Conserved Protein Domain Family
AdeC

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cd01295: AdeC 
Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source in bacteria and archea.
Statistics
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PSSM-Id: 238620
View PSSM: cd01295
Aligned: 25 rows
Threshold Bit Score: 477.872
Threshold Setting Gi: 27378276
Created: 6-Mar-2002
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
active site
Feature 1:active site [active site]
Evidence:
  • Comment:active site is based on homology to other members of the amidohydrolase family

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                     # #                                                               
gi 3912984   53 DLKGKYLSPTFIDGHIHIESSHLIPsEFEKFVLKSGVSKVVIDPHEIANIAGKe-GILFmln---daKILDVYVMLPSCV 128
gi 15890557  78 DAGGAYVSPGLIDTHMHIESSMITPaAYAAAVVARGVTTIVWDPHEFGNVHGVd-GVRWaaka-ienLPLRAILLAPSCV 155
gi 18310250  50 DGEDKYIIPGLIDIHMHIESSMTIPrEFSKAAIKHGVTTVVADPHEIANVFGVr-GIEEfik---fkGNLDIFYGIPSSV 125
gi 13470448  81 DAGGRYLVPGLCDAHMHVESGMVTVtEFCRAVIPHGTTSMFIDPHEIANVLGLp-GVRLmhde-avaMPINVHVQMPSCV 158
gi 29375795  50 NAENQWMIPGLIDAHMHIESSMTTPtIFSKAVVRYGVTTVIADAHEMANVFGLe-GLKAfma---aeTELDIFHAIPSSV 125
gi 20094265  94 IDVDGIICPGFVDAHVHVESSGLRPaRYAEIVVREGTTAVVWDPHEVVNVSGEl-GLEWavktaeeaLPFKFYIALPSCV 172
gi 16263397  65 DAADRYLTPGMIDGHLHVECSKLSLtSFAKAVLPLGTTSIVSGLDQIIVVGGPd-AAREflde-vrqTPLKVFWGAPCKT 142
gi 27378276  79 DAAGAIIAPGLVDPHIHIESSMVTAcAYAEAALLNGTTTIFCDSHEIGNVMDVa-GVEAmled-arqAPLSIFLTVPSTV 156
gi 15613200  74 DCGQQVIVPGYIEHHAHPFQLYNPH-SFANYAAAMGTTTLINDNLMFFLALEKkkALSMies--ldeLPSSMYWWCRYDP 150
gi 3915461   73 DCEGKYIVPGYIEPHAHPFQIYNPQ-TLAEYVSQYGTTTFVNDNLFLLLQSGKkkALTIlne--lkkQPVQYFWWSRYDL 149
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                          #            
gi 3912984  129 PATnle--tsGAEITAENIEELILld-nvLGLGEVmnypa-vinedEEMLKKIEVAKky--nkLIDGHCPKLk-gWELNK 201
gi 15890557 156 PSApgl-ergGADFDAAILADLLSwp-eiGGIAEImnmrg-vierdPRMSGIVQAGLaa--ekLVCGHARGLk-nADLNA 229
gi 18310250 126 PSTssslettGEKITHNEVKRLLEyd-niICLGEVmnfkdliedddSNINKIINISKek--niPLEGHCPKIq-gVDLSL 201
gi 13470448 159 PSApgl-ehaGAELTVADVAEAMTwe-niIGLGEVmnfpg-vaandPVMSGEIAATVra--gkTVGGHYASRdlgLPFHG 233
gi 29375795 126 PSTtpelettGGIIGLAEVAELLKep-kvICLGEAmnfkgisyepdSLIRQIIDLCQkqrptmPLEGHCPKIe-dQELAD 203
gi 20094265 173 PALgppyetvEGEITVDVARKFAShp-mvVSVGELmdvag-vmegeKDEFIELKSLYg----lTVDGHAPGLt-gFEAMR 245
gi 16263397 143 PYTmpr-stvGHYFSPKDHRDTHHwp-ecVGIWETvrefi--qeedEDVLQAIEIGQan--rlPVLGCCPMTr-gARLNG 215
gi 27378276 157 PATsaeletaGGDLTPDKIAGLFDrwpeaVALGEKmdfvp-vtmgdERSHAILAAALkr--grPVSGHVYGR---EFVAA 230
gi 15613200 151 QTEmn---deEGHFLNSKIKEWLEhp-lvVQGGELtswpk-vitgdDGILHWMQETRrl--rkPIEGHFPGAs--EKTLT 221
