1DD8,1FJ8


Conserved Protein Domain Family
elong_cond_enzymes

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cd00828: elong_cond_enzymes 
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"elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP) thioesters as primer substrates, as well as the nature of their active site residues.
Statistics
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PSSM-Id: 238424
View PSSM: cd00828
Aligned: 28 rows
Threshold Bit Score: 142.193
Threshold Setting Gi: 24984371
Created: 6-Mar-2002
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
active site
Conserved site includes 3 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Structure:1FJ8; E.coli KASI with bound inhibitor
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                      
1DD8_A       2 KRVVITGLGIVSSIGNn---------QQEVLASLREGRSGItfsqelk----------------dsgmrshVWGNVKldt 56   Escherichia coli
AAC38075    10 EPIAIIGSGCRFAKGAs--------tPEAFWELLRAGTDFVgpvpaerwdtaaiydesaaetgttyskvgaFLEHIDrfd 81   Pseudomonas fluo...
P23156      14 RRAVVTGLGVLSPHGTg---------VEAHWKAVADGTSSLgpvtreg----------------cahlplrVAGEVHgfd 68   Streptomyces coe...
1FJ8_A       2 KRAVITGLGIVSSIGNn---------QQEVLASLREGRSGItfsqelk----------------dsgmrshVWGNVKldt 56   Escherichia coli
AAD37451     8 LRLSGAGFVLPGPDGRac------tdLDTFWGVVRDGASCLspyahp-------------------elplrIAGTVNgwd 62   Streptomyces gri...
BAC90793     6 SGYAVTGIGLATPMGCe---------AQTVWNHLSQGRPLFgkdc-----------------------pgaGAGRVDdhh 53   Gloeobacter viol...
AAN68389    45 QAVAIAGAGCVLPSGWg---------VESFWAAATEGRSAItalnarr----------------fsservvAFGQIQdqd 99   Pseudomonas puti...
EAA66312    13 CSSVLLAWGVLSPVSKvprtavgkdhQLAYGQFSLEGAIEMa----------------------------wLMGYIRh-- 62   Aspergillus nidu...
CAE51175     1 MSIVITGIGAVTPAGDg---------VEPLWNSAREGTSHLatidrfd----------------agdyacpVAGQADfda 55   Streptomyces res...
AAQ61610     2 REVAITGIGVVGPHGVglagvldgrfVFSAWPDSASPPHAEsli-------------------------asVGDYPRtr- 55   Chromobacterium ...
Feature 1                                                                                      
1DD8_A      57 t---glidRKVVRFm-----sDASIYAFLSMEQAIADAGLSpeayqnnPRVGLIAGSGGG--------SPRFQVFGadam 120  Escherichia coli
AAC38075    82 ah-yfgisASEAKEm-----dPQQRLLLEVACESVARAGLTreq-lkgSRTAVYVGMLGM--------DYLALHSReagi 146  Pseudomonas fluo...
P23156      69 aa--etveDRFLVQt-----dRFTHFALSATQHALADARFGradvdspYSVGVVTAAGSG--------GGEFGQRElqnl 133  Streptomyces coe...
1FJ8_A      57 t---glidRKVVRFm-----sDASIYAFLSMEQAIADAGLSpeayqnnPRVGLIAGSGGG--------SPRFQVFGadam 120  Escherichia coli
AAD37451    63 petelplsERQIRRs-----sRAGLMATGAVHRALEHAGLSadd-ldpGRTALVACSLQFafpe-terYYALARDEg--- 132  Streptomyces gri...
BAC90793    54 ------ieRRIPARhaq-kldRFTMLAMIAGENALADSHFEiap-encYRVGLVVGNSTG--------GWTFLEPTmqal 117  Gloeobacter viol...
AAN68389   100 h----qrsRQDLAQnlqryctPAVIWGVSAVRQALEEAGLAdeq--pdVRFGLYCCQGGYthp--sleSYAELLHGcrqd 171  Pseudomonas puti...
EAA66312    63 -------fGGTIDGt------PYSGWVDSKTKKPVADVDIKt-----vYEKRILTHSGIQlvqpdqfeDPRFLYEIilqe 124  Aspergillus nidu...
CAE51175    56 d---aelpSRFVKRt-----dRFTHLAVHTVRRALADAGVAvgtdvspERTGVMVGNILG--------GWEFAERElrkl 119  Streptomyces res...
AAQ61610    56 ------yfSERALRlm----dKPMMLASFAAGAALEDAGYGdge--apEDCATLLGTARS--------EQTSVHKFslpl 115  Chromobacterium ...
Feature 1                                                                  #                   
1DD8_A     121 rgpr---------glkavgpYVVTKAMa------SGVSACLATPFKi---hGVNYSISSACATSAHCIGNAVEQIQLGk- 181  Escherichia coli
AAC38075   147 e---------------qinpYYAAGKEf------SFAAGRIAYHLGv---hGPAMTVTTACSSSLVAMHLACRALQAGe- 201  Pseudomonas fluo...
P23156     134 wgh----------gsrhvgpYQSIAWFy------AASTGQVSIRNDf---kGPCGVVAADEAGGLDALAHAALAVRNGt- 193  Streptomyces coe...
1FJ8_A     121 rgpr---------glkavgpYVVTKAMa------SGVSACLATPFKi---hGVNYSISSACATSAHCIGNAVEQIQLGk- 181  Escherichia coli
AAD37451   133 --------------------VAALGMEywlngtpPSVVGTVASGLRl---pCQTLSVAGSCNVALRTLHLVQQMFRCGd- 188  Streptomyces gri...
BAC90793   118 yse----------gmkavnsYTATAWFp------TAAQGEISIHHRi---gGYSKTVCADRLSAGFALELASVAVERGr- 177  Gloeobacter viol...
AAN68389   172 gvadmaafakrilqdraqdpFLVLKGLs------NCLLGVTSLALKl---vGECNAYMQGVAGNLAALREATAALQAGri 242  Pseudomonas puti...
EAA66312   125 dlkpl------hvrllkgarLYIPRAMns----nRTVAGLIPSGWDprtygDPEDVVTQVDPVTLYTLVSTVEALLSSgi 194  Aspergillus nidu...
CAE51175   120 wtd----------gpravspYQATAWFp------AAPQGNICIDQGi---kGPARTFVADRASGAYALIGAAETLLRGr- 179  Streptomyces res...
AAQ61610   116 lqg----------rperinpAEFPLVAr------NIACGQMAIRFGl---rGPSSVLASGPLASLQAVARAAGLIRSGr- 175  Chromobacterium ...
Feature 1                                                                                      
1DD8_A     182 -------qDIVFAGGGEElc----------weMACEFDAM----GALStkyndtpekaSRTYDAHRDGFVIAGGGGMVVV 240  Escherichia coli
AAC38075   202 -------aDMALAGGVNLmla---------pdLTIYMSQI----RAISps------grCRVFDAAADGIVRGEGCGVTVL 255  Pseudomonas fluo...
P23156     194 --------DTVVCGATEApla---------pySIVCQLGY----PELSrate--pdraYRPFTEAACGFAPAEGGAVLVV 250  Streptomyces coe...
1FJ8_A     182 -------qDIVFAGGGEElc----------weMACEFDAM----GALStkyndtpekaSRTYDAHRDGFVIAGGGGMVVV 240  Escherichia coli
AAD37451   189 -------iDRAIVVGVDTtvdp------vfvaGTSHTGRSg--yRASSlsdd---padVRPHDEIQTGNATGEGALAVVL 250  Streptomyces gri...
BAC90793   178 -------vEAVVVGGTEApls---------dfVLNAYAGA----GCLSps------gcYAPFEETADGRLLAEGSAMLVL 231  Gloeobacter viol...
AAN68389   243 ------daAIVVGAGSELda-----------lALSGLVQA----GVISang----sntLLPFDLRGTGGIAGEGAAALVL 297  Pseudomonas puti...
EAA66312   195 tdpyelyqYIHVSEDVLQetfinttgawvnmlLLSAAGPLrtpvGACAtaies-lelgYETNATGKAQFCLVGSCDVLIP 273  Aspergillus nidu...
CAE51175   180 -------aDVVLAGGVEAplspy----gwlclETSGLVAK----ARGSlap----helYRPFDAGHGGSVFAEGSVFLVM 240  Streptomyces res...
AAQ61610   176 -------aKVALAGGVEAl-------------SRFALRFC----RDYYgdaa--lagrPAFFGERGGGLIPSEGACMLVL 229  Chromobacterium ...
Feature 1                                                                                      
1DD8_A     241 EELEHAlar---------gahIYAEIVGYGATSDGADMVAps---gEGAVRCMKMAMHgv------------dtPIDYLN 296  Escherichia coli
AAC38075   256 KRLADAlrd---------gdpIQAVIRGSAINQDGASAGQtvp-naNAQAAVISQALKvagl---------svdDIDYVE 316  Pseudomonas fluo...
P23156     251 EEEAAArer---------gadVRATVAGHAATFTGAGRWAes---rEGLARAIQGALAeagc---------rpeEVDVVF 309  Streptomyces coe...
1FJ8_A     241 EELEHAlar---------gahIYAEIVGYGATSDGADMVAps---gEGAVRCMKMAMHgv------------dtPIDYLN 296  Escherichia coli
AAD37451   251 ENPAATgdrpgl---lhrahlRTSRSNGPSTVATGPPANVvg--dvLATLASARRGLG----------------DLAFVN 309  Streptomyces gri...
