Conserved Protein Domain Family
Phospholipase_B_like

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cd01824: Phospholipase_B_like 
Phospholipase-B_like. This subgroup of the SGNH-family of lipolytic enzymes may have both esterase and phospholipase-A/lysophospholipase activity. It's members may be involved in the conversion of phosphatidylcholine to fatty acids and glycerophosphocholine, perhaps in the context of dietary lipid uptake. Members may be membrane proteins. The tertiary fold of the SGNH-hydrolases is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; Its active site closely resembles two of the three components of typical Ser-His-Asp(Glu) triad from other serine hydrolases.
Statistics
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PSSM-Id: 238862
View PSSM: cd01824
Aligned: 21 rows
Threshold Bit Score: 227.225
Threshold Setting Gi: 17565618
Created: 16-Aug-2004
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
Feature 1:active site [active site]
Evidence:
  • Comment:the active site resembles the typical Ser-His-Asp(Glu) triad from other serine hydrolases
  • Comment:by similarity to other SGNH-hydrolases
  • Citation:PMID 7773790

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                          #                                                             
gi 464376    382 SVHRLKPADIKVIGAMGDSLTAGngags-----------------qpgniLDVltq---yrGLSWSVGGdqnistvTTLA 441
gi 58388632    8 SVDRLRPGDIDIIGAIGDSLTAGngam-------------------atniLEVlie---nkGLSWSIGGqgtwrqfLTLP 65
gi 17861684   95 SVHRLRPGDIDVIGAMGDSLTAGngif-------------------atnlLHVtve---nrGVVWSIGGqydwrkyLTLP 152
gi 17536677   41 SAHSVRFADIKVIGALGDSLTAAngag--------------------aqpGDPlavilqyrGLAFQIGGdksldehITVA 100
gi 24582016  123 SIEHLRPGDIDIIAAFGDSLSAGngil-------------------snnaIDMine---frGLTFSGGGlanwrrfVTLP 180
gi 7499049    66 SVHQLHPSQIGVIAALGDSVSVAqaak-------------------sssiLDLfdq---fpGVSFVTGDdvklneqATFI 123
gi 57222994   59 VAKDVRPDDFRVVMALGDSITAGllargsrsssassapsqvdpqrpllpfLDIqe----yrGLSYPIGSdp---gaITIP 131
gi 32564557  142 NVGNISPEDITIIAAMGDALATGigl---------------------wpnADIef-----rGASFPIGGdstidglITIP 195
gi 17569873   93 SVAQLSPEDIQIVGAMGDSLASGrgl---------------------wpfTDVef-----rGAAFPIGGdanmdglVTIP 146
gi 76096366   61 SVHSLKPSDIKFVAAIGNLEIPPdp-----------------------gtGDLekqdwterPQQVCMGVm------TVLS 111
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                   #                                                                    
gi 464376    442 NILREFNPSLQGFSvgtgre-----------------ttsqaFFNQAVAGARADGlipqaqrlvalmkndtrinfqeDWK 504
gi 58388632   66 NILKEYNPKLYGYPtkdgls-----------------trkasLFNAAEGGAMSQDipyqarnlvkrmlsdrkvdinnHWK 128
gi 17861684  153 NILKEFNPNLYGYAikdgis-----------------tdrssRFDVAELAAMSRDmphmakvlvrrmqrdprvnmtsDWK 215
gi 17536677  101 NVLRKFNPTLVGASkgigse----------------nvwevsHLNMGVPGAESKDiigqaralvntmhahseinvkeDWK 164
gi 24582016  181 NILKIFNPKLYGFAvsnslv----------------inhrssRLNIAEPMIMSRDlpfqarvlidllrrdrhvdmkrHWK 244
gi 7499049   124 NIFRKFAPRIKGGSsdfv--------------------qkfyDFNMAIPGSFSSElpeqalklastlkkklgretsdTWK 183
gi 57222994  132 EILRHFSPSAKEIPgsskgkhppvtclngwgikgcaerpeedGLNAAVSGSVSSGllrqvedfilp-rlkdmeirkeDWK 210
gi 32564557  196 NILREFSPKLVGVShgmga------------------dlpnhQLNVAVTGATTEDlpdqarrltrrlkklseldyhnEWI 257
