Conserved Protein Domain Family
SerRS_core

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cd00770: SerRS_core 
Click on image for an interactive view with Cn3D
Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme bound aminoacyl-adenylate. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs in the core domain. SerRS synthetase is a homodimer.
Statistics
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PSSM-Id: 238393
View PSSM: cd00770
Aligned: 42 rows
Threshold Bit Score: 406.946
Threshold Setting Gi: 7300003
Created: 24-Sep-2002
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 19 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Structure:1SES_A; T. thermophilus SerRS bound to Seryl-hydroxamate-AMP using 3.5A
    View structure with Cn3D
  • Structure:1SER_A; T. thermophilus SerRS bound to 3' end of tRNA using 3.5A
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                        #              
1SES_A      116 ANREIKRVGgppef-----------------------sfpplDHVALMEKNgww--epRISQVSGSRSYALKGDLALYEL 170
gi 8928378  124 ATRPIEFWGkpkvwkghvdafreqteaygfkvdheviewrprGHADMMEEVlklgdtlRAARVAGSRFYYLFEDLVFLDL 203
gi 30173195 120 DSIPVRHWGvvkttkdvvdkld-------kgvdylvvekapvGHADMAEVVlkmadtlKAGEVAGSRFYYLFDDLVWLDF 192
gi 13878795 120 NNQLVRYVGhakvfrddieefkkn---sgnsqdyevlderpkSHVDLGLDLnvi-dleSAARISGSRFYFIKNRLLKLEM 195
gi 7489823  167 SSVLRKEVGsqrsf-----------------------nfaikDHLQLGKELdlf-dfdAAAEVSGSKFYYLKNEAVLLEM 222
gi 6094414  118 DNLEIKRCGvppcf-----------------------sfsprDHVELARLLdiv-dfeAGKKVSGIKFYYLKREGVLLEQ 173
gi 23822219 185 QARVLHMVGdkpvf-----------------------sfqprGHLEIGEKLdii-rqkRLSHVSGHRSYYLRGAGALLQH 240
gi 3915062  118 DNFEIKRVGvvpqf-----------------------dfkpkDHLELGRDLdll-dfdRAREISGSKFYYLKNEAVFLEI 173
gi 33416907 185 QARVVEVVGekref-----------------------dfkpkGHLQIGESLdii-rqrRLSHVSGHRSYYLRGAGAQLQF 240
gi 7300003  100 PRELAQYVHrqltp-----------------------qsrlkEFSELARALnly-rmdHLGNYTGHKSYYLTGQLATLEQ 155
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                 # #                   
1SES_A      171 ALLRFAMDFMARRgFLPMTLPSYAREKAFLGTGHFp-AYRDQVWAIAe---TDLYLTGTAEVVLNALHSGEILPYeaLPL 246
gi 8928378  204 ALLMYAIDFMTSKgYVLVLPPYMLRYNVMSRVIDLe-TFKDAIYEIAg---EDLYLIATAEHPLAALYYNSEIYDedLPL 279
gi 30173195 193 ALAMYALDYLAQKgFRPVIPPYMLKYDLIRRVLDFd-TFKDAIYKIDg---EDLYLIATAEHGIAAYLYKRELLEeeLPQ 268
gi 13878795 196 ALENYAVDFLSQRgFSIVEPPYMLNLESMRGATDLe-TFKDTLYKIEg---EDLYLIATSEHSIAAMLSNQFLEEkdLPL 271
gi 7489823  223 ALVIWAISEVSKKgFTPLITPEIVRSSVVEKCGFSk-GKNTQVYSIEd---SDQCLIGTAEIPVGGIHMDSILAEsaLPL 298
gi 6094414  174 ALIMFGLQFLQERgFVPFLTPDIAREGMVCGLGFNprGSGSNIYRIEg---EHRCLVATAEITLGAYHAGEVLEErsLPR 250
gi 23822219 241 GLVNFTFNKLLRRgFTPMTVPDLLRGAVFEGCGMTpnANPSQIYNIDparfKDLNLAGTAEVGLAGYFMDHTVAFrdLPV 320
gi 3915062  174 ALINFSLNKLRDKgFDVFITPDVAREFIVDGIGFNprGNESNIYKIEd---TDKYLVGTSEITLGGYYYNKIIDLt-LPI 249
gi 33416907 241 ALQNFAMDLLQKRgFIPMVVPDILKSVVFEGCGMQphAQKSQVYSLNpkrsPDLNLAGTGKVGVAGYFMDHAVNLkdLPV 320
