Conserved Protein Domain Family
OAT_like

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cd00610: OAT_like 
Click on image for an interactive view with Cn3D
Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase, alanine-glyoxylate aminotransferase, dialkylglycine decarboxylase, 4-aminobutyrate aminotransferase, beta-alanine-pyruvate aminotransferase, adenosylmethionine-8-amino-7-oxononanoate aminotransferase, and glutamate-1-semialdehyde 2,1-aminomutase. All the enzymes belonging to this family act on basic amino acids and their derivatives are involved in transamination or decarboxylation.
Statistics
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PSSM-Id: 99735
View PSSM: cd00610
Aligned: 161 rows
Threshold Bit Score: 268.668
Threshold Setting Gi: 15891268
Created: 6-Mar-2002
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site include 1 residue -Click on image for an interactive view with Cn3D
Feature 1:catalytic residue [active site]
Evidence:
  • Comment:pyridoxal 5'-phosphate (PLP) forms an internal aldimine bond (Schiff base linkage) with the catalytic residue lysine
  • Structure:2EO5_A; 4-Aminobutyrate-Aminotransferase catalytic residue (lys) and cofactor (PLP)
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                       
2EO5_A        6 IIEESDIYlatstr-------dpelfpLVIDhGEGVWIYDvdgNKYLDftsgigVNNLGWpSHPEVIKIgieqmqklaHA 78
gi 16262971  21 LFDRAKGVftdgttra---sverdpfpIYAQrGEGAYLVDvdgNRLLDlnnnftTLIHGH-GFAHVSEAvvdllrlgtCF 96
gi 24217074  23 LFERAKKVspggvhspvrsfrsvggtpVFFAsAKGATLTDisgKEYIDyclsfgPLILGH-RDPEVEEVvretteiawSF 101
2EPJ_A       15 LFERTKELfpggvnspv--raavkpypFYVKrGEGAYLYTvdgARIVDlvlaygPLILGH-KHPRVLEAveealargwLY 91
gi 15897133  14 LWAQAKQLfaggvnspv--raavkpfpFYVErGKGAYIYTvdgKKFIDyvlgygPLILGH-SPESVKRRiveqlergwLF 90
gi 24211734  13 LFKRAERVmpggvssp---vrrfdpypFYVErAEGSRLYTvdgHVLIDyclafgPLILGH-AHPEVVEAvvervregfHY 88
gi 14195648  11 LFEEAKKYlvggvnsp---vryfkpypFFVEkAKDCYLFDvdgNCYIDyclaygPMVLGH-ANDAVIKAvkeqlelgsAY 86
gi 32490822  10 LYVEAKKIipggvnsparsfyfvkeipVIAKrSKGPYIFDvdnNKYIDyicswgASILGH-NNYYITSKiieyskkglNF 88
gi 14194780  12 TFEEACQVfpggvnspvracrsvgvtpPIVSsAQGDIFLDthgREFIDfcggwgALIHGH-SHPKIVKAiqktalkgtSY 90
gi 13474293  40 KVGNGLPGffggvpmhw-mndwptpfpILVDsAKGAAITDidgNRLDDfclgdtGSMFGH-SPPPVARAirrqagrglTY 117
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                       
2EO5_A       79 AandfynIPQLELAKKLVTyspgnfqkKVFFSNSGTEAIEASIKVVKNtg-rkYIIAFLGGFHGRTfgsisltaska--- 154
gi 16262971  97 Anp---tEHEIALAELLTArip--ameRVRFVNSGTEAVMFAIKAARAftarpAIARIEGAYHGAYdwaeagqgvspgkd 171
