1QFL


Conserved Protein Domain Family
nondecarbox_cond_enzymes

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cd00826: nondecarbox_cond_enzymes 
Click on image for an interactive view with Cn3D
nondecarboxylating condensing enzymes; In general, thiolases catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. There are 2 functional different classes: thiolase-I (3-ketoacyl-CoA thiolase) and thiolase-II (acetoacetyl-CoA thiolase). Thiolase-I can cleave longer fatty acid molecules and plays an important role in the beta-oxidative degradation of fatty acids. Thiolase-II has a high substrate specificity. Although it can cleave acetoacyl-CoA, its main function is the synthesis of acetoacyl-CoA from two molecules of acetyl-CoA, which gives it importance in several biosynthetic pathways.
Statistics
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PSSM-Id: 238422
View PSSM: cd00826
Aligned: 2 rows
Threshold Bit Score: 485.46
Threshold Setting Gi: 7767028
Created: 6-Mar-2002
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
active site
Conserved site includes 3 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Structure:1QFL; Zoogloea ramigera biosynthetic thiolase with bound reaction intermediate
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                     
1QFL_A      5 ASAARTAVGSFn---GAFANTPAHELGATVISAVLEragvaagevNEVILGQVLPagegqNPARQAAMKAGvpqeATAWG 81  Zoogloea ramigera
A39368     17 VGVGMTKFMKPggenSRDYPDLAKEAGQKALADAQIpys----avEQACVGYVYGe---sTCGQRAIYHSLgltgIPIIN 89  Norway rat
Feature 1         #                                                                           
1QFL_A     82 MNQLXGSGLRAVALGMQQIATGdaSIIVAGGMESMSmaphcahlrggvkmgdfkmidtmikdgltdafygyhmgTTAENV 161 Zoogloea ramigera
A39368     90 VNNNCSTGSTALFMAQQLVQGGlaNCVLALGFEKMEkgsl-------------------------------gtkYSDRSN 138 Norway rat
Feature 1                                                                                     
1QFL_A    162 AKQWql--------sRDEQDAFAVASQNKAEAAQKDGRFkdEIVPFIvkgrkgdiTVDADEYIRhg--aTLDSMAKLRPA 231 Zoogloea ramigera
A39368    139 PLEKhidvlinkygmSACPFAPQLFGSAGKEHMETYGTKveHFAKIGwkn---hkHSVNNPYSQfqdeySLDEIMKSRPV 215 Norway rat
Feature 1                                                                                     
1QFL_A    232 fdkegTVTAGNASGLNDGAAAALLMSEaeas-------rrgIQPLGRIVSWATVGVdpk----vmgTGPIPASRKALERA 300 Zoogloea ramigera
A39368    216 f---dFLTVLQCCPTSDGAAAAIVSSEefvqkhglqskaveIVAQEMVTDMPSTFEeksvikmvgyDMSKEAARKCYEKS 292 Norway rat
Feature 1                                                                   #                 
1QFL_A    301 GWKIGDLDLVEANEAFAAQACAVNKDLGWDp------------------sIVNVNGGAIAIGHPIGASGARILnTLLFEm 362 Zoogloea ramigera
A39368    293 GLGPSDVDVIELHDCFSTNELLTYEALGLCpegqggalvdrgdntyggkwVINPSGGLISKGHPLGATGLAQCaELCWQl 372 Norway rat
Feature 1                      #             
1QFL_A    363 krr-----garKGLATLCIGGGMGVAMCIES 388 Zoogloea ramigera
A39368    373 rgeagkrqvpgAKVALQHNLGLGGAAVVTLY 403 Norway rat

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