Conserved Protein Domain Family
IGPS

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cd00331: IGPS 
Click on image for an interactive view with Cn3D
Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the release of carbon dioxide and water. IGPS is active as a separate monomer in most organisms, but is also found fused to other enzymes as part of a bifunctional or multifunctional enzyme involved in tryptophan biosynthesis.
Statistics
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PSSM-Id: 238203
View PSSM: cd00331
Aligned: 133 rows
Threshold Bit Score: 172.648
Threshold Setting Gi: 10640085
Created: 6-Mar-2002
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 17 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Structure:1LBL; Sulfolobus solfataricus IGPS with bound CdRP substrate; contacts at 3.5A
    View structure with Cn3D
  • Comment:The IGPS active site consists of four subsites: the phosphate-binding site, the ribulose/triose-binding site, the anthranilate (substrate)- binding pocket and the indole (product)-binding pocket.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                         # #  ###                                   #                  
1PII         39 FYDALQga----rTAFILECKKASPSkgvirdDFDPARIAAIYKHy---aSAISVLTDEKyFQGSFNFLPIVSQia---- 107
1LBL_A       32 LNERILefnkrniTAIIAEYKRKSPSgl--dvERDPIEYSKFMERy---aVGLSILTEEKyFNGSYETLRKIASsv---- 102
gi 10640085  26 LRRAIElcngegrRGLIAEYKRRSPSgf---sTDEDISSYLSYVKmh-riAGLSILSEPThFSGSFDDVTLAHRig---- 97
gi 14325289  26 LKERIIelnrsgkRGVIAEYKRRSPSgl---kVDYSIEDYLSYVMeh-riAGLSILTEPSfFNGSFQDVVVAHRyn---- 97
gi 29541726  36 FKRIISst----pTTIIAEIKRRSPSkghlaeIADPVALAKQYVQgg--aAGVSVLTDKLaFDGSIRDLQQVSLelrd-- 107
gi 29834671  47 FATALKep----gLSIIGEIKRQSPTrgkirsIDSPADLALKYCCgg--aSAISVLTDTQgFGGSFLDMQQVNQklqsqy 120
gi 32261549  36 IKPHLDs------VFFIAEIKRSSPSagtikeIPSVTKLAGDYLNgg--vGAISVLCEEHyFGGSLLDLMSVKSayp--- 104
gi 48430060  33 MNFNLNk-----kIGIIAEFKRRSPSgf---vNNENTDIFKYYDVihnsiAGMSILTEERyFNGNQMDVVSVQRyn---- 100
gi 78220925  36 FSQALRrp----gLVTIAEYKRASPSkgdiapELTPEQVAAAYAGag--aGALSVLTEETyFRGSLGYLERMAFcg---- 105
gi 89358072  86 AASFKAng----aPGIIAELKGGSPFdpsfrtMVPYKALAEDFDAvg--aAALSVAVERQaFRGSYSDLATVRDav---- 155
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1              # #                    #                              #                  
1PII        108 -pqPILCKDFIIDPYQIYLARyyqadACLLMLSVLdd-----dQYRQLAAVAHSLEMGVLTEVSNEEEQERAIalgaKVV 181
1LBL_A      103 -siPILMKDFIVKESQIDDAYnlgadTVLLIVKILte-----rELESLLEYARSYGMEPLIEINDENDLDIALrigaRFI 176
gi 10640085  98 --vPVLVKDFAPDDHFVESAYnaggdAVLAILDFLps-----eDVERIVRRSADLGMDVIEEYHDRKALKKFVdgdnVIL 170
gi 14325289  98 --iPILVKDFVPDSEFVDYGFnaggdAVLVILDFLdy-----eSIKRIVERAADLGMDVLEEFHNQDALKRQYirdnVMI 170
gi 29541726 108 rpvAVLRKDFILDPLQIEEAAvagadAILLIVAILk------dATKILLQKAHECGLEALVEVHNRQELDQAIeigaEII 181
gi 29834671 121 shvSVLRKDFILHPLQLAEAIffgahAVLLIVSVVg------eNLKFLIQEAQRLGLEVLTEIHDLSELELALeaeaPII 194
gi 32261549 105 -naCILRKDFIQYPQEVDVSYragadMVLLIVAMFinedggfsHFKMIYEECLKVGITPLIEVHTQAEIDFIAplqaPLI 183
gi 48430060 101 --iPILIKDFVSNDEMIESSYmiggdVILLIADFLer-----dKIEMLNRKIKSLGMEALIEFHDLKAFERITtdenVII 173
gi 78220925 106 --lPMLRKDFILHPLQVVQTAatpasALLLVVRMLeg----adGVRRLIEAAHEKSLEAVVEVFDEQDLEIARkagaRII 179
gi 89358072 156 -diPLLAQDIIFDLYQILEARlagadAVVLSAALLg------pQLAEFRERAASVAMDALVQVHTPQEVEAALaagaDFV 228
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
Feature 1         # # #                              ##                    ##               
1PII        182 GINNRDLrdLSIDl---nRTRELApklg-hnvTVISESGINTyAQVRELSHf-ANGFLIGSALMAHddlhAAVRRV 252
1LBL_A      177 GINSRDLetLEINk---eNQRKLIsmip-snvVKVAESGISErNEIEELRKlgVNAFLIGSSLMRNp---EKIKEF 245
gi 10640085 171 GYNRRDLvsLKTG-----EDQDMPqy-----dITILESGINI-DNVVHVDMr-YSGFLIGTSILKRd---GTLEYL 231
gi 14325289 171 GYNRRDLtnLLMDe----KIPDFSg------eVRILESGISI-DNVKNLDLk-FQGYLIGTSILKKd---GTLEYL 231
gi 29541726 182 GVNNRNLttFSVDp---nNALKLKpyip-dhiISVAESGIHTvSDAKRYISagYNAVLVGEALVKSenpqQFISAI 253
gi 29834671 195 GVNHRNLqtFEIDl---nLSEILKpfip-pqiITVAESGIHHpTQAKRMRElgFDAILVGEALVSSkdpsLLIKQM 266
gi 32261549 184 GINSRSLhtFEINi---pAACALKnal--shsKIIFESGIDSpYSAFIIGSldFDGLLCGSYLVSHknptTALQSL 254
gi 48430060 174 GYNRRNLktLKIEdesfdAQDLIRst----glLSVLESGITS-ENILKMPR--YNAMLIGSSILSNdsvlKSAGMI 242
gi 78220925 180 QVNNRDLstLRTSl---aISGRLVkerd-aaeCWISASGITGtNHRKYVEAlgFDAMLVGTVLMSGgdpaGNLVRL 251
gi 89358072 229 CATNRNIhtFELVp---gTCETLIplipaakaLVVAEGGLGTaADRERLGAagAKALLIGTAMMKDadpaGVLEQV 301

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