gi 17569873  147 NILSQFGSNLEGIShgmgsk----------------ralpdyQFNVAEIGAETEDlpqqalelvhriqryigrslknKWA 210
gi 76096366  112 DIIRYFSPSVPMPVch-------------------------tGKRVIPHDGAEDLwiqaqelvrnm-kenlqldfqfDWK 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                #                                                                       
gi 464376    505 IITVFIGGNDLCd-FCndpvr------yspqNFTDNIGTALDILHAEIPRAFVNL-----VKVLEISKLrelyqetkvSC 572
gi 58388632  129 MITLMIGGNDFCaeICymatp-----ekilqYHEKNIVSALRTFRDYLPRTFVNLaaspnVTVLRTFSPrp------aSC 197
gi 17861684  216 LVTLFIGNNDFCtdICyypep-----ektvdWHERNMLKTYRYLRDNVPRLMLNI-----VPAPNLRFLtnlt-glppIC 284
gi 17536677  165 LVNIFIGANDICv-YCedpyfns-talhgnaTFEKNIIAAVQILQDNLPRTIVSL-----TGMFNMRMLrkid-kkkyFC 236
gi 24582016  245 LLTVYVGNNDICsdLChwdtp-----qsfldQHARDLRQAFRLLRDHVPRLLINL-----IVVPNIPLVlstmtkvplQC 314
gi 7499049   184 FVNIFIGHNDLCn-ICnnett------fgpeTFGKSLHSALTIIQTNVPKVFVNI-----MPPINVKIHsqah-klskFC 250
gi 57222994  211 FVNLGIGANDICs-FClysnmtdidfngspkRFAKDIKRAVNALRKNVPNIIINI-----IGLFRVSAIyklt-lkdpYC 283
gi 32564557  258 MIIITIGTEELCs-RCe-------------gPSYDNIRKAIEHLQIEIPKALVVL-----LGPVHVSSFh-------eQK 311
gi 17569873  211 LITIVTGSEEFCe-KCe-------------pPSRTSIRRALGVLRRGLPRALIVL-----LGPVHVASTy-------rQN 264
gi 76096366  166 LINVFFSNASQCy-LCpsaqq-----nglaaGGVDELMGVLDYLQQEVPRAFVNL-----VDLSEVAEVsr------qYH 228
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 464376    573 PRMILRSl-------CPCVLkfddnste-iaslietIKEYQERTQQLIDsgrydtrddFTVVLQPFFEKvnmpktqdg-l 643
gi 58388632  198 VTTHAFE--------CPCVFgtryasf--qprleyiIHQWNRIQQSVAEreefnnatdFVVNFQPFPEQltlptlqng-d 266
gi 17861684  285 YSTLRFE--------CPCLMgkgkgql---dylegiMKRWIAKDFEIANreef-ntetFTINVQPFSQFqdfprtrsg-q 351
gi 17536677  237 EGLHTFE--------CDCESnkqftdd--diqgvcfGYMNAEKDIQNTGlfdn--kddFTFVVQPFFNGildppyaspgv 304
gi 24582016  315 FVVHRVG--------CHCLIndrlnrte-fnermdtLTRWQQLDMEIARlpef-rrqdFAIVAHPMLTKltaptlpdg-s 383
gi 7499049   251 EFSHRKT--------CSCIFelnekey---qnikkqFDEQLNEVVEQFNqkyg-nsstFAVVIAPAMDLksipllknq-- 316
gi 57222994  284 QPPLFPYpiphfplgCSCALlpgptgdwtrqkmdelGEAYDEAVLEIVRewekeddehFGAIWQPGTAIdlpnypi---- 359
gi 32564557  312 SNLLKAR--------CACSRdqtegfm---ydvsrkWSKVWRDVQKFVEngvt-arptFGMISYPMVTItsryps----- 374
gi 17569873  265 INLMRPR--------CKCLEkmtgsny---rklfdvWKRYFVEFETEFNvdn----gtFGVLSIPSLAIhsrnpq----- 324
gi 76096366  229 GTWLSPApe-----pCNCSEettrlak---vvmqwsYQEAWNSLLASSRyse---qesFTVVFQPFFYEttp-------- 289
                        330       340       350
                 ....*....|....*....|....*....|....
Feature 1                #  #                      
gi 464376    644 pdnsffapDCFHFSSKAHAHAASALWNNMLEPVG 677
gi 58388632  267 tdagiasvDCFHFSQRGHAIAANSYWNNLIDMEG 300
gi 17861684  352 tdtrffseDCFHLSQRGHAAAANSIWNNMLELPG 385
gi 17536677  305 vdmtffapDCFHFSAYGHGNIGMHLWNTIVQPVG 338
gi 24582016  384 tdwrffshDCFHFSQRGHAIISNLLWNSMLLPDD 417
gi 7499049   317 pnigllalDCFHLSPIAHDIAAKQIWKGLFEPID 350
gi 57222994  360 --talspiDCFHPSEASHQRMAAGIWNRLTLSLE 391
gi 32564557  375 ---glfirDKPLLNRRGHNYATKWLWNRLIGGDL 405
gi 17569873  325 ---tllvpGKPLLNRKGHSYAAKWLWNRLIAGPN 355
gi 76096366  290 ------slHSEDPRLQDSTTLAWHLWNRMMEPAG 317

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