1EBL,1EE0,1QLV


Conserved Protein Domain Family
init_cond_enzymes

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cd00827: init_cond_enzymes 
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"initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are characterized by the utlization of CoA substrate primers, as well as the nature of their active site residues.
Statistics
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PSSM-Id: 238423
View PSSM: cd00827
Aligned: 84 rows
Threshold Bit Score: 99.4295
Threshold Setting Gi: 46314333
Created: 6-Mar-2002
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
active sitedimer interface
Conserved site includes 3 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Structure:1EEO; Gerbera 2-pyrone synthase with bound acetoacetyl-Coa
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                       
1EBL_A        2 YTKIIGTGSYLPEQVRTNADLEKxvdtsd------------ewivtrTGIRERHIaap---------------------- 47  Escherichia coli
1EE0_A       21 LATILAIGTATPPNCVAQADYADyyfrvtksehmvdlkekfkricekTAIKKRYLaltedylqenptmcef-----maps 95  Gerbera hybrid c...
CAG36546      2 SVYITDIASFLPNAPVDNEQMEEilgmvnqlps-----rtrriilrnNRIKTRYYaidpvt------------------- 57  Desulfotalea psy...
ZP_00309989   5 NVYITKTASFFPNDPISNDEMEEylglinekns-----kskrivlrnNGIKRRFYa------------------------ 55  Cytophaga hutchi...
ZP_00106774   5 PVGIRSIALSFPTIRRTNNYYVEkypeli-------------aqaeqKGLARMFSltgtppanefdmemlpylsdpfrgt 71  Nostoc punctifor...
AAN18032      5 FAYITKTSTYMPGEAVDNDTMESilgyvggrps-----rsrqvvlrnNGIKQRYYvld---------------------- 57  Pseudomonas aura...
NP_623458   137 SRLKEGVSLEEIERQIENKAVPLrfng-----------------kivGCVKKAHDkditlssh----------------- 182 Thermoanaerobact...
CAE14457      4 NVYITKVSAFMPGNPIDNNTMESvlgfvggrps-----rsrhivlrnNGIKYRHYa------------------------ 54  Photorhabdus lum...
NP_348630    10 YVKLLGIGACLPGNPIKFEDINNyigqi---------------pnapKKIKTWISrvqpimkemlgidyc-------yya 67  Clostridium acet...
CAC14302    109 SFDLVKLTADFSKAVVEKLKAHElfsdaelekf----kdseeidsikTFVNEHHAeglynmgelvgcvkrah---evdns 181 Clostridium stic...
Feature 1                                                                                       
1EBL_A       48 --------netVSTXGFEAATRAIEXAG----------IEKDQIGLIVVATTSAtha-----fpSAACQIQSXLGik-gC 103 Escherichia coli
1EE0_A       96 lnarqdlvvtgVPMLGKEAAVKAIDEWG----------LPKSKITHLIFCTTAGvd------mpGADYQLVKLLGlspsV 159 Gerbera hybrid c...
CAG36546     58 ------getthSNTQLTAEAVRRLRPAAn---------FQLDEIECLCCGTSSPdql-----mpGHAPMVHGELGn--aA 115 Desulfotalea psy...
ZP_00309989  56 -----------IQKDGTPTHTNAQMASLairkl-fsnrEELKNIELLSCGTSSPdqm-----mpSHAVMVHGWLPe---T 115 Cytophaga hutchi...
ZP_00106774  72 ierwvlsheesSLTLEYCAATDALNAAK----------LSINDIDLMIVASVWPeqi-----gfGNAAFLARKLGl--vG 134 Nostoc punctifor...
AAN18032     58 --------pqtGIPRFTNAQITAEAIKGlvg-----dgFTLDSMQCLSTGTTLPdql-----mpNHGVMVHGELGnk-pC 118 Pseudomonas aura...
NP_623458   183 ----vmlenlaTKASAVLAFKHLLKNTG----------MSPEEIDYIIECSEEAcgdmnqrgggNFAKAIGEIVGcs-nA 247 Thermoanaerobact...
CAE14457     55 -----------LDPETGEATYTSAQLAAeavkglvdehFSLDDMQSLAASSGTSdqi-----ipGHGVMVHGELKnk-pC 117 Photorhabdus lum...
NP_348630    68 fngktrkfdedNLSLSVKASKLALQDAK----------IKPQDIDLLIYAGNYSyq------mpPISTRIQEELGid-iC 130 Clostridium acet...
