4A9A


Conserved Protein Domain Family
TGS_DRG

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cd01666: TGS_DRG 
Click on image for an interactive view with Cn3D
TGS (ThrRS, GTPase and SpoT) domain found in developmentally regulated GTP binding protein (DRG) family
DRG-1 and DRG-2 comprise a highly conserved DRG subfamily of GTP-binding proteins found in archaea, plants, fungi and animals. The exact function of DRG proteins is unknown, although phylogenetic and biochemical fraction studies have linked them to translation, differentiation and growth. Their abnormal expressions may trigger cell transformation or cell cycle arrest. DRG-1 and DRG-2 bind to DFRP1 (DRG family regulatory protein 1) and DFRP2, respectively. Both DRG-1 and DRG-2 contain a domain of characteristic Obg-type G-motifs that may be the core of GTPase activity, as well as the C-terminal TGS (ThrRS, GTPase and SpoT) domain, which has a predominantly beta-grasp ubiquitin-like fold and may be related to RNA binding. DRG subfamily belongs to the Obg family of GTPases.
Statistics
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PSSM-Id: 340457
Aligned: 23 rows
Threshold Bit Score: 113.87
Created: 5-Aug-2004
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
polypeptidekey conserved
Conserved site includes 18 residues -Click on image for an interactive view with Cn3D
Feature 1:polypeptide substrate binding site [polypeptide binding site]
Evidence:
  • Structure:4A9A; Saccharomyces cerevisiae Rbg1p in complex with Tma46p DFRP domain, contacts at 4A.
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1           ##        # #    #           # #  #  #      ### #                # #  ###
4A9A_A    298 LNLVRIYTKPKGqiPDFTDPVVLRsdRCSVKDFCNQIHKSLVDDFRNALVYGSSVkh-qPQYVGLSHILEDEDVVTILK 375 baker's yeast
AAK42533  275 LEVIRVYTKEPGe-EPTKDPLILKk-GSTVLDVARKLHSSLAENFRYARVWGKSVkf-qGQKVGPSHILEDRDIVEIHV 350 Sulfolobus solfatar...
AAM02412  313 LGIIRVYTKKPGg-KPQKPPIVLPk-GATVEDVAREIHSDLAKNLKYARVWGKSVkk-dGMMVGRDHVLEDGDVVELHG 388 Methanopyrus kandle...
AAL63629  312 TGRIRVFTKPIHskTYTPKPIVVKa-GSTVGEVAAMIHSSLAETFKYAVVWRREDfpnrPKRVGRDYVLSDNEIVEIHA 389 Pyrobaculum aerophi...
KPK22983  253 LRIIRVYSKSPGkkPDYTTPFVLKr-GSTVADFAGRIHKDFLERFKAARVWGVSVf--dGQMVQRDYVLQDGDVVELRI 328 Nitrospira bacteriu...
KPK20964   95 LEIIRVYTKTPGqkPDMSDPIILGk-GSTLTDAAEAVHKDFKARLKYARLWGSGKh--dGIMVKRDHVLQDGDIIELHV 170 Dehalococcoidia bac...
KPK86676  253 LDIVRSYTKAPGknPDFDDPVILSk-GSRVLDFASQIHKDFAQKLKYARIWGKEKy--nGQMVPRDYVLKDGDVIELHI 328 Deltaproteobacteria...
BAF58650  253 LKVIRIYTKVPGkePDMNTPFILKq-GSTVVELAEAIHRDLPRLMKAARVWGSARf--eGQSVTRDYVLHDRDIVEISR 328 Pelotomaculum therm...
KPL24648  251 LGIIRVYAKPPGkaADMDEPFTLPa-GSTVMDLAVAIHRQLAEKLQAARIWGTGVy--dGQNVQLTHVLNDKDIIELHF 326 Phycisphaerae bacte...
ACB06761  267 LGLIRVFTKSKNekSPSDKAVILPr-NSSVIDLAEFIHESFKERFKYAKVWAKRLpy-sPMRVGPDFLLEDGDIVEIVV 343 Candidatus Korarcha...

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