1K0U,1V8B,3CE6,3G1U,3GVP,3N58,1A7A,1LI4,3D64,3H9U,3OND


Conserved Protein Domain Family
SAHH

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cd00401: SAHH 
Click on image for an interactive view with Cn3D
S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains
S-adenosyl-L-homocysteine hydrolase (SAHH, AdoHycase) catalyzes the hydrolysis of S-adenosyl-L-homocysteine (AdoHyc) to form adenosine (Ado) and homocysteine (Hcy). The equilibrium lies far on the side of AdoHyc synthesis, but in nature the removal of Ado and Hyc is sufficiently fast, so that the net reaction is in the direction of hydrolysis. Since AdoHyc is a potent inhibitor of S-adenosyl-L-methionine dependent methyltransferases, AdoHycase plays a critical role in the modulation of the activity of various methyltransferases. The enzyme forms homotetramers, with each monomer binding one molecule of NAD+.
Statistics
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PSSM-Id: 240619
Aligned: 108 rows
Threshold Bit Score: 510.846
Created: 6-Mar-2002
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 25 residues -Click on image for an interactive view with Cn3D
Feature 1:NAD binding site [chemical binding site]
Evidence:
  • Structure:1K0U: Rattus norvegicus S-Adenosylhomocysteine Hydrolase bound to NAD; contacts at 4A
    View structure with Cn3D
  • Structure:1A7A: Human placental S-Adenosylhomocysteine Hydrolase bound to NAD; contacts at 4A
    View structure with Cn3D
  • Citation:PMID 9586999
  • Structure:1V8B: Plasmodium falciparum S-adenosyl-L-homocysteine hydrolase bound to NAD; contacts at 4A
    View structure with Cn3D
  • Structure:3CE6: Mycobacterium tuberculosis S-adenosyl-L-homocysteine hydrolase bound to NAD; contacts at 4A
    View structure with Cn3D
  • Comment:GxGxxG(17x)E NAD binding site motif resembles GxGxxG(17-19x)D motif typical of FDH-like proteins

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                     
1K0U_A     15 AWGRKALDIAENEMPGLMrMREMYSASKPLKGARIAGCLHMTVETAVLIETLVALGAEVRWSSCNIFSTQDHAAAAIAKa 94  Norway rat
O67240     12 EEGLKRIEWAEMDMPVLRqIRERFSKEKPLKGKKISACLHVTTETANLMRTLKEGGAEVYLTASNPLSTQDDVAAALVKy 91  Aquifex aeolicus
Q8YX05     19 PLGRQRIEWAGREMPVLRqIRDRFAQEKPFAGLRLVACAHITTETAHLAIALKAGGADAVLIASNPLSTQDDVAASLVLd 98  Nostoc sp. PCC 7120
BAG14103   25 EKGSKRILWAEKKMPVLKqIKEKFLREKPLKGKKISSCLHVTAETANLAVALKAGGAEVYLCASNPLTTQDDVAASLVKh 104 uncultured Termite...
ACI20794   13 EKGKLRIEWAEMDMPVLRmIRDRFKKEKPLKGVKLAACLHVTTETANLMITLKEGGAELALCASNPLSTQDDVASALVKy 92  Thermodesulfovibri...
ACL26402   14 EQGRKRIEWAEKEMPVLRlIRERFARERPLAGLRISACLHVTTETANLMRTLVAGGADVVLVASNPLSTQDDVAAALVAy 93  Chloroflexus aggre...
ACO34570   19 DQGRKRIEWANQSMPVLQsIRKDFIKNQPLKGLRISACLHVTTETANLMITLRDGGADVALCASNPLSTQDDVAASLARd 98  Acidobacterium cap...
ADH62679   15 DLGQDRINWAAQEMPVLRqIKERFAREKPLQGVRIAACLHVTSETANLMRALKAGGAEVALCASNPLSTQDDVAASLVIh 94  Meiothermus silvan...
ADV63140   27 DVGHERIVWAERDMPVLReIRARFEAEKPLNGLRMSACLHVTAETANLARTLKAGGADLVLVASNPLSTQDDVAAALVRd 106 Isosphaera pallida...
AEB09250   27 DRGKLRVEWARQDMPVLSgIADRFRREKPLQGLRLAACLHVTTETAVLMATLKAGGAQVVVCASNPLSTQDDVAAYLARd 106 Desulfobacca aceto...
Feature 1                                                                                     
1K0U_A     95 -GIPVFAWKGETDEEYLWCIEqtlhfkdgPLNMILDDGGDLTn-LIHTKHPQLl-----------------------sGI 149 Norway rat
O67240     92 fEIPVFAIRGEDRETYYKHLRavi---ekEPDVVIDDGADLIs-TLHKEYPGLa-----------------------eKV 144 Aquifex aeolicus
Q8YX05     99 hEIPVFAQKGEDNATYNRHVQial---dhRPNIIIDDGSDVVatLVQERQHQIa------------------------DL 151 Nostoc sp. PCC 7120
BAG14103  105 yNIPVFAVKGENNETYYKHINavl---diKPQITMDDGADLVt-TVLLKRRDLl-----------------------kDI 157 uncultured Termite...
