1G8Y


Conserved Protein Domain Family
repA

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cd01125: repA 
Click on image for an interactive view with Cn3D
Hexameric Replicative Helicase RepA. RepA is encoded by a plasmid, which is found in most Gram negative bacteria. RepA is a 5'-3' DNA helicase which can utilize ATP, GTP and CTP to a lesser extent.
Statistics
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PSSM-Id: 238545
View PSSM: cd01125
Aligned: 12 rows
Threshold Bit Score: 236.927
Threshold Setting Gi: 10957055
Created: 10-Jan-2006
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
Conserved Features/SitesClick to see Conserved Features Help
 
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:NTP binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                 # ###                                        #        #               
1G8Y_A       30 GTVGALVSPGGAGKSMLALQLAAQIAggpdlle--------vgelptgPVIYLPAEDPPTAIHHRLHALgahl-----sa 96
gi 23109971  78 KFLSLDIAPGGLGKSSVKIVEALAMTtgrnllgk-------dchegplNVWLYNLEDPAEETERRIHAAaqwfeigpddv 150
gi 23001079 350 GVPGMFAAIGGAGKSMLLMDLAAKVAlsesgnpiplealggpivpatgTAVMLTAEDDHAEVHRRLFEVlpgr-----pn 424
gi 96374     26 GTVGALVAPGATGKSFFALEAAMSIAcsvaggdlv-----gltpahtgRVVYLAGEDPQPALVRRVHAIgqhl-----nq 95
gi 46916540 188 GEVAMLTGAGGSGKSFSTIHLAVSVAlglsafigyn---rpfkptkagKVVVLGGEDFRDDYKRRVRSVltamecntqsm 264
gi 40850641  81 GTVGALVAPGATGKSFFALEAAMSIAcsvaggdlv-----glapahtgRVVYLAGEDPQPALVRRVHAIgqhl-----nq 150
gi 39937604 391 GFVSATVAPGGIGKSSLTIVEALAMTsgkpllg--------erspenlRVWIWNGEDPVDELQRRVAAAmhhysvgpadv 462
gi 22957163  64 RMLSGTISPGGLGKSSLALVDALAMAtgrkrlhs------wvhsreglRVWYWCGEDPVEEISRRLEAAcihygisddei 137
gi 23013615  46 GYVSLTVAPGATGKSSLLIADALAMSanrnlvgt------pvyagrplRVWIWNLEDPIDELQRRITATaiqyqihstdi 119
gi 15837235 121 EDVGVFVALGGTGKTTLLLFQVIHLVlglelfg--------yevinpgTVIILTAEDSRETLVARLRYMcaqlq--lspa 190
gi 42520438 319 GVTSILAAMGDTGKGMLLLDLALKVAsrkdqpcgf-----gplvtehgSVVIFSAEDDMSEIHRRLERLdsqce--rlky 391
gi 10957055  22 GYVSILYGDSGVGKTTISLYLCLLAGagknlfhn------llkvkepkKVAYISLELYKEDILEKLEPIrk--------- 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                 #                     
1G8Y_A       97 eERQAVAd----GLLIQPLIGslpn-------imapEWFDGLKraa----egrRLMVLDTLRRf-HIEEENASGPMAQVI 160
gi 23109971 151 gERLFVD-----SGREQPICIaeetdg---garivrPVVEAVIeqlk--drriDVLSIDPFVSs-HAISENDNRAIDMVA 219
gi 23001079 425 pKRLIIVpmpnaGGTLPLISMsreg-------pilsEEFHDIReelle-ipnlRLVVIDPLQNfaGGDVNSDPAAGALFF 496
gi 96374     96 sAREAIAe----NLMLEPIMGkrln-------vmddAHLRRVIdys----agaRLIVLDTLSRi-HILDENSNGDMAHLV 159
gi 46916540 265 kNRLVENlh-itSLVGDDIRIiaedrgs-akltgfvDNIAREVeel----gdvRLVILDPMSAf-YGAQENDNHSATMFV 337
gi 40850641 151 sAREAIAe----NLMLEPIMGkrln-------vmdeAHLRRVIdys----agaRLIVLDTLSRi-HSLDENSNGDMAHLV 214
gi 39937604 463 gDRLLID-----SGMEQPITLaedgrsgarlnedvmAELVRVIksr-----kiDAVIVDPLVSs-HRVSENDNGAVDLVV 531
gi 22957163 138 gGRLHVD-----SGRDQPIKIaaadre---gvkvakPVVAALVaqmr--arriDALIIDPFITc-HTVPENDNTAMNAVI 206
