Conserved Protein Domain Family
fatty_acyltransferase_like

?
cd01846: fatty_acyltransferase_like 
Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely resembles the Ser-His-Asp(Glu) triad found in other serine hydrolases. Might catalyze fatty acid transfer between phosphatidylcholine and sterols.
Statistics
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PSSM-Id: 238882
Aligned: 58 rows
Threshold Bit Score: 139.051
Created: 7-Oct-2004
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
Feature 1:active site [active site]
Evidence:
  • Comment:by similarity to other members of this super-family
  • Comment:the active site resembles the typical Ser-His-Asp(Glu) triad from other serine hydrolases
  • Citation:PMID 7773790

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1               #                                                                        
P10480        27 RIVMFGDSLSDTGKmyskmrg----------------ylpsspPYYEGRFSNGPVWLEQLTNEFpg-------------- 76  Aeromonas hydro...
YP_436892     44 ALYVFGDSLSDTGNiggylsl----------------etdlpsPFYDNRISNGKLIVDYVAESLnlevepsl------yl 101 Hahella chejuen...
EAA76677      30 RLIVFGDSFSDNGNgswivsn---------------gtwpadpAYYRHSFSNGLKWNDLVAKDLgl-------------- 80  Gibberella zeae...
NP_967006     14 NFYVLGDSLSDNGAiigilnnlsf----------aksvkfddpFYQGRSFSNGPTAVEYIAKYLdldefkpgwsysffgr 83  Wolbachia endos...
XP_755409     37 YLLTFGDSYTYVQGthghqnysfigdqlnfeydwrtllsnkivQNQTATAEGGPNWVEFLTNCGvkkglts-------pl 109 Aspergillus fum...
EAA57793      39 NLIAFGDSYTFIQGthgypnysfigdqlnyaydartlltdkivQNQTGTSAGGPNWVEFLTGCGlkeglts-------pi 111 Aspergillus nid...
CAK98956      62 NYYILGDSLSDSHGieklvknsfkld-----ikigtndpnnleNYQNGSLSNGNTAAVLLNAKLgfdkirpgi----pnd 132 Spiroplasma citri
YP_527785     35 SVVIFSGVFGDTGNyaslh-------------------gdlppVFWQNRFANGPVVADYFAENLgfdaepsl------hw 89  Saccharophagus ...
XP_001213166  54 RLVVFGDSWSDNNAgkl-----------------------qgsVWTDTLCSLFSCHQENLAQTArslrgn---------- 100 Aspergillus ter...
EAS36129     146 RLVVFGDSWSDDGTiyrp---------------------lqtqVWPEMLCAQFQCTLEVTTDSPdpsf------------ 192 Coccidioides im...
Feature 1                    #                                                                   
P10480        77 ---ltIANEAEGGPTavaynkis--wnpkyqviNNLDYEVTQFlqkds----------------------fkpdDLVILW 129 Aeromonas hydro...
YP_436892    102 geitdGTNYAVAGGQada------------dqnIDLDFQVDTYmeyhse--------------------easpkALYLFF 149 Hahella chejuen...
EAA76677      81 ----eLINLATGGATtnnnfvaggtgaqstipvPSASDQVFSFlswnk----------------------prpdDVFVHW 134 Gibberella zeae...
NP_967006     84 cheqqGQNYAVSYATase------------ifdPIFSYFFNKFrlanqldavi------------khhpdigkeDLFCII 139 Wolbachia endos...
XP_755409    110 scekqLWDFAFAGADisieytp-----lhhnytVSLVNQVIQYeqyghpvl---------------kniihpsrTLVAIW 169 Aspergillus fum...
EAA57793     112 sctkqLWDFAFAGAGvsaehip-----lhhpytISLVNQIRQFtiyghlvltsssqhpshkatlsaapildpasTLTAIW 186 Aspergillus nid...
CAK98956     133 yagdfGRNYAIGGATavdvvgt----agmllnrVTIEKQAQALvsqhk----------------------lrstDLVLFE 186 Spiroplasma citri
YP_527785     90 tgeegGYNYSTRNSWaal------------ggeNGVNEMVSAYltrvdn--------------------aippdALIFFW 137 Saccharophagus ...
XP_001213166 101 yigsvVDNSELTGTLlniy----------ksplADFKAQVRQWaaaeheavqllg-------gneaaiqhrqnrTILAVS 163 Aspergillus ter...
EAS36129     193 --gaiIDNSELNNTGge--------------taADLNDQMSGWlnkeedaargv---------lgkatsrlkqnTIFVVS 247 Coccidioides im...
Feature 1           #                                                                            
P10480       130 VGANDYLaygw---------nteQDAKRVRDAISDAANRmv---lnGAKEILLFNLPDLGQNPSarsqkvve-------a 190 Aeromonas hydro...
YP_436892    150 IGGNDILeqrget-----spnntNALNLAADKVAANVQEvi---dkGGKNIVVLTVPDVGKTPKvlkesaepgqegrsql 221 Hahella chejuen...
EAA76677     135 IGANDILfn------------tsITGGQVTSLINENVDRly---haGAKRIILANYLKITTFPAtysspdy--------- 190 Gibberella zeae...
NP_967006    140 IGGNDVMvatayd-----dtkaeEVLEQAVSEICNALKVln---ehGVKRVVVANAPEVGSIPAfnrdeeare------l 205 Wolbachia endos...
XP_755409    170 IGINDINdsaky------avhfpTLYNRMMTTLFTSVQTly---nlGYRSYLFMNLPPLDRTPAnqarsnps-------p 233 Aspergillus fum...