CAC14302    182 ltahimfenlvVKASGVLAVKHLMKNSS----------VKADEVEYVIECSEEAcgdmnqrgggNFAKSIAEACSft-nA 250 Clostridium stic...
Feature 1                  #                                                                    
1EBL_A      104 PAFDVa---aACAGFTYALSVADQYVKSGav---------kYALVVGSDVLARtcdp--------------tdrGTIIIF 157 Escherichia coli
1EE0_A      160 KRYMLyq--qGXAAGGTVLRLAKDLAENNkg---------sRVLIVCSEITAIlfhgpne--------nhldslVAQALF 220 Gerbera hybrid c...
CAG36546    116 CEVMTaa--gICTSGMTAMRYAWLNVLAGqssnavatgselASTFMRSRLCNSvvseekieqmekqpvlsfeadFLRWML 193 Desulfotalea psy...
ZP_00309989 116 NAIEVvspsgVCCAGMHALKYAFLSIRSGdvstavasaserLSKVLRSETFEDevqkllelee--npsisfekeFLRWML 193 Cytophaga hutchi...
ZP_00106774 135 AAWNLd---gTCGSTPVVLQTASALVRAGey---------rNVLVVISCSYSRvfd---------------eqdTVSWFL 187 Nostoc punctifor...
AAN18032    119 EVVSTa---gICLAGLTALKYAYLSVLSGas---------sNAVATASEVLSPvlhar------------nfdaENEALV 174 Pseudomonas aura...
NP_623458   248 TGADVr---gFCAGPAHALLNAASLVKAGvf---------kNIVVVAGGATAKlgmngr----------dhvkkGLPVLE 305 Thermoanaerobact...
CAE14457    118 EVISTs---gACAAGMTAMKYAYLSVLSGatsnavsttsevPSTVLHARNFQSenearvaele-rrpeiafekdFLRWML 193 Photorhabdus lum...
NP_348630   131 SEYHIh---sNCSSIYKAIKLADTFLKSGey---------kNALVVSSMVSSAhfipeyynq----qkvtkedvFLRWYL 194 Clostridium acet...
CAC14302    251 TGSDTr---gFCAGPTHALINAAALVKSGvy---------kHVVVVGGGATAKlgmna-----------kdhikKNIPVL 307 Clostridium stic...
Feature 1                                                                                       
1EBL_A      158 GDGAGAAVLAASee--------------pGIISTHLHADgsy---------geLLTLpnadrvn---------pensihL 205 Escherichia coli
1EE0_A      221 GDGAAALIVGSGphlav-------erpifEIVSTDQTILpdt---------ekAMKLhlre--------------ggltF 270 Gerbera hybrid c...
CAG36546    194 SDGAGAAYLTNAprae---------glslKIEWIDLLSFahelpt---cmyagASKGksgalvgwr-----ehapvdalS 256 Desulfotalea psy...
ZP_00309989 194 SDGAGAFLLSDKpntegis----lridwmEAVSYANQVEp-------------CMYMasekledg-------tlksymdY 249 Cytophaga hutchi...
ZP_00106774 188 GDGAGAFVVSSMegnq----------gilGTKTVHTGALc------------eVVSAe---------------------L 224 Nostoc punctifor...
AAN18032    175 AQLAARPEIAFEkdflrwmlsdgagafliENQPRAGSLSlridwv---difsyANELptcmyagaeka-eddsltgwklL 250 Pseudomonas aura...
NP_623458   306 DVLGGFAVLVSQd---------------dGINPIIRLDSigrhtigagaspqaVMHAvaveplerlg--lkvtdvdkysV 368 Thermoanaerobact...
CAE14457    194 SDGAGAALLENKprpdgvs----lridwiDIYSFANEQEtcmysgg-ekladgSLKGwaqmsqadwl--aysvfcikqdV 266 Photorhabdus lum...
NP_348630   195 CDGAGAVVLSSKdtvd----------ngfYLKNTYVESAggk--------kesVMGNnfpsyfsnpltayengehhirqV 256 Clostridium acet...
CAC14302    308 EDVLGGFAVLVSed--------------dGISPVFNTDLvgrhtvgtgsspqaVITSlitmpldkgg--lkitdiskysV 371 Clostridium stic...
Feature 1                                                              #                        
1EBL_A      206 TXAgn---------eVFKVAVTELAHIVDETLAAnnndr--------sqldWLVPHQANl---------rIISATAKKLg 259 Escherichia coli
1EE0_A      271 QLHr----------dVPLMVAKNIENAAEKALSPlgitd--------wnsvFWMVHPGGr---------aILDQVERKLn 323 Gerbera hybrid c...
