1TQY


Conserved Protein Domain Family
CLF

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cd00832: CLF 
Click on image for an interactive view with Cn3D
Chain-length factor (CLF) is a factor required for polyketide chain initiation of aromatic antibiotic-producing polyketide synthases (PKSs) of filamentous bacteria. CLFs have been shown to have decarboxylase activity towards malonyl-acyl carrier protein (ACP). CLFs are similar to other elongation ketosynthase domains, but their active site cysteine is replaced by a conserved glutamine.
Statistics
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PSSM-Id: 238428
View PSSM: cd00832
Aligned: 17 rows
Threshold Bit Score: 503.431
Threshold Setting Gi: 125240
Created: 6-Mar-2002
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
active site
Conserved site includes 3 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                     
1TQY_H      9 KSVLITGVGVVAPNGLgLAPYWSAVLDGRHGLGPVTRFDVSRYPATLAGQIDDFhAPDHIPGRLLPQTDPSTRLALTAAD 88  Streptomyces coeli...
BAA23145    7 DAPAVTGIGVVAPTGIgVEEHWAATLRGVPVIGPLTRFDASRYPSPFGGEVPGFdAAERVPGRLIPQTDHWTHLALAATD 86  Actinomadura hibisca
P16539      5 APVVVTGLGIVAPNGTgTEEYWAATLAGKSGIDVIQRFDPHGYPVRVGGEVLAFdAAAHLPGRLLPQTDRMTQHALVAAE 84  Streptomyces glauc...
AAP69574    1 MTAHITGIDIVSPLGLsREEHWKALLDGCSGLRATQSFDSSRYDNPISGEVPHF-APEGLPKRLLPATDRMTQMSLVAAA 79  Streptomyces grise...
AAR30161   22 HQALVTGIGITAPNGLgAPAYWDALLSGRSGLGPITRFDASGYPVRIAGEITDFaDEEHIPSRLLPSTDRSTRLALAAAQ 101 Streptomyces ambof...
NP_823551  17 PRAVITGLGVVAPNGFdTDEYWDAVLHGRGGIDRVTRFDPEQYPATLAGEVADYdVRAYIPGRLVPQTDQTTRLVLMAAD 96  Streptomyces averm...
P23156     14 RRAVVTGLGVLSPHGTgVEAHWKAVADGTSSLGPVTREGCAHLPLRVAGEVHGFdAAETVEDRFLVQTDRFTHFALSATQ 93  Streptomyces coeli...
Q02579     11 RRTAVTGIGVVAPNGLhADTYWKSVKEGASVLDRITREGCEHLPLRVAGEVRGFdPSALIEETFLVQTDLFTHFALAAAD 90  Streptomyces cyaneus
P16541      7 RRAVVTGLSVAAPGGLgTERYWKSLLTGENGIAELSRFDASRYPSRLAGQIDDFeASEHLPSRLLPQTDVSTRYALAAAD 86  Streptomyces viola...
Q02062      1 MSVLITGVGVVAPNGLgLAPYWSAVLDGRHGLGPVTRFDVSRYPATLAGQIDDFhAPDHIPGRLLPQTDPSTRLALTAAD 80  Streptomyces coeli...
Feature 1                                                                                     
1TQY_H     89 WALQDAKADpes---ltdYDMGVVTANACGGFDFTHREFRKLWSEGPKSVSVYESFAWFYAVNTGQISIRHGmrGPSSAL 165 Streptomyces coeli...
BAA23145   87 LALADAGVVpae---lpeYEMAVVTASSSGGVEFGQREIQALWRDGPRHVGAYQSIAWFYAATTGQISIRHGmrGPCGVV 163 Actinomadura hibisca
P16539     85 WALADAGLEpek---qdeYGLGVLTAAGAGGFEFGQREMQKLWGTGPERVSAYQSFAWFYAVNTGQISIRHGmrGHSSVF 161 Streptomyces glauc...
AAP69574   80 GAFDDSGVDtsr---vdpLGVGVMTASTAGGYAFGQKELQNLWSKGPRYVSTHQSYAWFYAVNTGQISIRHGcqGHSGVI 156 Streptomyces grise...
AAR30161  102 EALDDAGAGpqe---tagNQAGVMTASLAGGAEFGQRGLAALWSKGATHVSAYQSFASFHAAAPAQISIRHRlrGHGSAI 178 Streptomyces ambof...
