Conserved Protein Domain Family
gltB_C

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cd00982: gltB_C 
Click on image for an interactive view with Cn3D
gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the transfer of ammonia and electrons among three distinct active centers that carry out L-Gln hydrolysis, conversion of 2-oxoglutarate into L-Glu, and electron uptake from a donor. These catalytic sites appear to occur in other domains within the protein, and not the domain in this CD. This particular domain has no known function, but it likely has a structural role as it interacts with the amidotransferase and FMN-binding domains of gltS.
Statistics
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PSSM-Id: 238482
View PSSM: cd00982
Aligned: 41 rows
Threshold Bit Score: 357.608
Threshold Setting Gi: 15887499
Created: 6-Mar-2002
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
domain
Conserved site includes 43 residues -Click on image for an interactive view with Cn3D
Feature 1:domain interface
Evidence:
  • Structure:1EAO_A: beta-helix domain interface with other domains, defined using 4.0 A contacts
    View structure with Cn3D
  • Comment:Sharp inward bend along one face of the domain allows it to wedge itself into the helix core of the protein

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                             ##  #  ##                                  
1EA0_A      1211 LDARIVADarplf----eegeKMQLAYNARNTQRAIGTRLSSMVTRKFGmfgl--------------------qpghITI 1266
gi 23100554 1238 LDYQELLPicesa---iedgtPVEFSVAIRNINRVTGALLGHAITERYGehgl--------------------pedtIKL 1294
gi 15887499 1379 LDDAFIELvrsalvdsrreniELGGNRFLNNCNKSVGGQLAVDIERMLNhelsdeqldalpavkrdsrgrrfleagsVRI 1458
gi 15791406 1222 IDYRILLPlckna---vekkePIKLSLEVGNQSRTFATMLSSEILKTYGkdal--------------------dedsIHI 1278
gi 16803774 1238 LDMRELVPliqpa---lengeKVTGTFAVRNVDRAIGTIAGSFISKKYGaagl--------------------pedtISL 1294
gi 1781097  1248 LDQQLIVMsreal----dsgkPVRFSTTIGNVNRTVGTMLGHELTKAYGgqgl--------------------pdgtIDI 1303
gi 23113493 1254 LDMKKLLRvcqpa---lenqkPIRAKLKINNVDRVVGTIIGSEISKRYGeqgl--------------------pedtIKL 1310
gi 1707984  1261 LDITQLLDlcqpa---iakgeKVTATLPITNINRVVGTIVGNEITKRHWeglp---------------------edtVHL 1316
gi 21673240 1199 LDMRVLMAicepa---ikrgeKVSTTLPIKNTNRAAGTIVGHEVTKAYGskgl--------------------pddtIHL 1255
gi 17387031 1236 IDEKIFLDkfkda---ienkiKTNFEIDVTNTDRALGTILGSEITRVNGtdgl--------------------pedtISI 1292
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1            #  ##   #           ###    #  #                    ####  #  #  #        ####
1EA0_A      1267 RLRGTAGQSLGAFAvqGIKLEVMGDANDYVGKGLSGGTIVVRPttssp--letnKNTIIGNTVLYGATAGKLFAAGQAGE 1344
gi 23100554 1295 NFNGSAGQSFGAFIpkGMSLKLIGDANDFVGKGLSGGKIIVRPsstvt--fepeKNIIIGNVAFYGASAGEAYIRGIAGE 1372
