1DD8,1J3N,1E5M,1TQY,1FJ8,1KAS,1OXH


Conserved Protein Domain Family
KAS_I_II

?
cd00834: KAS_I_II 
Click on image for an interactive view with Cn3D
Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen condensation of malonyl-acyl carrier protein (ACP) with acyl-ACP.
Statistics
?
PSSM-Id: 238430
View PSSM: cd00834
Aligned: 151 rows
Threshold Bit Score: 285.201
Threshold Setting Gi: 51245692
Created: 6-Mar-2002
Updated: 17-Jan-2013
Structure
?
Program:
Drawing:
Aligned Rows:
 
dimer interfaceactive site
Conserved site includes 31 residues -Click on image for an interactive view with Cn3D
Feature 1:dimer interface [polypeptide binding site]
Evidence:

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                       
1DD8_A        2 KRVVITGLGIVSSIGNnQQEVLASLREGRSGItfsqelkdsgmrsHVWGNVKldttglidRKVVRFm-------sDASIY 74  Escherichia coli
BAC90461      6 RSVVITGLGIVSCLGGeARTTWKRLLAGERGY-------------EPGEPVG--------RAGTVQ---------AETGR 55  Gloeobacter viol...
ZP_00129303  11 RRVVITGAGAVTPLGHtPQDIRQSVLTGRTVFep---------tsVPAGYAQapa--qfdADDALRgwrhrrylnRGAAM 79  Desulfovibrio de...
NP_488326     2 IEVVITGIGLVSALGKsLEESWQGLIAGKSGIkw----------hQPFPELPplp--lglIGEKPT---------SLHSL 60  Nostoc sp. PCC 7120
YP_048723     6 SPVWVTGMAWSTALGDeIPTVWQYLLEGISGIt------------DLESTLSl-------RSNLAAp-------iPDIPL 59  Erwinia carotovo...
NP_441410    17 MGVVVTGLALDTALGD-QLQTWTKLLQGKTAIkp----------kQPFINLPsfp--lalQGNYPR---------SLGQL 74  Synechocystis sp...
NP_681411     1 MNVVITGIGLWTALGDtAIATWQRYCQGKTAL-------------IATPQGL--------VGATTL---------PIEKI 50  Thermosynechococ...
YP_065576     2 RDVVVVGGDILTPLGD-GQSTWQALLAGKTGI-------------SLQKFGSl-------EGEWPL---------GFIPD 51  Desulfotalea psy...
ZP_00328046   1 MKVLVTGIGLTSSLGN-LFQSWEKLLDGKSAIrl----------vKPFAELPp------lPLGLINsq-----pvDLTNL 58  Trichodesmium er...
AAO58127      6 VEVWVTGMAWSTALGDdLEVVWQSLLAGRSGIr------------SVDFPVAl-------RSPLASp-------lPDLDP 59  Pseudomonas syri...
Feature 1                                      #      ##   # ##                 #             # 
1DD8_A       75 AFLSMEQAIADAGLSpeayqnnPRVGLIAGSGGGSPRFQVFGADAMRGprgl-----kavgPYVVTKAMa--------SG 141 Escherichia coli
BAC90461     56 VVALVQQAAREALADa-----gSREAFDFGVAIGSSRGLQADWENGRT-------------GPLIGLDA---------PA 108 Gloeobacter viol...
ZP_00129303  80 AVHAARQAAGAAGFAag---lpGYCGIFAGSGPHLDMDSDYAQPQHLPqr---------hdTLCALWMLry-----lpNT 142 Desulfovibrio de...
NP_488326    61 TQVVVDAAIKDAGLVpp----lTDCALVIGSSRGYQGSWEKLARQIYTgddsadeaeklenWLDVLPHM---------NT 127 Nostoc sp. PCC 7120
YP_048723    60 EWEGARRQHVLTVKT-------LRKALEDASIPADDPDILAVLGTSYGh------------HLDSPDTFs-------lSE 113 Erwinia carotovo...
NP_441410    75 VPPLVQAAIDDAQLDpa----eQPWGVAIGSSRANQCHWEDWVGRNIK-------------PPVAPNFKlvdwwqtlpDQ 137 Synechocystis sp...