NP_823551  97 AAVRDSSLDpaa---lpeDQVGIVTGLSAGGLEYSQRELEKLWSLGSDHVSAYLSFSWFYAVNTGQISIRHGw-HGPGGV 172 Streptomyces averm...
P23156     94 HALADARFGradv--dspYSVGVVTAAGSGGGEFGQRELQNLWGHGSRHVGPYQSIAWFYAASTGQVSIRNDfkGPCGVV 171 Streptomyces coeli...
Q02579     91 AALQDAGLTkaaavadspYSVGVVTAAGSGGGEFGQRELQKLWGQGSRFVGPYQSIAWFYAASTGQISIRSGfkGPCGVV 170 Streptomyces cyaneus
P16541     87 WALADAGVGpesg--lddYDLGVVTSTAQGGFDFTHREFHKLWSQGPAYVSVYESFAWFYAVNTGQISIRNTmrGPSAAL 164 Streptomyces viola...
Q02062     81 WALQDAKADpes---ltdYDMGVVTANACGGFDFTHREFRKLWSEGPKSVSVYESFAWFYAVNTGQISIRHGmrGPSSAL 157 Streptomyces coeli...
Feature 1        #                                                                            
1TQY_H    166 VAEQAGGLDALGHARRTIRRGt--PLVVSGGVDSaldpwGWVSQIASGRISTATDPDRAYLPFDERAAGYVPGEGGAILV 243 Streptomyces coeli...
BAA23145  164 VAEQAGALESFAQARRYLADGa--RVVVSGGTDApfspyGLTCQLGSGRLSTGADPARAYLPFDAAANGFVPGEGGAILI 241 Actinomadura hibisca
P16539    162 VTEQAGGLDAAAHAARLLRKGt-lNTALTGGCEAslcpwGLVAQIPSGFLSEATDPHDAYLPFDARAAGYVPGEGGAMLV 240 Streptomyces glauc...
AAP69574  157 VADDAGGLDAISFAARRLARGn--RVMLTGSVDStmcpwGRVAHTSTGMLSASTDARAAYLPFDARANGWVNGEGGAHLV 234 Streptomyces grise...
AAR30161  179 ITEQAGGIDALARARRRIRDGa--PLMVTGGVDStlcpwGWAAHLADGRLSPSGEPHHAYRPFAATADGHTVGEGGALLV 256 Streptomyces ambof...
NP_823551 173 LTGNTSGLDAIAQARRHVVDGl--PVVMCGAVESamcplGWTIELTTGRMSTVADRTQAYLPFDTAASGYVPGEGGAMVV 250 Streptomyces averm...
P23156    172 AADEAGGLDALAHAALAVRNGt--DTVVCGATEAplapySIVCQLGYPELSRATEPDRAYRPFTEAACGFAPAEGGAVLV 249 Streptomyces coeli...
Q02579    171 ASDEAGGLDAVAHAARVVERGt--DVVVVGAAEAplapySMVCQLGYPELSTDEDPAIAYRPFTSAARGFVPAEGGAVLI 248 Streptomyces cyaneus
P16541    165 VGEQAGGLDAIGHARRTVRRGpgwCSAVASTRRStr--gASSSQLSGGLVSTVADPERAYLPFDVDASGYVPGEGGAVLI 242 Streptomyces viola...
Q02062    158 VAEQAGGLDALGHARRTIRRGt--PLVVSGGVDSaldpwGWVSQIASGRISTATDPDRAYLPFDERAAGYVPGEGGAILV 235 Streptomyces coeli...
Feature 1                                                                    #                
1TQY_H    244 LEDSAAAeargrhdAYGELAGCASTFDPAPGSGr--PAGLERAIRLALNdagtgpeDVDVVFADGAGVPELDAAEARAIG 321 Streptomyces coeli...
BAA23145  242 IEQAATAqd----rSYGRIAGYAATFDPPPGSGr--PPTLERAVRAALDdarltpaDVDVVFADAAGVPDLDRAEADAIG 315 Actinomadura hibisca
P16539    241 AERADSArerdaatVYGRIAGHASTFDARPGTGr--PTGPARAIRLALEearvapeDVDVVYADAAGVPALDRAEAEALA 318 Streptomyces glauc...
AAP69574  235 LQTHSDG-------RYAAVLGHGATMDDPRAAP---GTGLVRAIHLALGaarlrpgDISVVFADAAGTREADTAEAAALA 304 Streptomyces grise...
AAR30161  257 LEDARSAarr-gatGYGTVAGCASTFDGPRRPRl-rEAAELALAQAGLTp-----aHVDVVFADGAGRRSADRTESTALC 329 Streptomyces ambof...
NP_823551 251 VEEAGHArgr-garPYSEIAGYATTFDPRPGSAr--EPGLRRAIESALAdagvtpdEVDVVFADAAGVGELDRAEAAAVT 327 Streptomyces averm...
P23156    250 VEEEAAArer-gadVRATVAGHAATFTGAGRWAe-sREGLARAIQGALAeagcrpeEVDVVFADALGVPEADRAEALALA 327 Streptomyces coeli...
Q02579    249 VEEADRAhrr-gavVRATVAGHAATFTGASHWDq-sREGLAHAIHGALDeagcapeEIDVVFADAMGVPEADRAEALALV 326 Streptomyces cyaneus
P16541    243 VEDADSAr-----aRGAERIYVRSPLRRDPAPGsgrPPALGRAAELALAeagltpaDISVVFADGAGVPELDRAEADTLA 317 Streptomyces viola...
Q02062    236 LEDSAAAeargrhdAYGELAGCASTFDPAPGSGr--PAGLERAIRLALNdagtgpeDVDVVFADGAGVPELDAAEARAIG 313 Streptomyces coeli...
Feature 1                         #                                                           
1TQY_H    322 RVFgre--gvPVTVPKTTTGRLYSGGGPLDVVTALMSLReGVIAPTAGVtsvpreygIDLVLGEPRSTap-----rTALV 394 Streptomyces coeli...
BAA23145  316 AVFgpr--gvPVTAPKSLTGRLYAGGPALDAATALLAMHdSVIPPTAGGadvppgyaLDLVGAEPRPArl-----rTALI 388 Actinomadura hibisca
P16539    319 EVFgpg--avPVTAPKTMTGRLYAGGAALDVATALLSIRdCVVPPTVGTgapapglgIDLVLHQPRELrv-----dTALV 391 Streptomyces glauc...
AAP69574  305 EVFgpd--svPVTAPKAATGRMGCGTAALDVATAVLALRdQTIPPTVNVq-------ADASLGVNLCSvathhpltNVLV 375 Streptomyces grise...
AAR30161  330 ALFgpy--gvPVTVPKTMTGRLGAGGAALDVATALLALNaKTVPPTTGTtrvagdcpLDLVTAPRRLPhl-----qVALV 402 Streptomyces ambof...
NP_823551 328 AVFgpr--gvPVTAPKTMTGRLYSGGPALDVATASLSMRhGVIPPMINVtdpvrsdqLDLVLDRPRETtv-----sTALV 400 Streptomyces averm...
P23156    328 DALgphaarvPVTAPKTGTGRAYCAAPVLDVATAVLAMEhGLIPPTPHVldv--chdLDLVTGRARPAep-----rTALV 400 Streptomyces coeli...
Q02579    327 DALgrhaprvPVTAPKTGIGRSYCGAALLDIAAGAGMEH-GQIPPTPNVfdi--chqIDLVTATARPAs------sAPLV 397 Streptomyces cyaneus
P16541    318 RLFgpr--gvPVTAPKALTGRLCAGGGPADLAAALLALRdQVIPATGRHravpdayaLDLVTGRPREAal-----sAALV 390 Streptomyces viola...
Q02062    314 RVFgre--gvPVTVPKTTTGRLYSGGGPLDVVTALMSLReGVIAPTAGVtsvpreygIDLVLGEPRSTap-----rTALV 386 Streptomyces coeli...
Feature 1                   
1TQY_H    395 LARGRWGFNSAAVL 408 Streptomyces coelicolor
BAA23145  389 IARGYGGFNAALVL 402 Actinomadura hibisca
P16539    392 VARGMGGFNSALVV 405 Streptomyces glaucescens
AAP69574  376 LARGVGGFNSALIV 389 Streptomyces griseoflavus
AAR30161  403 LARGRGGFNAATVL 416 Streptomyces ambofaciens
NP_823551 401 LARSDGINSAVVLT 414 Streptomyces avermitilis MA-4680
P23156    401 LARGLMGSNSALVL 414 Streptomyces coelicolor
Q02579    398 LSRGLMGSNAALVL 411 Streptomyces cyaneus
P16541    391 LARGRHGFNSAVVV 404 Streptomyces violaceoruber
Q02062    387 LARGRWGFNSAAVL 400 Streptomyces coelicolor

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