Conserved Protein Domain Family
AMPD

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cd01319: AMPD 
AMP deaminase (AMPD) catalyzes the hydrolytic deamination of adensosine monophosphate (AMP) at position 6 of the adenine nucleotide ring. AMPD is a diverse and highly regulated eukaryotic key enzyme of the adenylate catabolic pathway.
Statistics
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PSSM-Id: 238644
View PSSM: cd01319
Aligned: 11 rows
Threshold Bit Score: 838.947
Threshold Setting Gi: 23484684
Created: 6-Mar-2002
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
active site
Feature 1:active site [active site]
Evidence:
  • Comment:active site is based on homology to other members of the adenosine deaminase family

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 32564194  256 FLNDTEKLTAMIVDGPL-KSFCFRRLSYLENKFQLHVLL-NELRELHEQKGVS--------------------------- 306
gi 23484684   97 EYLEAIQEIMTTAQDPAcKSFCYQRLKYLEQKFDFHIMF-NGPLELKETANIK--------------------------- 148
gi 12644299  271 YYIDLEFLLSASSDGPS-KSFSFRRLQYLEGRWNMYMLL-NEYQELADTKKVP--------------------------- 321
gi 28927174  381 YYLDLEAILSVSSDGPS-KSFAFRRLQYLEKRFDLYVLL-EGYDETADCKKVP--------------------------- 431
gi 1351916   299 YYLDLEKMISISSDGPA-KSFAYRRLQYLEARWNLYYLL-NEYQETSVSKRNP--------------------------- 349
gi 34898232  304 FFTDMHYILRVLAAGDI-RTVCYKRLNLLEQKFNLHLMV-NADRELLAQKAAP--------------------------- 354
gi 7638159   111 YYKDINNLMMLSSYGPA-KTFTFKRLQLLESKFNMHTLL-NDSLELFQQKTAP--------------------------- 161
gi 18859679  193 FVNDMQVMCNMIADGPL-KSFCYRRLCYLSSKYQMHVLL-NELRELAAQKAVP--------------------------- 243
gi 113697    240 FLDDMNFLLALIAQGPV-KTYTHRRLKFLSSKFQVHQML-NEMDELKELKNNP--------------------------- 290
gi 28277529  266 FAIDLSHVLAMIADGPT-KTYCHRRLNFLTSKFQLHEML-NEMAELKELKCVP--------------------------- 316
gi 11071770 1004 FQKDTRMLRRLASADPTvAKYASKRLDMLESKYRLHAALtNDDEEDYTITTATataaenaegdsteararaaptsrrcvv 1083
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                       # #                                                              
gi 32564194  307 ---HRDFYNIRKVDTHIHAASSMNQKHLLRFIKKKIKTea--dtVVLNNNGTKVTMKEVFK------------------- 362
gi 23484684  149 ---HRDFYNIRKVDAHVHHSACMQQKSLLRFIREKYNTepd-tiVYVNENGKKIKLKELFDd------------------ 206
gi 12644299  322 ---HRDFYNVRKVDTHVHHSALANQKHLLRFIKAKLRKcp--neKVIWRDGKFLTLQEVFD------------------- 377
gi 28927174  432 ---HRDFYNVRKVDTHVHHSACMNQKHLLRFIKSKIKKyp--deIVLYRDGKYLTLAEVFE------------------- 487
