1LNZ,2QTF,1MKY,1PUI,3LX5,1MKY,1XZQ,1X18


Conserved Protein Domain Family
Era_like

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cd00880: Era_like 
Click on image for an interactive view with Cn3D
E. coli Ras-like protein (Era)-like GTPase
The Era (E. coli Ras-like protein)-like family includes several distinct subfamilies (TrmE/ThdF, FeoB, YihA (EngB), Era, and EngA/YfgK) that generally show sequence conservation in the region between the Walker A and B motifs (G1 and G3 box motifs), to the exclusion of other GTPases. TrmE is ubiquitous in bacteria and is a widespread mitochondrial protein in eukaryotes, but is absent from archaea. The yeast member of TrmE family, MSS1, is involved in mitochondrial translation; bacterial members are often present in translation-related operons. FeoB represents an unusual adaptation of GTPases for high-affinity iron (II) transport. YihA (EngB) family of GTPases is typified by the E. coli YihA, which is an essential protein involved in cell division control. Era is characterized by a distinct derivative of the KH domain (the pseudo-KH domain) which is located C-terminal to the GTPase domain. EngA and its orthologs are composed of two GTPase domains and, since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that an ancient gene duplication, rather than a fusion of evolutionarily distinct GTPases, gave rise to this family.
Statistics
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PSSM-Id: 206646
View PSSM: cd00880
Aligned: 68 rows
Threshold Bit Score: 102.709
Threshold Setting Gi: 33358154
Created: 7-Oct-2002
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
  next features
Conserved site includes 11 residues -Click on image for an interactive view with Cn3D
Feature 1:GTP/Mg2+ binding site [chemical binding site]
Evidence:
  • Structure:1LNZ: Bacillus subtilis Obg binds guanosine-5',3'-tetraphosphate, a GTP analog and Mg2+, defined using 3.5 A contacts
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1             ######                                                                    
1LNZ_B      162 GLVGFPSVGKSTLLSVVssakpk-iadyhfTTLVPNLGXVEtdd--grSFVXADLPGLiegahqgvgl-----ghqflrh 233
gi 31544597   8 VITGLASVGKSTLINKIanskvaiiskydqTTRNVIAHKIVhd---kiDYLLLDTPGFhksfnklslf----lnseikqa 80
gi 68126865 156 AFLGPQNAGKTSLVNSMalsnvgavsnrygSTKDWTKAVATvh---etQLLLLDTPGIvprdtqrvrrkfasgtakayda 232
2QTF_A      183 GIVGYTNSGKTSLFNSLtgltqk-vdtklfTTMSPKRYAIPin---nrKIMLVDTVGFirgippqivd----affvtlse 254
gi 71667159  94 ALLGPQNSGKTSLLNALslshigavsnrsgSTKDWIKGVATvh---ntQLVLLDTPGVviinsdkdrrrhaapsarawda 170
gi 33862000  52 GIYGKAGVGKSSILNLIlnknvfktgiingTTKNIEREEWNfkhqslrTIELIDAPGFdfcdikdp--------enifsq 123
gi 71754451  96 VIVGTQNSGKTSLLNALslshigavsnrsgVTREWTRGVATvh---ntQLVLLDTPGIvicngekdrrrhaapvartwda 172
gi 67921883 134 VIFGTGSAGKTSLVNALfgdivgdveatmgTTKIGETYSLKlkg-isrEILITDTPGIleagiegser-----etlarql 207
gi 16332122 133 VVFGTGSAGKTSLVNALlgqiqgevaptmgTTIAGEKYYLYldg-vsrDLEITDTPGIleagvrgter-----etaarql 206
gi 81300518 130 VIFGTGSAGKTSLINALlgrivgkveatmgSTEEGQTYRLGlrg-vgrDILITDTPGIleagvagrlr-----eklarql 203
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                       ## #                            
1LNZ_B      234 ieRTRVIVHVIDXsglegrdpyddyltinqelseynlrlterPQIIVANKXDxpeaaenlea-------fkekltddyPV 306
gi 31544597  81 ykHAHACILIVDStkkptddfinl--------lkimksyemnDLIVIYSKIDliknedhinea----qqlinelfkvvKM 148
gi 68126865 233 lfVSDLVVLALPVgvgfvekehkvva----tevvrraagrelPVVIAMTMMDkvqtpwhrelyfamrtdleslglptaAT 308
2QTF_A      255 akYSDALILVIDStfsenllietlqs---sfeilreigvsgkPILVTLNKIDkingdlykkldlv-eklskelyspifDV 330
gi 71667159 171 lmVTELVLLTIPAglgfvepeqkava----revvhraslrkmPVVLVITMMDkvqtpkhrel------yfsmrtdfesMC 240
gi 33862000 124 inSSELILFTITGdinrnevsq-----------insfikngkKIILVFNKIDmweghdlkeilk--nirlklpqyikiPI 190
gi 71754451 173 ftVTDLVMLTLPAglgfvepeqktva----revvhraslrkmPVVLVITMMDrvqtprhrelyf---amrtdleslclPI 245
gi 67921883 208 atEADLLLFVVDNdlrqseynp-----------leilvnlgkRSLLIFNKIDlyteeeenqileq-lkervksiiaekDV 275
gi 16332122 207 atEADLLLFVVDNdlrqseyep-----------lqalakigkRSLLILNKTDlyppdevevllqt-lrqrvkafippeDV 274
gi 81300518 204 avEADLLLFVVDNdlrrselep-----------cldlarigkRSLLIFNKADlyedrdreailar-lrerlkglippsDI 271
                       170       180       190
                ....*....|....*....|....*....|....*
Feature 1          ##                              
1LNZ_B      307 FPISAVtre-------------glRELLFEVANQL 328
gi 31544597 149 IKANLLsdh-------------lnDQIDEGLEQLL 170
gi 68126865 309 HEVSVKggs-------------glVELKDCLCQYA 330
2QTF_A      331 IPISALkrt-------------nlELLRDKIYQLA 352
gi 71667159 241 LPIAAVhetsvk-------gcsglLELKDFLCRYA 268
gi 33862000 191 IINSKNnirn-----------qlsELINNYGESLL 214
gi 71754451 246 ACVSETsvkg----------gnglVELKDLLCRYA 270
gi 67921883 276 ISLSAKpqsitsqngkkvqplpniTPLIKRLAAIL 310
gi 16332122 275 LAIAARpqdvaiqpgllmrpepeiEPLVKRLVSVL 309
gi 81300518 272 LTAIASpqpvrlpdgsflqpepevTTLLKRMAAVL 306

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