1HRK,1LBQ,1LD3,1C9E


Conserved Protein Domain Family
Ferrochelatase_C

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cd00419: Ferrochelatase_C 
Click on image for an interactive view with Cn3D
Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is ubiquitous in nature and widely distributed in bacteria and eukaryotes. Recently, some archaeal members have been identified. The oligomeric state of these enzymes varies depending on the presence of a dimerization motif at the C-terminus.
Statistics
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PSSM-Id: 238240
View PSSM: cd00419
Aligned: 136 rows
Threshold Bit Score: 92.9779
Threshold Setting Gi: 78165895
Created: 6-Mar-2002
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
active siteN-terminal
Conserved site includes 4 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Structure:1C9E_A; Bacillus subtilis ferrochelatase with bound inhibitor, N-MeMP; contacts at 3.5A
    View structure with Cn3D
  • Comment:Structure has Cu2+ inserted into the porphyrin moiety.
  • Comment:The active site is located in a cleft between the N- and C-terminal domains. The active site is partially but not completely symmetrical, containing some residues from equivalent positions in both domains. An insert at the N-terminus of ferrochelatase makes additional contributions to the active site.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                     #    #                                            
1HRK_A      171 QCFADHILKEldhfpl--ekrsevVILFSAHSLPMSVvn----rgDPYPQEVSATVQKVMErle-----ycnPYRLVWQS 239 human
1C9E_A      151 TYWVDRVKETyasmpe--derenaMLIVSAHSLPEKIke----fgDPYPDQLHESAKLIAEgag------vsEYAVGWQS 218 Bacillus subtilis
ZP_00511916 174 QLCAAHVVAAsaeprl--grserhVLLLLFHGTLVTDgsgelpafRTGLDETMAFAASLTEllgsdvrhpygRIMTAFLN 251 Chlorobium limic...
ABB27904    178 QLYATYLYERlsvepnf-prqgklGLLLVVHGTLVRDrkgrppsvFTGLEATMQFFQAMKQvmqqhpdcmfaDVRQGCLN 256 Chlorobium chlor...
ABB23615    173 RIYVDHLFSKlegssfm-esrkklGLVLVIHGTLVRDragnppkvFTGLDETGRFFEMMKRrimedprnvftDIRQGCMN 251 Pelodictyon lute...
AAM72000    178 RLYLDHLFSSlpaawqgakggekqGLVLVIHGTIVKNrkgekpsvFTGLDETMEFFRLMKEkimadprnvfgEVKLGCLN 257 Chlorobium tepid...
ZP_00588306 170 SIYCDHLFEQrslrqa--pgseaqTLLLLFHGTLVADtkgntpqfRTGLDETRHFARRLQQlieedprnpysRIETVYLN 247 Pelodictyon phae...
ZP_00530133 170 ALYLSHLFEQiamrpv--vehenrVLLLLFHGTLVADakgrppafRTGHEEVVVFSESIRSavvkdvrnpysEVLVAYLN 247 Chlorobium phaeo...
ZP_00661087 169 RVYLNHLFSHasge-------egpALLLTFHGTLVKDrkgnepgfRTGYPEILRMGSALREavrndprspyqHVDIAYLN 241 Prosthecochloris...
ABB22993    179 RVYVNHVFRYgrnd-------pgaALLLAFHGTIIRDargcepgfHTGADEIGSMACALRNavladprnhyaRVEVTHYN 251 Pelodictyon lute...
Feature 1              #                                 #                             
1HRK_A      240 KVgp-mPWLGPQTDESIKGLCerg-rkNILLVPIAFTSDHIETLYELDIEYSqvLAKEcgveNIRRAESLN 308 human
1C9E_A      219 EGntpdPWLGPDVQDLTRDLFeqkgyqAFVYVPVGFVADHLEVLYDNDYECKv-VTDDig-aSYYRPEMPN 287 Bacillus subtilis
ZP_00511916 252 HDvg-gEWTRPSFEETAALLAdsg-vsNVALFAAGYFADGNETVYREQELRSm-LPAC----TITTIPCLN 315 Chlorobium limicola DSM 245
ABB27904    257 HSrg-gEWTSDTIEKALESFKrdg-ydGVVMFPYGFFADNSETDYDAFNRLKr-AAFP----YSLYVPCVN 320 Chlorobium chlorochromati...
ABB23615    252 HTag-gEWTSETVEKALEEFRreg-crGVVMFPYGFFADNSETEYQARELLEs-AGFP----LSRYVPCIN 315 Pelodictyon luteolum DSM 273
AAM72000    258 HSrg-gEWTPETVELALDEFAreg-frSVAMFPFGYFADNSETDYEAKKLLDr-SSAD----RKHYIPCVN 321 Chlorobium tepidum TLS
ZP_00588306 248 HNvg-gEWTKPSFEESCAKLRqng-agSVDLFAGGYFADGNETIHRAAELAAt-ASVK----NVTSIPCIN 311 Pelodictyon phaeoclathrat...
ZP_00530133 248 HEvg-gEWTKPSFEQVCRQLRqsg-arRIDLFAGGYFADGNETIYRAGELAAl-AETA----NVVSFPCVN 311 Chlorobium phaeobacteroid...
ZP_00661087 242 HQvg-gTWTEPSLLDSLREVAksg-itRADVFSVGYFSDGTEILRHAKEEAEa-SPVE----SVRLIPCLN 305 Prosthecochloris vibriofo...
ABB22993    252 HDig-gTWTRPAFPASLNALGdag-vdRADVFSCGYFSDGTETLLYAGRHAEr-GPVG----DVHFLPCVN 315 Pelodictyon luteolum DSM 273

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