Conserved Protein Domain Family
INT_C_like_4

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cd01194: INT_C_like_4 
Uncharacterized site-specific tyrosine recombinase, C-terminal catalytic domain
Tyrosine recombinase (integrase) belongs to a DNA breaking-rejoining enzyme superfamily. The catalytic domain contains six conserved active site residues. The recombination reaction involves cleavage of a single strand of a DNA duplex by nucleophilic attack of a conserved tyrosine to give a 3' phosphotyrosyl protein-DNA adduct. In the second rejoining step, a terminal 5' hydroxyl attacks the covalent adduct to release the enzyme and generate duplex DNA. Many DNA breaking-rejoining enzymes also have N-terminal domains, which show little sequence or structure similarity.
Statistics
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PSSM-Id: 271194
View PSSM: cd01194
Aligned: 8 rows
Threshold Bit Score: 239.969
Threshold Setting Gi: 118501383
Created: 20-Mar-2013
Updated: 2-Mar-2014
Structure
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Aligned Rows:
 
active site
Feature 1:active site [active site]
Evidence:
  • Comment:The catalytic residue tyrosine is surrounded by three basic residues at the active site

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                           #                                         
NP_957522 124 LTSRQAKEVLANIktd---teeGLRNYAILSLMVTGGLRTIEVSRADVGDLRtvgentVLFVQGKGReekTEYIKISaPV 200 Streptococcus ther...
EEG30587  139 LTPAQMQAVLGALsgh---dlmSRRDFALVSVAVTGGLRTVELVRADVGDLRnrgehtVLYIQGKGQmekADYVKLPfPV 215 Clostridium methyl...
EFB40272  126 LTVEQIRTALSSFdve---tsdGLRDYALFNLLVRTGLRTVEISRATVGDLRqesgeaILQIQGKGRdskDDFVLLVdET 202 Parachlamydia sp. ...
AEN72348  130 LTRVEIEQLLAVLdqdt--sqiGLRDRAIVHMMLFAGLSEVEIVRADVRDLDqtllgwYLRVQGKGHtakDQQVPLDpPV 207 Rhodothermus marin...
ADN17792  125 LDLTEAKQLIESLpndd--slpSLRDRALIEIMVWQGCRTVELYRLNVGDIIkrnedlGLNVQGKRS---RRIVPLTpDL 199 Cyanothece sp. PCC...
EHR38600  140 LTLEQLRDLLNIIpdydekhieYLRDKIIIMLMALEGLRTVEVHRMSVNDINwe--mkTIYIHGKGH---NDFIYPRdDV 214 Megamonas funiform...
ABX81201  109 LSESESRQLLKLAqinsdkniiKYRDYVMVLLMLTTGMRTVEVERADVSDLNviddgeILYVHGKGKtskSSFVRLSpLV 188 Acholeplasma laidl...
ABK97865  139 LTAGQAELLIMHLpelg--sikGLRDRAIIALMLLEGLRRVEIKRANVEDIEdveggvRILVHGKRK---DGYIYPReDT 213 Pelobacter propion...
Feature 1                                                                                     
NP_957522 201 EKAIRTYLKARdl-----------ttEEQPLFTSTSnn-srGKRITTRTVSAVVKNALKNAGyd---------------- 252 Streptococcus ther...
EEG30587  216 LEAVNAYLTMRgk-----------trPEDALFASLShr-ngGGRLTTRSVSRIVKTAFRRAGwd---------------- 267 Clostridium methyl...
EFB40272  203 LRPLRKYLASRga-----------lsEKDPLFSSTSnr-tnGEPLKERTISWIIKETLRRIDid---------------- 254 Parachlamydia sp. ...
AEN72348  208 VEALQAYLNTRvp-----------lhPSEPLFVSHGhr-seGQRLNTRSVRSRIKQHLEAAGit---------------- 259 Rhodothermus marin...
ADN17792  200 AQLLQKYLKARkkag-------eilkADTPLFTSLTrn--kGSRLTRRSIARIVDKYLKINGwknnnldehqvdhddfdd 270 Cyanothece sp. PCC...
EHR38600  215 LFLLQAYLKIRpfdfa------fideFGEPVFTTLTnq-vkGKRMDRRGIRYNVDKWLTKAGlk---------------- 271 Megamonas funiform...
ABX81201  189 NKAIETYIMKRs-------------dQYEPLFIDHKpk-ylGQRMKTRNIRRIIKDLLRDIGfd---------------- 238 Acholeplasma laidl...
ABK97865  214 VAAIRAYLAARgevtveettihnrqaFVTPMFLSVRkngrgRGRISRIGLNSVIDGYLSKAGlk---------------- 277 Pelobacter propion...
Feature 1                #  ##                              #  
NP_957522 253 -----sARLTAHSLRHTAITLALLAGREItEVQQFARHANLNTTMIYNH 296 Streptococcus thermophilus
EEG30587  268 -----sDRLTAHSLRHTAATLNLLGGGSLeETQQLLRHSDINTTMVYLH 311 Clostridium methylpentosum DSM 5476
EFB40272  255 -----dSRLTAHSLRHTAVSLSIKNGASLiQAQAMARHSDPKTTMIYFH 298 Parachlamydia sp. Hall's coccus
AEN72348  260 -----rRGVTPHSLTHTAALIWLNQGMSIeEVQRRMRHGTLETTMIYYR 303 Rhodothermus marinus SG0.5JP17-172
ADN17792  271 lficspRKLSAHSLRHTCGTLALWAGVSLrQVQDLLGHRDPETTALYAH 319 Cyanothece sp. PCC 7822
EHR38600  272 -----kEGISCHMLRHTCGTLLYKDTKDLqIVKQVLRHSNVNITSKYAH 315 Megamonas funiformis YIT 11815
ABX81201  239 -----dDKHTAHSLRHTTATLARQYGANKdDTQKIMRHSDPATTEIYMH 282 Acholeplasma laidlawii PG-8A
ABK97865  278 -----rKRVSCHALRHTCGTMLYDVTKDIrAVQDTLRHEDISTSAIYAA 321 Pelobacter propionicus DSM 2379

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