gi 24217074 102 Gaa---ePYSLELAELISSrvp--waeKVRFVNSGTEAVMSALRVARAatgreKILKFDGCYHGHLdsllvkagsglage 176
2EPJ_A       92 Gap---gEAEVLLAEKILGyvk--rggMIRFVNSGTEATMTAIRLARGytgrdLILKFDGCYHGSHdavlvaagsaaahy 166
gi 15897133  91 Gtp---sELEIELARKIRShip--saqKIRFVNSGTEATMAAIRLARGytkrsKILKFSGNYHGAHdyalveagsaatey 165
gi 24211734  89 Gtp---tLPELKLAEKVVElvp--nveKVRLVNTGTEATMSAIRLARAytgreKIVKFEGCYHGAHdavlvragsgasel 163
gi 14195648  87 Gcp---tEKEIILAKEVVKrvp--caeMVRFVNSGTEATMSAIRLARGvtgrkKIIKFDGAYHGAHdyvlvksgsgalth 161
gi 32490822  89 Gll---tEIEIKIARLISKyip--sieMIRMVNSGTEATMSAIRLARSytkknKIIKFDGCYHGHAdfllansnldpydl 163
gi 14194780  91 Glt---sEEEILFATMLLSslkl-kehKIRFVSSGTEATMTAVRLARGitnrsIIIKFIGGYHGHAdtllggistteeti 166
gi 13474293 118 Mlp---sEDALAIGPLLQQrfg---lpFWQIATTATDANRFSLRVARAvtgreKILVFNGCYHGSVdetmvrliggkpvn 191
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                       
2EO5_A      155 ----------vqrsivgpfmpGVIHVPYpnpyrnpwhingyenpselvnrvIEFIEDYIfvnlvppeeVAGIFFEpIQGe 224
gi 16262971 172 gwdpipiptptyrgtpssvadEVHLLRFn---------------------dVEGLERRLsaa---sdrIACVLIDpMPSr 227
gi 24217074 177 -------sssdsagisatsiaNTLVLPLd---------------------dEASVERVFete---gknIAALIIEpLPAn 225
2EPJ_A      167 -------gvptsagvpeavarLTLVTPYn---------------------dVEALERVFaey---gdrIAGVIVEpVIAn 215
gi 15897133 166 -------nvatsdgvpmeimkTVEICEFn---------------------dLDCVDKKLrn-----edIATVILEpVMGn 212
gi 24211734 164 -------gapdspgipesvaeNTLVCPFn---------------------dVEAFVETVerf---deeIGAVIVEpVLGn 212
gi 14195648 162 -------ghpnspgipeettkNTILIPFn---------------------dEDAVKKAInen---kdeIACIIVEpIMGn 210
gi 32490822 164 f-----ssnpissgipknilkDTLICPYn---------------------dYESIEKIFdly---pnkIACIIVEpIAGn 214
gi 14194780 167 -------dnltslihtpsphsLLISLPYn---------------------nSQILHHVMeal---gpqVAGIIFEpICAn 215
gi 13474293 192 --------rpglagefrdltrTAKVIEFn---------------------dVAALEAALkd-----rdVACVIAEpVLTn 237
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                               #                       
2EO5_A      225 ggYVIPpknFFAELQKLAKKYgILLVDDEVQMGlgRTGKLFAIEnfntvPDVITLAKALgggimpIGATIFRkdldf--- 301
gi 16262971 228 agLLHPeptFIEALSETAHKYgILIVADEVLNL--RQGYAGASPryglkPDLVTAGKIIggg-fpIGAIGGReevmrvfg 304
gi 24217074 226 ygLLIQrkeFLLKIVETARKYgTLVVFDEVISGf-RVGFQGMSGllgiwPDLVTYGKIIggg-fpVGCYAGKkdlldlva 303
2EPJ_A      216 agVIPPrreFLAALQRLSRESgALLILDEVVTGf-RLGLEGAQGyfnieGDIIVLGKIIggg-fpVGAVAGSrevmsllt 293
gi 15897133 213 agVILPekdFLFGLRELTKTYnSLLIFDEVITGf-RISIGGAQSyyqiyPDITTLGKIIggg-fpIGAVAGKaeiidnft 290
gi 24211734 213 agCVPPdeeFLKVLREYCDGTeRLLIFDEVITGf-RLELGGAQEyygidADLVCLGKILggg-lpIGAFGGPeeymsrva 290
