Conserved Protein Domain Family
SCP-x_thiolase

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cd00829: SCP-x_thiolase 
Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal 3-ketacyl-Coa thiolase specific for branched-chain acyl CoAs, which is proteolytically cleaved from the sterol carrier protein.
Statistics
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PSSM-Id: 238425
View PSSM: cd00829
Aligned: 125 rows
Threshold Bit Score: 147.795
Threshold Setting Gi: 41406996
Created: 6-Mar-2002
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
active site
Feature 1:active site [active site]
Evidence:None

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                       
A39368       17 VGVGMTKFMKPgg----enSRDYPDLAKEAGQKALADAQIpys----avEQACVGYVYGe-------sTCGQRAIYHSLg 81  Norway rat
ZP_00280498   1 MGASAIPIGRHqsdpngplQTLEHEILAKLVVQAARDAHIe--------KDDIGGLVFTsprtytrqkYLHTFMANYLRl 72  Burkholderia fun...
NP_420774     9 IGAGQFTYRGEaa-----nSPSPLELLKVAAERAVLDAGLsgtvlaeldALAVVAFSID---------APGGLSKLPLPr 74  Caulobacter cres...
EAA75378     12 IGIGESRQKDFti----etCREPAELILSAIRDASKDSSInav---eklDSISVVPPWSwn-----ydDLPKLLAQRLG- 78  Gibberella zeae ...
CAE27197     14 AGVGEIADHPKdi----aqGLEPLALLEAAVQRAGDDSAVsll---pqiDSLDVVNFLSwr-----yhAPAEQLATRLGi 81  Rhodopseudomonas...
NP_959832     9 VIVGVGQFTERieds-gyrGMSSVELATEAARAALHDCGAda-----taLAAAVDTVAAirqfelsgrTPAPMGKSNNYp 82  Mycobacterium av...
NP_960511    11 IGYGQVNHRDDidp--avrSVEPVDLMAAAVERAADAAVIea------vDSIRVVNILSaq-----yrDPGLLLGQRIGa 77  Mycobacterium av...
AAN51312     22 EWTGERKVLEHykks-iydLLEFLEMKPETLKEILTDFVSi--------EPASLGKAGY---------GHSARIANELGy 83  Leptospira inter...
YP_025402     9 GGYAETPVVFGs-------GRSAYDLAADVLDELARKYGIapa----diDGLAVTAALSeg------sNPFHAAFMSDAl 71  Wautersia eutropha
AAK50624     23 VGIAEIPSGRYp-------NRPFIGSLVEVAVAAVRDAGMqis----diDTVLLIPCLHsadd--qadLIFSRVVEELGl 89  Rhodococcus sp. ...
Feature 1                            #                                                          
A39368       82 l---------tgIPIINVNNNCSTGSTALFMAQQLVQGGl----------aNCVLALGFEKMEkgsl-----------gt 131 Norway rat
ZP_00280498  73 p---------cdGTVMEVMGNGMTAALAFDEAANQIRLGr----------aKVVLALGINMESai--------------- 118 Burkholderia fun...
NP_420774    75 lsdppaslaravSASPRWSVYTETGGNSPQQAVNVVCERiaq------gesDLALVTGAEFLGslmkrmkgglgfegwgd 148 Caulobacter cres...
EAA75378     79 ------------IQPSHLELASHGGNTPALLCDKAAARVasg-------dvKMAVVTGGEALAslfacqkagkipppgwt 139 Gibberella zeae ...
CAE27197     82 ------------APRHCFYGPVGGESPIRFIHEAALRIArg--------eaKVAVVCGAEAQStatkaara---kldlpw 138 Rhodopseudomonas...
NP_959832    83 -----------rSVARRIGAAPARAVLEPIGGQGPQHLVtefagiiaagdaEVVMIFGSENTSsiryfad-----rekpd 146 Mycobacterium av...
NP_960511    78 r----------dFGTLYTPVGGNVPQSLVNQACLDIQRGr----------aNVVLLAGAETWRtrrglrak---ggklvw 134 Mycobacterium av...
AAN51312     84 t----------gFRSHLMDLGGASVTGALGQARIILQSDp----------eAVVLIAAADIPKs---------------- 127 Leptospira inter...
YP_025402    72 ------------GLALDWLATGTTGGCAMLSAVAATASAlrd------ghcKVALVLGADAPSt---------------- 117 Wautersia eutropha
AAK50624     90 hg--------raKASAMLHSGGSTSDNITRTAAGLIASGq----------aKNILVVQADKWGsapva--------dmvd 143 Rhodococcus sp. ...
Feature 1                                                                                       
A39368      132 kYSDRSNPLEKhidvli-----nkygmSACPFAPQLFGSAGKEHMETYGTKv--------eHFAKIGwkn---hkHSVNN 195 Norway rat
ZP_00280498 119 sSTEHAMSSMRatgdi-------dfhaTAGFIPISWYAMDATRYMYQYGATr--------eQIASVAvkn---ryHASLN 180 Burkholderia fun...