gi 1351916   350 ---HRDFYNVRKVDTHVHHSACMNQKHLLRFIKHKLRHsk--deKVIFRDGKLLTLDEVFR------------------- 405
gi 34898232  355 ---HRDFYNVRKVDTHVHHSACMNQKHLLRFIKSKLRKep--deVVIFRDGTYLTLKEVFE------------------- 410
gi 7638159   162 ---HRDFYNVRKVDTHVHHSSSMNQKHLLKFIKRKLKEnp--neIVIFRDDKYLTLAEVFK------------------- 217
gi 18859679  244 ---HRDFYNTRKVDTHIHAASCMNQKHLLRFIKKTLKNna--neVVTVTNGQQMTLAQVFQ------------------- 299
gi 113697    291 ---HRDFYNCRKVDTHIHAAACMNQKHLLRFIKKSYQIda--drVVYSTKEKNLTLKELFA------------------- 346
gi 28277529  317 ---HRDFYNVRKVDTHIHAAACMNQKHLLKFIQDSYQTea--drVVLEKGGKKFTLKQVFE------------------- 372
gi 11071770 1084 qpaCGDAHNCVKVDVHCHMASGMTAKSLLQFMQRKIRDhpddvvGVDSKTGAPITLVEFFDevlgeqlkpkpsavaqgdn 1163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 32564194  363 ----------------------------KMGIDAYDLSVDmLDVHADRNTFHrfdkfNTKYNPVGESTLREIFIKTDNYV 414
gi 23484684  207 ----------------------------ELKFSAHQATVDnLDVHALGNCFHrfdlfNEKYNPFGQKLLRDIFLKTDNYI 258
gi 12644299  378 ----------------------------SLKLTSYDLSIDtLDMHAHTDTFHrfdkfNLKYNPIGESRLRTIFLKTDNDI 429
gi 28927174  488 ----------------------------SLNLTAYDLSIDtLDMHAHTDSFHrfdkfNLKYNPIGESRLRTIFLKTDNFI 539
gi 1351916   406 ----------------------------SLHLTGYDLSIDtLDMHAHKDTFHrfdkfNLKYNPIGESRLREIFLKTNNYI 457
gi 34898232  411 ----------------------------SLDLTGYDLNVDlLDVHADKSTFHrfdkfNLKYNPCGQSRLREIFLKQDNLI 462
gi 7638159   218 ----------------------------SLNLDVDELSVDtLDVHADNNTFHrfdkfNLKYNPCGQSRLREIFLKTDNLI 269
gi 18859679  300 ----------------------------SMNLTTYDLTVDmLDVHADRNTFHrfdkfNSKYNPIGESRLREVFLKTDNYL 351
gi 113697    347 ----------------------------KLKMHPYDLTVDsLDVHAGRQTFQrfdkfNDKYNPVGASELRDLYLKTDNYI 398
gi 28277529  373 ----------------------------NLKMDPYDLTVDsLDVHAGRQTFHrfdkfNSKYNPVGANELREIYLKTDNYI 424
gi 11071770 1164 stavrraapvfaaegdevvaaasakaarVAHLLAGMPVAA-LQVHAGKATFHrfdrfNHRFSPMGMTSLRSLFLKTENFM 1242
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 32564194  415 GGKYFADLLKEVLSDLEDSKYQHAEPRLSIYGRSKNEWDnlAKWALTHDVWSPNARWLVQIPRLYDVYRAkNMVKNFDDM 494
gi 23484684  259 EGKYLAEITKQEINILEKSKYQHVEWRISIYGKDKNEWTklAKWVLNNNLTSVRVRWIIQIPRLYHIYKKrKLIYSFQNF 338
gi 12644299  430 NGRYLAELTKEVFTDLRTQKYQMAEYRISIYGRNREEWDklAAWIIDNELFSPNVRWLIQVPRLYDVYKKsGIVETFEEV 509
gi 28927174  540 NGRYLAEITKEVIADLESSKYQMVEWRVSIYGKSLDEWDklASWVVDNKLFSHNVRWLVQIPRLYDVYKAsGGVNTFEEI 619
gi 1351916   458 KGTYLADITKQVIFDLENSKYQNCEYRISVYGRSLDEWDklASWVIDNKVISHNVRWLVQIPRLYDIYKKtGIVQSFQDI 537