NP_681411    51 IETTTTQALNDAKLTap----lGSAGVVVGSSRGFQAQWETWLRQPSLs-----------rERWLQTLP---------AT 106 Thermosynechococ...
YP_065576    52 LAGEPGSLQRQNDMF-------KRLLASLPQLSPATQLFCATTKAATD-------------EFLLRSGReeg----qpWQ 107 Desulfotalea psy...
ZP_00328046  59 IKQTVETAVKSSGLKlp----lPECGVVIGSSRAYQRMLENLAKKQFVddgq------dhsQKDYGSFInf-----wpHQ 123 Trichodesmium er...
AAO58127     60 ALPLPERQHRLTVATl------RRALQDAGLAKATEEVVPVLATSYGH-------------HLDVPETEs-------lSR 113 Pseudomonas syri...
Feature 1         #   #     # # ###           #  ##  #                    ##  ##                
1DD8_A      142 VSACLATPFKihGVNYSISSACATSAHCIGNAVEQIQLGkqDIVFAGGGEElc-wEMACEFDAMGALStkynd---tpek 217 Escherichia coli
BAC90461    109 HAVAALAGTQ--GPLAALSCACASGAWAIGTGYRWIRWGlcDRVLVGAADAaitpLNLAGFRRAGALArd---------- 176 Gloeobacter viol...
ZP_00129303 143 AASAISQLLGarGESLVTGTACAASLQAVGEAFRRIRHGvlPVALAGGGDSrlsyGGLLAYAKAGALApcsedthaaaaa 222 Desulfovibrio de...
NP_488326   128 IAAARQIGAT--GAVIAPMAACATGIWAIAQAAILIQTGqyQRVIAGATEAaitpLTLSGFQQMGALAkt---------- 195 Nostoc sp. PCC 7120
YP_048723   114 WSTQAVKAVGcvKSPITVSTACSAGSDAILTGLSFIKAGltEICVCGGADVlt-lGKRLSHSRLGTMStd---------- 182 Erwinia carotovo...
NP_441410   138 AARLAAQLLPevTVMQCPMAACATGLWAIAQGVELIRTGhcQRVLAGAVEApitpLTLAGFSKMATLApd---------- 207 Synechocystis sp...
NP_681411   107 VSQQVAQIAGiqGIVLNPTAACATGLWAIAQGALLIAQGycDLVLAGGVESaispLTLAGFRQLGVLApe---------- 176 Thermosynechococ...
YP_065576   108 VAEELAQRLGi-KAGTTVSAACVSGLIAVIQGAMRIKAGecDHALIIGFDLls-qFVLSGFSSLKALSat---------- 175 Desulfotalea psy...
ZP_00328046 124 PAILTASQIGtkGTVLSPMAACATGILAIARGFELIQTGqcQQVIAGAVESpitpLTIAGFRKMGALAqi---------- 193 Trichodesmium er...
AAO58127    114 WAVEAAREAGcqHAPITVSTACSAGADALLLGLSLIRRGftDTCLCGGADIlt-pAKRLGHSQLGTLSad---------- 182 Pseudomonas syri...
Feature 1                                                    #####             #                
1DD8_A      218 aSRTYDAHRDGFVIAGGGGMVVVEELEHAlargahIYAEIVGYGATSDGADMVAps--gEGAVRCMKMAMHgv---dtPI 292 Escherichia coli
BAC90461    177 aCLPFDRCHSGFVLAEGASVLVLEAEEVAhg---rPYTRIRGFSATCDAFHPTAphpegEGLARAVERCRKqap--glSV 251 Gloeobacter viol...
ZP_00129303 223 aCRPFDTGRQGFAAGEGAAFFVLESLDHAqkrgavPLAEVCGYGCSMDGHAMTAphpqgMHAEQAVRTALHeagagpaDV 302 Desulfovibrio de...
NP_488326   196 gAYPFDLQREGLVLGEGAAVFVLESRQLAkkrkakIYGQILGFGLINDAYHSTQlepegKGAIASIQQCLArsqltltDI 275 Nostoc sp. PCC 7120
YP_048723   183 gLRAFDISHNGTVLGEGAAFLILESERHArrrgakPYGILAGAGSANDAASAVSpdlsgQNVILTVERALNsaglkpeDI 262 Erwinia carotovo...
NP_441410   208 gCYPFDRQRQGLVLGEGGALLVLETRELAqkrkarIYGEILGWGFSCDALHRSTpafdnHSAQQAVKHCLTrsgltpeQI 287 Synechocystis sp...
NP_681411   177 rAAPFDRQRQGFGLAAGGALLVLESPERArsrgiePYARIAGVGLSADAENMAApsvnqTGALLAIQKALAqaeltppQI 256 Thermosynechococ...
