1JJ2,1ML5,1I4J,1XBP,1S1I,2AWB,1BXE,1YJ9


Conserved Protein Domain Family
Ribosomal_L22

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cd00336: Ribosomal_L22 
Click on image for an interactive view with Cn3D
Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper folding and stabilizing the conformation of 23S rRNA. L22 is the largest protein contributor to the surface of the polypeptide exit channel, the tunnel through which the polypeptide product passes. L22 is also one of six proteins located at the putative translocon binding site on the exterior surface of the ribosome.
Statistics
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PSSM-Id: 238205
View PSSM: cd00336
Aligned: 132 rows
Threshold Bit Score: 66.3602
Threshold Setting Gi: 40068721
Created: 6-Mar-2002
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
protein-rRNAputative
Conserved site includes 24 residues -Click on image for an interactive view with Cn3D
Feature 1:protein-rRNA interface [nucleic acid binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1          # #  # ###  #   #  #                                                         
1JJ2_Q       14 AKAMLRERQMSFKHSKAIAREIKGKTAGEAVDYLEAViegdqpvpfkqhnsgv--ghkskvdgwdagrypeKASKAFLDL 91
gi 56469407  15 AQARGDNLKVHFKNTYETADAIRGMKVARAQEFLKNViikkeivpfrkhnggvgrkaqckglncafgrwpvKSAQFILKL 94
gi 68352243  15 AKAYGAYLRVHFKNTYETATAIKGMLVKDAKRYLNDVierkrcvpfrkfrggvgrcaqakafkhtqgrwpeKSCKFLLDL 94
gi 32400993  17 VKARGSDLRVSFKNTYETGSAIKGMKLERAQKYLQNVidkkeivpfrrykigvkgkpqcrthkvavgrwprKSCEFILGL 96
gi 57231446  15 CKAKGTNFRVHYKNTSETGRAIKGMHLHKARSYLSNVvehkqcipfrrhkggvgrcaqaknfnttqgrwpkKSCEFMLQL 94
gi 13794392   8 ISCMLKNQKVHLKNTREVGCCIIGMTLGRAENFLKNVilkkeivpfkvyrygigrksqvnqsknisgrwpkKSAKIILSL 87
gi 54659731  15 VMCKGSDLRVSYKNTYETATAIKGMYLLDARQYLLDViakkrcvpfrrfnggvgrtakanefkltqgrfpeKSCRFLLDL 94
gi 70833943  15 AKAKIADLRCHYKNTFETANVINGMKLRKAQQLYRQVlaktrcipfkryngkigntaqakewgqtkgrwprKSVVAMLSL 94
gi 29247827  14 GKSRRDGVKASFKNTYSTCRAIKGMGVKRAFAYLDNVlnhkeivpffkfykgvgrhsqargsgtdkgrwpeKSVVVVKDI 93
gi 62660923 604 GQLQMGLLHSPEKNTRETAQAIKGIHTRKATKYPKDVtl-------------------------------kKQCVPFRWY 652
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*..
Feature 1         #   #  #            # ### #  #           ######        
1JJ2_Q       92 LENAVGNADHqgfd-geaMTIKHVAAHKVGEQQGRkpramgraSAWNSPQVDVELIL 147
gi 56469407  95 LKNAVDNAKAkgln-talLTVSHIAVQEARSSRRRlyrahgsiNSFSSSPCHIELIL 150
gi 68352243  95 LKNLESNAEVkgle-qskLRLEHVQVNRAPVGRRRsyrahgriIPFLSHPCHVELIA 150
gi 32400993  97 LKNAESNAELrgid-tdaLVVTHMQVNKARRGRRRtfrahgriNAFMSQPCHVEMFL 152
gi 57231446  95 LKNAESNAELrgld-vdsLVVAHVSVDAAAKMRRRtyrahgriNPYMSSPCHIELCL 150
gi 13794392  88 IKNLNSIVSKnkse-dnpFYIKNININQAVRGRRRtfrahgrvNSFESNPCHIRISL 143
gi 54659731  95 LQNAESNCDMkgld-vdrLMLVSVVVTHAPFNRRRtfrahgriTPFKSQPCNIQLIF 150
gi 70833943  95 LKNAEANAIEkgld-pgkMVIKHVQVDQAPRVRRRtfrahgriTPYMRSPCHVQLFM 150
gi 29247827  94 LKQAVSNAKHahkkeedeLYVISYCVNRARGRRRRtfrahgriSKYESQPCHVELIV 150
gi 62660923 653 NGGVGFGCRF--------SVIEHIQVNMAPKTRQRtyrahgriNPSMSSPCHTEMIL 701

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