gi 34898232  463 QGRFLAELTKEVFSDLEASKYQMAEYRISIYGRKKSEWDqmASWIVNNELYSENVVWLIQIPRIYNVYREmGTINSFQNL 542
gi 7638159   270 KGKYLAEISKEVFTDLESSKYQCAEYRLSIYGRKMSEWDtlASWIVDNDLFSTKVRWLIQVPRLYDVYRE-TSTTTFQDF 348
gi 18859679  352 NGKYFAQIIKEVAFDLEESKYQNAELRLSIYGKSPDEWYklAKWAIDNDVYSSNIRWLIQIPRLFDIFKSnKMMKSFQEI 431
gi 113697    399 NGEYFATIIKEVGADLVEAKYQHAEPRLSIYGRSPDEWSklSSWFVCNRIHCPNMTWMIQVPRIYDVFRSkNFLPHFGKM 478
gi 28277529  425 NGEYFARLIKEVAHDLEESKYQHAEPRLSIYGRAPEEWEslSKWFIMQKLHSPNMRWMIQVPRIYDIFRSkKIIANFAKM 504
gi 11071770 1243 QGRYFAELIRIAFKQNELEGGTFTENRLSIYGRHKDEWDrlSRWLVFHGLSHRTNSWMIQVPRLFHLYQRsGQLRSFQEM 1322
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 32564194  495 LDNLFTPLFEVTNDPSSHPELHLFLQQISGIDSVDDESk-hEFVNFDRSTPCPpeYTDLENPPYNYYLFYMYRNICALNA 573
gi 23484684  339 LSNIFEPCFEAIKNPEQNKEIFLFLQQIVGWDSVDDESiisKYTLKGGVLPSPdkYISDTNPPYSYYAYYMYANIRALND 418
gi 12644299  510 VRNVFEPLFEVTKDPRTHPKLHVFLQRVIGFDSVDDESk--PERRTFRKFPYPkhWDINLNPPYSYWLYYMYANMTSLNS 587
gi 28927174  620 VRNIFEPLFEVTKDPSSHPKLHIFLQRVIGLDSVDDESk--VERRLFRKFPVPkiWDGKQNPPYSYWIYYLYANMASLNH 697
gi 1351916   538 CKNLFQPLFEVTKNPQSHPKLHVFLQRVIGFDSVDDESk--VDRRFHRKYPKPslWEAPQNPPYSYYLYYLYSNVASLNQ 615
gi 34898232  543 LDNIFLPLFEVTVDPASHPQLHVFLQQVVGLDLVDDESk--PERRPTKHMPTPeqWTNVFNPAYAYYVYYCYANLYTLNK 620
gi 7638159   349 LNNVFHPLFEVTKDPSSHPKLHLFLQQVVGIDCVDDESk--FEKKFTEKFPVPgeWSSEHNPPYTYYLYYLYANLYTLNQ 426
gi 18859679  432 LNNIFLPLFEATARPSKHPELHRFLQYVIGFDSVDDESk-pENPLFDNDVPRPeeWTYEENPPYAYYIYYMYANMTVLNK 510
gi 113697    479 LENIFMPVFEATINPQADPELSVFLKHITGFDSVDDESk-hSGHMFSSKSPKPqeWTLEKNPSYTYYAYYMYANIMVLNS 557
gi 28277529  505 LENIFLPLFQATVNPQKHKEMHVFLKHVTGFNSVDDESk-hSDHIFNYKSPKPeeWTSEENPPYTYYLFHMYANIMVLNN 583
gi 11071770 1323 LTNIFEPLWHASLHPDKYPYLHFFLSHVSGFDSVDNESd--REPDQTIDIPPAq-WTSAENPPFAYYMFYMWINITTLNL 1399
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                      #  #                  #                                           
gi 32564194  574 FRRARGLNTFALRPHCGEAGHVSHLLTGYLTSESIAHGILLRKVPvLQYLYYLTQIGIAMSPLSNNSLFISYQRNPLPEY 653
gi 23484684  419 FMIARKLRPLTFRPHCGEVGNISHLASMFLLANRINHGIALRKSPvLLYLYYLKQIGLAMSPLSNNALFLSIEKNPFKQF 498
gi 12644299  588 WRKIRGFNTFVLRPHCGEAGDTDHLASAFLLSHGINHGILLRKVPfLQYLWYLDQIPIAMSPLSNNALFLAYDKNPFLTY 667
gi 28927174  698 WRKRRGFNTFVLRPHCGEAGDSEHLAVAALCCHSISHGLLLRKVPvLQYVFYLEKIGIAMSPLSNNALFLAYERNPMHQY 777
gi 1351916   616 WRAKRGFNTLVLRPHCGEAGDPEHLVSAYLLAHGISHGILLRKVPfVQYLYYLDQVGIAMSPLSNNALFLTYDKNPFPRY 695