YP_065576   176 aARPFAKDRDGLSLGDGAGWILLSAAEVAep--ssVLATLGPWSISCDANHITApsryaTGLIAALEQIKAea----gDI 249 Desulfotalea psy...
ZP_00328046 194 gAYPFDRAREGFVLGEGAAILLLESANFAkkrsakVYGQIRSFGLTNDGIHSVIpdlsgKSAMLAIARSLArsglapeEI 273 Trichodesmium er...
AAO58127    183 gLRAFDRAHSGTVLGEGAGFLVLETRAAAlargarPYGILAGAGSANDAVSAVApdlsgDCLALAVRRALCdagltahEV 262 Pseudomonas syri...
Feature 1                                                                                       
1DD8_A      293 DYLNSHGTSTPVGDVKELAAIREVFgd--ksPAISATKAMTGHSLGAAGVQEAIYSLLMLEhGFIAPSINIEEldeqaag 370 Escherichia coli
BAC90461    252 GAVHAHGTGTAAGDPVEAAVIARLYap---gTPVIACKGSLGHSLGASSAMEAALACLALQtGQLPPIAGLTDpl---ap 325 Gloeobacter viol...
ZP_00129303 303 TAVCAHGTGTRRNDTAESVMLTRLFaptghrPPVLALKSWTGHCASACGAVELAVLLACARhGFLPPVRNLQTplc--ds 380 Desulfovibrio de...
NP_488326   276 DYIHAHGTATQLNDRVESQVIKHLFps---kVAVSSTKGSTGHTLGASGALGVAFSLLALEqKIIPPCVGFQEpe---fd 349 Nostoc sp. PCC 7120
YP_048723   263 SIINAHGTGTQVNDSVEAKAYSAFFsplphpPTLFATKGAFGHTLGATGAIEAIAVLQALKtQRLPPIHGLYDpit-psd 341 Erwinia carotovo...
NP_441410   288 DLIHPHGTGTLFNDQREAALIQTLFpq---nPLITSSKGATGHTLGASGAIAVALTLLSLHqQKLPPCVGLKEpe---fp 361 Synechocystis sp...
NP_681411   257 DYIHSHGTGTRRNDAAEAAWIETLFgh---rVAVTSHKGALGHTLGAAGAIAIALSCLSLReQQIPPCVGCQTpn---fe 330 Thermosynechococ...
YP_065576   250 GGINAHGTATVYNDAMELLAFSKVFap---gMPVCSVKGALGHSLAASGIVETVLSLYSLRdMILPPTVGLEVpa----e 322 Desulfotalea psy...
ZP_00328046 274 DYVHAHGTATKLNDRHEANLIQQIFph---kVAVSSTKGATGHTLGASGALGAAFCLMAVKhQVLPPCVGLNSpe---fd 347 Trichodesmium er...
AAO58127    263 GCISTHGTGTRLNDEVETKTYSDLFassprlPLLFGTKGAFGHTLGATGALEAISLLLALGnQQVPPIVGLENp------ 336 Pseudomonas syri...
Feature 1                                          # #      
1DD8_A      371 LNIVt-----ETTDRel--------tTVMSNSFGFGGTNATLVM 401 Escherichia coli
BAC90461    326 LAFVr-----EAFRTsv--------tTLMLHSLGFGGQNTALLL 356 Gloeobacter violaceus PCC 7421
ZP_00129303 381 LSFVrrihpcTAAELyaagrpeklsaLTLLQSFGFGGQNAALAV 424 Desulfovibrio desulfuricans G20
NP_488326   350 LNIVk-----TAQHSqi--------qQVLCLSFGFGGQNAAIAL 380 Nostoc sp. PCC 7120
YP_048723   342 LPIA------NQKNMpct------atAGLSITLGFGGFNTCLVF 373 Erwinia carotovora subsp. atroseptica SCRI1043
NP_441410   362 LNFVri---eSVQPAtsp------lnYGLCLSFGFGGQNGAIAV 396 Synechocystis sp. PCC 6803
NP_681411   331 LDIVq-----QTRSApl--------eHILCCSYGFGGQNAVVVL 361 Thermosynechococcus elongatus BP-1
YP_065576   323 TDCQl-----SGSEAlal-----ghpSIITCNSGFGGINAALLL 356 Desulfotalea psychrophila LSv54
ZP_00328046 348 LDLVr-----YARQSqv--------kNVLCLSFGFGGQNAALVL 378 Trichodesmium erythraeum IMS101
AAO58127    337 LTGIal--plAMRTAlac-----paeVGISVTLGFGGFDTCLVF 373 Pseudomonas syringae pv. tomato str. DC3000

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap