Conserved Protein Domain Family
Rad51_DMC1_radA

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cd01123: Rad51_DMC1_radA 
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Rad51_DMC1_radA,B. This group of recombinases includes the eukaryotic proteins RAD51, RAD55/57 and the meiosis-specific protein DMC1, and the archaeal proteins radA and radB. They are closely related to the bacterial RecA group. Rad51 proteins catalyze a similiar recombination reaction as RecA, using ATP-dependent DNA binding activity and a DNA-dependent ATPase. However, this reaction is less efficient and requires accessory proteins such as RAD55/57 .
Statistics
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PSSM-Id: 238543
View PSSM: cd01123
Aligned: 42 rows
Threshold Bit Score: 191.258
Threshold Setting Gi: 6174940
Created: 7-Mar-2002
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 7 residues -Click on image for an interactive view with Cn3D
Feature 1:ATP binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                  #   ##                        # # #                  
1N0W_A        6 ITTGSKELDKLLQGGIETGSITEXFGEFRTGKTQICHTLAVTCQlpidrgggegkAXYIDTEGTFRPERLLAVAErygl- 84
gi 13161340  90 INTGSADLNNILGGGIHCKEVTEIGGVPGVGKTQLGIQLAINVQipveygglggkAVYIDTEGSFMVERVYQIAEgcisd 169
gi 3914534  100 IITFCSALDDILGGGVPLMKTTEICGAPGVGKTQLCMQLAVDVQipecfggvageAVFIDTEGSFMVDRVVDLATaciqh 179
gi 3914524   83 LSTTLSALDEALHGGVACGSLTEITGPPGCGKTQFCIMMSILATlptnmgglegaVVYIDTESAFSAERLVEIAEsrfpr 162
gi 30354420  79 FSTSLPALDRLLHGGLPRGALTEVTGPSGCGKTQLCMMLSVLATlpkslggldsgVIYIDTESAFSAERLVEMAQsrfpe 158
gi 16903198  93 IISMARDLDALLGGGVAAGQVTEFCGVPGVGKTQLGMQLAVNVQiprslsgpegqAVYIDTEGSFMAERCADIAEgavrh 172
gi 20178063  75 LTTGDVKLDETLHGGIPVGQLTEICGESGSGKSQFCMQLCLMVQlplslggmnkaAVFISTESGLETKRLFELARylper 154
gi 131784   100 FTTADVAMDELLGGGIFTHGITEIFGESSTGKSQLLMQLALSVQlsepagglggkCVYITTEGDLPTQRLESMLSsrpay 179
gi 18313927  82 KTGVAEFDEKTPWRGIREAFIYEFAGEFGAGKSMLAHQASVAALregf----terVVYIDTEGTFNEALIEAVARrfel- 156
gi 3914533   83 LSTTLCALDEALHGGVPCGSLTEITGPPGCGKTQFCIMMSVLATlptslgglegaVVYIDTESAFTAERLVEIAEsrfpq 162
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                           #           
1N0W_A       85 ------------------------sgsDVLDNVAYARAFntDHQTQLLYQASAXXVes---ryALLIVDSATALYRtdys 137
gi 13161340 170 ileyfphch-----dkapagqeklkpeSFLADIYYFRICsyTEQIAVINYLEKFLGehk--dvRIVIIDSVTFHFRqdfd 242
gi 3914534  180 lqliaekhk----geehrkaledftldNILSHIYYFRCRdyTELLAQVYLLPDFLSehs--kvRLVIVDGIAFPFRhdld 253
gi 3914524  163 yf------------------nteekllLTSSKVHLYRELtcDEVLQRIESLEEEIIsk---giKLVILDSVASVVRkefd 221
gi 30354420 159 ff------------------svkerllEMAARVHLFRELtcQDVLKRLERLEEDIIac---raGLVILDSVASVVRkefd 217
gi 16903198 173 vqsilekkasmgqpellhdgerpftleNVMRGIYLFRVHdhVEQLGLVNMLPRFLEqys--qvRLIVIDSVTFHFRqdfp 250
gi 20178063 155 ypka---------------dkkdiiikNPGDRVYTILCPdlESQEHIIQYQLPILFnrd--kiGLVILDSVASNYRaelr 217
gi 131784   180 -----------------------eklgITQSNIFTVSCNdlINQEHIINVQLPILLerskgsiKLVIIDSISHHLRvelq 236
gi 18313927 157 ------------------------dveRIADSIYVYQPAnvVQLEQIVKFDVPKHIqe---gcRLLVIDTITALYRaefv 209
gi 3914533  163 yf------------------nteekllLTSSRVHLCRELtcEGLLQRLESLEEEIIsk---gvKLVIVDSIASVVRkefd 221
