Conserved Protein Domain Family
PBEF_like

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cd01569: PBEF_like 
pre-B-cell colony-enhancing factor (PBEF)-like. The mammalian members of this group of nicotinate phosphoribosyltransferases (NAPRTases) were originally identified as genes whose expression is upregulated upon activation in lymphoid cells. In general, nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction in the NAD salvage synthesis.
Statistics
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PSSM-Id: 238803
View PSSM: cd01569
Aligned: 21 rows
Threshold Bit Score: 547.644
Threshold Setting Gi: 31544821
Created: 10-Jan-2006
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
active site
Feature 1:active site [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                       
gi 15805325  11 ILDTDSYKSSHFLQYPPGTTRLFSYLESRGgr-------yPVTRFFGLQYILSRYLTRRVTMEm---------------- 67
gi 1001813    6 ILDVDSYKVSHWLQYPPDTTAMYSYVESRGgr-------yPVTVFFGLQYILKRYLTQSIEPWm---------------- 62
gi 46314204  16 ILNTDSYKASHFLQYPPDASAMFSYVESRGgr-------yDRTVFFGLQMLLKEYLCKPITHAm---------------- 72
gi 33148741  16 SLLCDFYKTSHRIMYPECSQIIYSTFTPRSneqa---pylTQVVSFGFQAFIIKYLIHYFNDNff--------------s 78
gi 1351466   16 LLACDAYKLSHRLMYPQDTQNLYSMLTARGvy-------gDFKEFVWNHDFAKEILLNVFNGFvnsvievkknkllaaal 88
gi 24373545   6 VTAIDGYKVDHRRQYPDNTQVIFSNLTARKsrr----gytDQMVFFGLQYFIKHYLIDSWNRDff--------------- 66
gi 48696497   5 TLMCDFYKLSHREQYPEGTEIVYSTLVPRSnkyy---ehsDNIVVFGIQSLVKKYFIDMFNKEff--------------- 66
gi 23136720   6 LLMTDGYKTSHHKMYPAGTTLVYSNFTPRNvkym--peqaKQIVVFGTQYTVKYIFDLYNEQFfk--------------- 68
gi 38707886  11 GLNADAYKSSHIYQYPDATQYLMLNLTPRSdkwfnsplaiDGVVAFGIQRFVKDYLIDHWNATff--------------e 76
gi 46202776   7 ILAVDSYKASHKWQYPPETDFVSSYVEARAdnsg---ldlPGTLVFGLQPLLRRLAAHPVGEGd---------------- 67
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                       
gi 15805325  68 vEEARAVIEAHGe------PFPYEGWRRVVEVHgg-kLPLEIRAVPEGTLVpi-hnVLMSCTNTDPELpWLPGWFETMLM 139
gi 1001813   63 vEEANRLLTAHGl------PFNYGGWRYIAEDLqg-rLPVRIKAVPEGSVIpv-hnVLMTVESTDPKVfWLVSWLETLLM 134
gi 46314204  73 iDEARDFFTVHGe------PFNEAGWRTIVERYdg-yLPVKIRAVPEGSVVpv-hnVLMTVECDDPQVfWLASYLETMLL 144
gi 33148741  79 rDKHDVVTEYSAfie--ktLQLEDTGEHIAKLHelgyLPIRIKAIPEGKTVai-kvPVMTIENTHSDFfWLTNYLETLIN 155
gi 1351466   89 tDKLVSVFNDHElan--efTQHICHLASFLEKNkkmpLVAKIHESDQSLPFrtpliTIEGVENIPNNFvWLVNYFETVLL 166
gi 24373545  67 qQPKEQVICQFSrrinnylGPNNVGTQHIEELHdlgyLPIKIMALPEGSVYpl-kvPCLILYNTDERFfWLTNYLETILS 145
gi 48696497  67 nRPKEEVINEYKrtvkftlGQENPDAKHLEQLHdlgyLPIDVRALKEGTVVhp-ntPVMTIENTHSDFfWLTNYLETIIS 145
gi 23136720  69 rPKAEVCGEAKKyls--syLNCDYDVSHFEALHdlqyLPIAVKSLKEGSIIda-kiPILTFYNTLPEFyWLPNFLETLIS 145
gi 38707886  77 rDKKEAVDEILEvmn-gvlGKDAIGREHWEALHdlgyLPVEVYAVEEGTVVpm-rvPMIVFQNTVSGFhWVAGYLEDAFS 154
