1WGK,2PKO,1XO3,2QJL,2AX5,2K9X,4IDI


Conserved Protein Domain Family
Ubl_Urm1

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cd01764: Ubl_Urm1 
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ubiquitin-like (Ubl) domain found in ubiquitin-related modifier 1 (Urm1)
Urm1 acts as a sulfur carrier in the thiolation of eukaryotic tRNA via a mechanism that requires the formation of a thiocarboxylated Urm1, which is similar to that of prokaryotic sulfur carrier proteins such as ThiS and MoaD, containing the beta-grasp ubiquitin-like (Ubl) fold. Urm1 can be covalently conjugated to lysine residues of other proteins through a mechanism involving the E1-like protein Uba4. Urm1 is involved in yeast bioprocesses such as budding, nutrient sensing, high temperature sensitivity, antioxidant stress response and post-translation modification of the elongator subunit.
Statistics
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PSSM-Id: 340463
View PSSM: cd01764
Aligned: 48 rows
Threshold Bit Score: 96.441
Threshold Setting Gi: 123977125
Created: 9-Jun-2017
Updated: 9-Jun-2017
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1WGK_A        14 VKVEFGGGAELLFdgvKKHQVALpgqeepwDIRNLLVWIKKNLLk--ERPELFIqg------------------------ 67
2PKO_A         4 VKVEFLGGLDAIFgkqRVHKIKMdke-dpvTVGDLIDHIVSTMInnpNDVSIFIed------------------------ 58
2QJL_A         4 VKVEFLGGLDAIFgkqRVHKIKMdke-dpvTVGDLIDHIVSTMInnpNDVSIFIed------------------------ 58
2AX5_A         4 VKVEFLGGLDAIFgkqRVHKIKMdke-dpvTVGDLIDHIVSTMInnpNDVSIFIed------------------------ 58
4IDI_A        24 IELKFLGGLESYLedkSKNYVTLeidskelNFENLIAFIRDNII---EKKFVFSdydivsadeklckvxvdnkeysnynl 100
gi 313235904   3 VTLEFCGGAETAHn-rGEKFLTFksenkepKVSDIFAQVRRKKLi--DDIDALIes------------------------ 55
gi 46229814    4 IKVEFSGGLEVLAgdrQNVEVNLnnl-kssSMKSLILYVEENIIq--YRKDHFIet------------------------ 56
gi 295442748   3 IKVELLGGLDLLFnkqKALSLSLsnl-gstKLGSLIDYMAQIIEk-pSQKDLFIln------------------------ 56
gi 392896488   6 VTIDFSGGAEFLVk-aKAQKVQIpa---dsTLRDVLKFVRDNLVtdvHRINMLLndd----------------------- 58
gi 67483722    3 VKIELSGGLEYDAk-tTHFEIEIgn---ikTMRDVIHKIKEIQT---GLAPIFTe------------------------- 50
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
1WGK_A        68 ---dSVRPGILVLINDADWELLGElDYQLQDQDSILFISTLHGG 108
2PKO_A        59 ---dSIRPGIITLINDTDWELEGEkDYILEDGDIISFTSTLHGG 99
2QJL_A        59 ---dSIRPGIITLINDTDWELEGEkDYILEDGDIISFTSTLHGG 99
2AX5_A        59 ---dSIRPGIITLINDTDWELEGEkDYILEDGDIISFTSTLHGG 99
4IDI_A       101 kdkaKIKPGIIVLVNEYDWEILGTySYQIKNDDKICFLSTLHGG 144
gi 313235904  56 --dkDVKPGVLVLINDADWELFNEaEYQVCKNDRITFVSTLHGG 97
gi 46229814   57 --gsKIKPGIIVLVNNCDWEILGGeNYALSDGDLVTFIMTLHGG 98
gi 295442748  57 ---gTVRPGIIVLVNDQDWELLEKeEYNLEEGDEVVFVSTLHGG 97
gi 392896488  59 --asEVAHGVITLINDTDTGLLLEyDTVIEAGDTITFVSTLHGG 100
gi 67483722   51 ---eSVIPGIIVLINDADWELVGMlDSEVHDGDVISLISSIHGG 91
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