NP_420774   149 dITTAPQRIGDprpgvtr--qeaahglGYPVNTYPLFENALRARDGRSQEEhq-------kQLGAFFapf---tkVAAAN 216 Caulobacter cres...
EAA75378    140 eMSPDAKRYSPgdtslkkgagathsigNPIQVYPLYENAYRKQNQQSYIENhhesa-elytQFDKIAcqhp-nswRAEET 217 Gibberella zeae ...
CAE27197    139 tPFAHDAPEPKrgaafq----qpiastLGVARPITVYPLYEAATAAHWGQTprq-----alDESGVLwsr--yaaAAERN 207 Rhodopseudomonas...
NP_959832   147 hSETVEGSLEDrgfgyegl-fddytvaHGLIGAPAQYGLLENARRARLGLSvadyrrrmgeLFAPFTk-------VAAKN 218 Mycobacterium av...
NP_960511   135 tEQDRSVPMAEvsgedvam-ageaeirISLDRPAYVYPLFEQALRVATGESve-------dHLTRIGrlwarfnaVAVDN 206 Mycobacterium av...
AAN51312    128 -AFKQISDLKRlnetvc----hplyelNYGATLISMYGLLMKRMMYENSITq--------kDLEQITkrf---raNAIIN 191 Leptospira inter...
YP_025402   118 hFAAEFRGYHDefi-----------apTGMTRPPGFFALLHNAYEQRYGALd--------aALGKIVltq---rgHALEN 175 Wautersia eutropha
AAK50624    144 mLSGYGIPREWe--------------rPTGLTFNAVGALITQRYMAASGSTp--------eEMAAVCval---rqWARLN 198 Rhodococcus sp. ...
Feature 1                                                                                       
A39368      196 PYSQfqd----eySLDEIMKSRPVf------dFLTVLQCCPTSDGAAAAIVSSEefvqkhg------lqskaveIVAQEM 259 Norway rat
ZP_00280498 181 PLAQyrk----piSLEDVLAQRPIv------ePLGLYEVPPRGDGAACIVLASEevarst--------grpyalLRGRGF 242 Burkholderia fun...
NP_420774   217 PHAWfpvertaeeLVTVTDRNRMVgy-----pYPKYLNAIMEVDQSAAVLIASVrkarelgv-----pedkwvfLHGCAD 286 Caulobacter cres...
EAA75378    218 PRTLe-------dIKTVSKRNRMIct----pyPLLMNAFNGVNLAAACIITSTEyatklgv------prekwvyVTGGAG 280 Gibberella zeae ...
CAE27197    208 PNAWikrafapneITTPSSDNRLIaw-----pYTKLMVANPSVNLGAAVLLTSLakaraagi-----pedkliyIHGGAS 277 Rhodopseudomonas...
NP_959832   219 PSASapv----erSVDELITVTPSnrmicdpyPRLLVARDQVNQGAAALLMSVAaarrlrv------peerwvfLHGHAD 288 Mycobacterium av...
NP_960511   207 PHAWirt----phSADDICRAGPHnrmi-swpYTKLMNSNNMVDQGAALVLTSVeqarrlkv-----pperwvyPLAGTD 276 Mycobacterium av...
AAN51312    192 PRAS---------VYGQEITEKQItrt--ivdPYSAPMIAIVTDHGFATLLVSEkkakklqtqgkikkginpmyLIGAGQ 260 Leptospira inter...
YP_025402   176 ERACeklr--rplALDDYLKSRKVs------dPLRLLDSVMFCDGANGVLMMRAetas-------------amgLSKCAR 234 Wautersia eutropha
AAK50624    199 PNAMykd---kdlTVEQVLGSKMVc------dPIHAMECPMLADGATAYVMTSTenarkt--------hdrwvrIAGSGG 261 Rhodococcus sp. ...
Feature 1                                                       #                               
A39368      260 VTDMPSTFEeksvi--kmvgyDMSKEAARKCYEKSGLGPSDV-DVIELHDCFSTNELLTYEALGLCPEGQGgal------ 330 Norway rat
ZP_00280498 243 HHEGAHQISevpnd---miefNAAVRAGAAAYREAGIEARDI-DIAEVYAPCTIVEVIVSEALGFFARGEGaaa------ 312 Burkholderia fun...
NP_420774   287 ACDLWYPLErqdy-----hssPAMRLTGQRAFEMAGISVDDL-DVIDLYSCFPSAVRIGAEEIGLALDDPR--------- 351 Caulobacter cres...
EAA75378    281 SNDSSDFWErsny-----yssPAIEYSIDNALKAAGLKKDEI-DCFDFYSCFPIVPKIACKHVGLDLLNPKkpit----- 349 Gibberella zeae ...
