3YGS,4I16,4DWN,2VGQ,2NZ7,1DGN,3KAT,3CRD,3YGS,3T6P


Conserved Protein Domain Family
CARD

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cd01671: CARD 
Click on image for an interactive view with Cn3D
Caspase activation and recruitment domain: a protein-protein interaction domain
Caspase activation and recruitment domains (CARDs) are death domains (DDs) found associated with caspases. Caspases are aspartate-specific cysteine proteases with functions in apoptosis, immune signaling, inflammation, and host-defense mechanisms. In addition to caspases, proteins containing CARDs include adaptor proteins such as RAIDD, CARD9, and RIG-I-like helicases, which can form multiprotein complexes and play important roles in mediating the signals to induce immune and inflammatory responses. In general, DDs are protein-protein interaction domains found in a variety of domain architectures. Their common feature is that they form homodimers by self-association or heterodimers by associating with other members of the DD superfamily including PYRIN and DED (Death Effector Domain). They serve as adaptors in signaling pathways and can recruit other proteins into signaling complexes.
Statistics
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PSSM-Id: 260018
Aligned: 191 rows
Threshold Bit Score: 35.9553
Created: 12-Dec-2003
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3YGS_P         10 LRRCRLRLVeel---qvDQLWDVLLsreLFRPHMIEDIQRAgsgsrrDQARQLIIDLEtRGSQALPLFISCLEDtg--qd 84   human
XP_002590607    9 LHHYRQKLVgevy-pnvAALLACLVtdgTFSPEEEYTVLSLpn--rhNQVRALLDILEtKENKVFGSFTNSLRSic--yt 83   Florida lancelet
EEN45329       35 LKKHRVELVnni--kdvDSVLDHLVsegVIDEYEEKEIKDReg--rkAQVRKLLATLAeKQGNSFHSFCTALKNsr--qk 108  Florida lancelet
EEN63724        9 LTQFRVELVnti--vnvAGVLDQLVterVLLAEEEDDVRTRrm--qtDQIRTLLTILPtKGNRAFLAFCKALDNtg--nt 82   Florida lancelet
EKC34841       11 LTRHRASLVrdl---dtNKILPHLVakeVISTSEERQVLDVsd--prERTEVLLDIVGkRGLGAFHDFCSCLEKva---p 82   Pacific oyster
EEN55651        9 LQLHRLDLVvnls-yniDTVVDYLYrgeVITREEKDTIICHgr--qeDRVKCLLDILEtKDDDAFYDFRDILVKtg--pp 83   Florida lancelet
EEN44191       12 LRRYHRQLVrdm---qtTRVLVQMLa--VFDQSEEAEVLAGqt--ptDRATRFLKILPqKGAEAFEAFVKVLEKkq---p 81   Florida lancelet
ELK16872       32 PATYRETILrdl---svSRLLPRLVydgVFSVWEYRDILSRdg--hpQRVESFLLKLCsKGPKAFCAFCSHLEAfc---p 103  black flying fox
CBN81509        9 LEKCYQNLVesi--teaDRVVDVLAhcgTLSQSERYELGHNcas-nsEKVDLLLKILIsKDRDHFAEFCTALEKth---p 82   European seabass
EEN57303       26 LRKYRVELRdgmtpitlKLVLDKLMafkVLTDEEEDLILNDgkt-rkDKIRNLLDILPsKGQGAIARFKTALAQvdepss 104  Florida lancelet
3YGS_P         85 MLASFL 90   human
XP_002590607   84 HLAKAL 89   Florida lancelet
EEN45329      109 RLAELL 114  Florida lancelet
EEN63724       83 HLSNLL 88   Florida lancelet
EKC34841       83 HLLTGF 88   Pacific oyster
EEN55651       84 HLPLLL 89   Florida lancelet
EEN44191       82 ELARPL 87   Florida lancelet
ELK16872      104 YLLTCF 109  black flying fox
CBN81509       83 HLHSVL 88   European seabass
EEN57303      105 QLVKNL 110  Florida lancelet
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