1NI5


Conserved Protein Domain Family
PP-ATPase

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cd01992: PP-ATPase 
Click on image for an interactive view with Cn3D
N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This domain has a strongly conserved motif SGGXD at the N terminus.
Statistics
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PSSM-Id: 238950
View PSSM: cd01992
Aligned: 119 rows
Threshold Bit Score: 113.816
Threshold Setting Gi: 16127457
Created: 12-Oct-2004
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
Ligand Binding
Conserved site includes 9 residues -Click on image for an interactive view with Cn3D
Feature 1:Ligand Binding Site [chemical binding site]
Evidence:
  • Comment:adenosine nucleotide binding site predicted by similar proteins.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1           ### ####                       # #                                          
1NI5_A       15 QILVAFSGGLDSTVLLHQLVQWrtenp-gvalRAIHVHHGLsana-----------------dawVTHCENvcqqwqvpl 76
gi 28572333  30 LVLIALSGGRDSLAAMVIASWViprl--ngrvGAVVVDHGLqensariadevriraeqfalnpilIKRVSPsrvsagpea 107
gi 23326973  45 LVLVACSGGRDSMALAAVSHIVctsm--gvrcGAVIVDHGLqags-----------------ervASEAADrcralglgp 105
gi 50839350  26 RFVVGCSGGPDSLALALASKWAsrrc--esgvRVVIVDHQLqqgs-----------------devAERTRDllvrrgmda 86
gi 48836170  27 LVLVACSGGPDSLALAGATAFVaprl--glraGGVTVDHGLqegs-----------------aerADTVAAllrnlgfdp 87
gi 5531226   26 ALVLAVSGGPDSIALMWLAARWqrslargprlTVVTVDHGLraea-----------------areAREVKRlatelglph 88
gi 33596889  37 RLAVAVSGGADSAMLAVAAAAVlppg---ctlRLFHVHHGLqaaa-----------------dqwAAQVRGlgallgvpv 96
gi 54042637  27 RWSVGLSGGPDSLALTAVAARLwp-------tTALIVDHGLqpg------------------satVAETARiqaislgcv 81
gi 28476599  30 LVLIALSGGRDSLAAMVIASWViprl--ngrvGAVVVDHGLqens-----------------ariADEVRIraeqfalnp 90
gi 16127457  21 PLAVGFSGGGDSLFLLKTVLDWarpl--drpvLALVVDHQLqpqs-----------------tawTAEAVAkaralgaaa 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                       
1NI5_A       77 vve--------------rvqlaqeglgiEAQARQARYQAFARtll---------------------pgeVLVTAQHLDDQ 121
gi 28572333 108 sariaryaafydtleetkayaiilahtlDDQAETVLLGLMRGsgpsslrgmkavsytpedcrymnnkacNSVTAVYAHNT 187
gi 23326973 106 vim-------------rnatvqargeglEAAARQARYDELCAaahe-------------------sgaiAVLLAHTMDDQ 153
gi 50839350  87 cvr-------------rvdvdaddpdgpEAAARTARRAALLDvag----------------------dePVLLGHTRDDQ 131
gi 48836170  88 ver--------------vsvtvgtaggpEAAARSARYAALEKtadv-------------------hqaaAVLLGHTRDDQ 134
gi 5531226   89 rtl--------------rwrgakpktglPAAAREARYRLLMQaars-------------------agasHVLTAHTRDDQ 135
gi 33596889  97 dea-------------rvtvppgqglgmEAAARLARYQALAGlarq-------------------hgvrHILLAHHRNDQ 144
gi 54042637  82 dar-------------vlcvqvgaaggrEAAARSARYSALEEhr-----------------------dgPVLLAHTLDDQ 125
gi 28476599  91 ili-------------krvspsrvsagpEASARIARYAAFYDalee-------------------tkayAIILAHTLDDQ 138
gi 16127457  82 lgl--------------twtdqkprtglPAAARRARHALLATaare-------------------agarVLILGHTASDL 128
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                       
1NI5_A      122 CETFLLALKRGsgpaglsaxa----------------------------------------------------------- 142
gi 28572333 188 QRCSCDSRPYPpppeprnenrsyfphpsckc------------------------------------------------- 218
gi 23326973 154 AETVLIGLLRSrgvdalagmp----------------------------------------------------------- 174
gi 50839350 132 AEQVLLSLARGsgatslag------------------------------------------------------------- 150
gi 48836170 135 AETVLLRLARGsgarslaa------------------------------------------------------------- 153
gi 5531226  136 AETLLMRLVRGsglaglsama----------------------------------------------------------- 156
gi 33596889 145 AETVLLRLLRGtglqgmaama----------------------------------------------------------- 165
gi 54042637 126 AETVLLGLGRGsgarsiag------------------------------------------------------------- 144
gi 28476599 139 AETVLLGLMRGsgpsslrgmkavsytpedcrymnnkacnsvtavyahntqrcscdstqrcscdsrpyppppeprnenrsy 218
gi 16127457 129 AEGVAMRAEGSsvsnprawaps---------------------------------------------------------- 150
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
Feature 1                                                                                    
1NI5_A      143 ------------------evsefagtrLIRPLLARTRGELvqwar----qydlrWIEDESNQDDSYDRNFLRLRVVP 197
gi 28572333 219 --------vegsatrftnadidsrfgvFIRPFLDITRHETgkice----fygldYWNDPHNEDVRFSRVRIRHNVMP 283
gi 23326973 175 ------------------qvftrsgatFARPLLTLTRAETtgice----dlgveYWDDPTNGDAVDGELPNDYPLRS 229
gi 50839350 151 --------------------irprsgqFWHPLLEVRRAQTvqacr----ewevePWQDPHNGDPRFLRSRVRTELMP 203
gi 48836170 154 --------------------matrtgrYLRPFLDVDRRTVheaas----lmgfePWSDPHNTDPAYTRSRVRHEALP 206
gi 5531226  157 ------------------rlterdgivLARPLLDVPKAQLiatlk----rakigFADDPTNRDTAFTRPRLRALLPQ 211
gi 33596889 166 ------------------plserdgvaYLRPWLDVDRAAIlalagavraqcgwqAVQDPTNTDPRYARAAVRTQLAP 224
gi 54042637 145 --------------------mrpydppWCRPLLGVRRSVThaacr----elgltAWQDPHNTDRRFTRTRLRTEVLP 197
gi 28476599 219 fphpsckcvegsatrftnadidsrfgvFIRPFLDITRHETgkice----fygldYWNDPHNEDVRFSRVRIRHNVMP 291
gi 16127457 151 -----------------pvwpegrglfVLRPLLTLTRAEIrdalt----regetWLDDPANLDLRYARARARAAGAL 206

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