG------------SGLAVVGIGQATGk 256
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
1FSZ_A       260 krAKEAVSMALNSPLLDvd---idGATGALIHVMGPedLTLEEAREVVATVSSRLDp-------nATIIWGATIDENle- 328
gi 341578456 265 nrATKAVEKAFQNNLYSte---icGAERFLINIQYDksATLNEIKTAVDEVNKFLNtnss--ideDDIIIGQERIEGet- 338
gi 343128250 230 daWKKAVEQALLNQLNEfe---lsDPKKIIIIFKMKq-SSFKEIEEAKKLIDQYLNvkd----ddVEILLGIKYLENvde 301
gi 292553094 247 drAEKAINKAFANNLYTyn---fqGAKRFLVNIQHDakATGRDMSKAMDTIRQHLGvded--dedVDIIFGHETIPDvs- 320
gi 1346051   247 -sIEQFAKQFKNFEKVSyfdhsivGAKKVLLKANINqkIVKLNFKQIQDIIWTKIDny------qLEIRLGVDFVTTip- 318
gi 2494601   249 -tIEHFSHKLKNFEYEGffdhkveGAQKVILKVLVNqgLYPLDLTQIQEIIWAKIDnh------nLEVQLGVDFTDAnp- 320
gi 480549585 228 dkVTNAFEAARDSSSFIdk---ptSFATLLTNCTVDtkISYADILELRKKIIEEYQlp-----edIDGKFGIDYKEHeds 299
gi 238809923 237 drAIKAVDDALMTPLFQse---ikNCQKVAILFQCDkrASLDDIETAKNRIDEYLAnn-----leAQTFIGLQYIDTqdr 308
gi 640837483 230 nkIQSVFANATESANIIdk---pqSFSHVIFHCLLDqhSAYSEIIALKNSLIEHFNmds---tidTRLAIGNYESPDskd 303
gi 144575078 257 drATKAVEKAFEQNLYEyp---ikSANKILVNIQHDkkATLHEINTAIKKVHEILSqnrsddqeeYDCIIGQEAVETkdn 333
                        330
                 ....*....|...
Feature 1                     
1FSZ_A       329 --ntVRVLLVITG 339
gi 341578456 339 --dlFKVSVIAGR 349
gi 343128250 302 rdksFSLTVIASG 314
gi 292553094 321 --eyFKVSIVAAG 331
gi 1346051   319 ---nIQIFILSEH 328
gi 2494601   321 ---sVQLFFLMEK 330
gi 480549585 300 rddyLKFSYILTQ 312
gi 238809923 309 -eeiFRISIIASN 320
gi 640837483 304 --dsLQFSFIATE 314
gi 144575078 334 -aevFKVSVIAGE 345

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