gi 34898232  621 LRESKGMTTIKLRPHCGEAGDIDHLAAAFLTSHNIAHGVNLKKSPvLQYLYYLAQIGLAMSPLSNNSLFIDYHRNPFPTF 700
gi 7638159   427 FREEKGLNILTLRPHSGEAGEVDHMGAAFYLAHGINHGINLRKTPvLQYLYYLTQIGIAMSPLSNNSLFLTYNRNPFPAF 506
gi 18859679  511 FRQSRNMNTFVLRPHCGEAGPVQHLVCGFLMAENISHGLLLRKVPvLQYLYYLTQIGIAMSPLSNNSLFLNYHRNPLPEY 590
gi 113697    558 LRKERGMNTFLFRPHCGEAGALTHLMTAFMIADDISHGLNLKKSPvLQYLFFLAQIPIAMSPLSNNSLFLEYAKNPFLDF 637
gi 28277529  584 LRKERGLNTFLFRPHCGEAGSITHLVSAFLTADNISHGLNLKKSPvLQYLYYLAQVPIAMSPLSNNSLFLEYSKNPLREF 663
gi 11071770 1400 YRAARGFNTFQFRPHAGESGDPDHMADVFLLADGIGHGINLDKRPvMQYLYYLTQIPLAITPMSNNTLFCRYKDHPLPNF 1479
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                   ##                                                                   
gi 32564194  654 LQKGLNVSLSTDDPLQFHYTKEALMEEFSIAAQVWKLSSCDMCELARNSVMQSGFEDKVKIHWLGPNYkeegvl-gndih 732
gi 23484684  499 FKIGLNVSLSTDDPLMFHFTTEPLLEEYSVCAHVWRLTTMDLCEIARNSIIQSGYEPSFKRHWLGKGGeknspnftsipe 578
gi 12644299  668 FKRGLNVSLSTDDPLQFAFTREPLIEEYAVAAQIYKLSAVDMCELARNSVLQSGFERQLKERWLGVDFqd--------id 739
gi 28927174  778 FKRGLNVSLSTDDPLQFAFTKEPLIEEYAVAAQIYKLSPVDMCELAKNSVKQSGYERSIKEQWLGKNFdlpgaq-gntmv 856
gi 1351916   696 FKRGLNVSLSTDDPLQFSYTREPLIEEYSVAAQIYKLSNVDMCELARNSVLQSGWEAQIKKHWIGKDFdksgve-gndvv 774
gi 34898232  701 FLRGLNVSLSTDDPLQIHLTKEPLVEEYSIAASLWKLSSCDLCEIARNSVYQSGFSHRLKSHWIGRNYykrghd-gndih 779
gi 7638159   507 FARGLNVSISTDDPLQFHYTKEPLMEEYSIATQVWRLSVCDICEIARNSVLQSGFEHNVKSHWLGPDYansgg---ndik 583
gi 18859679  591 LARGLIISLSTDDPLQFHFTKEPLMEEYSIAAQVWKLSSCDMCELARNSVMMSGFPHAIKQQWLGPIYyedgim-gndit 669
gi 113697    638 LQKGLMISLSTDDPMQFHFTKEPLMEEYAIAAQVFKLSTCDMCEVARNSVLQCGISHEEKVKFLGDNYleegpa-gndir 716
gi 28277529  664 LQKGLCVSLSTDDPLQFHYTKEALMEEYAIAAQLWKLSTCDTCEIARNSVLQSGLSHQEKKYFLGEKYlddgpe-gndir 742
gi 11071770 1480 LYRGLHVAIGTDCPLIFHRTEQPLLEEYGTAEALWNLSAADICELAANSVRASGFPASRKREWLGPLYhlrsva-gndva 1558
                        570       580
                 ....*....|....*....|
Feature 1                            
gi 32564194  733 RTNVPDIRVSFRheALVDEL 752
gi 23484684  579 KTNIPKTRMSYRkkTWNEEN 598
gi 12644299  740 RTNVPIIRLAYRalTLTQEI 759
gi 28927174  857 KTNVPDRREEFRyrTLLEER 876
gi 1351916   775 RTNVPDIRINYRydTLSTEL 794
gi 34898232  780 QTNVPHIRIEFRhtIWKEEM 799
gi 7638159   584 KTNISDIRVCFRneTLIEEL 603
gi 18859679  670 RTNVPEIRVAYRyeTLLDEL 689
gi 113697    717 RTNVAQIRMAYRyeTWCYEL 736
gi 28277529  743 KTNVAQIRMAYRheTLCNEL 762
gi 11071770 1559 RSHVPQTRCAFRyeAYMEEV 1578

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