gi 23013615 120 eGRLFVD-----SGRDQSLCIarqghn---gieildPVIDALQaeil--areiDVLIVDPFVSs-HQVSENDNGAIDAVA 188
gi 15837235 191 dVRKVQE-----GVIITDVSGkgiklaa-iesdvvvPSKFLDRfivdasevhpSLIIIDPMVSf-GVGESRINDSEQAMI 263
gi 42520438 392 kDRLFIVplpnvSGSLTIIKSvsgkv------ietsPEFELITkqlnk-iknlKLIVFDPLASfvHADLNTDPAVGDYLI 464
gi 10957055  87 rYRISTS-----EMEIMDLDDis-----------dyRSFEKILeqk-----ryDFVVVDSFVAfyEGKSIYDPVEVKEFI 145
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                         #                                                             
1G8Y_A      161 GRMEAIAADTgCSIVFLHHASKgaammga---gdqqqasRGSSVLVDN-IRWQSYLSSmtsaeaeew------------- 223
gi 23109971 220 KEWSRIADICdCAINLVHHVRKtngaev------taessRGAVSLIGA-ARSVVVYNRmtkeegera------------- 279
gi 23001079 497 SGLGRIAAETgATVLATHHFKKnsgktigt-aaeareaiRGTTALVDS-GRWSYALWEvedseakk-------------- 560
gi 96374    160 SVLEHIAATTgAAVLYLHHVNKgsardgq---tdqqqaaRGASALIDN-ARWCGYVAKmteqeaermsdrg--------- 226
gi 46916540 338 NAVNRICKATgAAVLMVHHSSKgsa-----------gsaRGASGFIDR-SRTHISLKTvaqvkeqakrkkd--------- 396
gi 40850641 215 SVLEHIAATTgAAVLYLHHVNKgsardgq---tdqqqaaRGASALIDN-ARWCGYVAKmteqeaerlsdrg--------- 281
gi 39937604 532 KAWGRIAFQTgASVMLVHHVRKtngdai------tvedaRGASALVNG-TRVARALTPmtpnegak-------------- 590
gi 22957163 207 DAWRDVANQTnAAIELIHHANKagtgd-------sindgRGGSAFRDG-IRAGRVLAPmtfeegekm------------- 265
gi 23013615 189 KKWGAIADRTgCAIELVHHLRKlphgie-----ataesaRGAVSLVAA-ARSVRVLNRmakeealq-------------- 248
gi 15837235 264 DAARRIRNMLrCAVLYVHHTGKanardkt----ldqysgRGGSALADG-ARMVHVLQRldpeawteqtgdtlegeesgfv 338
gi 42520438 465 SLLSDLAGSTgASIITAHHMRKpksekpistveqardaiRGTSALVNG-VRCSYAFWSveda------------------ 525
gi 10957055 146 KKTRKLARNSeSHIMFIHHTIKssgkn-------ktdryQGVSTIKFLtTPFMQAYTEgksfrvlti------------- 205
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
Feature 1                                                                          
1G8Y_A      224 --------------gvdddqrrFFVRFGVSKanyg------------apfaDRWFRRHdg--gVLKP 262
gi 23109971 280 --------------gieprqlgFYFRTQNDKanla------------ppeaADWFRMNn----VDLP 316
gi 23001079 561 ---------------vckligqRFQRESVYRgavvksn-------wptdktVRIYARNpn--sGLLS 603
gi 96374    227 ----------fdrspsgnerrgLFVRFGVSKqnyd------------atplDRWYQRHsg--gVLLP 269
gi 46916540 397 ----------gpitvedkntviVNLEKTNHVkfw---------------eePIYLKRSe---nGAFT 435
gi 40850641 282 ----------fdrapignerrgLFVRFGVSKqnyd------------atplDRWYQRHtg--gVLLP 324
gi 39937604 591 ---------------lgvekpwLFFRSGGVTknnlapa------eaapaekASWFALQs----VPLG 632
gi 22957163 266 --------------glapaeaaRIFRAMDGAktnms----------arggaFTWYRMQs----VPLG 304
gi 23013615 249 ---------------cgltsnkGHFKVSDDKnnlaa-----------atdsENWFRMEs----VQLD 285
gi 15837235 339 larpkmtwcppqpniylkrqhyLFERFYPVEstegagl-------vidrdaDKVFQFVk---dEYLK 395
gi 42520438 526 ------------------akptIFKSIGESVrqnalfygaivkangladrtLRTYLRNee--tGLLE 572
gi 10957055 206 -------------ekhnfaypfEKIYYYINKng-----------------aITWYINEkakyeEILH 242

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