gi 3915461  150 QTEvl---neDHVLPFDVRKQWIEhp-dvIQGGEMtgwpr-lvdgdDLMLHCMQATKkq--rkRIEGHFPGAs--DKTLT 220
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                 #                                                       #             
gi 3912984  202 YIs-hGIMSDHESVDedeALEKLRLGLKLMIREgta----skNIYLLNickki---kdfrnIMLVSDDVCIKDLd--GYM 271
gi 15890557 230 FMa-aGVSSDHELVSgedLMAKLRAGLTIELRGshdh--llpEFVAALntlgh----lpqtVTLCTDDVFPDDLlqgGGL 302
gi 18310250 202 YIy-rGVNGDHTQQSvgsLQEKIQNGMFIEMQHksm---tleNIKFLIennl------yehFALVTDDVMADKLv-kGHL 270
gi 13470448 234 YVa-gGPEDDHEGTRaedAIARVRQGMKAMLRLgsa----wyDVASQIkavteg-gidprnFILCTDDSHSGTLvheGHM 307
gi 29375795 204 FLy-sGITSDHTHQFpktLKEKIEAGVFIQFQNksi---tpeNIQVIVdndf------ynyASIITDDVMADDLl-kGHL 272
gi 20094265 246 YFa-aGPETDHECSTaeeFTSRRELGVWTFVRQgss----skDMEVALetle-----dlrgVCFVTDDLHVKDMd-eISL 314
gi 16263397 216 YMq-sGVRADHESYTpeeMLEKLRAGMHVVVREssishflsdNLRIVTemgvk----alrrISFCTDDVVASDIlsrGHL 290
gi 27378276 231 YAa-sGVTDTHEAIDrdiADDLLDAGVWVFLRGgppt-tpwhSLPQAIrtitel-gashkrTAVCTDDRDADDLl-lFGL 306
gi 15613200 222 QMsllGVTSDHEAMTgeeVIRRLDLGYMTSLRHssi----rsDLAKILremkelgiddfsrCMLTTDGSPPSFYe-qGIM 296
gi 3915461  221 KMklfGADCDHEAMTgdeVMRRLELGYYVSLRNssi----rpDVRKILqelhekgfryydhFFYTTDGATPNFYk-gGMT 295
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                       
gi 3912984  272 LNILRKATNyvs-piEAIQMVTINPANYfgf--dvGIKAGNE-ASFVIFEDLDNFKVYNIVIKGrflddvlnelnknkkr 347
gi 15890557 303 DDVVRRLVRyglkpeWALRAATLNAAQRlgr-sdlGLIAAGRrADIVVFEDLNGFSARHVLASGravaeggrmlvdiptc 381
gi 18310250 271 DEILKEAVKlgmsieNAIYASTYTPARRmnl-ldrGTIAPGKlADFILLDSIEDFNIYEVYKNGemvfnrdkglkeeffe 349
gi 13470448 308 DRVVRHAIQqglkpvTAIQMATINTAQHfrlereiGSIAPGRlADLLIVSDLAAMTIDEVYARGvrlakggkldidipay 387
gi 29375795 273 NENVKKAVHaglpieKAIYMATYTPAKRmgl-hdrGEIAPGKkADFLLLNDLESFDINTVYKSGkvvfekgepfhypeki 351
gi 20094265 315 RKIVGRAIEagfdplESLSAVTLNPSLCygl--qsGRLVPGFhADIVVVEDLDENMELTDVWIGgkrservrfrdaeael 392
gi 16263397 291 DNMVRMAMAmgispmAAIQMATINGAEAlridhkvGSISPGRtADILIVNDLRDFRIEAVVANGtvaardgrmvvklvpp 370
gi 27378276 307 DWVVREAVKagmspeQAWSMGSLHGATRfgmegdiGGLGGGRrADLVLMDDQLKPQCTWYGGELvvehgkitprldqals 386
gi 15613200 297 DRLIKIALDegippkDAYGMATYYVARYygldyelGMIAPGRiAHLNFLDNVFNPVPTSVLAKGqwvvrdgqrygsdsvf 376
gi 3915461  296 NELIRIALEegvpaiDAYNMASFNIAKYyqmddylGVVGPGRlASLNILEDPLNPNPVTVLSKGtilrengcdlkaftkt 375
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                       
gi 3912984  348 kipeklmntlkyqyknegdflikgid-----ykerdgfirvikplkdsliteelifsteeikillnenainkIFVIERHK 422
gi 15890557 382 dttvlkgsmklplrmandflvks-----------qgakvrlatidrprftqwgeteadvkdgfvvppegatmISVTHRHG 450
gi 18310250 350 dkskldyrfynsielnnitkeslevkvpnkyknkvncrtmkvlknttfteegevtlnvynnilqweksscalIAVFERYG 429
gi 13470448 388 dypktakntvklgkklragdfditapk--ganevrvrvigvienqaptraleadlpvedglvamdrrndvcqIALVERHR 465