gi 7300003  156 AIIQYALQAVTEHgFKLISVPDILPKEVIESCGMRteGERTQVYKLD----TGECLSGTSEMALAGFFANKLLSEdqLPL 231
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                # #     #  #  # #  # # #                                               
1SES_A      247 RYAGYAPAFRSEagsfgKDVRGLMRVHQFHKVEQYVLTEas-lEASDRAFQELLENAEEILRLLelPYRLVEVATgdmgp 325
gi 8928378  280 KLVGVSPCFRKEagagnRDLKGIFRVHQFHKVEQFVYSLp---EESSKLHEELISNAKEIFKGLeiPFRVVNIASgdlga 356
gi 30173195 269 LYVGWSPCFRKEagagsRDIKGIFRVHIFHKVEQFVFSLp---EDSWKWHEEITKNTEELIRGLglPYRVVNICAhdlga 345
gi 13878795 272 RVAGISACFRREagahgKDTKGIFRVHQFNKIEQFVFCKp---EDSWDFLEEILGNAEAIYRSLgiPYRVVNVCSgelgr 348
gi 7489823  299 KYVAYSHCFRTEagaagAATRGLYRVHQFSKVEMFIFCRp---EESGKWHEELITIEEDLYASLglHFKTLDMATgdlga 375
gi 6094414  251 LYAGLSHCFRKEagaagQFSRGLYRVHQFTKLEMFAYCTp---SDSECLHERLRSLEEEIFTALeiPFRVVEVCAgdlga 327
gi 23822219 321 RMVCSSTCYRAEtn-tgQEPRGLYRVHHFTKVEMFGVTGpg-lEQSSQLLEEFLSLQMEILTELglHFRVLDMPTqelgl 398
gi 3915062  250 RMAGFSHCFRKEagaygQLSKGLYRVHQFSKVEMFCFCKa---EESGVIHDEFLSIQEQIFTELeiPYRVLNICSfdlgs 326
gi 33416907 321 RTVCSSTCYRAEtd-tgRETWGLYRVHHFTKIEMLGVSAnetgEESSQLLDQFVTLQKEIFSSLklHYRVLDMPTqelgp 399
gi 7300003  232 KVTAVSRCYRAEts-glQEEKGIYRVHQFNKVEMFAICTe---EQSEAELEEFKNIEVDLFRRLglNFRLLDMPPcelga 307
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                             ####                                             # #     #
1SES_A      326 gkWRQVDIEVYLPS---EGRYRETHSCSALLDWQARRANLRYRDPe----------------GRVRYAYTLNNTALAtpR 386
gi 8928378  357 caVKKYDLEAWMPA---QGKYREMVSASNCTDWQAYRLGIRLVRRk---------------gMERGYVHTLNATAVAstR 418
gi 30173195 346 paAKKYDIEVWYPS---QGMYRELASCSNVTDWQSYRLGIRVTRKg----------------MKREYVHTLNCTGLAttR 406
gi 13878795 349 laAKKYDIEAWFPA---QGKFREIVSASNDTDYQARSLNIKYRTS-----------------EGNRFVHTLNSTAIAttR 408
gi 7489823  376 paYRKFDIEAWMPG---LERYGEISSASNCTDYQSRRLGIRYRPSpseppststkkgkgaasGPTQFVHTLNATAVAvpR 452
gi 6094414  328 paYRKWDLEAWMPGr-qGGSWGEVTSASNCTDYQARRLNVRYKDAe----------------GKKHYVHMLNGTALAisR 390
gi 23822219 399 paYRKFDIEAWMPG---RGRFGEVTSASNCTDFQSRRLHIMFQTEa----------------GELQFAHTVNATACAvpR 459
gi 3915062  327 paYKKYDIEAWMPGrdgKGGYGEVTSTSNCTDYQSRRLKIRYKDQd----------------GQNKFAHMVNGTAIAttR 390
gi 33416907 400 paYRKFDIEAWMPG---RGSFGEISSASNCTDYQSRRLDIRYEGEd----------------GKLQYAHTVNATACAipR 460
gi 7300003  308 paYQKYDIEAWMPG---RQMWGEISSCSNCTDYQARRLGIRYRRSa---------------dGQILHAHTINGTATAipR 369
                       330       340
                ....*....|....*....|....*.
Feature 1                                 
1SES_A      387 ILAMLLENHQLQDGRVRvpQALIPYM 412
gi 8928378  419 TITAILENFQDEEGVVAipRALRRYL 444
gi 30173195 407 TITAILENFQREDGAVEipKVLRQYL 432
gi 13878795 409 ILVAIMENFQEGDRIRIp-DVLVPYT 433
gi 7489823  453 LIVCILENFQQGDGSIVvpEPLRPYM 478
gi 6094414  391 VLIALLENGQDAEGRVRipQALVPFC 416
gi 23822219 460 LLIALLESNQQKDGSVLvpPALQSYL 485
gi 3915062  391 VIISILENFQDQKGGVRipKSLVKYT 416
gi 33416907 461 TIIAILETYQTKKGTVQvpEVLQQYI 486
gi 7300003  370 LLIALLESYQKEDGIEIp-AVLRPFM 394

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