CAG36546    257 QGAmli------kqdVKLLNEEIITTAVERTLPRliekydl----qaeeidWFLPHYSSdyf-----rlaFYERMEKIGf 321 Desulfotalea psy...
ZP_00309989 250 TPEevvnqsilsikqDVKLLSKYIIEYGYDKLKAslekhgq----svkdvdYFLPHMSSdff-----knkISEKLIENGm 320 Cytophaga hutchi...
ZP_00106774 225 TKDeqg-------nsRVRMQTGNGAKALRETAAE-----------------FLSICCEGaias----agvTLEQIDFFLf 276 Nostoc punctifor...
AAN18032    251 TPEqwaar---sifaIKQDVRLLNENVVKYTLGRplkevmikhnlspesidWFLPHMSSeyf-----rkpIAECLENTEm 322 Pseudomonas aura...
NP_623458   369 EMQnpeitepagagdVPKANYKMIAALGVKRGDIeksqidef--ilkhgmpGFAPTQGHipsgv-pvlghIREKILKGEi 445 Thermoanaerobact...
CAE14457    267 RYL------------NERVVKFTLTEPLRRIVADrnlss--------esidWFLPHYSSeyf------rmKFSEGLDDI- 319 Photorhabdus lum...
NP_348630   257 TLDkmr------kyvVDENGKTIFYNALKRMLDKqkidl--------stlkYFMVNMPSk---------fVREYITNECv 313 Clostridium acet...
CAC14302    372 EMQnpditkpagagdVPEANYKMIAALGVKRGDLeksslptf--gkehgmpGFAPTQGHipsgvpfigfaIDEMKENKLd 449 Clostridium stic...
Feature 1                                        #                                              
1EBL_A      260 xs---------xdNVVVT----------LDRHGNTSAASVPCALDEAVRDgrik-------pgqlVLLEAFGGGFTWGSA 313 Escherichia coli
1EE0_A      324 lk---------edKLRASrh-------vLSEYGNLISACVLFIIDEVRKRsmaegksttgegldcGVLFGFGPGMTVETV 387 Gerbera hybrid c...
CAG36546    322 -------------AIPLDrwf-----tnLTSKGNTGSASIYIILAELFHSgrikr------gekiLCFIPESGRFSMCYM 377 Desulfotalea psy...
ZP_00309989 321 ei--------pfeKWFTN----------LYTVGNVGAGSMYLMIDELFNSgklkk------gekiLLLVPESSRFSYVFS 376 Cytophaga hutchi...
ZP_00106774 277 ntptawmtrfctrLLNINpertidlyplYANIGPVLTVANLYHAAHLGKIhen----------dlVLIYGSGAAGVASAS 346 Nostoc punctifor...
AAN18032    323 -------------AIPQErwy-----tnLSERGNTGAASIYIMVHELLESgrlh-------kgqrVLCFVPESGRFSGGF 377 Pseudomonas aura...
NP_623458   446 kramii-gkgslfLARMTn--------lFDGISMIIEANPGVKEEKGVEEke------------iRKMIAKALRDLAEHL 504 Thermoanaerobact...
CAE14457    320 -------------NFSIEqerw---ftnLTVKGNTGSASIYIMLDELMKSgklkk------dqrlLCFIPESARFTGAFM 377 Photorhabdus lum...
NP_348630   314 g-----------lGISPDkfy-----svSQKIGYAGPPAAIISLDRLLKNndf---------knnDLIFSFVLEVSKFMQ 368 Clostridium acet...
CAC14302    450 ------------kVMIVGkgs-----lfLGRMTNQFDGVSFVMEKNDGKGedkapq---vdeqqiKSMIADAMRKLAENL 509 Clostridium stic...
Feature 1         
1EBL_A      314 LV 315 Escherichia coli
1EE0_A      388 VL 389 Gerbera hybrid cultivar
CAG36546    378 LL 379 Desulfotalea psychrophila LSv54
ZP_00309989 377 ML 378 Cytophaga hutchinsonii
ZP_00106774 347 VM 348 Nostoc punctiforme PCC 73102
AAN18032    378 MH 379 Pseudomonas aurantiaca
NP_623458   505 IG 506 Thermoanaerobacter tengcongensis
CAE14457    378 HL 379 Photorhabdus luminescens subsp. laumondii TTO1
NP_348630   369 GG 370 Clostridium acetobutylicum ATCC 824
CAC14302    510 GQ 511 Clostridium sticklandii

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