1QLV,1TED,1CGZ,1EE0,1CML


Conserved Protein Domain Family
CHS_like

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cd00831: CHS_like 
Click on image for an interactive view with Cn3D
Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy, after the starter molecule is loaded onto the active site cysteine, a carboxylative condensation reation extends the polyketide chain. Plant-specific PKS are dimeric iterative PKSs, using coenzyme A esters to deliver substrate to the active site, but they differ in the choice of starter molecule and the number of condensation reactions.
Statistics
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PSSM-Id: 238427
View PSSM: cd00831
Aligned: 67 rows
Threshold Bit Score: 242.515
Threshold Setting Gi: 21225498
Created: 6-Mar-2002
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 3 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Structure:1EEO; Gerbera 2-pyrone synthase with bound acetoacetyl-Coa
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                       
1QLV_A       21 LATILAIGTATPPNCVAQADYADYYFRVTkseh---------mvdLKEKFKRICEk---------TAIKKRYLALTEDYL 82  Gerbera hybrid c...
1EE0_A       21 LATILAIGTATPPNCVAQADYADYYFRVTkseh---------mvdLKEKFKRICEk---------TAIKKRYLALTEDYL 82  Gerbera hybrid c...
AAB48106      1 MSTLCKPSLLFPHYKITQQQMIDHLEQLHdd------------hpRMALAKRMIQn---------TQVNERYLVLPIDEL 59  Pseudomonas fluo...
NP_216176     1 MSVIAGVFGALPPYRYSQRELTDSFVSIPdf------------egYEDIVRQLHAs---------AKVNSRHLVLPLEKY 59  Mycobacterium tu...
P54157        1 MAFILSIGTSLPAYNVNQEKAAEFARYMFqhs-----------fkDIDRLLSSFKn---------GQIHSRQFVKPIEWY 60  Bacillus subtilis
BAB91443      1 MPRLCKPAMMAPEHIITVEETLEFAEKAHag------------kpQLPLALRLIRn---------TGVQKRHIVQPIEQT 59  Streptomyces ant...
NP_631277     2 AAYLCAPAVIHGEHSVETREIVEEVRGRHphapwapridgiaastGIESRGWMLPleaavapgggGDLGAAREALVRDGF 81  Streptomyces coe...
NP_631710    33 GPRIAAVRCALPPHRYAQHELTGPIGDLClsp-----------gaDRALLHRVHAs---------AGVRTRHLALPIERY 92  Streptomyces coe...
NP_961576     4 SPSITGVAVKFPPNRYTQSEAIRALTDIA----------------GPEFRRFAHS----------SGVEFRNTALRLPRY 57  Mycobacterium av...
ZP_00209010   1 MSRVVAVGTSLPAHAYRQDEISRVTSELLtdd-----------pvRRALTRRLHAh---------AGVETRHLALPLEDY 60  Magnetospirillum...
Feature 1                                                                                       
1QLV_A       83 Qenptmc-------efmapsLNARQDLVVTGVPMLGKEAAVKAIDEWG-----LPKSKITHLIFCTTAGVDMPGADYQLV 150 Gerbera hybrid c...
1EE0_A       83 Qenptmc-------efmapsLNARQDLVVTGVPMLGKEAAVKAIDEWG-----LPKSKITHLIFCTTAGVDMPGADYQLV 150 Gerbera hybrid c...
AAB48106     60 Avh---------------tgFTHRSIVYEREARRMSSIAARQAIENAG-----LTTDDIRMVAVTSCTGFMMPSLTAHLI 119 Pseudomonas fluo...
NP_216176    60 Pkl---------------tdFGEANKIFIEKAVDLGVQALAGALDESG-----LRPEDLDVLITATVTGLAVPSLDARIA 119 Mycobacterium tu...
P54157       61 Keg---------------hsFEEKNQIYIEETLKHSRAAVRECLSHPEffqeaIPYEKVEAVFFVSSTGLSTPSIEARLM 125 Bacillus subtilis
BAB91443     60 Lrh---------------pgFEERNRIYEVESKKRTPEVIERALANAE-----LRARDIDAIIYVSCTGFMMPSLTAWLI 119 Streptomyces ant...
NP_631277    82 TeqdanraiaalkavpasqtVQERTAPAWEAVQAYGERAARGALQIAG-----LDVADVDCLITSNSTTPALPGLDVALA 156 Streptomyces coe...