CAE27197    278 AEEPRDYLArdq------fvqSHAQNAVLETIKAMVGGDGRAfDAIELYSCFPVVPKMARRTLGLGDDVEPtvtggltff 351 Rhodopseudomonas...
NP_959832   289 MVDQPLLDRldl------tynSASVLAVQEALAGAGIGIDDV-STFDLYSCFPVPVFNFCDGTGLATDDPR--------- 352 Mycobacterium av...
NP_960511   277 AHDTASIAErhel-----hrsAAIRIAGARALQLAGLGIDDV-DHVDLYSCFPSAVQVAAAELGLGLDDPArplt----- 345 Mycobacterium av...
AAN51312    261 AVHSEYFMFkgd-------faTPAGRAGDLAFSTAGIEREEI-DYAWIYDCFVGMIILQSSEYFGVSKKEI--------- 323 Leptospira inter...
YP_025402   235 LAGYAERTNhdvqeqppdllaSGFVQAGPRALRQAGLTVQEI-DMLQLYDDFTIAVLMQLEHMGFCGRGEGaaf------ 307 Wautersia eutropha
AAK50624    262 CVSHYSIGQend------latMGWRRAGERAYEQAGWGPDDA-DIAQVYDSYAAVLTIGLEGLGLCKLHEGarl------ 328 Rhodococcus sp. ...
Feature 1                                             #                                         
A39368      331 ----vdrGDNTYGGKW----------VINPSGGLISKGHPLGATGLAQCa----ELCWQLRGea----------gkRQVp 382 Norway rat
ZP_00280498 313 ----aaaKETTLGGRI----------PISTSGGLTSRGHPALVTSLYNVv----ELVDQLLNra----------geRQVt 364 Burkholderia fun...
NP_420774   352 -------GLTITGGLPyfggpgnnyaLHAIAEMVAKLRARPGAYGLSTAng--wFLTKQSVGiy----------stRPVe 412 Caulobacter cres...
EAA75378    350 ----llgGLTSFGGAGnny----slhAIAEMVRVIRKGKYQNGLVLANGg----VLSWQHAIclsakp--krngsaYEAp 415 Gibberella zeae ...
CAE27197    352 gaplntyMTHAACAMArrlrdgakvgLLYGQGGFVTKHHGLIVSGTPPQqplseDVSVQAKAda-----------aYGVv 420 Rhodopseudomonas...
NP_959832   353 -------GLTLTGGLPyfggpgnnysLHGIAETVSEMRDRPGQFGLVAAng--gIMSKYSVGvy----------stTPVn 413 Mycobacterium av...
NP_960511   346 ----vtgGLTFAGGPWsny----vmhSIATMAELLVANPGRRGLITANGg----YLTKHSFGvygteppaefrwedTQSa 413 Mycobacterium av...
AAN51312    324 -------SESLKNGIIkfkn--gktiLVNQMGGILNYQAAMSVSAATGLvd--vAAHYGLYSke-----------sPNVl 381 Leptospira inter...
YP_025402   308 ----iekTDLRFSGGL----------PLNTGGGQLSAGQPGLAAGGLGLv----EAVRQLFGeg----------gaTQVe 359 Wautersia eutropha
AAK50624    329 ----faaGEFSPGGRL----------PVNTNGGLLSAGHTGVGGGTALLv----EGIRQLLGrae---------daRQIs 381 Rhodococcus sp. ...
Feature 1                                               
A39368      383 ---------gAKVALQHNL----------GLGGAAVVTLY 403 Norway rat
ZP_00280498 365 ---------dARWGLTTGE----------LGNYNAALVHV 385 Burkholderia fungorum LB400
NP_420774   413 gkw----erePPSVIQARIdalphpeiieKPQGRAVIETY 448 Caulobacter crescentus CB15
EAA75378    416 avl---dngqTSQGPTFTA----------QAQGEAIIETY 442 Gibberella zeae PH-1
CAE27197    421 prfv-teasgDGTVETFTViyd-----grGEVQHGVVMLR 454 Rhodopseudomonas palustris CGA009
NP_959832   414 wkpdnsaalrAEVAARPTVpv------tvRADGRATIETY 447 Mycobacterium avium subsp. paratuberculosis str. k10
NP_960511   414 vd------rePTTDAAVEWe---------GVGTVEAWTTP 438 Mycobacterium avium subsp. paratuberculosis str. k10
AAN51312    382 ---------iTRPGKTLLGg--------nGGIDSINSVAI 404 Leptospira interrogans serovar Lai str. 56601
YP_025402   360 ---------dPRNALVTGI----------GGLAYGRAWMM 380 Wautersia eutropha
AAK50624    382 dcr---ravcGGSGGTYMD----------SQVLLLERVDK 408 Rhodococcus sp. NCIMB 9784

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