gi 29375795 352 eefpatyqqtiqckklteedlllkvat---tketvrcnviqkqeigtfteritkeipvengllqwqkancalLIVMERYG 428
gi 20094265 393 pdvelsvdprevsfqdgky------------------evrcvglvrgsirteeivreitvkdgavkdddvafLVVTDRYG 454
gi 16263397 371 qrsagllrsvkttpvtaadiavpftgt--tpfaevlaiavtpekvfvrtrrdvrlpvvdgkiladasqnvqyVTVVERYG 448
gi 27378276 387 qryqypkaayatvklpekvkltpelp----akactvnaiktalpgitlihekvaiepakdwptlfaryglcfVTVVERHG 462
gi 15613200 377 pwedfgmkrltidwdlsvdelh-------------fsmpmgielvnsvilkpyqvsveasrdtlaedhdecfFLLLDKHG 443
gi 3915461  376 dwhkgglvplelsydmtmddlq-------------fsmpmgvkmrnavimepymieidnsmeqlsfdhdesyLTMLDRHG 442
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                       
gi 3912984  423 ntgn-igkGLIYNFLEe--GALASSYaHDSHNVIAIGnneKDLALAVNKLKDIGGGFIAAKDGevVEYLPLPVGGIMGdd 499
gi 15890557 451 maepttktGFLTGWGRw-nGAFATTVsHDSHNLTVFGgnaGDMALAANAVIGTGGGMAVASEGkvTAILPLPLSGLVSda 529
gi 18310250 430 knnn-isfGLVEGEIIk-eGAIATTWaHDHHNLMVMGrniSDMTIAANEVINSRGGYVVSKNNevIAKLELPIGGIISde 507
gi 13470448 466 gtgg-vtnAFVSGFGYmgdCAMASSVaHDAHHIICVGtnkQDMALAVNRLGQVGGGVVLFSKGkeLALVEMPIAGLMSde 544
gi 29375795 429 kngn-isfSLMDQPLSe-kGAIATTWaHDHHNLMVMGntiEDILLAQNELLAMQGGYLVASDQqvMATCPLPIGGILSqa 506
gi 20094265 455 qgs--wsiGFVEGFEEl-dCAVVSTVaHDSHNVVVAGrrlDDVRRALQLVSEVGGCVGAVAGDr-AEFVRLDVAGLMSss 530
gi 16263397 449 ktln-rpvAFVSGFNLk-sGAIASSTaPDDNNIICIGadpQDMAIAINHLVANNGGQVVVDKGevVEFLHLPIGGIVSdi 526
gi 27378276 463 ksagnvayGLLKDFGLk-rGAVASSVgHDSHNIIVAGtnePDMQVAIAAIKEHQGAVCVVADGkvRALVPLPIAGLLSdk 541
gi 15613200 444 kwk---ipTMIKGFAKk-vSGLASSF-STTGDIILIGkciQDMIVAFNALKQQGGGIVLVENGevISNIPLEIMGLLSsk 518
gi 3915461  443 kwr---vnTMIKGFASs-vQGFVSSF-TTTGDIVAIGknkADMLLAFARMKEIGGGIVLAENGniLHEIPLALCGCASse 517
                       490       500       510       520       530
                ....*....|....*....|....*....|....*....|....*....|....
Feature 1                                                             
gi 3912984  500 --gKYIAEKInaLYKKIEGWSsf-eNPFLSMS--FFSLPVIPELk-iTDKGLVK 547
gi 15890557 530 -plEEVARAFedLREAVGKVVew-qPPYLVFKacFGATLACNIGphqTDMGIAD 581
gi 18310250 508 -piEIIGEKLgeVRNAMRDLGynhmNEIMSFS--TLSLPVSPALk-iTDKGLID 557
gi 13470448 545 -raEIVAAKAekLTEAMRKMGcslnNAYMQHS--LLALVVIPELr-iSDVGLID 594
gi 29375795 507 -piEQLGASLqkVRQAMQALGyqnmNEIMSFS--TLSLPVSPAIk-vTDFGMMD 556
gi 20094265 531 -dpEEVKKSYedVLELIRSSSgvdwDPFQALS--FVTLPVVPELr-lTDRGLVK 580
gi 16263397 527 dpaEMAAFELr-LDEAARRLGcdlpWPFMYMF--VLQITAIPDYa-mTDLGVVD 576
gi 27378276 542 -rvTEVAEEVkvLKKEWAEAGc--tIPYMGFN--LIPLSVIPEIr-iTDKGLVL 589
gi 15613200 519 -pmEEVMEEEkkFVKALRERGyehdDPIYSLL--FFSSTHLPYIr-vTQRGIYD 568
gi 3915461  518 -ayEDVLEKEqkLRDLLTERGyefcDPIYTLL--FLQSTHLPYIr-iTPRGIFD 567

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