ACI20794   93 yKIPVFAIKGEDRDTYYKHIYqal---eiKPHITMDDGADLVs-TLHKEKRKLl-----------------------sHV 145 Thermodesulfovibri...
ACL26402   94 eEIPVFAIKGESNEVYYSHIRaal---dhNPQLTMDDGADLVt-GVLKERPDLi-----------------------pHM 146 Chloroflexus aggre...
ACO34570   99 fNIKTYAIKGEDNDTYYSHILaai---dhKPQVTMDDGCDLVt-ILHTKRKDAl-----------------------eGV 151 Acidobacterium cap...
ADH62679   95 dGIPVYAIKGEDKDTYYAHLEatl---asGPHFTMDDGCDLVt-LLHQQRHDLl-----------------------pGI 147 Meiothermus silvan...
ADV63140  107 fGVAVYAIKGEDEHSYYRHIAaal---rhLPNVTMDDGADLVs-AMIFIALGRmddlhpevrawaatlstearaklvsDV 182 Isosphaera pallida...
AEB09250  107 eEIPTFAIKGEDNETYYQHIQaal---diKPNITMDDGADLVf-TLHSTRQELl-----------------------pEV 159 Desulfobacca aceto...
Feature 1           ###                               #   #                        # ###      
1K0U_A    150 RGISEETTTGVHNLYKMmaNGILKVPAINVNDSVTKSKFDNLYGCRESLIDGIKRATDVMIAGKVAVVAGYGDVGKGCAQ 229 Norway rat
O67240    145 LGGMEETTTGVIRLRAMaeQGVLKFPIIAVNDAYTKHMFDNRYGTGQSTIDGILRATNRLLAGSYFVVAGYGWCGKGVAQ 224 Aquifex aeolicus
Q8YX05    152 IGTTEETTTGIVRLRAMfkDGVLTFPAVNVNDADTKHFFDNRYGTGQSTLDGIIRATNILLAGKNVVVVGYGWCGKGTAL 231 Nostoc sp. PCC 7120
BAG14103  158 IGGTEETTTGVVRLKAMakDKALAYPVIAVNDALTKHFFDNRYGTGQSTIDGIIRATNILLAGKVVVSAGYGWCGRGFAM 237 uncultured Termite...
ACI20794  146 LGGTEETTTGVIRLRAMadDGALKYPVIAVNDAYTKHLFDNRYGTGQSTIDGILRATNRLLAGSIFVVCGYGWCGRGVAM 225 Thermodesulfovibri...
ACL26402  147 VGSTEETTTGVIRLKAMakQGVLPFPVIAVNDSDTKHMFDNRYGTGQSTLDGIIRATNILLAGKTFVVAGYGWCSRGIAE 226 Chloroflexus aggre...
ACO34570  152 IGGTEETTTGVIRLHAMakEGVLNFPVVAVNDALTKHMFDNRYGTGQSTIDGIVRSTNVLLAGSKFVVAGYGWCGRGLAS 231 Acidobacterium cap...
ADH62679  148 FGGTEETTTGVIRLRAMaeDGVLAYPVIAVNDALTKHMFDNRYGTGQSTIDAILRATNVLLAGKTVVVAGYGWCGRGVAS 227 Meiothermus silvan...
ADV63140  183 VASMEETTTGVIRLRAMekDGVLKLPVLAVNDAETKHLFDNRYGTGQSTIDGIVRATDMLISGRRIVVVGYGWCGKGVAM 262 Isosphaera pallida...
AEB09250  160 FGGTEETTTGVIRLKAMaaQGVLRYPVIAVNDSQTKYMFDNRYGTGQSTVDGILRATNRLLAGSVVVVAGYGWCGRGFAM 239 Desulfobacca aceto...
Feature 1                ####  #                          ####  #                 ###         
1K0U_A    230 ALRGFGARVIITEIDPINALQAAMEGYEVTTMDEAckEGNIFVTTTGCVDIILGRHFEQMKDDAIVCNIGHFDVEIDVKW 309 Norway rat
O67240    225 RARGMGAIVIVTEVDPIKALEARMDGFLVMPMEEAakLGDFFVTVTGNIHVIRREHFEVMKDGAIVANSGHFNVEIDIPA 304 Aquifex aeolicus
Q8YX05    232 RARGMGANVIVTEIDPIKAIEAVMDGFRVLPMAEAapQGDIFITVTGNKHVVRGEHFDVMKDGAIVCNSGHFDLELDLKY 311 Nostoc sp. PCC 7120
BAG14103  238 RAKGLGAHVIVTEVDHLKAIEAAMDGFEVMPMREAaeKGDIFVTLTGNLNVIGGSHFPLMKDGAIVCNGGHFNDEIDLKA 317 uncultured Termite...
ACI20794  226 RAKGMGARVVVTEVDPLKALEAVMDGFDVMPIIDAakIGDIFVTVTGNINVISENVFSKMKNGAIVANTGHFNVEIDIEG 305 Thermodesulfovibri...
