Conserved Protein Domain Family
Transaldolase_TalAB

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cd00957: Transaldolase_TalAB 
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Transaldolases including both TalA and TalB
Transaldolases including both TalA and TalB. The enzyme catalyses the reversible transfer of a dyhydroxyacetone moiety, derived from fructose-6-phosphate to erythrose-4-phosphate yielding sedoheptulose-7-phosphate and glyceraldehyde-3-phosphate. The catalytic mechanism is similar to other class I aldolases. The enzyme is found in the non-oxidative branch of the pentose phosphate pathway and forms a dimer in solution.
Statistics
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PSSM-Id: 188644
View PSSM: cd00957
Aligned: 24 rows
Threshold Bit Score: 334.972
Threshold Setting Gi: 13186327
Created: 6-Mar-2002
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 11 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                     #               # ##                                              
1F05_A       13 SALDQLKqfTTVVADTGDFHAIDEYKPQDATTNPSLILAAAQMP--AYQELVEEAIAYGRklgg-sqeDQIKNAIDKLFV 89
gi 6647830    3 NQFDQLKklSTIVCDSGDPELVKASGSQDATTNPSLILKVAQEP--KFQELLNEAVVWGIrqng-ddlQTLSFILDKIQV 79
gi 13186327   2 NLFNFVKkkIKISIDSADLNLIKKYNFDSLTSNPSLILLSFLNN--SYNKILKFFFKNNNkkil-ldpDTEISFYDYLLI 78
gi 13186351   2 KFFDFIKnkTKISIDSADINFIKNKLFNAATTNPSLILKSILSK--VYNKLLYAFLLKNFkkki-idsDYNISLYDKLLV 78
gi 21594999  69 NELNAVSafSEIVPDTVVFDDFERFPPTAATVSSALLLGICGLPdtIFRNAVDMALADSScagletteSRLSCFFNKAIV 148
gi 21702595   4 SALQFLSqhSELSMDSARFLEALRFRPTHATTNPSLILSACQNN--EYNSLVNETIRLHRn-------EGYRNIADHIRL 74
gi 39932115   2 NQLDNLKkfSKISADTGDVDLIRTYQIQHATTNPSLILKSPLFT--TYLKLFNDAIDYAQkigg-nqnTKITNASDRLIV 78
gi 39932179   2 NQLECLKkyTDIVVDSGDLVSINKFKLGDVTTNPSLIRQVMSLQ--KYQYIIYDSIRYAKkkgg-shkFKLENAIDKVSV 78
gi 39932188   2 NQLDYIKkfTNVVIDSGNIKYIKKYSPKDVTTNPSLILRESKSK--HYYPLLMDAISYAKkkgg-nlnSYIINANDKLLV 78
gi 46447325   4 NKLDQLKsmTTIVIDTGDIEAIKEYSPTDATTNPSLILSAVEKP--AYKPLMEEAYHYSQkak--ssgEQISLFLDKLFV 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                     # #                                   #                      # #  
1F05_A       90 LFGAEILKKIPGRVSTEVDARLSFDKDAMVARARRLIELYKEAgisKDRILIKLSSTWEGIQAGKELEeQHGIHCNMTLL 169
gi 6647830   80 NFALEIIKNIPGRISLEIDARLSFNVEAMVQRAVFLSQLFEAMggdKKRLLVKIPGTWEGIRAVEFLE-AKGIACNVTLI 158
gi 13186327  79 FVVCNLIKFIKDKISIEIPARISYNYNKIIIYSQKILFLCDQFginKNRILIKIPATDSGIKAASKLK-LSGIECNLTLI 157
gi 13186351  79 NIIANIIPYIEEKISIEIPARISFNYNKIIFYSYKIIYLCEKIginLKKILIKIPATNSGIKAAKQLK-NNNINSNLTLI 157
gi 21594999 149 NVGGDLVKLVPGRVSTEVDARLAYDTNGIIRKVHDLLRLYNEIdvpHDRLLFKIPATWQGIEAARLLE-SEGIQTHMTFV 227
gi 21702595  75 RFCTELLDRIPGMVSVEIDACCAFNVDASIAHARRIVQLCRPTd-aRDRILVKIPATWQGVQAAAALR-AEGVQCNMTLV 152
gi 39932115  79 NIGSEILANISGYISTEIDAQLSFNTDLTIKKAHKLITMYQKKnidTSRVLIKIAATWEGIQAAEELE-KSGIKCNLTLV 157