BAC90793   232 ELSPAAa-------------aRGAKVHCEILAIAGGDDLA------QAMRSCLHSAGVsp-------------eAVDYIV 279  Gloeobacter viol...
AAN68389   298 RRREDLsagpqacladmtahaSLGRLSLPDSPTDVLVCSGtgd-ahKDRVLCQTLALA----------------RASHIT 360  Pseudomonas puti...
EAA66312   274 ETSREFanmkatv--nteeelARGRPPTRCLVRQPAPMGLp----iRGIVAFVNTSSDkagrsvpaparemalqNLDVEV 347  Aspergillus nidu...
CAE51175   241 ERREHAerr---------garVLGELAGWGVSTDGYMPYYtveptgRVLGRAMRTATEragi---------sdgDLGAVF 302  Streptomyces res...
AAQ61610   230 EDAEHAaar---------garVYARLGGWHAGRLGRGDAVqs--llDGWRRAADMAPAl---------------LLPGAG 283  Chromobacterium ...
Feature 1       #                                         #                                    
1DD8_A     297 SHGTSTPVGDVKELAAIREVFgdk-------spAISATKAMTGHSLGAAGVQEAIYSLLMLEh-GFIAPSINIeeldeqa 368  Escherichia coli
AAC38075   317 AHGTGTPLGDPIELSSLDSAFqgre-----rplWVGSVKANMGHLDAAAGMASVIKTMMVLKh-AEVPAQLHLaqlnplv 390  Pseudomonas fluo...
P23156     310 ADALGVPEADRAEALALADALgpha-----arvPVTAPKTGTGRAYCAAPVLDVATAVLAMEh-GLIPPTPHVldvchd- 382  Streptomyces coe...
1FJ8_A     297 SHGTSTPVGDVKELAAIREVFgdk-------spAISATKAMTGHSLGAAGVQEAIYSLLMLEh-GFIAPSINIeeldeqa 368  Escherichia coli
AAD37451   310 DYADGNRFVEDHLCQALAGVKeaagy---ggelRLTNQEAVFGHVAGTGGLVKLLGSLLMLRh-GHIAPSANTlvp---- 381  Streptomyces gri...
BAC90793   280 LDAFGTPQRDDEEYRAIGEVFanh------aqlRMSAPKSMYGDLVGAGVAMDVIIACMSIEr-QAVLPTAGTparvksp 352  Gloeobacter viol...
AAN68389   361 SGLAINGILSAAPSLVDLMLA------------RCALQAQSVPPIAGLQQPVANLPFIQGAPh-AASLAHCLV------- 420  Pseudomonas puti...
EAA66312   348 SAVAAQDPTVNVDAYVHERRQqlltdftreeseARFKIGDNFWCNDPHIAPLSGALATWGLTinDLTAASFHDtstvlnd 427  Aspergillus nidu...
CAE51175   303 AHGSGIPFEDVTEGYGLWEAFgpga-----arvPVTAPKSGFGHLLGAAAPADVALALRAMAa-GSVPPTVNLdrqapgi 376  Streptomyces res...
AAQ61610   284 GAGRAHERLETLALRRWQAEGaaq-------psRLLAARALAGEGESWSGALQVALAAASLAr-RHAPATPDVaada--- 352  Chromobacterium ...
Feature 1                                                   
1DD8_A     369 ----aglnivtETTDRel--------tTVMSNSFGFGGTNATLVM 401  Escherichia coli
AAC38075   391 dwkrsrlavptAIESLpdr------prLAGISGFGLSGTNVHMIL 429  Pseudomonas fluorescens
P23156     383 -----ldlvtgRARPAep--------rTALVLARGLMGSNSALVL 414  Streptomyces coelicolor
1FJ8_A     369 ----aglnivtETTDRel--------tTVMSNSFGFGGTNATLVM 401  Escherichia coli
AAD37451   382 --------yagLPGDPvlagglatggdSALVLASGAGGDATSMVI 418  Streptomyces griseus subsp. griseus
BAC90793   353 p---vgrhvvgRPEAApi--------rYALVNARDEAGRSLALLL 386  Gloeobacter violaceus PCC 7421
AAN68389   421 -----------LNRDD-----------NGFSAAYQVHYSAKVTQD 443  Pseudomonas putida KT2440
EAA66312   428 k--nessviqtQLRSL-----------GHSKGAAGAWMLNGALQM 459  Aspergillus nidulans FGSC A4
CAE51175   377 ----eldivrgAARPApe-------weHTLVVSRGLGGVNACLLL 410  Streptomyces resistomycificus
AAQ61610   353 --------dpaLARAAaggtl--pddaAALVLGNDAAGAFCALGL 387  Chromobacterium violaceum ATCC 12472

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