Conserved Protein Domain Family
PTH

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cd00462: PTH 
Click on image for an interactive view with Cn3D
Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through abortion of translation and is essential for cell viability.This group also contains chloroplast RNA splicing 2 (CRS2), which is closely related nuclear-encoded protein required for the splicing of nine group II introns in chloroplasts.
Statistics
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PSSM-Id: 238259
View PSSM: cd00462
Aligned: 153 rows
Threshold Bit Score: 109.486
Threshold Setting Gi: 46444384
Created: 6-Mar-2002
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site include 1 residue -Click on image for an interactive view with Cn3D
Feature 1:catalytic residue [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                       #                                                               
2PTH          4 LIVGLANPGaeyaaTRHNAGAWFVDLLAer-----lRAPLREEak---ffGYTSRVTlgg--edVRLLVPTTFMNLSGKA 73
gi 42546881   7 LVVSLGNPLpk-yqSLHSAGHFALNGLA--------NVLRNPSfqektfgGQSCLVSqg---pkYTLVQSPTLMNISGRF 74
gi 49652995  11 MIASIGNPEpqyqgTRHNVGHWALDELItnhw-tsfNQFQNHKni---pdGVYSTSRvedlsdiFLFKSIYSFMNLQGAP 86
gi 46445460  25 FIASIGNPEpqyanTRHNAGHRLMNQLIdv----ywKDHVYKKg------PYYLSTKys---nlVLFKSNDSLMNLQGLP 91
gi 44985038  18 CLTGLGNPEpqyrnTRHNAGLILLDLLKahy---apGKPWMPCtvp-rvaASYCHASrh---dlLLLRSDGAFMNRSGQN 90
gi 49528969  20 CLTGIGNPEpsykgTRHNVGLTVLDLLIkqlv-prdQHVFRRE-------GKVHVLRtp---tiTFIRSDIGFMNLSGRS 88
gi 731759     8 VLTGIGNPEpqyagTRHNVGLYMLELLRkrl--glqGRTYSPVpn---tgGKVHYIEde---hcTILRSDGQYMNLSGEQ 79
gi 49652805  10 IIFSIGNPGs---tNRHSTGHIVMKALIeyf---gaKQLFKPLs-----nSMYSMTEvd----nIALVKSNNYMNDSNKL 74
gi 46444384  10 IFFSIGNPGp---iTRHSVGHFMLKRLMesssttsiKQLSNYS-------SYSLSVDsf---nnIIYIKSNTYMNESSKA 76
gi 3687505   32 IIYGLGNPGsafvkSRHSLGKLMVSMYAd-------SMAFPKN-------WPSTKEN-------LTLVLSTSYMNDSGKQ 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                       
2PTH         74 VAAMASFfri-----------------npdEILVAHDELDLPPGVAKFKLGGGHG----GHNGLKDIISKLgnn------ 126
gi 42546881  75 VARAWNDmikqq-------------dpsslSLIIVHDELEAKKGAVSLRAWDRSPr---GHNGIKDVKNKLsqdky---- 134
gi 49652995  87 VSKTWQKvsnyqk------------atrspALVVLHDELQVPFGKFQIRKQLSSAr---GHNGLRSIDSLMgg------- 144
gi 46445460  92 ISKHFGKhdq-----------------gksALVVLHDELQVDLGKYQIRKPGTSSr---GHNGLKSIDKYLkn------- 144
gi 44985038  91 VVPLWQRig-------------------gaTRVVVHDELSLPLGKVQLRAPGRSPr---GHNGLKSIIAAGaq------- 141
gi 49528969  89 VVPMWQKlyt-----------------dhtDYAVIHDELSLRTGALQLRQPQASLr---GHNGLRDISAHWrh------- 141
gi 731759    80 VCKVWARyak-----------------yqaRHVVIHDELSVACGKVQLRAPSTSIr---GHNGLRSLLKCSggr------ 133
gi 49652805  75 LKQYIEQekig---------------lrqaVLIVVYDEFDLDLGKVKISPFKKNE----SHNGIRSIKEYIsrqs----- 130
gi 46444384  77 WNKFKLSkeyrsfikeqdqdqdqdhhdqivSVIILYDDFENNLGTIKLKQFKKKSnnneSHNGLKNLKLSMidgnsn--- 153
gi 3687505   91 LKKISNDfvrkvs------------pldkiVYVVVHDELELDLGKVKLRLPGGSHr---GHNGIRSCQEFLgkevrytfn 155
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|.
Feature 1                                                                    
2PTH        127 -----pnFHRLRIGIGHPgdk-----nkVVGFVLGKPPv-SEQKLIDEAIDEAARCTEMWF 176
gi 42546881 135 ---ptspFVRIAVGIGRPsdger-drntVSDYVLNRISn-EERRIFEEDEVPRMVAQQLIQ 190
gi 49652995 145 ------gYTKISIGIGKPta------kdLSNYVLSPFTp-LEQEVLTYDVMPQIVNVLQEM 192
gi 46445460 145 ------rYFKLGIGIGRPpas-----qsVVHYVLKNFSs-QELDVIDWEVLPKCVKDLENM 193
gi 44985038 142 -----gtYYSLAVGIDRPetrk---paaIADYVLSRFSr-AELSQLEQDALPAALGHLNGL 193
gi 49528969 142 ------qYYKLAIGIDRPesrd---pqaVADYVLSKVPq-RDATYIENTTTSKALELLQRQ 192
gi 731759   134 -----vpFAKLAIGIGREpgsrsrdpasVSRWVLGALTp-QELQTLLTQSEPAAWRALTQY 188
gi 49652805 131 ---adltVYKLGIGIGPKpsna--ttstMSSWVLSNFKp-DERQIIDNLSIPLAIDYIDHV 185
gi 46444384 154 -natgeaIYLLGIGIGPKpnnnp-sgeiMRQWILSPFNkqSEKYKLETESFKLLQLYIDTM 212
gi 3687505  156 fitnsksFYRIGLGIGRCesrn---redVSDYVLSKFNs-NEMKLIETDIFHKFCNILQQL 212

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