ACL26402  227 RARGLGANVIVTEIDPVKALEAVMDGFRVMPMVEAarQADFIVTATGNKHVIDQNAFEVMKDGCVIANSGHFNVEINIPA 306 Chloroflexus aggre...
ACO34570  232 RARGMGADVIVTEVDPTRALEAVMDGYRVMSMAEAakIGDIFCTVTGNKSVLRQEHFEAMKNGAIVANSGHFNVEIDIPA 311 Acidobacterium cap...
ADH62679  228 RARGMGAHVVVTEINPLKALEAVMDGFAVMPMREAarVGDIFITVTGNINVLDAQHYALMKDGAILCNAGHFNVEINIPA 307 Meiothermus silvan...
ADV63140  263 RARGMGGLVTVVETNPIRALEAAMDGFDVRDAKSAaaIGDLFVTVTGNMHALRGEHFALMKDGAMICNSGHFNVELALDQ 342 Isosphaera pallida...
AEB09250  240 RARGAGARVIITEVNPLKGLEAIMDGFQVLPMTEAapQGDIFCTLTGDINVIRQEHFLAMKDGAIACNSGHFNVELDIPG 319 Desulfobacca aceto...
Feature 1                                      # #      #                                     
1K0U_A    310 LNenavEKVNIKPQVDRYLLkNGHRIILLAEGRLVNLGCaMGHPSFVMSNSFTNQVMAQIELWTHpdkypVGVHFLPKKL 389 Norway rat
O67240    305 LEemavEKREIRKEVTEYKLkDGRRIYLLAEGRLVNLAAaEGHPASVMDMSFSNQALSAEYIVKHhkeleKKVYRVPREI 384 Aquifex aeolicus
Q8YX05    312 LAanakEIKEVRPFTEEYKLtNGKSVVVLGQGRLINLAAaEGHPSAVMDMSFANQALACEYLVKNkgklaPGLHSIPVEV 391 Nostoc sp. PCC 7120
BAG14103  318 LKkiskSVKNVRDFVDEYTLrNNKALCVLGEGRLINLVAaEGHPASVMDMSFANQAFSVRYLVKNyknleNNVHIVPEKF 397 uncultured Termite...
ACI20794  306 LNklskSKRVIREFVEEYTLkDGRRIYLLAEGRLVNLSAaEGHPAAVMDMSFANQALSAEYIFKNakkleKKVYSVPEEI 385 Thermodesulfovibri...
ACL26402  307 LEslsvEKRRPRAFVDQYILrDGRVINLLGEGRLVNLASaEGHPSAVMDMSFANQALASEFLLRNqgklpVGVHALPKEL 386 Chloroflexus aggre...
ACO34570  312 LArlasSKRAGREFVDEYALrDGRKIYLLGEGRLINLAAaEGHPASVMDMSFANQALAAEYLVKNhanleKKVYSVPVDL 391 Acidobacterium cap...
ADH62679  308 LEsaarEKRMGRPFIEQYTVeGGRSINLLAEGRLVNLAAaEGHPSAVMDMSFANQALSVEYMLQHkgqmkAGVYPVPEAI 387 Meiothermus silvan...
ADV63140  343 LKeqstEIKRVRQFVEEYQLkNGRKLYVLGEGRLINLAAaHGHPASVMDMSFAAQALATEWALKNkgrlgHTVHNVPKEV 422 Isosphaera pallida...
AEB09250  320 LEavtvGRRHIREFVEEFTLtNGKRVNILGDGRLINLAAaEGHPSVVMDMSFANQSLAAEYISKNhdkfeKKVYMLPTEL 399 Desulfobacca aceto...
Feature 1                                   
1K0U_A    390 DEAVAEAHLGKLNVKLTKLTEKQAQYLGMP 419 Norway rat
O67240    385 DEAVARLKLNALGIKIDELTEEQKKYLSSW 414 Aquifex aeolicus
Q8YX05    392 DQEIARLKLQAMGIYIDSLTPEQIEYINSW 421 Nostoc sp. PCC 7120
BAG14103  398 DNEIASLKLNSMSIKIDVLTAEQKEYLNSW 427 uncultured Termite group 1 bacterium phylotype Rs-D17
ACI20794  386 DREIARLKLESMGIKIDKLTKEQDKYLHSW 415 Thermodesulfovibrio yellowstonii DSM 11347
ACL26402  387 DREIAALKLAAMGVTIDTLTPEQEAYLNSW 416 Chloroflexus aggregans DSM 9485
ACO34570  392 DKRVARLKLEAMGIGIDRLTPEQEEYLASW 421 Acidobacterium capsulatum ATCC 51196
ADH62679  388 DQEIARLKLEAMGMQIDTLTPEQERYLNSW 417 Meiothermus silvanus DSM 9946
ADV63140  423 DEYVATLKLQTMGITLETLTPEQKKYLESW 452 Isosphaera pallida ATCC 43644
AEB09250  400 DMEIARLKLQSMLVDIDTLTEEQVKYLSSF 429 Desulfobacca acetoxidans DSM 11109

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