gi 46202776  68 iVRAARLFAAHGv------PFHEDGWRHILTRHgg-rLPLEIRAVPEGTLVpf-snVVAQVVNTDPQAfWLTSYIETMLQ 139
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                  ###                      ##          
gi 15805325 140 R-VWYPTTVCTQSWHIREIIRQALEDTSdrAAEELPFKLHDFGSRGVSSResAGIGGLAHLVNFQGSDTLealrvg---- 214
gi 1001813  135 R-VWYPITVATQSWHLKQRIYQSLCRTAddPDGEINFKLHDFGARGVSSGesSGIGGLAHLVNFQGSDTVkalvyg---- 209
gi 46314204 145 R-VWYPVTVATRSWHLRQTIRRFLEKTDd-DLAQLPFKLHDFGARGVSSAesAAIGGAAHLVNFMGSDTVlgvlaa---- 218
gi 33148741 156 VsLWQPMTSASIAFAYRTALIKFANETCd-NQEHVPFQSHDFSMRGMSSLesAETSGAGHLTSFLGTDTIpalsfv---e 231
gi 1351466  167 EnIWLFQTASTVAKRIKSLLEKYAKETAd-ETSFINFQCHDFSMRGMSSLqsALYVARAHLQYFTGSDTIl--------- 236
gi 24373545 146 AnVWGMCTSATTALQYRKIFEAYALETDg-DIAFVDWQGHDFSFRGMYGVeaAIMSGAAHLLSFTGTDTIpaidfleqyy 224
gi 48696497 146 TqTWQAMTSATLAYDMRKMLDKYAMETVg-NIEAVDFQGHDFSMRGMSSLetAQLSSAGHAISFKGSDTVpvvdflesyy 224
gi 23136720 146 SlLWKPLHSASLAYGYKKLLSEAAKNTDekNIGFVDFQGHDFSSRGMQHPeaAVSSSLGFLTSFKGTDTIpaleaa---- 221
gi 38707886 155 AeIWKACTIATIALHYKRICKKWADLTCd-NDLHLPYQCHDFAMRGMSGFtdDAFNAVGHLTSFKGTDSFpavytakriy 233
gi 46202776 140 RaLWYPSTVATVSWAVKRILREFWTLTSdePEGSLDFKLHDFGARGASSGesAALGGLAHLVNFKGTDTIeallaa---- 215
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                       
gi 15805325 215 rnyygAELAGFSIPAAEHSTITSWGk--------------eHEVDAYRNMVRQFGkpgkvYAVVSDSYDLKhainVHWGE 280
gi 1001813  210 qqyynCPMAAYSIPAAEHSTITAWGr--------------eGEVLAYENMLTQFAkpgsvLAVVSDSYDLWnaidHLWGD 275
gi 46314204 219 nrfyrEPMAAYSVPAAEHSTITSWGr--------------eHEADAYRNMIRRFGlpgaiVSVVSDSYDLFaa-lDLWGG 283
gi 33148741 232 ayygsSSLIGTSIPASEHSVMSSHGv---------------DELSTFRYLMAKFPhn--mLSIVSDTTDFWhn-iTVNLP 293
gi 1351466  237 -----GGDNSRSILASEHSVMCADGs--------------kHELKTFQRLLEKFKdk--kLSLVIDSYDMWnv-lDNIIP 294
gi 24373545 225 ladsdKELVGGSVPATEHSVMCAGGm--------------eNELETFRRLIEDIYpt-giVSIVSDSWDFWqv-mTEFTL 288
gi 48696497 225 nadveKEMVVASIPATEHSVMCANGnye-----------tmDEYETYKRMLTEIYpt-giFSIVSDTWDFWgn-mTKTLP 291
gi 23136720 222 ayyynEKDVAFSVPASEHAVMTAYGr--------------eDEIQGFKRLMEQYPtg--iLSVVSDSFDLWkv-cTEFVT 284
gi 38707886 234 gqaypISDIGSSVPATEHSVMCANIaweggnelveeerrfkGELQTFRRFLTETYpt-giASIVSDTYNFWrt-vSEILP 311
gi 46202776 216 eehyaEPMAGFSIPAAEHSTITSWGr--------------aGEVEAYANMLEQFGgpgrlVAVVSDSYDVFhaveNLWGR 281
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                          #                                                            
gi 15805325 281 TLRKEVees--ggtLVVRPDSGDPPAMVRLAVNALAa------------------------------------------- 315
gi 1001813  276 HLRAQVlds--gatVVIRPDSGDPVAIVAQTLERLEa------------------------------------------- 310
gi 46314204 284 ELRQAVlds--gatLVVRPDSGDPVAIVLQTVRALDe------------------------------------------- 318
gi 33148741 294 LLKQEIiarpenarLVIRPDSGNFFAIICGDPTADTeherkgl------------------------------------- 336
