Conserved Protein Domain Family
Chemokine_CXC

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cd00273: Chemokine_CXC 
Click on image for an interactive view with Cn3D
Chemokine_CXC: 1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteine residues; includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; many members contain an RCxC motif which may be a general requirement for binding to CXC chemokine receptors; those with the ELR motif are chemotatic for neutrophils and have been shown to be angiogenic, while those without the motif act on T and B cells, and are typically angiostatic; exist as monomers and dimers, but are believed to be functional as monomers; found only in vertebrates and a few viruses. See CDs: Chemokine (cd00169) for the general alignment of chemokines, or Chemokine_CC (cd00272), Chemokine_C (cd00271), and Chemokine_CX3C (cd00274) for the additional chemokine subgroups.
Statistics
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PSSM-Id: 238171
View PSSM: cd00273
Aligned: 28 rows
Threshold Bit Score: 58.8125
Threshold Setting Gi: 2914268
Created: 1-Nov-2000
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
  next features
Conserved site includes 19 residues -Click on image for an interactive view with Cn3D
Feature 1:tetramer interface [polypeptide binding site]
Evidence:
  • Comment:composed of dimer interface I and a dimer interface distinct from the P form
  • Comment:1TVX_A/B, C/D (NAP-2) dimers interact to form a dimer of dimers
  • Citation:PMID 7706245
  • Structure:1TVX_A,B,C,D; NAP-2 forms a homotetramer
    View structure with Cn3D
  • Citation:PMID 2914894
  • Comment:some members of the CC subgroup also form tetramers

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
Feature 1        #  #             ##  ###         #### #    ##  #      #   #  ## 
1TVX_A        7 ELRCLCIKTTSg-IHPKNIQSLEVIgkGTHCnQVEVIATLK-DGRKICLDPDAPRIKKIVQKKLA 69
1SDF          6 SYRCPCRFFESh-VARANVKHLKILn-TPNC-ALQIVARLKnNNRQVCIDPKLKWIQEYLEKALN 67
gi 15822533  29 TLKCRCSGMVSgvIHPSFIEQIQVRyrGNGCpKDEVLISTK-NKKIVCVNPQAKWLQIVLKLLRS 92
gi 7673946   29 NLKCRCSGVIStvVGLNIIDRIQVTppGNGCpKTEVVIWTK-MKKVICVNPRAKWLQRLLRHVQS 92
gi 7673945   30 SLRCRCVQESSvfIPRRFIDRIQILprGNGCpRKEIIVWKK-NKSIVCVDPQAEWIQRMMEVLRK 93
gi 9635092   31 DKRCKCVKVTNrpTGLGPIIAVDVIppGIHCrRTEIIFALK-KNRKVCVDPEAPWVQQFIKKLER 94
gi 17907349  27 VYRCPCRYFESn-VPKSNIKHLKILs-TSNC-SLQIVARLKhNGKQICLDPKTKWIQEYLEKALN 88
gi 24209771  29 AERCFCQKKALekVRPALVKKFEVFppSASCsNTEIILSLK-QGMKVCLDPEGNQGQKVLTGQKL 92
gi 20270901  30 KARCLCLNGLVnrVKPLHIEKLEVYtsSNSCrNMEIIVTLKnGKGKKCLNPEAPFAKKTIEKIMK 94
gi 30231262  29 VERCWCRSTVNt-VPQRSIRELKFLh-TPNC-PFQVIAKLK-NNKEVCINPETKWLQQYLKNAIN 89

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