NP_631710    93 Arl---------------gdFGRSNGAWLETGLELGEEALSGALREAG-----LTPADVDLLVFASITGVSAPSLDARLA 152 Streptomyces coe...
NP_961576    58 Rel---------------sgFSEANDAYLEVALDLGEQALVAALDRGK-----VKPSEVDIVFSTTVTGLAVPTLEARLA 117 Mycobacterium av...
ZP_00209010  61 Ggl----------------sFGSANDAFLALGTDLAEQACRAALDDAG-----LRPDEVDHVVLTTVTGVGAPTLDVLVA 119 Magnetospirillum...
Feature 1                         #                                                             
1QLV_A      151 KLLGLSPSVKRYMLYqQGXAAGGTVLRLAKDLAENNkgSRVLIVCSEITAI-LFHGPnenhLDSLVAQALFGDGAAALIV 229 Gerbera hybrid c...
1EE0_A      151 KLLGLSPSVKRYMLYqQGXAAGGTVLRLAKDLAENNkgSRVLIVCSEITAI-LFHGPnenhLDSLVAQALFGDGAAALIV 229 Gerbera hybrid c...
AAB48106    120 NDLGLRTSTVQLPIAqLGCVAGAAAINRANDFASLSpdNHALIVSLEFSSL-CYQPQdt-kLHAFISAALFGDAVSACVM 197 Pseudomonas fluo...
NP_216176   120 GRLGLRADVRRVPLFgLGCVAGAAGVARLHDYLRGApdGVAALVSVELCSL-TYPGYkp-tLPGLVGSALFADGAAAVVA 197 Mycobacterium tu...
P54157      126 NELPFSPYTKRIPIWgLGCAGGASGLARAAEYCKAYpeAFVLVISAELCSL-TFQPEdk-tKSNLIGTSLFGDGIAAALL 203 Bacillus subtilis
BAB91443    120 NKLGFRPDTRQIPIAqLGCAAGGAAINRAHDFCVAHpgSNVLIVSCELCSL-CYQPEad-dIGSLLSDGLFGDAVAAAVV 197 Streptomyces ant...
NP_631277   157 NRLPLRGDTMLLPATqWACVAGTRSLALAADLVAADpdRVVLVVISEALST-TYQPAdd-tLESLIVRLLFADTAVAAVV 234 Streptomyces coe...
NP_631710   153 GRMGLRPDVKRLPLFgLGCVAGAAGLARVHDHLRGHpeDTAVLLTVELCSLtLQRGDa--sRANLVAGALFGDGAAALVA 230 Streptomyces coe...
NP_961576   118 TRVGLRPDVKRVPLFgLGCVAGAAGVARMHDYLRAFpdQTAALLAVELCSL-TIQRHdt-sIANLVATSLFGDGAAAVIT 195 Mycobacterium av...
ZP_00209010 120 ARLGLRPDVRRTPSFgWGCAGGAAGLARADDLLRGRprDVALLVAVELCSL-TLQRTdp-sTANIVASGLFGDGAGAAVL 197 Magnetospirillum...
Feature 1                                                                                       
1QLV_A      230 GSGphlav---------erpifEIVSTDQTILPdt---------ekAMKLHLRe---------gGLTFQLHrdVPLMVAK 282 Gerbera hybrid c...
1EE0_A      230 GSGphlav---------erpifEIVSTDQTILPdt---------ekAMKLHLRe---------gGLTFQLHrdVPLMVAK 282 Gerbera hybrid c...
AAB48106    198 RADdka-------------pgfKIAKTGSYFLPds---------ehYIKYDVKd---------sGFHFTLDk-AVMNSIK 245 Pseudomonas fluo...
NP_216176   198 AGVkraqdi--------gadgpDILDSRSHLYPds---------lrTMGYDVGs---------aGFELVLSrdLAAVVEQ 251 Mycobacterium tu...
P54157      204 CGEkadrrvs------klklapKIMDAQSVLMKqs---------edVMGWDFTd---------qGFKVIFSrdIPTLVEK 259 Bacillus subtilis
BAB91443    198 RGIggn--------------giELERNASYLIPnt---------edWISYAVKd---------tGFHFQLDr-RVPGTME 244 Streptomyces ant...
NP_631277   235 TGRprpe------------svlRLDAAWHHTLPg------------TRDLHRLetr------adGTHFVMDrrGPRAVQE 284 Streptomyces coe...
NP_631710   231 RGGntdgvntddggsgsgsgsgSGSGSGSGSGTvapasgprvvatrSHLYPGTegllgweigaaGFRVVIDagVPDIVRG 310 Streptomyces coe...
NP_961576   196 EGArraga---------ehtgpRILATRSRIYPdt---------eeVMGWKIGg---------dGFRIVLSadVANIAEK 248 Mycobacterium av...
ZP_00209010 198 VGDehrlarrp---gpygragaGVRARGVRVVDsrshlh--agttgDLGWRVGd---------tGFEIVLSarLPELIGA 263 Magnetospirillum...
Feature 1                                  #                                #                   
1QLV_A      283 NIENAAEKALSPl--gITDWNSVFWMVHPGGRAILDQVERKLNLKEDKLRASRHVLSEYGNLISACVLFIIDEVRKRSma 360 Gerbera hybrid c...
1EE0_A      283 NIENAAEKALSPl--gITDWNSVFWMVHPGGRAILDQVERKLNLKEDKLRASRHVLSEYGNLISACVLFIIDEVRKRSma 360 Gerbera hybrid c...
AAB48106    246 DVAPMMEELNFEtf-nQHCAQNDFFIFHTGGRKILDELVLQLDLEPGRVAQSRDSLSEAGNIASVVVFDVLKRQFDSGpa 324 Pseudomonas fluo...
NP_216176   252 YLGNDVTTFLASh--gLSTTDVGAWVTHPGGPKIINAITETLDLSPQALELTWRSLGEIGNLSSASVLHVLRDTIAKPpp 329 Mycobacterium tu...
P54157      260 WLKTNVQIFLDKh--kLSFHDISVFLAHPGGKKVIDAYIKSLGLSSEKLSSAQSILQKHGNMSSATILYVIKDHLQNGhk 337 Bacillus subtilis
BAB91443    245 PLAPVLRELAKDh--sWDAGKLDFYIVHAGGPRILDDLAKFLEVDRDVFRHSWSTLSEYGNIASAVVLEAARRLFEEDap 322 Streptomyces ant...
NP_631277   285 TVTAMWEWLRVRyeddPSSWHPDVLLAHPGGTRVLEYMEQTMPDEWPSGLLSYSRDSYTSGNRGGAAVFDILRRAHDAgq 364 Streptomyces coe...
NP_631710   311 HFGRHLRAFLAEh--eLTVDDIGTWICHPGGPRILSAVSETLGLSEDALDRSRRSLAAVGNMSSVSVLHILEDVRARRap 388 Streptomyces coe...
NP_961576   249 YLGEDVRDFLADh--gLAPRDVTTWVCHPGGPRVIEAVESVLDLPADALDHTRNSLRENGNLSSVSVLDVLAANLADPpa 326 Mycobacterium av...
ZP_00209010 264 HLLGDVKALLAEh--dLEPGDVGAWVVHAGGPRVLDAVRETLGLAEEELALSRASLRDVGNLSSASVLHVLGATLARTdv 341 Magnetospirillum...
Feature 1                                    
1QLV_A      361 egksttgeglDCGVLFGFGPGMTVETVVL 389 Gerbera hybrid cultivar
1EE0_A      361 egksttgeglDCGVLFGFGPGMTVETVVL 389 Gerbera hybrid cultivar
AAB48106    325 --------ngATGMLAAFGPGFTAEMAVG 345 Pseudomonas fluorescens
NP_216176   330 --------sgSPGLMIAMGPGFCSELVLL 350 Mycobacterium tuberculosis H37Rv
P54157      338 k-------eaERGLIGALGPGFSSELLLF 359 Bacillus subtilis
BAB91443    323 a-------pgATGLIAGFGPGITAEMALG 344 Streptomyces antibioticus
NP_631277   365 k-------tgSRAVLYAAAPGLTATALEG 386 Streptomyces coelicolor A3(2)
NP_631710   389 e-------pgTWGLLLAMGPGFCSELVLL 410 Streptomyces coelicolor A3(2)
NP_961576   327 --------pgSIGLMIAMGPAFCSELVLL 347 Mycobacterium avium subsp. paratuberculosis str. k10
ZP_00209010 342 p-------pgAPAVLMAFGPGVSPSSSCC 363 Magnetospirillum magnetotacticum

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