gi 39932179  79 ILGSEILKNISGKISTEIDSRLSFNTNLCIERAKKLISMYEEHdihRDRVLIKLAATWESVSAAKELK-KENIQSNLTLL 157
gi 39932188  79 NIGREILKIIDGRISIEIDVRLSFSYLDLIIRAKKIISLYNSYgieNNRILIKIAATWEGIQAAKFLE-KSGINCNLTLI 157
gi 46447325  80 NVGCEILKLIPGRVSTEVDARLSFDVEGSIQKAQSLIALYKEMgieKERILIKLASTWEGGLAAKQLE-KMGIHCNMTLL 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                        #    #                                                         
1F05_A      170 FSFAQAVACAEAGVTLISPFVGRILDWHvantdkk----syepleDPGVKSVTKIYNYYKKFSYKTIVMGASFRNTGEIK 245
gi 6647830  159 FNLVQAIAAAKAKATLISPFVGRIYDWWiaaygde----gysidaDPGVASVSNIYAYYKKFGIPTQIMAASFRTKEQVL 234
gi 13186327 158 FDLNQVKKCFDNEIYIISPFVGRISDIInc-------------nfDSGVNFVKNIYNYKKNYNYKTKIMAASFRNLNQIL 224
gi 13186351 158 FNLTQAKKCFDSGIYIISPFVGRVSDSIyc-------------kyDSGVNFVKNLVNLKNNNNYSTKIMAASFRNINQII 224
gi 21594999 228 YSFAQAAAASQAGASVIQIFVGRLRDWArnhsgdteiksaiksgeDPGLALVKRSYNYIHKYGYKSKLMAAAVRNKQDLF 307
gi 21702595 153 FSMLQALVCARNGAYLISPFVGRLSDRMpamqg-------ssatqDQGVALALRIYSRLRQEGHATRVMAASFRGEQQVI 225
gi 39932115 158 FSFAQARACAERNIYLISPFIGRIYDWYnqrnlik----tsyindDPGIQSIKKIYHYYKTYGYNTIIMGASFRRLEQIL 233
gi 39932179 158 FSFAQAKICAEAGVFLISPFVGRIYDWYkskslik----samiddDPGVNAVRKIYQYYKEYGYHTIIMGASFRNVDQVL 233
gi 39932188 158 FSLVQAIACAESNVYLISPFVGRVNDWYiknfkl-----nknskiDPGVKLVYKIFYFYQKYGYKTFVMGASFRNIDQII 232
gi 46447325 159 FSMPQAIHCAEAQATLISPFVGRILDWYkkhdnvp----gyapaeDPGVKSVTTIYHYFKKFSYKTQIMGASFRNKEEIL 234
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                       
1F05_A      246 ALAGCDFLTISPKLLGELlqdnaklvpvlsak---aaqasdlekihldEKSFRWLHNEDq-----MAVEKLSDGIRKFAA 317
gi 6647830  235 ALAGCDLLTISPKLLDELkksqhpvkkeldpa---eakkldvqpieltESFFRFLMNEDa-----MATEKLAEGIRIFAG 306
gi 13186327 225 NLLFCDYITISPIYFEKLlnkkin-------------------fnindFQIFKINFNLNfl--nlISSKLLINGIIQFEK 283
gi 13186351 225 NLTCCDFITISPIYYNKLkninyk------------------nsvlnyKSNIDFCNNENy-----NSIKLLNNGIKQFDI 281
gi 21594999 308 SLLGVDYVIAPLKVLQSLkdspaipddekysfvrkltpetathyhftnKELVKWDQLSLassmgpASVELLSAGVEGYAN 387
gi 21702595 226 MASACGMVTVGEHIMRRLaamrasampkpcqq---fseamqhcptprdLHAFERALAQNr-----TAWLELKHGIEAFAC 297
gi 39932115 234 ALSGCDYLTISPHFLKQLyqntnsvtrqlfp----pktiishhipvldQSEFFQEHNKNq-----MAVEKLNEGIQQFSI 304
gi 39932179 234 ALSGCDRLTISPNLLHKLqlsddlvirklip-----pkhkklqpvcmsKSEFCWFHNEDa-----MAVEKLSEGIRQFGK 303
gi 39932188 233 SIIGCDAITISPDFVNKLnnlklkkiknfir----vnleskikknkllEKEFRWKFNQNf-----MAVEKLSEGIRLFLR 303
gi 46447325 235 ELAGCDLLTISPHFLQELhdasgnveqkldaa---kskqlniepikmnEKAFRLALNDDa-----MATEKLSEGIRNFAK 306

                ....*....
Feature 1                
1F05_A      318 DAVKLERML 326
gi 6647830  307 DTQILETAI 315
gi 13186327 284 DHNSLIKLI 292
gi 13186351 282 DHNRLIKLI 290
gi 21594999 388 QAKRVEELF 396
gi 21702595 298 NETQLELLI 306
gi 39932115 305 DQQKLHKLL 313
gi 39932179 304 DQQELENII 312
gi 39932188 304 DQKKIDSFF 312
gi 46447325 307 DAQKLEKML 315

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