gi 14195648 211 vgCILPkegYLEFLREITEENdILLIFDEVITGf-RLAKGGAQEyfgvvPDIATLGKILggg-fpIGAIVGRrelmeqfs 288
gi 32490822 215 mgCVLPeknFLYKLRMLCNKFnSLLIMDEIITGf-RISLGGAQSyyniyPDITCLGKIIggg-lpIGAFGGKkrimnhvs 292
gi 14194780 216 mgIVLPkaeFLDDIIELCKRFgSLSIMDEVVTGf-RVAFQGAKDifnlsPDITIYGKILggg-lpAAALVGHrsildhlm 293
gi 13474293 238 scMVLAdpgFHDALRRLTRETgTLLLIDETHTI--STGPGGYTRkyglePDFFVLGKPIagg-vpASVWGMSdevasrya 314
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                       
2EO5_A      302 --------kpgmhSNTFGGNALACAIGSKVIDIVk--dLLPHVNEIGKIFAEELQgl------adDVRGIGLAWGLEYne 365
gi 16262971 305 t---enarpllpqGGTFSANPVSMAAGLAAMEAMtp-dAFDRLEAMGERLRAGLRasias-rdarFSVTGAASLFRIHpk 379
gi 24217074 304 ------psgpvyqAGTLSANPFGMRAGLATLKKVqrdsIYSVLDDRTKIFTDTMTkllnkksnqeWEAVIHSSLFWFRkk 377
2EPJ_A      294 ------pqgkvfnAGTFNAHPITMAAGLATLKALeeepVYSVSREAAKALEEAASevldrtglpyTINRVESMMQLFIgv 367
gi 15897133 291 ------pagkvfnAGTFNANPISMIAGIATIEELekeyPYIIANQAAKTLVEELErllk---tkhTINHVGSMFQIFFgi 361
gi 24211734 291 ------pegkvyqAGTFNGNPVSATAGLVTLEVLererPYDELSSKAERLASALEdgledrgiegVVNRVESMFQVYFgi 364
gi 14195648 289 ------plgaiyqAGTFNGNPISITAGIATLKQLdd-rFYKETARTAKILADTLReladkhnikaKVYNIASMFQIYFnd 361
gi 32490822 293 ------psgsvyqAGTFSGNPISMISGYACLKLLkspdLYNKLNKKTEYLVNELRssacdnkipvVINSLGSMFSIFFtn 366
gi 14194780 294 ------pegtifqAGTMSGNFLAMATGHAAIQLCqsegFYDHLSQLEALFYSPIEeeirsqgfpvSLVHQGTMFSLFFte 367
gi 13474293 315 dynrtkepgysgmGTTLSANPLQFAAMRATLEEVmtaeNYDRMDHLAERLDAGLTgvidryrlpwHVARVGARVEFICap 394
                       410       420       430       440       450       460
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
Feature 1                                                                         
2EO5_A      366 k----------------kvrDRIIGESFKRGLLLlpagrsaIRVIPPLVIseEEAKQGLDILKKVI 415
gi 16262971 380 rvapleyrdahlsaeeawimRTMSRYFLEAGILLpy---gaAACLSTPMVh-SDIDRILSAFDEFL 441
gi 24217074 378 tqqpirrid-lipeghkesfAKVFHTFLKNGIYLaps--gyEVGFLSWAHddEIIAKTLEIADKAL 440
2EPJ_A      368 eevsnaaq---arkadkkfyVKLHEEMLRRGVFIaps--nlEAVFTGLPHqgEALEIAVEGLRSSL 428
gi 15897133 362 devrnysd---akradkeyyIKFHERLLKEGVFIpps--qyETIFTSAAHkdDVIADTIDKLMKVI 422
gi 24211734 365 eevrdyad---vnsadhdafKRFHRELLEHGVWIaas--nyEAWFLSIAHteTDLERTEEAFEEAL 425
gi 14195648 362 kevvnyei---akqsdtekfMKYFWRLLEKGVFVpps--qfECCFTSIKHddEVVDKTIKAMEDVF 422
gi 32490822 367 ldkikcyk--dvsscnykkfILFFNEIKKLGILFsps--lfESNFITLMHkkKDLEKTIDSANKVF 428
gi 14194780 368 saptnfde---aknsdvekfQTFYSEVFDNGVYLsps--plEANFISSAHteENLTYAQNIIIDSL 428
gi 13474293 395 gplrngae--aetahapeleAAIHVALVNRGVLIap---fhNMMLISPATsgAQVNRLIAAFGAVA 455

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