1QE0,1ADJ,1KMM


Conserved Protein Domain Family
HisRS_anticodon

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cd00859: HisRS_anticodon 
Click on image for an interactive view with Cn3D
HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is transferred to a ribose 3' OH group of the appropriate tRNA only.
Statistics
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PSSM-Id: 238436
View PSSM: cd00859
Aligned: 51 rows
Threshold Bit Score: 78.7356
Threshold Setting Gi: 15616899
Created: 24-Sep-2002
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
anticodon
Conserved site includes 7 residues -Click on image for an interactive view with Cn3D
Feature 1:anticodon binding site
Evidence:
  • Comment:based upon similarity with ProRS anticodon binding domain interaction with tRNA anticodon stem
  • Citation:PMID 9493271

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1               ##                                             #     #       #         #
1QE0_A      329 NLDLFIVTMGd--QADRYAVKLLNHLRHNg------IKADKDYLq---rKIKGQMKQADRLGAKFTIVIGDQELENNKID 397
gi 3915061  348 RSKVLIVNLDs--ALQNYYYELATRFRNHdyskvknISCEVYFKnkngkNIKEQIEYALSKEIRFLVFVGQEEYKENKMK 425
gi 6226180  326 IKPVFVLPIGk--NNICYALDIVDKLRLQn------IVSIIDPIg----KIAKRIQRVLNEDAKFIIFIGDEEKMNNNLK 393
gi 7674358  345 QAKVLIACMHe--EYFSYANRLAESLRQSg------IFSEVYPEa---qKIKKPFSYANHKGHEFVAVIGEEEFKSETLS 413
gi 15888019 379 LAPVLITVMDgdvESMGRYQRFTQALRAEg------IRAEMYQGnw--kKFGNQLKYADRLGSPIAIIQGGDERAEGVVQ 450
gi 17989401 377 VGPVVVLVMDkdtQNLSRYQKMVSDLRKAg------IRAEMYVGg---sGMKAQMKYADRRAAPCVVIQGSQEREAGEVQ 447
gi 16127743 382 RGPVVVITFDq--AHMGEYFSVVGQLRAAg------IAAEVYLGt---sGMKPQMKYADRRGAPAVVMLGGDEIAAGTVT 450
gi 15892335 349 VKPVFVLPIGk--NNICYALEIVDKLRTEn------IAIIIESLg----KIAKRMQRIFNENAQFIIFIGDEEQANNNLK 416
gi 15838813 367 SVQAMVVLMDe--ATLDDALDIARCLRIGg------INTEVQMEa---kKVSKQFQYASRAGIRFVVLAGDDERARGVVA 435
gi 17232504 368 PAQVVVVNMQd--ELMPTYLKVSQQLRQAg------LNVITNFEk---rQLGKQFQAADKQGIRFCVIIGADEAAAQKSS 436
                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
Feature 1        #                                       
1QE0_A      398 VKNMT------------------TGESETIEL-DALVEYFK 419
gi 3915061  426 VRDLT------------------KKEELLLSF-EESINLIK 447
gi 6226180  394 FKDLK------------------NQKEYIIDF-EKVLELLK 415
gi 7674358  414 LKNMH------------------SGMQLNCLSfLKALEIIG 436
gi 15888019 451 IKDLIegkrlsgeiednaswreaRVAQVSVPE-AELVAKVR 490
gi 17989401 448 IKDLVegkrlsaeiednvtwresRPAQITVRE-DGLVDAVR 487
gi 16127743 451 IKDLDagrmaaegltdnaawkaeRPGQQTIPR-DQLVDAVR 490
gi 15892335 417 IKDLK------------------KAEEYIVDF-AKALELLK 438
gi 15838813 436 VKDLT------------------REQQFEIPR-EELASTLQ 457
gi 17232504 437 LKDLQ------------------SGEQVEVAL-ADLAEEIK 458

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