EAA57793     187 IGINDINdsaknssissfpdfynTLLQTAFSGLQTLVSLgy----kDFVDFVVLNLPPLDRTPAnqartlrnet---aap 259 Aspergillus nid...
CAK98956     187 IGGNDLFqiidtt----dpqtelELMHQSVERIKIALFTll---nnGIRKILFSDAPNVSAIPRynnqntddtl---kkr 256 Spiroplasma citri
YP_527785    138 SGGHDVIeaistp-----gevpyYMIDDAVDGLELQLRRli---eaGAQHIFAPTYADTSFSPAyqrrgian-------r 202 Saccharophagus ...
XP_001213166 164 FGVWDVWnlldkgye-vasqtvdRSVGVIMDQLSVLSQTle----sNDLKVILTLTPDVTFLPGfrpvatqhvnr--hkd 236 Aspergillus ter...
EAS36129     248 FGTWDLWqlaaed-----ldtarESVQRIVEKMFAYLDElaeiwsrKHTKIILSLPVDVTFLPAfktrqgvlq-----kd 317 Coccidioides im...
Feature 1                                                                                        
P10480       191 ashvsayHNQLLLNLARQLApt---gmVKLFEIDkqf------------------------------------------- 224 Aeromonas hydro...
YP_436892    222 vsdltvyFNSQVELKLSQLNmg----dTKVTMINsyqi-----------------------------------------a 256 Hahella chejuen...
EAA76677     191 dipsvevYSSALTQGLKNIAaay-sayAQTAVIDvgnl-----------------------------------------f 228 Gibberella zeae...
NP_967006    206 atkltesFNAKLAKGLDYMKks---tnLEIKAFDlnskmrsmfseykskglncqdactsniadqvgrfkenikillklif 282 Wolbachia endos...
XP_755409    234 natqitwFNNALSQHAMSFArah--pnATVQVFDahta-----------------------------------------l 270 Aspergillus fum...
EAA57793     260 datqvgwFNSAITSQARRFGrrn--pdTNVLVFDahrv-----------------------------------------l 296 Aspergillus nid...
CAK98956     257 annisteFHARVAKMIELANtyyknaiRNWGLYDnlsvl---------------------------------------mt 297 Spiroplasma citri
YP_527785    203 vshvtsvYNYKFRRMLNKVErq---tgQRIYRFDfdky-----------------------------------------v 238 Saccharophagus ...
XP_001213166 237 avkiteyWNRQLRGAAEKWDq------GTIYLFDtsafladli-------------------------------rdwqlf 279 Aspergillus ter...
EAS36129     318 avnltdhWHNEVRSRAEQWKt------GSIFLLDtnsflidqv-------------------------------rerqlw 360 Coccidioides im...
Feature 1                                                                                        
P10480       225 aemLRDPQNFGlsdqrnacyggsyvwkpfasrsastdsqlsafnpqerlaiagnpllaqavaspmaarsastlncegKMF 304 Aeromonas hydro...
YP_436892    257 ldiLNNAADYGftnttdgcyvtedl---------------------------------------efsdicseeqfdnFYY 297 Hahella chejuen...
EAA76677     229 kdiTLDPESYGfdekylnpptacltgv----------------------------------ytsegvprhlcndpqkHVF 274 Gibberella zeae...
NP_967006    283 kgeLDVHYNPGcske----------------------------------------------------------tlkdYFF 304 Wolbachia endos...
XP_755409    271 snmMDHPAQYGivnttnfcagynqpdi-----------------------------------etnylaygcptpldtYFW 315 Aspergillus fum...
EAA57793     297 shvLDFPDQYGivnttdfcpgydqpdi-----------------------------------eteyqaygcptslgtYFW 341 Aspergillus nid...
CAK98956     298 efkARHPKGNItvnfnnlnldfikiieek------------------------------mlnaqrnpalpananiddYFF 347 Spiroplasma citri
YP_527785    239 dtlIQTHKYYGlantvdpcwek---------------------------------------------qaegacnpdtFMF 273 Saccharophagus ...
XP_001213166 280 aagIEEPNGLGknvepgwenvddacvess-------------------------------qqlvmtstqrmcdnpekYLF 328 Aspergillus ter...
EAS36129     361 vggLIEGEDFGkngiawenvnepcvgp-----------------------------------aksrlkrktcsdpekFLF 405 Coccidioides im...
Feature 1         #  #                
P10480       305 WDQVHPTTVVHAALSEPAATF 325 Aeromonas hydrophila
YP_436892    298 FDNIHPSGKTHRLIGEKVAAE 318 Hahella chejuensis KCTC 2396
EAA76677     275 FDSYHPGKEVHALIAKLFEQE 295 Gibberella zeae PH-1
NP_967006    305 FDYFHPTAELHHEVGNEVYEL 325 Wolbachia endosymbiont of Drosophila melanogaster
XP_755409    316 FNSGHLTSHVHKELAEILEAQ 336 Aspergillus fumigatus Af293
EAA57793     342 FNSGHITSRLHEILAAQLSKT 362 Aspergillus nidulans FGSC A4
CAK98956     348 FDIVHPTREVHQLAMEHYYQT 368 Spiroplasma citri
YP_527785    274 LSEVLITSKTHQLIADAFSQD 294 Saccharophagus degradans 2-40
XP_001213166 329 WNEMHMGPSAHRLMGTEVFHG 349 Aspergillus terreus NIH2624
EAS36129     406 WDSLHLGPAAQQLLAAEVFNA 426 Coccidioides immitis RS

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