gi 1351466  295 RLKNLIlmr--gatLYLRADSGNYQTLICNPNYKKQdkstwam------------------------------------- 335
gi 24373545 289 ALKDRIlar--dgkVVFRPDTGCPVKIICGDPQAPIgspeykga------------------------------------ 330
gi 48696497 292 RLKDIImer--ngkVVIRPDSGDPVKIICGDPDADTeyerkga------------------------------------- 332
gi 23136720 285 TLKEQIlar--dgkLVIRPDSGDPVDIICGTSEPYGkyegnwenapa--------------------------------- 329
gi 38707886 312 ALRKEImer--dgrLVIRPDSGDPVHIVTGYKAIHLecakkayyehlskleasdtmlnsvlnmklenisygiagwllseg 389
gi 46202776 282 ELRAQVldm--ggtLVIRPDSGDPVEVVSQVLRLAAa------------------------------------------- 316
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                          ##           
gi 15805325 316 ----------------------------------------------kYGTTTNSKGFKVLQ-HVRVIQGDGIDESTIRQI 348
gi 1001813  311 ----------------------------------------------cFGSTLNSKGFRVLN-AVRVIQGDGVDEESISAI 343
gi 46314204 319 ----------------------------------------------sFGSTVNSKGRRVLN-RVRVIQGDGVDELSIEAI 351
gi 33148741 337 ----------------------------------------ieclwdiFGGTVNQKGYKVINpHIGAIYGDGVTYEKMFKI 376
gi 1351466  336 ----------------------------------------idyldhhFSSTINKKGYKVLNkKIGIIYGDGITYQKIEWI 375
gi 24373545 331 ----------------------------------------ieclwdvFGGSTTAKGYKLLDsHVGLIYGDSITIERAEAI 370
gi 48696497 333 ----------------------------------------vevlwdtFGGTETEKGYKVLDeHVGLIYGDSINYERAQQI 372
gi 23136720 330 ------------------------------------skgviellwntFGGTVNAQGYKVLDpHIGAIYGDSITLERAQHI 373
gi 38707886 390 yemvvdredfevadtvmlknaymvgsanvvtrpvaeidgaiktlyniFGGTINSKGFKVLDeHIGLIYGDSITLERANEI 469
gi 46202776 317 ----------------------------------------------aFGTTRNSKGFRVLNpAVRIIQGDGVNPKSIRAI 350
                       490       500       510       520       530       540
                ....*....|....*....|....*....|....*....|....*....|....*....|....
Feature 1                       # ##  #                                         
gi 15805325 349 LQNlyvdgFSAENVTFGMGGALLQkVDRDTQRFAYKASAGLIDGEYRGIYKDPVTDPGKRSKDG 412
gi 1001813  344 LEKteslgFSTTNLAFGMGGALLQkVNRDTQKFAMKCSEVTVEDKAIPVYKDPVTDPGKTSKKG 407
gi 46314204 352 LSAlddsgYAAGNVVFGMGGGLLQqVNRDTQRFAMKCSAIRRGGVWHDVRKDPVTDQGKRSKKG 415
gi 33148741 377 LEGlqakgFASSNIVFGVGAQTYQrNTRDTLGFALKATSITINGEEKSIFKNPKTDDGFKKSQK 440
gi 1351466  376 LNClknhgYCSSNIIFGVGSSTYQnLNRDTLGFVYKLTAIKRNNRWIGVKKTPITDLSKSSKGG 439
gi 24373545 371 CAGlkakgFASTNIVFGIGSFTYQhVTRDTDGYAVKATFAKVDGKDREIFKDPKTDDGTKKSAK 434
gi 48696497 373 CEGlkekgFASINVVLGVGSFSYQfNTRDTHGFAIKATYAKIKNEEKLIYKNPKTDSGKRSHKG 436
gi 23136720 374 CARlkakgFASTNIVLGVGSYSMGyATRDNQGGAVKATYCEVNGIGREIFKDPITDDGTKKSAK 437
gi 38707886 470 LKRlyemgFASSNVVFGVGSYTYQyMTRDTFAFAVKATLASIGGKEIMLAKDPKTDSGVKKSAF 533
gi 46202776 351 LARmvddgFAIDNIAFGMGGALLQkVDRDTFSWAMKASAVRVAGHWRDVYKEPVTDGGKGSKRG 414

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