gi 15887499 1459 DTSGSAGQSFGAFCndGMIMVHTGTCNDGVGKSACGGTIVVRSpgggs--ketgGNVLVGNFALFGATGGRTFVEGQAGD 1536
gi 15791406 1279 KAIGNAGNSFGAFLlkGIKLEIIGDSNDYLGKGLSGGKIIAKIsneat--fspeENIIAGNACLYGATKGEVYLDGIAGE 1356
gi 16803774 1295 DFVGSAGQSFGAYTplGMTLRIHGDANDYFGKGLSGGKLIVSPdaktp--ikphDSAIVGNVTLYGATGGFAYMHGKAGA 1372
gi 1781097  1304 TFDGSAGNSFGAFVpkGITLRVYGDANDYVGKGLSGGRIVVRPsddapqdyvaeDNIIGGNVILFGATSGEVYLRGVVGE 1383
gi 23113493 1311 AFVGSAGQSFGAFVpkGLTLELEGDSNDYLGKGLSGGKIAVYPprtad--fvpeENILIGNVAFYGATSGEAYINGIAGE 1388
gi 1707984  1317 HFQGSAGQSFGAFIpkGMTLELEGDANDYLGKGLSGGKIIVYPpkgss--fiasENIIAGNVCLYGATAGEVYISGMVGE 1394
gi 21673240 1256 KFIGSAGQSLGAFIpkGMTIELVGDANDYIGKGLSGGRIIAYPpkssk--fvpeENIIVGNVAFYGATSGEAFIRGMAGE 1333
gi 17387031 1293 KCNGAAGQSFGAFIpkGLTFEVEGDANDYFGKGLSGGKLIVYPpkkst--fiaeDNILIGNVALYGATSGKVFINGIAGE 1370
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        #  ## #        ####  ## #            #  #  #               ####                 
1EA0_A      1345 RFAVRNSGATVVVEGCGSNGCEYMTGGTAVILGRVGDNFAAGMTGGMAYVYDld-dsLPLYINDESVIFQRIe-----vG 1418
gi 23100554 1373 RFAVRNSGASIVVEGIGDHGCEYMTGGQVIVLGKTGRNFAAGMSGGVAYVFDee-deFKNMVNNSLVQVERVt-----dA 1446
gi 15887499 1537 RFAVRNSGATAVVEGVGDFACEYMTNGAVLNLGSFGKGFGNGMSGGFVYQYDpy-gdLPKKVSHDSILLGSItgedeqaA 1615
gi 15791406 1357 RFCVRNSGALAVVLGTGVHGCEYMTGGQVVVLGDVGANFAAGMSGGVVYIFGr---hNEAHVNTELVDIKDLn------A 1427
gi 16803774 1373 RFAVRNSGATAVVEGIGDNGCEYMTGGAVVVLGDIGENFAAGMSGGVAYIYTnnkqaTTAKINHELVNSRSTf-----sT 1447
gi 1781097  1384 RFAVRNSGAHAVVEGVGDHGCEYMTGGRVVILGRTGRNFAAGMSGGVAYVYDpd-geLPANLNSEMVELETLd------E 1456
gi 23113493 1389 RFCVRNSGVHAVVEGVGDHGCEYMTGGKVVILGKTGRNFAAGMSGGVAYILDf----DENYCNKSMVLLENIq-----sE 1459
gi 1707984  1395 RFCVRNSGVNTVVEAVGDHGCEYMTGGKVVVLGQTGRNFAAGMSGGVAYIFDet-gdFATRCNSAMVGLEKLe-----dP 1468
gi 21673240 1334 RFCVRNSGMEAVVESVGDHGCEYMTGGKVVILGKTGRNFAAGMSGGVAYVYDvd-gaFTGRCNLEMVSLSAVe-----aE 1407
gi 17387031 1371 RFCVRNSGATAVVEGVGAHGLEYMTGGKVVVLGKTGINFAAGMSGGVAYIYEed-pnFRINLNEEMILLEELn------I 1443
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
Feature 1                                                  
1EA0_A      1419 HYESQLKHLIEEHVTETqSRFAAEILNDWarevtKFWQVVPK 1460
gi 23100554 1447 NELEELYASIEKHVEYTdSGHAARILAYWekysiSFSRVIPK 1488
gi 15887499 1616 IHNQAVHQLLTLHVAETgSAKAAWLLENWeseqhNFAYGMPR 1657
gi 15791406 1428 KDEKELKAVIEKHITYTdSKKAKDILEKFdk--kDFFKVMPR 1467
gi 16803774 1448 SELTKLKQLIEQHANLTgSDFAQDILQNWeaekaNFIFVIPN 1489
gi 1781097  1457 DDADWLHGTIQVHVDATdSAVGQRILSDWsgqqrHFVKVMPR 1498
gi 23113493 1460 AELDEVKEMIRKHVEYThSPQGGKVLADWesyatRFTKVIPK 1501
gi 1707984  1469 EEIKDLKELIQNHVNYTdSAKGKAVLADWeasipKFVKVMPR 1510
gi 21673240 1408 DELEWLRSKIEQHVEVTgSELGKGLLATWpnasqRFVKVLPN 1449
gi 17387031 1444 DDEEELKALIEEHVKVTgSPKANKILYNFetekvKFHKIIPK 1485

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