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                       
1N0W_A      138 grge---------lsarqxhLARFLRXLLRLADEFGVAVVITNQVvaqvdgaa--------------------------- 181
gi 13161340 243 dm------------alrtrvLSGLSLKLMKLSKAYNLAVVLLNQVttkfte----------------------------- 281
gi 3914534  254 dl------------slrtrlLNGLAQQMISLANNHRLAVILTNQMttkidr----------------------------- 292
gi 3914524  222 aqlqg-------nlkernkfLAREASSLKYLAEEFSIPVILTNQItthlsgalasqadlvsp------------------ 276
gi 30354420 218 tslpg-------nlthrsnfLGQEAAVLKYLSQEFCIPVVLTNQItthvgeklhcpqwn--------------------- 269
gi 16903198 251 dm------------aqrtrvVTGMAQQLISLAQTHNVAVVLMNQVttkvleg---------------------------- 290
gi 20178063 218 ynrskshfrdldniakrgnqLGKLAMTLRTLAHQHEAAVVIANQVsdriprdydaiglfsldy----------------- 280
gi 131784   237 nksfr-------esqenknyLDRMAEKLQILAHDYSLSVVVANQVgdkplanspvahrtyvtdydyqlgwlvgwknstil 309
gi 18313927 210 grey---------latrqqrIHYLVDWLRRHARTFGLTTVLTNQVmdvpeif---------------------------- 252
gi 3914533  222 pklqg-------nikernkfLGKGASLLKYLAGEFSIPVILTNQItthlsgalpsqadlvsp------------------ 276
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                       
1N0W_A      182 --------------------------------------------------------------------xfaadpkkPIGG 193
gi 13161340 282 ----------------------------------------------------------------------gsfqltLALG 291
gi 3914534  293 ----------------------------------------------------------------------nqallvPALG 302
gi 3914524  277 -----------------------------------------------------------addlslsegtsgsscviAALG 297
gi 30354420 270 --------------------------------------------------------------qtdasfeedsgfvtAALG 287
gi 16903198 291 ----------------------------------------------------------------------ggsklvPALG 300
gi 20178063 281 -----------------------------------------------------------qsqwfsgwddtdpnpkiPSLG 301
gi 131784   310 yrqmnsllgassnndeilsddedymliervmstvndrnydffskkkppiienktvernssspisrqskkrkfdyrvPNLG 389
gi 18313927 253 ----------------------------------------------------------------------aagvkrPAGG 262
gi 3914533  277 -----------------------------------------------------------addlslsegtsgssclvAALG 297
                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                             
1N0W_A      194 NIIAHASTTRLYLRKGr-----------------------gETRICKIYDSPCLP-EAEAXFAINADGVG 239
gi 13161340 292 DSWSHSCTNRLILYWNg------------------------NERYGFLDKSPSLP-VASAPYAVTVKGVR 336
gi 3914534  303 ESWGHAATIRLIFHWDr------------------------KQRLATLYKSPSQK-ECTVLFQIKPQGFR 347
gi 3914524  298 NTWSHSVNTRLILQYLd-----------------------sERRQILIAKSPLAP-FTSFVYTIKEEGLV 343
gi 30354420 288 NTWSHSVNTRLIVQYEd-----------------------sERRQIVIAKSPVAP-FAVLSYTIQKEGIR 333
gi 16903198 301 ESWGHAASTRVMLTWGp-----------------------dNERHAQMIKSPHLP-LGDAAFAVTADGLR 346
gi 20178063 302 LVWTNNISTRLALIKKtdsa------------------tnnSGRIFRVVYSPNSP-RLDVRICIGSVGIY 352
gi 131784   390 LTWSNHVSTRILLQKSfkastiiqrgeahlykggdsasfwqVKRTMKVVYSTFAK-PGQIAYQITKRGIE 458
gi 18313927 263 NVLAHAVNARFMMVRPnk---------------------tkPEGYIWPLDVPGMApDIRIEYRITGAGLE 311
gi 3914533  298 NTWGHCVNTRLILQYLd-----------------------sERRQILIAKSPLAA-FTSFVYTIKGEGLV 343

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