1CPZ,1FVQ,1AFJ,2AW0,1JK9,1CC8,1FE4,1K0V


Conserved Protein Domain Family
HMA

?
cd00371: HMA 
Click on image for an interactive view with Cn3D
Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain contains two cysteine residues that are important in binding and transfer of metal ions, such as copper, cadmium, cobalt and zinc. In the case of copper, stoichiometry of binding is one Cu+ ion per binding domain. Repeats of the HMA domain in copper chaperone has been associated with Menkes/Wilson disease due to binding of multiple copper ions.
Statistics
?
PSSM-Id: 238219
View PSSM: cd00371
Aligned: 105 rows
Threshold Bit Score: 30.6517
Threshold Setting Gi: 6522569
Created: 6-Mar-2002
Updated: 17-Jan-2013
Structure
?
Program:
Drawing:
Aligned Rows:
 
metal-binding
Conserved site includes 4 residues -Click on image for an interactive view with Cn3D
Feature 1:metal-binding site [ion binding site]
Evidence:
  • Comment:conserved metal binding sequence motif: M-[T/H]-C-X-X-C
  • Structure:1K0V_A:B. subtilis copper-transport CopZ protein bound to Cu ion
    View structure with Cn3D
  • Structure:2AWO: human Menkes Copper-transporting ATPase bound to Ag ion
    View structure with Cn3D
  • Citation:PMID 9437429
  • Structure:1FE4_A: Hah1 metallochaperone protein bound to Hg ion
    View structure with Cn3D

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....
Feature 1             ###  #                                                    
1CPZ_A        3 EFSVKgMSCNHCVARIEEAVGRIsGVkKVKVQLkkeKAVVKFDeanvQATEICQAINELGYQAE 66
1K0V_A        5 TLQVEgMSCQHCVKAVETSVGELdGVsAVHVNLeagKVDVSFDadkvSVKDIADAIEDQGYDVA 68
gi 3108347   24 EFMVD-MTCEGCVNAVKNKLETIeGIeKVEVDLsnqVVRILGSs---PVKAMTQALEQTGRKAR 83
gi 3929319   12 EFMVD-MTCEGCVSAVKNSMLKLdGVsGVDVDLsnqLVRVIGSv---PVKTMLKALEQTGRNAR 71
gi 6522569    4 EIRVPnLDCEGCASKLRKTLLKLkGVeEVEVEMetqKVTARGYr--lEEKKVLKAVRRAGKAAE 65
gi 4469010   19 EMMVP-LYSYGCEKKVKRALSHLkGIySVKVDYynqKVTVWGIc---NKLDVLAMVKKKRKEAR 78
gi 3377812   29 ALRVArIDCEGCERKIKHVLSGVkGVkSVDVDVklqKVTVTGYi---DPKKVLEAAKSTKKKVE 89
gi 18424719 174 VLKVH-MHCEACATEIKKRIMRMkGVeSAESDLkssQVTVKGVf--ePQKLVEYVYKRTGKHAA 234
gi 5759320   95 EFMVD-MSCQGCVSAVKSKLQTVeGVkNVDVDLdnqVVRILGSs---PVKTMTEALEQTGRKAR 154
gi 3080439   35 ELKVR-MDCDGCVLKIKNSLSSLkGVkTVEINKkqqKVTVSGYa---DASKVLKKAKATGKKAE 94

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap